• Archives of design research
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• v.15 no.4
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• pp.33-46
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• 2002

The present times is rapidly growing and changing. As both an industry and a social legislation are running after a generality, relatively the number of people who are out of it is gradually increasing. Those people are getting skeptical about their positions as well as their existences, so that a social deviant phenomenon has been continuously arising by themselves in public and private area. It is the Vandalism . People are often exposed to this Vandalism which is occurring around their life. Accordingly this study analyzed cause-and-effect Vandalism. As a means of impediment against the progressing Vandalism in design process, the study as been developed by approaching to an ergonomics design, a simple shape design (minimalism), a semantic design, a re-useful design. As a result, it comes to the fact that the Vandalism from the view of design is caused by a lack of ergonomics and user-interface, a failure of simple structure, a complication of excessive functions. Furthermore, it comes to the conclusion that industrial design is playing an important role in the contribution of social development, to create a design obstructing the vandalism will bring development of sound society.

• Journal of Biomedical Engineering Research
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• v.28 no.3
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• pp.387-391
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• 2007

An oxygenator is a very important artificial organ and widely used for patients with lung failure or during open heart surgery. Although an oxygenator has been widely studied worldwide to enhance its efficiency, studies on oxygenators, in particular when using a pulsatile blood flow, are domestically limited. Therefore, a new oxygenator was developed in the lab and animal experimental results are described in the paper. The oxygenator is composed of polycarbonate housing and polypropylene hollow fibers. It has a total length of 400 mm and a surface area of $1.7 m^2$. The animal experiment lasted for 4 hours. The blood flow rate was set to 2 L/min and a pulsatile blood pump, T-PLS (Twin-Pulse Life Support), was used. Samples were drawn at the oxygenator's inlet and outlet. The total hemoglobin (Hb), saturation oxygen ($sO_2$), and partial oxygen pressure ($pO_2$), partial $CO_2$ pressure ($pCO_2$), and plasma bicarbonate ion concentration ($HCO_3^-$) were measured. The oxygen and carbon dioxide transfer rates were also calculated based on the experimental data in order to estimate the oxygenator's gas transfer efficiency. The oxygen and carbon dioxide transfer rates were $16.4{\pm}1.58$ and $165.7{\pm}10.96 mL/min$, respectively. The results showed a higher carbon dioxide transfer rate was achieved with the oxygenator. Also, the mean inlet and outlet blood pressures were 162.79 and 137.92 mmHg, respectively. The oxygenator has a low pressure drop between its inlet and outlet. The aim of own preliminary study was to make a new oxygenator and review its performance when applying a pulsatile blood pump thus, confirming the possibility of a new oxygenator suitable for pulsatile flow.

• Journal of Embryo Transfer
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• v.28 no.2
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• pp.157-162
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• 2013

Methoxychlor (MXC) was developed to be a replacement for the banned pesticide DDT. HPTE [2,2-bis (p-hydroxyphenyl)-1,1,1-trichloroethane], which is an in vivo metabolite of MXC, has strong oestrogenic and anti-androgenic effects. MXC and HPTE are thought to produce potentially adverse effects by acting through oestrogen and androgen receptors. Of the two, HPTE binds to sex-steroid receptors with greater affinity, and it inhibits testosterone biosynthesis in Leydig cells by inhibiting cholesterol side-chain cleavage enzyme activity and cholesterol utilisation. In a previous study, MXC was shown to induce Leydig cell apoptosis by decreasing testosterone concentrations. I focused on the effects of MXC on male mice that resulted from interactions with sex-steroid hormone receptors. Sex-steroid hormones affect other organs including the kidney and liver. Accordingly, I hypothesised that MXC can act through sex-steroid receptors to produce adverse effects on the testis, kidney and liver, and I designed our experiments to confirm the different effects of MXC exposure on the male reproductive system, kidney and liver. In these experiments, I used pre-pubescent ICR mice; the puberty period in ICR mice is from postnatal day (PND) 45 to PND60. I treated the experimental group with 0, 100, 200, 400 mg MXC/kg b.w. delivered by an intra-peritoneal injection with sesame oil used as vehicle for 4 weeks. At the end of the experiment, the mice were sacrificed under anaesthesia. The testes and accessory reproductive organs were collected, weighed and prepared for histological investigation. I performed a chemiluminescence immune assay to observe the serum levels of testosterone, LH and FSH. Blood biochemical determination was also performed to check for other effects. There were no significant differences in our histological observations or relative organ weights. Serum testosterone levels were decreased in a dose-dependent manner; a greater dose resulted in the production of less testosterone. Compared to the control group, testosterone concentrations differed in the 200 and 400 mg/kg dosage groups. In conclusion, I observed markedly negative effects of MXC exposure on testosterone concentrations in pre-pubescent male mice. From our biochemical determinations, I observed some changes that indicate renal and hepatic failure. Together, these data suggest that MXC produces adverse effects on the reproductive system, kidney and liver.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.10
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• pp.151-157
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• 2018

Among the various sensors for measuring traffic, PVDF (polyvinylidene fluoride) piezoelectric sensors are used to classify vehicles because they can detect the axle of the vehicle. Piezoelectric sensors are embedded in road pavements and are always exposed to traffic loads and environmental loads. Therefore, the life expectancy is very short, less than 6 years. Traffic control is essential for reinstallation and data collection is interrupted during the failure period. The lifespan will increase if the sensor installation depth is increased. In this study, the sensor signal output was analyzed with a variable depth of sensor installation to verify the possibility of deeper installation. Furthermore, various parameters, such as the weight and speed, were analyzed. The wheel load is applied using APT. As a result, the MSI BL sensor output signal is higher than 100mV when installed at 3cm, which is reliable. If the location of the sensor is deeper in the pavement, the expected lifetime of the sensor is also increased. On the other hand, the MSI cable was found to be less than 100mV at the shallowest depth of 1cm, making it impossible for field applications.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.10
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• pp.424-429
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• 2018

In this study, an expansion joint that is susceptible to waterhammer was tested for its vibration durability. The operation data for the hydraulic actuator was the expansion length of the expansion joint when the waterhammer occurred. In the case of the vibration durability test, the internal temperature status of the expansion joint was assumed to be a stress factor and a lifespan prediction model was assumed to follow the Arrhenius model. A test was carried out by increasing the internal temperature status at $30^{\circ}C$, $50^{\circ}C$, and $65^{\circ}C$. By a linear transformation of the lifespan data for each temperature, a constant value and activation energy coefficient was induced for the Arrhenius equation and verified by comparing the value of a lifetime prediction model with the experimental value at $85^{\circ}C$. The failure modes of the ongoing or finished test were leakage, bellows separation, and internal deformation. In the future, a composite lifespan prediction model, including two more stress factors, will be developed.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.2
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• pp.542-550
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• 2020

A stream serve the functions of different water utilization, flood control, and the environment, and contributes to the development of national life and culture. On the other hand, it is difficult to efficiently evaluate various projects, such as effectiveness verification and comparison between projects, because the evaluation procedures and evaluation techniques of projects are not uniform and different for each institution. Therefore, a standardization technology was developed for a post-assessment of stream projects that can recognize stream problems and comprehensively evaluate stream-related projects. To this end, various projects, such as project evaluation techniques, national R&D projects, and social welfare projects, were compared and analyzed, and the standardization stages of the project were first suggested. In addition, based on the standardization stage, the evaluation indices for each stage were derived to develop an evaluation table that can evaluate stream-related projects comprehensively. Finally, it is possible to prevent the repeated use of failure factors in the planned projects.

• Clinical and Experimental Pediatrics
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• v.51 no.3
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• pp.329-334
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• 2008

Kwashiorkor is a syndrome of severe protein malnutrition, which manifests itself in hypoalbuminemia, diarrhea, dermatitis, and edema. It can be life-threatening due to associated immune deficiency and an increased susceptibility to infections. Kwashiorkor should be treated early with nutritional support and the control of infection. Dilated cardiomyopathy may develop during the treatment and in such cases a poor prognosis is expected. Kwashiorkor has been known as a common disease of poor countries. To date, in fact, there has been no report of kwashiorkor leading to death in technically advanced countries. We here report a fatal case of a baby girl admitted with kwashiorkor. She had been fed only with cereal grain mixed with juice, without any protein supplement, for 2 months. This diet was deficient not because of poverty, but due to the illiteracy of her parents. The patient suffered from diarrhea, whole body edema, hypothermia, and dermatitis. Laboratory findings revealed an immune-deficient state featuring leukopenia and decreased immunoglobulin. Blood and urine cultures revealed Alcaligenes Xylosoxidans growth. The patient was fed frequent small amounts of protein-containing formula and intravenous albumin and micronutrients were administered for nutritional support. She was also treated with intravenous immunoglobulin and antibiotics in order to control infection. Nevertheless, she developed dilated cardiomyopathy and multi-organ failure and died. We review this case in light of the literature.

• Journal of Korean Society of Environmental Engineers
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• v.33 no.7
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• pp.544-551
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• 2011

The objective of this study was to analyze VIRULO model, a probabilistic quantitative model, which had been developed by US Environmental Protection Agency. The model could assess the viral attenuation capacity of soil as hydrogeologic barrier using Monte Carlo simulation. The governing equations used in the model were composed of unsaturated flow equations and viral transport equations. Among the model parameters, those related to water flow for 11 soil types were from UNDODA data, and those related to 5 virus species were from the literatures. The model compared the attenuation factor with threshold of attenuation to determine the probability of failure and presented the exceedances and Monte Carlo runs as output. The analysis indicated that among 11 USDA soil types, the viral attenuation capacity of loamy sand and sand were far lower than those of clay and silt soils. Also, there were differences in the attenuation in soil among 5 viruses with poliovirus showing the highest attenuation. The viral attenuation capacity of soil decreased sharply with increasing soil water content and increased nonlinearly with increasing soil barrier length. This study indicates that VIRULO model could be considered as a useful screening tool for viral risk assessment in subsurface environment.

• Journal of Korean Tunnelling and Underground Space Association
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• v.18 no.2
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• pp.143-154
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• 2016

This study investigated the occurrences, causes, and mitigation of the recent ground subsidence and underground cavity generation events in Korea. Two main causes of ground subsidence are (1) the soil erosion by seepage during tunneling and earth excavation and (2) the damage of underground pipes. The main cause of the soil erosion during tunneling was the uncontrolled groundwater flow. Especially, when excavating soft grounds using a tunnel boring machine (TBM), the ground near TBM operation halt points were found to be the most vulnerable to failure. The damage of underground pipes was mainly caused by poor construction, material deterioration, and differential settlement in soft soils. The ground subsidence during tunneling and earth excavation can be managed by monitoring the outflow of groundwater and eroded soils in construction sites. It is expected that the ground subsidence by the underground pipe damage can be managed or mitigated by life cycle analysis and maintenance of the buried pipes, and by controlling the earth pressure distribution or increasing the bearing capacity at the upper ground of the buried pipes.

• Journal of Korea Water Resources Association
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• v.51 no.8
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• pp.703-711
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• 2018

Water distribution system (WDS) pipe bursts are caused from excessive pressure, pipe aging, and ground shift from temperature change and earthquake. Prompt detection of and response to the failure event help prevent large-scale service interruption and catastrophic sinkhole generation. To that end, this study proposes a improved Western Electric Company (WECO) method to improve the detection effectiveness and efficiency of the original WECO method. The original WECO method is an univariate Statistical Process Control (SPC) technique used for identifying any non-random patterns in system output data. The improved WECO method multiples a threshold modifier (w) to each threshold of WECO sub-rules in order to control the sensitivity of anomaly detection in a water distribution network of interest. The Austin network was used to demonstrated the proposed method in which normal random and abnormal pipe flow data were generated. The best w value was identified from a sensitivity analysis, and the impact of measurement frequency (dt = 5, 10, 15 min etc.) was also investigated. The proposed method was compared to the original WECO method with respect to detection probability, false alarm rate, and averaged detection time. Finally, this study provides a set of guidelines on the use of the WECO method for real-life WDS pipe burst detection.