• Journal of Hospice and Palliative Care
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• 제6권1호
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• pp.51-57
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• 2003

배경 : Anorexia-cachexia syndrome은 말기 암 환자에서 흔한 증상이며, 암 환자의 주린 사망 원인이 되기도 한다. 이들 증상들은 주로 암 세포 성장과 암세포에서 분비되는 cytokines이 중요한 역할을 한다고 한다. 일부 의사들은 비타민 C가 선택적인 항암 효과를 가지고 있을 뿐만 아니라 여러 가지 말기 암 환자에서 임상 증상을 호전시키는 데 도움이 된다고 보고하였다. 이에 저자 등은 비타민 C가 anorexia-cachexia syndrome을 유발시키는 기전 중의 하나인 사이토카인에 어떤 영향을 주는 지를 알아보고자 한다. 방법 : 2002년 3월 1일부터 2002년 8월 31일까지 국민건강보험공단 일산병원 가정의학과에 입원한 환자 49명을 대상으로 22명은 비타민 C를 1주일동안 지속적으로 10 g을 정맥 주사하였고, 나머지 27명은 비타민 C를 주사하지 않았다. 대상이 된 환자의 비타민 C를 주기 전과 주고 1주일 지난 후의 혈액을 채취하여 cytokine의 변화가 있는 지를 wilcoxon rank sum test를 이용하여 비교분석하였다. 결과 : 대상이 된 총 49명의 환자 중 22명(남자 12명, 여자 10명)이 비타민 C를 사용하였고, 27명(남자18명, 여자 9명)이 비타민 C를 사용하지 않았다. 비타민 C를 사용한 환자에서 $IL-1{\beta}$는 사용 전에는 $6.19{\pm}5.47$이고, 사용 1주일 후에는 $8.76{\pm}5.72$로 $2.94{\pm}7.29$만큼 증가하였고, IL-6는 사용 전에는 $3.07{\pm}8.09$이고 사용 1주일 후라는 $1.31{\pm}2.36$로 $-1.57{\pm}7.96$만큼 감소하였으며, $TNF-{\alpha}$는 사용 전에는 $2.74{\pm}14.24$이고 사용 1주일 후에는 $0.50{\pm}2.00$로 $-4.13{\pm}18.74$만큼 감소하였다. 비타민 C를 사용하지 않은 환자에서는 $IL-1{\beta}$는 사용 전에는 $1.00{\pm}2.19$이고, 사용 1주일 전에는 $17.16{\pm}81.55$로 $16.50{\pm}81.71$만큼 증가하였고, IL-6는 사용 전에는 $2.50{\pm}3.58$이고, 사용 1주일 후에는 $6.49{\pm}12.01$로 $4.11{\pm}12.14$만큼 증가하였으며, $TNF-{\alpha}$는 사용 전에는 $1.19{\pm}2.98$이고, 사용 1주일 후에는 $1.27{\pm}1.52$로 $-0.07{\pm}4.36$만큼 감소하였다. 비타민 C를 사용한 환자와 사용하지 않은 환자에서 사이토카인 변화는 모두 비타민 C를 사용한 환자가 사용하지 않은 환자보다 감소하거나 더 적게 증가하였지만 각각 통계학적인 의미는 없었다($IL-1{\beta}$에서는 P=0.06, IL-6에서는 P=0.166, $TNF-{\alpha}$에서는 P=0.54). 결론 : 비타민 C 사용여부에 따른 cytokines의 변화는 비록 통계학적인 차이는 없지만 비타민 C를 사용한 환자의 cytokines이 모두 사용하지 않은 환자에 비해 감소하였음을 보였다. 비타민 C는 부작용이 거의 없는 안전한 약으로서 말기 암 환자에서 비타민 C사용은 임상 증상을 호전시키는 데 도움이 될 것이라 생각된다.

• 호스피스학술지
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• 제1권1호
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• pp.46-69
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• 2001

Hospice Care is the best way to care for terminally ill patients and their family members. However most of them can not receive the appropriate hospice service because the Korean health delivery system is mainly be focussed on acutly ill patients. This study was carried out to clarify the situation of hospice in Korea and to develop a hospice care delivery system model which is appropriate in the Korean context. The theoretical framework of this study that hospice care delivery system is composed of hospice resources with personnel, facilities, etc., government and non-government hospice organization, hospice finances, hospice management and hospice delivery, was taken from the Health Delivery System of WHO(1984). Data was obtained through data analysis of litreature, interview, questionairs, visiting and Delphi Technique, from October 1998 to April 1999 involving 56 hospices, 1 hospice research center, 3 non-government hospice organizations, 20 experts who have had hospice experience for more than 3 years(mean is 9 years and 5 months) and officials or members of 3 non-government hospice organizations. There are 61 hospices in Korea. Even though hospice personnel have tried to study and to provide qualified hospice serices, there is nor any formal hospice linkage or network in Korea. This is the result of this survey made to clarify the situation of Korean hospice. Results of the study by Delphi Technique were as follows: 1.Hospice Resources: Key hospice personnel were found to be hospice coordinator, doctor, nurse, clergy, social worker, volunteers. Necessary qualifications for all personnel was that they conditions were resulted as have good health, receive hospice education and have communication skills. Education for hospice personnel is divided into (i)basic training and (ii)special education, e.g. palliative medicine course for hospice specialist or palliative care course in master degree for hospice nurse specialist. Hospice facilities could be developed by adding a living room, a space for family members, a prayer room, a church, an interview room, a kitchen, a dining room, a bath facility, a hall for music, art or work therapy, volunteers' room, garden, etc. to hospital facilities. 2.Hospice Organization: Whilst there are three non-government hospice organizations active at present, in the near future an hospice officer in the Health&Welfare Ministry plus a government Hospice body are necessary. However a non-government council to further integrate hospice development is also strongly recommended. 3.Hospice Finances: A New insurance standards, I.e. the charge for hospice care services, public information and tax reduction for donations were found suggested as methods to rise the hospice budget. 4.Hospice Management: Two divisions of hospice management/care were considered to be necessary in future. The role of the hospice officer in the Health & Welfare Ministry would be quality control of hospice teams and facilities involved/associated with hospice insurance standards. New non-government integrating councils role supporting the development of hospice care, not insurance covered. 5.Hospice delivery: Linkage&networking between hospice facilities and first, second, third level medical institutions are needed in order to provide varied and continous hospice care. Hospice Acts need to be established within the limits of medical law with regards to standards for professional staff members, educational programs, etc. The results of this study could be utilizes towards the development to two hospice care delivery system models, A and B. Model A is based on the hospital, especially the hospice unit, because in this setting is more easily available the new medical insurance for hospice care. Therefore a hospice team is organized in the hospital and may operate in the hospice unit and in the home hospice care service. After Model A is set up and operating, Model B will be the next stage, in which medical insurance cover will be extended to home hospice care service. This model(B) is also based on the hospital, but the focus of the hospital hospice unit will be moved to home hospice care which is connected by local physicians, national public health centers, community parties as like churches or volunteer groups. Model B will contribute to the care of terminally ill patients and their family members and also assist hospital administrators in cost-effectiveness.

• 한국간호교육학회지
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• 제7권2호
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• pp.308-322
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• 2001

The purpose of this study was to investigate the relationship between climacteric symptoms and management of menopause of middle -aged women. The subjects of this study were 261 women(40 to 60 years old). Data were collected from Jun. 1 to Jul. 15, 2001 by a structured questionnaire. The instruments employed were : 1) The Climacteric Symptoms Scale developed by Aeri Song and Eun soon Chung(1998). 2) The Management of Menopause Scale developed by Aeri Song(1997). The data were analyzed by the SPSS p.c. program using t-test, ANOVA and Pearson correlation coefficient. The results of the study were as follows : 1. Mean score of climacteric symptoms was $2.18{\pm}0.39$(Maximum 4, Minimum 1). The mean scores among the categories of climacteric symptoms, in descending order, were : a) physical and physiological reactions ($2.62{\pm}0.53$), b) social and family relationships ($2.23{\pm}0.50$), c) psychiatric and psychological reactions ($2.08{\pm}0.49$), d) relationship with sexual partner($1.73{\pm}0.54$), e) genitourinary reactions ($1.72{\pm}0.55$). 2. Mean score of management of menopause was $1.79{\pm}0.45$ (Maximum 4, Minimum 1). The mean scores among the categories of management of menopause, in descending order, were : a) dietary management($2.57{\pm}0.52$), b) self control ($2.24{\pm}0.57$), c) management of exercise and physical activity($2.14{\pm}0.75$), d) management of sex life($1.71{\pm}0.47$), e) management of professional health maintenance($1.61{\pm}0.59$). 3. There were statistically significant differences in the score of middle-aged women's self reported climacteric symptoms according to : a) occupation (t=-2.79, p<0.001) b) marriage state (t=-2.29, p<0.05) c) age of menarche (F=4.66, p<0.001) d) method of Sanhujori (post natal care & treatment) (F=4.22, p<0.001) e) hormone replacement therapy (t=-3.09, p<0.05). From the above statistics, several significant findings were noted : a) There were more climacteric symptoms from those who were unemployed, those who had no partner or were divorced and those who started a menarche earlier. b) There were less climacteric symptoms reported from those on hormone replacement therapy and those who followed their parents or parents-in-law advice regarding Sanhujori (postnatal care) 4. There were statistically significant differences in the score of middle-aged women's self reported management of menopause according to : The educational background (F=7.63, p<0.001), religion (F=3.74, p<0.001), income (F=3.65, p<0.001), number of parity (F=4.87, p<0.001), method of Sanhujori(postnatal care) (F=5.73, p<0.001), period of Sanhujori (postnatal care) (F=2.81, p<0.05), hormone replacement therapy (t=3.81, p<0.001). Women with higher educational background, strong religion, higher income, large number of parity, managed their post natal care well, were on HRT, managed their menopause significantly better than the others who took part in the survey. 5. It will be noted from the above that women's degree of climacteric symptoms showed a negative correlation to the management of menopause(r=-0.2146, p<0.001). The findings shown above suggest the need to develop a variable management of menopause, in order to improve climacteric symptoms of middle-aged women. It is hoped that the above findings will stimulate more detailed research into this matter, and thereby enable guidance to be given to women going through the menopause to cope with it in a less stressful way.

• 기본간호학회지
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• 제3권2호
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• pp.213-233
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• 1996

This study was made on 274 apoplectics patients who received the rehabilitation therapy and tests on physical, psychological and social adaptations as outpatients in 23 general hospitals in the Seoul and Kyungi area. The basic data on degree of improvement of apoplectic patients studied from rehabilitation therapy. Data was collected over a period of 63 days, from February 21st till April, 23, 1996. The assigned physical therapist conducted direct interviews with patients after he answered the distributed questionnaires for each individual patient. The colleted data was processed by the $SPCC/C^+$ method. The results of the tests conducted to meascne the the degree of ADL dependency, depression and social activity corresponding to the physical, psychological, and social adaptation. The details are ; 1) The test to meascne the degree of ADL dependency, corresponding to the study of physical adaptation of CVA patients, indicated a mean score of 2.57(ideal score is 1.0) with a standard deviation of ${\pm}0.75$. The worst score was 3.95 while the best score was a perfect 1.0, representing a severe range of dependency. The distribution was centered with a median of 2.65 and a mode of 2.68. 2) The test to meascne the degree of depression which corresponds to the level of psychological adaptation yielded a mean of 2.99 which is higher than the normal limit of 2.45. The standard deviation was ${\pm}0.52$ and the worst score and the best score were 4.35 and Respectirdy. The distribution was centered with a median of 3.00 and a mode of 3.00. 3) The test to meascne the degree of social activities for the level of social adaptation indicated a very low mean score of 26.52 (perfect score is 144), with the standard deviation of ${\pm}16.23$. Some patients scored as high as 100, but others scored as low as 3. The distribution of social activities at a very low level was shifted to the left with a median of 24.00 and a mode of 20.00. 4) Factors influencing the level of physical, psychological and social adaptation are as follows : Factors significantly influencing the level of physical adaptation measured by ADL dependency are age, personal guardian, payer of medical expenses, and paralysis of the right arm, right leg and facial paralysis. Factors significantly influencing the level of psychological adaptation measured by the degree of depression, are age, marital status, education, medical history of individual and family, speech impediment, and facial paralysis. Factors significantly influencing the level of social adaptation measured by the degree of social activity are age, marital status, education, employment status, and the burden of medical expense. 5) The Corelationship is significant(9.00), between ADL dependeing as degree of physical adaptation and depreseion as degree of psychologial adaptation. ADL dependency is proportional to depression. But social activity is inversely protional to ADL dependeny and depression. In conclusion, the increased care for physical function of the patients is not the only necessary means to better facilitate the appropriate adaptation of CVA patients. The introduction of a solid rehabilitation program for psychological and social adaptation will also play the integral part of the treatment of CVA patients.

• The Journal of Korean Physical Therapy
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• 제3권1호
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• pp.151-174
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• 1991

The purpose of this study is to research the actual conditions of industrial accident patients and to produce worker satisfaction and a rational and effective counter measure plan. Direct interviews with 179 cases (in and out patients) were carried out during a three month period from April to July 1990, at six hospitals : two general hospitals Sun Lin and Sung Mo in Po Hang, and four general hospitals in Taegu : Kyung pooh University Hospital, Dong San Medical Center, Young Nam Medical Center and Catholic Hospital. The results of this study are summarized as fellows : 1. Among the 179 cases, $51.6\%$ were male and $48.4\%$ were female. The two largest age groups were 30-39, $31.8\%$ and 20-29, $27.4\%$. Among the 179 cases, $51.6\%$ were married, the largest family number was 2 to 3, $41.1\%$ and 4 to 5, $25.6\%$. Educationally, graduation from high school was the largest group, $46.4\%$ among ,the patients, followed by middle school and primary school. The largest group income level was from 40-69 만원, $45.2\%$. The largest group of patients who worked over 50 hrs. a week was $52.0\%$. The largest group of patients who worked less than 1 year was $44.7\%$, of the patients in work places of less than 100 people, $60.3\%$ were injured and in work places of 100-299 people, $20.1\%$ were injured. In manufacturing, the largest group injured was $55.3\%$, the next group was transport, storage, communication. The largest group of production workers injured was $40.2\%$. 2. The cause of injury in the largest group was facility problems, $33.5\%$. The next group was unsafe habits, $30.2\%$ ; a lack of safety knowledge, $17.9\%$ ; and insufficient supervision, $12.3\%$. The 30-39 year age group head the highest number of injuries, $40.4\%$ ; work places with more than 10 years of work, $44.4\%$ ; work places with more than 1000 people, $56.3\%$ and mining accidents, $80.0\%$. Among. these groups the highest cause of injury was due to facility problems. 3. The accident pattern showed machinery injuries $28.5\%$ as the largest group, followed by falls & falling objects $17.3\%$, fire & electric $15.1\%$, strucke by an object $14.5\%$, followed by overaction and vehicular accidents. The accident pattern showed $46.4\%$ among workers over the 50 year age group, workers in the 5-10 year group, $50.0\%$ ; places employing more than 1000 workers, $35.3\%$ ; construction $73.7\%$, and construction workers $57.1\%$, among these fall & falling objects caused the greatest number of injuries. 4. The largest group of injuries was fractures $54.8\%$, trauma $14.5\%$, amputation $11.7\%$, open wound, and burns. The largest number of fractures occurred in people in the 30-39 year age group, $63.2\%$ : over 10 years of work, $55.0\%$ ; in work places of 300-490 people, $63.6\%$ ; construction $63.2\%$ and general workers $57.2\%$. 5. The largest group of injuries was upper extremity $45.3\%$, lower extremity $24.0\%$, trunk $18.5\%$ and head or neck $12.2\%$. Of these groups, upper extremity injuries were the highest in those less than 20 years old $75.0\%$, less than 1 year or work $59.5\%$, in work places of 500-999 people $60.0\%$, manufacturing $56.6\%$ and production workers $55.6\%$. 6. Periods of injury showed 34 people injured in September, to be the largest followed by October, 32 ; August, 22 people : July, 19 people and the lowest December, 2 people. During the week, Friday had the largest group injured, 35 people ; followed by Saturday, 26 people and the lowest was Wednesday, 17 people, During the day 1400 hours had the largest group injured, 38 people ; followed by 800 hours, 31 people. 7. On a basis of 5 as the highest mark, the average, according to worker satisfaction showed facility safety 3.55, work environment 3.47, income 3.44, job 3.21 and treatment 2.98. 8. The correlation between general characteristics and injury showed that age was directly correlated to the duration of work (r=2591) p<0.01, age was directly correlated to industry (r=2311) p<0.01, and the duration was directly correlated to occupation (r=4372) p<0.001.

• 인간행동과 음악연구
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• 제5권1호
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• pp.67-90
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• 2008

MI란 Music and Imagery의 약자로 심리치료의 한 방법인 GIM(Guided Imagery and Music)을 현실에 맞게 축약적으로 접목시킨 방법이다. 이는 치료목표에 적합한 음악감상을 통해 다양한 심상을 경험함으로 인간의 내면세계를 탐색, 직면, 통찰, 해결하게 한다. 본 치료사례는 MI기법을 활용하여 우울한 내담자의 긍정적 내적자원에 따른 심상을 체험하고, 그 체험을 언어적으로 표현한다. 또한 그 이미지들을 일상생활에 긍정적인 변화를 적용할 수 있도록 유도하는 지지적 수준의 개인 치료사례이다. 지지적인 수준(Supportive Level)에서의 MI는 음악 안에서 안전하게 서로 지지하는 수준에서만 사용한다. 개인세션 도입은 특정 느낌이나 주제, 단어 혹은 시각적 이미지를 연상하고, 이러한 이미지는 갈등적인 내용이 아닌 긍정적인 경험을 유도한다. MI의 한 회기 별 첫 번째 단계는 초기면담(Prelude)으로 상담의 초기면담과 같이 구체적인 목표를 정한다. 두 번째 단계는 전환(Transition)으로 여러 가지 내담자의 이야기 중에 가장 지지적인 주제를 좀 더 초점화하여 구체적으로 느끼고 표현 할 수 있도록 한다. 세 번째 단계는 긴장완화 및 음악 감상(Music Listening)으로 여러 긴장이완법 등을 사용하여 음악 감상하는 동안 심상이 잘 떠오를 수 있도록 이완 시킨다. 그리고 음악 감상 동안 음악이 가져다주는 여러 가지 심상들을 탐색하고 연상 할 수 있도록 한다. 마지막 단계는 마무리(Process)시간으로 음악 감상 동안 경험되어진 심상을 그림으로 표현하고, 개인적인 심상경험을 언어적인 과정을 통해 치료사와 공유함으로써 긍정적인 경험을 확장시켜 내적인 힘을 키운다. A 내담자의 경우 내담자와의 라포 형성하기(공감, 이해, 지지), 내담자의 긍정적인 자원탐색(어린시절, 가족), 내담자의 감정표현 및 긍정적 지지(현재의 나)의 구체적인 목표를 설정하였다. 음악은 내담자가 선호하는 음악과 치료사가 선정한 음악 중에서 음의 전개가 단순하고, 멜로디가 반복적이며, 리듬이 규칙적이며, 협화음으로 구성된 안정적이고 구조화된 음악을 사용하였다. 그 결과 A는 1, 2회기에는 방어기제를 많이 사용하고 우울로 인한 감정조절의 어려움을 보였으나 3회기 이후 자신이 좋아하는 음악과 지지적인 음악을 치료사가 제공하는 것으로 인해 공감과 지지를 경험할 수 있게 되었다. 이를 통하여 4회기부터 안정감을 갖고 세션 안에서 부정적 정서를 긍정적인 정서로 전환하고, 자신의 내재된 힘을 발견하게 되었다. 6회기에는 과거 힘들었던 시간들이 앞으로 갖게 될 좋은 시간을 준비하는 단계라고 인식하기 시작하였다. B 내담자의 경우 내담자와의 라포 형성 및 탐색하기(공감, 이해, 지지), 내담자의 문제 탐색 및 긍정적 인식(어린시절, 가족), 내담자의 감정표현 및 통찰하기(현재와 미래의 나)의 구체적인 목표를 설정하였다. 음악은 1, 2회기에는 안정적이고 구조적인 음악을 사용하였으나, 3회기 이후 곡의 전개가 점점 커지고 주제 멜로디의 변주로 음의 고저가 많으며, 협화음과 불협화음이 넘나드는 고전파와 낭만파의 음악을 사용하였다. 그 결과 B 내담자는 1,2회기에서는 대인관계의 어려움을 종교적인 관계로 전환하여 현실회피하려는 경향이 나타났으나 자신이 좋아하는 음악과 지지적인 음악을 통하여 공감과 지지를 경험할 수 있었다. 3회기 이후 B는 자신의 현실 문제를 인식하고 직면하였으나 회피와 직면의 양가감정을 갖게 되었다. 4회기 이후 B는 우울로 인한 감정의 변화를 음악 안에서 경험하고, 자신의 문제에 직면하였다. 5, 6회기에서는 긍정적인 자원을 통해 내적인 힘을 키우고 해결하려는 태도와 미래에서의 내가 좀 더 당당하고 건강하게 살아가려는 의지가 나타났다. 이와 같이 MI 프로그램은 GIM 프로그램보다 좀 더 현실적이고 짧은 회기수로 내담자의 문제들을 해결할 수 있다는 가능성을 제기한다. GIM처럼 깊은 무의식속으로 접근 하지 않고도, MI는 현실주의 상담과도 같이 내담자의 현실적인 문제를 근거로 하여 문제인식 및 통찰, 해결해 나갈 수 있다. 특히 음악의 사용에 있어서도 다양한 장르의 곡을 내담자에게 맞게 사용할 수 있으며, 음악감상 시간도 GIM에 비해 짧고 곡의 기능들도 구조화되어 내담자의 감정을 심상으로 잘 표현 할 수 있다. 그러므로 MI는 내담자의 음악선호도와 음악의 다양한 기능들을 활용하여 개인과 그룹으로 성인뿐만 아니라 아동 및 청소년에게도 알맞게 수정 보완하여 사용할 수 있음을 시사한다.

• 대한간호
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• 제33권5호
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• pp.63-75
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• 1995

The need of oriental nursing role is recently increasing. The implication of this trend is enormous not only for the need of independent of independent oriental nursing intervention. Hence, this study was designed to describe the characteristics of oriental nursing activity and identify the meaning of nursing activity in oriental hospital. A total of 24 nurses were selected by convenience sampling from eight units at one oriental hospital. A total of 168 data were collected using minute-by-minute recording during nurse s work shift. The data were analyzed using nova and scheffe method as post-hoc test The results of this study are as follows; 1. the category of nursing activity in oriental hospital 74.4% of nursing activity was the patient-oriented nursing care. The nursing activity included others (18.28%), the function-oriented nursing care (7.07%), and staff-oriented care (0.2%). 29.1 % of the patient-oriented nursing care was the direct care, and 24. 5 % of the patient-oriented nursing care was the indirect care. There was a lack of patient education and the communication patient. 2. Nursing activity in oriental hospital by characteristics 1) Nursing activity by unit For patient-oriented nursing care, there was a statistically significant difference among 8 units. In the critical care unit, the patient-oriented nursing care was mostly performed. For function-oriented nursing care, there was statistically significant difference among 8 units. In the physical therapy unit, the function-oriented nursing care was mostly performed. 2) Nursing activity in oriental hospital For all kinds of nursing activity, there was a statistically significant difference between shifts. In night shift patient-oriented nursing care, function-oriented nursing care, and other kinds of nursing care was mostly performed. Patient-oriented nursing care included indirect care, treatment set management, and the breaktime. In day shift, staff-oriented nursing care was performed. 3) Nursing activity in oriental hospital For all kinds of nursing activity, there was not a statistically significant difference by day. The day has not impact on nursing activity. 3. the meaning of activity in oriental hospital The results of this study show that the patient-oriented care was vital check, input! output check, medication, bedsore prevention, nasogastric feeding, oral care, catheterization care, perinatal care, nursing care associated with acupuncture and moxacautery, observation (fever, sweating), heat and cold application communication with patent and family, and patient room management In conclusion, two issues associated with the findings of the research appeated to be involved in the difficulty of nursing activity in hospital. The first issue was the nursing care in oriental hospital provided by nurses who have a limited understading of the principles of oriental medicine. The second issue was the deficiency of systematic guideling for oriental nursing activity. The findings suggest the need to develop the systematic guideline for oriental nursing activity. The need of continuing education for nurses who work in the oriental hospital, and the need of nursing education including oriental nursing are critical.

• 한국산학기술학회논문지
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• 제13권11호
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• pp.5317-5325
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• 2012

본 연구는 대사증후군 및 대사증후군 진단기준 인자의 유병률을 파악하고, 인구사회학적 및 건강관련행위 요인과의 관련성을 검토하며, 진단기준 인자의 군집화를 통해 대사증후군 위험의 분포를 분석하고자 하였다. 조사는 한 대학병원 건강검진센터에서 종합건강검진을 받았던 30세 이상의 지역주민 1,388명을 대상으로 허리둘레, 중성지방, 고밀도지단백콜레스테롤, 수축기혈압, 확장기혈압, 및 공복 시 혈당 등 대사증후군 진단기준 인자를 측정하였다. 분석은 이들 대사증후군 위험인자에 대한 유병률을 파악하고 위험인자의 군집화를 통해 대사증후군 위험의 분포를 파악하였으며, 관련요인에 따른 대사증후군의 위험비를 구하였다. 연구결과 조사대상자의 대사증후군의 유병율은 21.7%로 나타났으며, 대사증후군 위험인자별 유병률은 HDL-C, 혈압, TG, 허리둘레, FBS의 순으로 나타났다. 또한 관련변수에 따른 위험비에서 BMI, 흡연습관, 식품섭취 및 당뇨에 대한 가족력 등이 대사증후군의 위험비를 높이는데 관련된 것으로 나타났다. 따라서 대사증후군의 위험 관리를 위해서는 모든 생활습관 요인에 대한 평가와 중재가 필요함을 시사하고 있다.

• 한국식품영양과학회지
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• 제45권12호
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• pp.1708-1716
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• 2016

Akt 및 mTOR는 세포 생존에 필수적인 경로로 세포 성장과 증식 등에서 중요한 역할을 하는 것으로 알려져 있다. 본 연구에서는 항암 및 항균 효과가 있는 것으로 알려진 개똥쑥(Artemisia annua L.)에 의한 HepG2 간암세포의 apoptosis 유도 효과를 확인하였다. 본 연구 결과에 의하면 개똥쑥 추출물의 처리 농도가 증가함에 따라 HepG2 세포의 생존율은 억제되었으며, 이는 apoptosis 유도 효과에 의한 것임을 세포의 형태적 변화와 flow cytometry를 통해 확인하였다. 그리고 mitopotential assay와 caspase-3/7 activity assay, western blotting으로 Bcl-2 family 단백질을 확인함으로써 apoptosis 경로 중 내인성 경로(intrinsic pathway)에 의해 apoptosis가 일어남을 알 수 있었다. 이러한 효과는 Akt/mTOR의 활성 저해와 연관이 있었으며 Akt/mTOR의 저해제인 LY294002/rapamycin을 개똥쑥 추출물과 병행처리하였을 경우 개똥쑥 추출물에 의한 apoptosis 효과를 더욱 증대시켰다. 따라서 Akt/mTOR의 저해는 개똥쑥 추출물의 apoptosis 효과를 상승시켰으며 이에 따라 미토콘드리아의 기능 손상과 caspase 활성의 증가를 통해 이루어짐을 확인하였다.

• BMB Reports
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• 제45권9호
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• pp.532-537
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• 2012

P18, a member of the INK4 family of cyclin-dependent kinase inhibitors, is a tumor suppressor protein and plays a key cell survival role in a variety of human cancers. Under pathophysiological conditions, the INK4 group proteins participate in novel biological functions associated with neuronal diseases and oxidative stress. Parkinson's disease (PD) is characterized by loss of dopaminergic neurons, and oxidative stress is important in its pathogenesis. Therefore, we examined the effects of PEP-1-p18 on oxidative stress-induced SH-SY5Y cells and in a PD mouse model. The transduced PEP-1-p18 markedly inhibited 1-methyl-4-phenyl pyridinium-induced SH-SY5Y cell death by inhibiting Bax expression levels and DNA fragmentation. Additionally, PEP-1-p18 prevented dopaminergic neuronal cell death in the substantia nigra of a 1-methyl-4-phenyl-1,2,3,6,-tetrahydropyridine-induced PD mouse model. These results indicate that PEP-1-p18 may be a useful therapeutic agent against various diseases and is a potential tool for treating PD.