• Journal of Korean Neurosurgical Society
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• v.53 no.1
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• pp.1-5
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• 2013

Objective : The purpose of this study was to evaluate the characteristics and surgical outcomes of familial hemifacial spasm (HFS) and to discuss the role of genetic susceptibility. Methods : Between 2001 and 2011, 20 familial HFS patients with ten different pedigrees visited our hospital. The data from comprehensive evaluation of these patients, including clinical, radiological and electrophysiological data and surgical outcomes were reviewed to characterize familial HFS and to compare the characteristics between familial HFS and sporadic HFS. Results : According to the family tree, the inheritance pattern was difficult to define clearly using these data. Radiologic findings suggested that the vertebral artery (VA) was a more frequent offender in familial HFS than in sporadic cases (35.0% vs. 10.0%, p<0.001). Chi-square test showed that there were no correlation between VA tortuosity and underlying morbidity such as diabetes or hypertension (p=0.391). Eighteen out of 19 patients who underwent microvascular decompression showed no residual spasm. Other features of familial HFS overlap with sporadic cases. These findings suggest that certain genetic susceptibilities rather than hypertension or diabetes may influence vascular tortuosity and HFS development. Conclusion : In this study, familial HFS seems not so different from sporadic cases. Authors thought familial HFS could have heterogeneous etiology. Further study of familial HFS including clinical, anatomic, genetic, and molecular information may help identify a gene or trait that can provide insight into the mechanisms of sporadic and familial HFS.

• Communications for Statistical Applications and Methods
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• v.31 no.3
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• pp.279-289
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• 2024

Familial searching is a useful technique in a forensic investigation. Using genetic information, it is possible to identify individuals, determine familial relationships, and obtain racial/ethnic information. The total number of shared alleles (TNSA) and likelihood ratio (LR) methods have traditionally been used, and novel data-mining classification methods have recently been applied here as well. However, it is difficult to apply these methods to identify familial relationships above the third degree (e.g., uncle-nephew and first cousins). Therefore, we propose to apply a stacking ensemble machine learning algorithm to improve the accuracy of familial relationship identification. Using real data analysis, we obtain superior relationship identification results when applying meta-classifiers with a stacking algorithm rather than applying traditional TNSA or LR methods and data mining techniques.

• Journal of the Korean Statistical Society
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• v.36 no.1
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• pp.77-91
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• 2007

This paper considers development of noninformative priors for the familial data when the families have equal number of offspring. Several noninformative priors including the widely used Jeffreys' prior as well as the different reference priors are derived. Also, a simultaneously-marginally-probability-matching prior is considered and probability matching priors are derived when the parameter of interest is inter- or intra-class correlation coefficient. The simulation study implemented by Gibbs sampler shows that two-group reference prior is slightly edge over the others in terms of coverage probability.

• Genomics & Informatics
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• v.3 no.4
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• pp.159-165
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• 2005

The Korean Twin Register (n=154,783 pairs) was reported in 2002 as the first nationwide twin study in Korea and the largest study in Asia. The Twin Register has the information of disease outcomes since 1990, and basic clinical and questionnaire data from biennial health examination provided by Korea National Health Service. The author attempted to calculate some of the genetic parameters of cancers in this population. Common cancers in Korea known to have familial aggregation (colon and breast) and cancers of which familial aggregation is unclear (stomach cancer) were examined for their familial recurrence risks. There were 699 stomach cancers, 438 breast and 491 colorectal cancers cases in the twin register between 1991 and 2003. Like-sex twins showed recurrence risks (${\lambda}_{LS}$) of 5.1 (95% CI 3.7-6.9) for stomach cancers, 15.5 (95% CI1 0.9-20.2) for female breast cancers, and 28.1 (95% CI 23.5-34.4) for colon cancers. Colorectal cancers of female like-sex twins show significantly higher familial recurrence risk 40.7 (95% CI 34.6-47.4), suggesting higher genetic contribution in women than in men. The results show increased familial risks compared with previous studies from the same register and are largely compatible with other studies. The data of the Twin Register could be used for estimating population level genetic parameters, as well as base of the various studies.

• International Journal of Human Ecology
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• v.6 no.1
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• pp.103-115
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• 2005

This study utilized data (a sample of 18,553 people born in 1958 in England, Scotland, and Wales) from the National Child Development Study of 1968 and 1991 to explore the influence of familial difficulties on the internalizing behavioral patterns during the early adolescent period and late life outcomes periods. In this paper, internalizing behavioral problems include 'depression', 'anxiety', 'hostility to adults', 'hostility to children', and 'withdrawal'. Late outcomes were analyzed in two different variables and one marital management domain: 'unemployment', 'seen doctors about emotional problems', 'divorce or separation; never lived as a couple; arguments end in violent behavior' The results indicate that young adolescents who had experienced familial difficulties also have internalizing behavioral problems giving them emotional and behavioral instability. The findings also show that familial difficulties during childhood positively contribute to late life outcomes such as unemployment, emotional problems, and marital management. This study suggests that in order to effectively respond to the needs of children and adolescents who have experienced various familial difficulties, counselors and educators must guide parents.

• Journal of Family Resource Management and Policy Review
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• v.17 no.1
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• pp.103-124
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• 2013

To improve family well-being of single-parents, the utilization of familial social resources-including formal supports, informal supports, and social capital-has become one of the most important family resource management issues. The purpose of this study was to compare the levels of familial social resources of single-parent households with those of two-parent households and to investigate the differences according to three factors, specifically poverty, family types by gender and age of parent, and householders' employment. In addition, the determinants of single-parent households' wellbeing were analyzed from two perspectives: economic wellbeing and psychological life satisfaction. Data from the 5th wave of the Korean Welfare Panel Study (KOWEPS) were used. The major findings were as follows. First, single-parent households utilized their familial social resources more actively than their counterparts, especially in terms of the formal support of child care. Second, single parent households utilized their familial social resources differently in relation to poverty, family types, and parents' employment. Third, the determinants of economic wellbeing and psychological life satisfaction were different according types of familial social resources. Based on these empirical results, policy implications for the future economic wellbeing of baby boomers were provided.

• Journal of the Korean Home Economics Association
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• v.46 no.6
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• pp.89-100
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• 2008

The purpose of this study was to provide basic data for the familial voluntary service of the Healthy Family Center and then verify the effectiveness of its application in order to improve family healthy through a familial voluntary service. Study subjects were both volunteers who belonged to family volunteer corps of 12 Healthy Family Centers. Collected data was analyzed SPSS WIN 12.0 program. The results were as followed. First, a 54.1% of subjects is taking part in a familial voluntary service, while a 45.9% of them is not. Their positive intention of future participation is a 77.4%. The period of participation is from 6 months to two years. The frequency of participation is once or twice a month, and the length of activities per participation is for 3 hours. They have taken part in the service with a variety of public relations, and their motive of participation is by and large selfish. Second, as for the influence of participation in a familial voluntary service upon family healthy, the family healthy of participant group is higher in all the four sub-variables of family healthy than that of other groups. The group of which frequency of participation is once a week is better in family communication than the group of which frequency of participation is once or twice per month. The group of which motive of participation is altruistic is higher in sharing a value system among families than the group of which motive of participation is selfish.

• International Journal of Human Ecology
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• v.5 no.1
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• pp.1-8
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• 2004

The current study uses longitudinal data, which show secondary school students' responses in a biennial data of surveys from England (n=4,326/boys=2,313;girls=2,413) and Scotland (n=3,528/boys=1,744;girls=1,784), to describe the association between availability of cigarette sales to minor, prosmoking attitudes of family members and drinking/drug use and smoking behaviours amongst adolescents. The findings provided strong evidence suggesting that availability of cigarette sales to minor, lack of familial interest on the child's smoking and other substance use were positively associated with the increased level of smoking behaviour in youth. Girls and boys also differed the likelihood of smoking and being a regular smoker. Boys were found to be more likely than girls to be smoking and to be a regular smoker. The implications of promising prevention programmes for preadolescents and areas for future research are presented

• Proceedings of the Korean Statistical Society Conference
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• 2005.05a
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• pp.53-57
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• 2005

In this paper, we develp the group ordering referecne priors for the differecne of the intraclass correlation coefficient in familial data. Using marginal posterior distributions under those priors, we compare frequentist coverage probabilities.

• Communications for Statistical Applications and Methods
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• v.12 no.2
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• pp.395-411
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• 2005

In this paper, we develop the Jeffreys' prior, reference prior and the the probability matching priors for the difference of intraclass correlation coefficients in familial data. e prove the sufficient condition for propriety of posterior distributions. Using marginal posterior distributions under those noninformative priors, we compare posterior quantiles and frequentist coverage probability.