• Title/Summary/Keyword: Failure risk factor

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Risk Factors to Predict Acute Respiratory Failure in Patients with Acute Pesticide Poisoning (급성 농약 중독환자에서 호흡 부전 발생의 위험 인자)

  • Cho, Nam-Jun;Park, Samel;Lee, Eun Young;Gil, Hyo-Wook
    • Journal of The Korean Society of Clinical Toxicology
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    • v.18 no.2
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    • pp.116-122
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    • 2020
  • Acute respiratory failure is an important risk factor for mortality in patients with acute pesticide poisoning. Therefore, it is necessary to investigate the risk factors to predict respiratory failure in these patients. This study retrospectively investigated the clinical features of respiratory failure among patients with acute pesticide poisoning requiring mechanical ventilation. This study included patients who were admitted with intentional poisoning by pesticide ingestion from January 2017 to December 2019. Paraquat intoxication was excluded. Among 469 patients with acute pesticide poisoning, 398 patients were enrolled in this study. The respiratory failure rate was 30.4%. The rate of respiratory failure according to the type of pesticide was carbamate (75.0%), organophosphate (52.6%), glufosinate (52.1%), glyphosate (23%), pyrethroid (8.9%), and others (17%). The mortality was 25.6% in the respiratory failure group. The risk factors for respiratory failure were old age, low body mass index, and ingestion of more than 300 mL. In conclusion, respiratory failure is a risk factor for mortality in pesticide poisoning. Old age, low body mass index, and ingestion of more than 300 mL are the risk factors for predicting respiratory failure.

Risk Assessment Program of underground buried Pipeline Development (지하매설배관의 위험성평가 프로그램 개발)

  • Kim Tae Wook;Sung Jun Sik;Cho Yong Hyun
    • Journal of the Korean Institute of Gas
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    • v.4 no.2 s.10
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    • pp.37-45
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    • 2000
  • The underground buried pipelines of Natural gas are relatively safer than any other pipelines of chemical plants, because Natural gas is non-corrosive fluid. But Natural gas is supplied normally the downtown area. So, it may be a disaster because of corrosion which is caused interference facilities, environment and third party accident which is caused facilities construction. Especially, it is very difficult to find out and inspect damages of pipeline because of buried pipelines. Therefore this paper approached to select and manage risk region pipelines according to introduction of underground buried pipeline's risk concept. Risk was indicated three parts - corrosion factor, design and construction factor, maintence and management factor - in this paper, Therefore qualitive risk of pipelines showed score as quantitative number. Also it was thought to be helpful in confidence and safety management that the concept of key index and failure supplementation measures to cost introduces this program. We developed this risk assessment program using visual basic tool and interfaced GIS.

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A Perspective on Pharmaceutical Industrial Research on Antihypertensive drugs

  • Lee, Jang-Yun;John F. DeBernardis
    • Archives of Pharmacal Research
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    • v.10 no.4
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    • pp.245-249
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    • 1987
  • Cardiovascular disease is at present the leading cause of deth in the United States and other in dustrilized countries. A major contributing factor of cardiovascular disease is essential hypertension. Untreated, essential hypertension is considered a risk factor for sudden death due to myocardial infarctions, as well as a risk factor for cerebral vascular disease, renal failure and congestive heart failure. During the last decade, significant progress has been made in the basic knowledge of the pathogenesis of hypertension as well as in the development of new antihypertensive drugs.

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The Case Study on Risk Assessment and Probability of Failure for Port Structure Reinforced by DCM Method (심층혼합처리공법이 적용된 항만 구조물의 파괴확률과 위험도 평가에 관한 사례 연구)

  • Kim, Byung Il;Park, Eon Sang
    • Journal of the Korean Geosynthetics Society
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    • v.17 no.4
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    • pp.53-64
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    • 2018
  • In this study, the evaluation to probability of failure for risk assessment of port structures on DCM reinforced soils, where stability and risk assessment are increasing in importance, was performed. As a random variables affecting the risk of DCM improved ground, the design strength, superposition (overlap) of construction, strength of the natural ground, internal friction angle and unit weight of the modified ground were selected and applied to the risk assessment. In addition, the failure probability for the entire system under ordinary conditions and under earthquake conditions were analyzed. As a result, it was found that the highest coefficient of variation in the random variable for the risk assessment of the DCM improved ground is the design strength, but this does not have a great influence on the safety factor, ie, the risk of the system. The main risk factor for the failure probability of the system for the DCM reinforced soils was evaluated as horizontal sliding in case of external stability and compression failure in case of internal stability both at ordinary condition and earthquake condition. In addition, the failure probability for ordinary horizontal sliding is higher than that for earthquake failure, and the failure probability for ordinary compression failure is lower than that for earthquake failure. The ordinary failure probability of the entire system is similar to the failure probability on earthquake condition, but in this case, the risk of earthquake is somewhat higher.

A Study on the Hazard Factor of Packaged Hydrogen Station by Failure Mode & Effects Analysis (패키지형 수소충전소의 고장형태별 영향 분석)

  • SEO, DOO HYOUN;RHIE, KWANG WON;KIM, TAE HUN
    • Transactions of the Korean hydrogen and new energy society
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    • v.31 no.1
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    • pp.65-72
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    • 2020
  • In this study, the purpose is to identify the risks of the facilities of packaged hydrogen stations. As a risk identification method, failure mode & effect analysis (FMEA), a qualitative risk assessment, was used to analyze failure mode and effects of component of each facility. The analysis criteria were used to derive the risk priority number (RPN) using the 5-point method according to severity, incidence, and detectability. The study analyzed a total of 141 components of 23 types that can be identified on the design of the packaged hydrogen filling station. As a result, 683 types of failures and their causes and effects were identified. and the RPN was number of a total of 1,485. Of these, 10 failure types with a RPN value of 40 or more were deemed necessary. In addition, a list of failure types with a severity score of 5 was identified and analyzed.

A Proposal for Risk Evaluation Method of Slope Failure due to Rainfalls (강우 시 사면 붕괴 위험도 평가에 관한 제안)

  • Chae, Jong-Gil;Jung, Min-Su;Tori, Nobuyaki;Okimura, Takashi
    • Proceedings of the Korean Geotechical Society Conference
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    • 2008.10a
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    • pp.893-903
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    • 2008
  • A method for predicting surface failures which occur during heavy rainfall on mountain slopes is proposed by using the digital land form model that is obtained by reading altitude on a topographical map at 10m grid point space. A depth of a potential failure layer is assumed at each grid point. In the layer, an infiltrated water movement from cell to cell is modeled in the study (cell is a square of the grid). Infiltrated ground water levels which show the three dimensional effects of a topographical factor in an area can be hourly calculated at every cell by the model. The safety factor of every cell is also calculated every hour by the infinite slope stability analysis method with the obtained infiltrated ground water level. Failure potential delineation is defined here as the time when the safety factor becomes less than unity under the assumptions that effective rainfall is 20mm/h and continues 20 hours.

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Anemia as a Risk Factor of Mortality and Rehospitalization in Patients with Heart Failure : An Integrative Review (심부전 환자의 빈혈과 사망률 및 재입원 간의 관계에 대한 통합적 고찰)

  • Son, Youn-Jung;Kim, Bo-Hwan
    • Journal of Korean Critical Care Nursing
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    • v.12 no.1
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    • pp.94-108
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    • 2019
  • Purpose : Heart failure (HF) is considered an important medical burden with rehospitalization and mortality. Anemia is a major risk factor associated with the severity of HF. To improve the understanding of the impact of anemia in the population with HF, we explored the prevalence of anemia, its guidelines, relationship between anemia and mortality or rehospitalization, and limitation of reviewed papers of various populations with HF. Method: We used Whittemore and Knafl's integrative review methodology (2005), and thirty research papers were analyzed. PubMed, CINAHL, Cochrane, PsychInfo, Embase, Web of Science were searched for papers published between January 1960-June 2018. Results: Anemia in individuals with HF was primarily defined using the World Health Organization guideline. The prevalence of anemia in patients with HF varied from 9% to 56.7%. Moreover, such a condition significantly increases the prevalence of mortality or rehospitalization in patients with HF. The analyzed majority were non-prospective cohort study including secondary data analysis. Conclusion: Anemia in individuals with HF is a significant risk factor of mortality and rehospitalization. Prospective cohort studies should be designed to identify the optimal value for screening anemia and the impact of anemia on rehospitalization and mortality among HF patients.

Implant survival and risk factor analysis in regenerated bone: results from a 5-year retrospective study

  • Hong, Ji-Youn;Shin, Eun-Young;Herr, Yeek;Chung, Jong-Hyuk;Lim, Hyun-Chang;Shin, Seung-Il
    • Journal of Periodontal and Implant Science
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    • v.50 no.6
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    • pp.379-391
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    • 2020
  • Purpose: The aims of this study were to evaluate the 5-year cumulative survival rate (CSR) of implants placed with guided bone regeneration (GBR) compared to implants placed in native bone, and to identify factors contributing to implant failure in regenerated bone. Methods: This retrospective cohort study included 240 patients who had implant placement either with a GBR procedure (regenerated bone group) or with pristine bone (native bone group). Data on demographic features (age, sex, smoking, and medical history), location of the implant, implant-specific features, and grafting procedures and materials were collected. The 5-year CSRs in both groups were estimated using Kaplan-Meier analysis. Risk factors for implant failure were analyzed with a Cox proportional hazards model. Results: In total, 264 implants in the native bone group and 133 implants in the regenerated bone group were analyzed. The 5-year CSRs were 96.4% in the regenerated bone group and 97.5% in the native bone group, which was not a significant difference. The multivariable analysis confirmed that bone status was not an independent risk factor for implant failure. However, smoking significantly increased the failure rate (hazard ratio, 10.7; P=0.002). Conclusions: The 5-year CSR of implants placed in regenerated bone using GBR was comparable to that of implants placed in native bone. Smoking significantly increased the risk of implant failure in both groups.

Economical selection of optimum pressurized hollow fiber membrane modules in water purification system using RbLCC

  • Lee, Chul-sung;Nam, Young-wook;Kim, Doo-il
    • Membrane and Water Treatment
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    • v.8 no.2
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    • pp.137-147
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    • 2017
  • A water treatment utility in South Korea operates a large system of pressurized hollow fiber membrane (PHFM) modules. The optimal selection of membrane module for the full scale plant was critical issue and carried out using Risk-based Life Cycle Cost (RbLCC) analysis based on the historical data of operation and maintenance. The RbLCC analysis was used in the process of decision-making for replacing aged modules. The initial purchasing cost and the value at risk during operation were considered together. The failure of modules occurs stochastically depending on the physical deterioration with usage over time. The life span of module was used as a factor for the failure of Poisson's probability model, which was used to obtain the probability of failure during the operation. The RbLCC was calculated by combining the initial cost and the value at risk without its warranty term. Additionally, the properties of membrane were considered to select the optimum product. Results showed that the module's life span in the system was ten years (120 month) with safety factor. The optimum product was selected from six candidates membrane for a full scale water treatment facility. This method could be used to make the optimum and rational decision for the operation of membrane water purification facility.

Probabilistic Safety Assessment of Nuclear Power Plants Using Alpha Factor Method for Common Cause Failure (알파모수 공통원인고장 평가 기법을 활용한 원자력발전소 안전성 평가)

  • Hwang, Seok-Won
    • Transactions of the Korean Society of Pressure Vessels and Piping
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    • v.10 no.1
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    • pp.51-55
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    • 2014
  • Based on the results of Probabilistic Safety Assessment(PSA) for a Nuclear Power Plant (NPP), Common Cause Failure(CCF) events have been recognized as one of the main contributors to the risk. Also, the CCF data and estimation method used in domestic PSA models have been pointed out as an issue with respect to the quality. The existing method of MGL and non-staggered testing even widely used were considered conservative in estimating the safety and had a limited capability in uncertainty analyses. Therefore, this paper presents the CCF estimation using a new generic data source and Alpha factor method. The analyses showed that Alpha factor and staggered method are effective in estimating the CCF contribution and risk insights of reference plant. This method will be a common bases for the optimization of new design for the construction plants as well as for the updating of safety assessment on the operating nuclear power plants.