• 한국임상약학회지
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• 제24권2호
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• pp.115-125
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• 2014

Purpose: The purpose of the present study was to assess the incidence of the potentially inappropriate medication (PIM) use in Korean elderly patients with heart failure, and to evaluate factors that influence PIM use. Method: Korean National Health Insurance claims database between January 2009 and December 2009 was used. Using 2012 updated Beers criteria, PIM use in heart failure patients aged 65 years or older was examined. Result: The incidence of PIM use in elderly heart failure patients was higher than in overall elderly patients. Among the 12,759 elderly patients with heart failure, 46.2% of study subjects were prescribed PIM(s) at least once. The number of PIM per 10 medications that patients received per patient was 1.53. The most commonly used PIMs in elderly heart failure patients were benzodiazepines (30.9%), non-steroidal anti-inflammatory drugs (NSAIDs) including COX-2 inhibitors (16.3%), digoxin (9.9%), and spironolactone (9.0%). Women (odds ratio, 1.20; 95% CI, 1.17-1.24), medical aid (odds ratio, 1.11; 95% CI, 1.08-1.13), and long-term facilities (odds ratio, 2.69; 95% CI, 2.44-2.96) were revealed to be important factors associated with PIM use. In addition, patient's age also seems to influence PIM use. Conclusion: Elderly heart failure patients are at a greater risk for adverse drug events attributed by inappropriate medication use. Efforts to increase awareness of PIM use in elderly heart failure patients are needed. In addition, various comprehensive strategies and policies to identify and prevent PIM use should be established nationwide.

• Asian-Australasian Journal of Animal Sciences
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• 제12권8호
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• pp.1298-1309
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• 1999

The nutritional value of protein varies between feedstuffs. It is possible to feed animals using crystalline amino acids as a sole nitrogen source, but in practice only some limiting amino acids are added to the diet. In order to use feedstuffs efficiently, it is important to determine exact amino acid requirements. Reported values differ widely because the requirements are affected by various factors. In this report, therefore, the factors affecting amino acid requirements are reviewed as follows: 1) availability of dietary amino acids, conversion factors of nitrogen to protein, interaction of amino acids, and strain, sex and age of animals; 2) amino acid requirements for maximum performance and maintenance, usefulness of non-essential amino acids; 3) plasma amino acid concentration as a parameter to determine amino acid requirements; and 4) nitrogen excretion to reduce environmental pollution. These factors should be considered, it is to improve the dietary efficiency, which is to reduce excess nitrogen excretion for environmental pollution.

• 기술혁신학회지
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• 제9권3호
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• pp.451-470
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• 2006

본 연구는 사원 개인을 분석단위로 사원제안제도의 활용에 영향을 미치는 요인을 살펴보았다. 또한 사원제안제도가 지금까지 제조업 중심으로 이루어져 왔지만 최근 서비스업을 중심으로 비제조업에도 사원제안제도가 확산됨에 따라 업종별 차이도 분석하였다. 연구 가설은 Unsworth(2001)의 개인 창의성 분류와 Frese et al.(1999)의 사원제안제도 일반 모형에서 도출하였다. 자동차 조립업체와 은행을 대상으로 자료를 수집하였고 PLS로 통계분석을 실시하였다. 연구결과를 보면 Frese et al.(1999)의 일반모형은 대체로 지지되었으며 업종간 유의한 차이를 발견하지는 못하였다. 그러나 모형 내부 변수들의 상관관계의 정도는 유의한 통계적 차이를 보였다. 이를 바탕으로 비제조업의 사원제안제도 활용에 대한 제언을 제시하였다.

• 한국임상약학회지
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• 제27권1호
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• pp.22-29
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• 2017

Objective: Infection is very common in the elderly, so there is a high prevalence of antibiotics use among this population. Especially, due to the emergence of resistant bacteria, the use of vancomycin is growing. The purpose of this study was to evaluate risk factors associated with vancomycin-induced nephrotoxicity in elderly patients. Methods: The subjects of this study were patients over 18 years old who received intravenous vancomycin in a general hospital located in Gangneung-si, Korea between August 1, 2013 and July 31, 2015. Data collection regarding vancomycin use and baseline characteristics was conducted using computerized hospital database. Logistic regression analysis was used to identify risk factors associated with vancomycin-induced nephrotoxicity. Results: A total of 290 patients were finally included, and 191(66%) out of these patients were age 65 or older. The incidence of vancomycin-induced nephrotoxicity was 11.0%, 12.6%, and 7.0% in the all adult patients, the elderly patients, and the non-elderly patients, respectively. There were significant differences in comorbidities between patients with nephrotoxicity and patients without nephrotoxicity in the all adult patients, and there were significant differences in vancomycin duration, comorbidities, and number of nephrotoxic agents between patients with nephrotoxicity and patients without nephrotoxicity in the elderly patients. However, according to the logistic regression analysis, there was no significant risk factor that increases the incidence of vancomycin-induced nephrotoxicity in all three age groups. Conclusion: There were no differences in risk factors that increase the incidence of vancomycin-induced nephrotoxicity between all adult patients, elderly patients, and non-elderly patients. Further studies with larger sample sizes to identify risk factors associated with vancomycin-induced nephrotoxicity in the elderly to improve the outcome of pharmacotherapy are required.

• Asian Pacific Journal of Cancer Prevention
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• 제14권5호
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• pp.2777-2782
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• 2013

The aim of the present study was to assess criterion validity and external reliability of a questionnaire on risk factors for breast cancer. Materials and Methods. Women with breast cancer diagnosis (the cases) (N=40) and matched individuals without cancer (the controls) (N=40) were asked to fill in a questionnaire twice: on a day of admission to hospital (Q1) and on a day before discharge (Q2), with a time interval of 4-6 days. The questionnaire included questions (N=150) on demographic and socioeconomic factors, diseases in the past, family history of cancer, woman's health, smoking, alcohol use, diet, physical activity, and work environment. Criterion validity of the questionnaire Q2 relative to reference questionnaire Q1 was assessed with the Spearman correlation coefficient (SCC); external reliability of the questionnaire was measured in terms of the intraclass correlation coefficient (ICC). Statistical analysis was performed with SPSS 16. Results. The responses to most of the questions on socioeconomic factors, family history on cancer, female health, lifestyle risk factors (smoking, alcohol use, physical activity) correlated substantially in both the cases and the controls with SCC and ICC>0.7 (p<0.01). Statistically non significant relationships defined only between the responses on amount of beer the cases drank at the ages up to 25 years and 26-35 years as well as time of use of estrogen and estrogens-progestin during menopause by the cases. Moderate and substantial SCC and ICC were determined for different food items. Only the response of the cases on veal consumption did not correlate significantly. Conclusions. The questionnaire on breast cancer risk factors is valid and reliable for most of the questions included.

• Journal of Information Technology Applications and Management
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• 제16권4호
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• pp.135-165
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• 2009

The major purpose of this study is to identify the factors influencing the implementation performance of ERP Systems from an integrated viewpoint. For this purpose, a research model is developed based on the literature reviews of ERP systems, contingency theory, and change management theory. The research model proposed fifteen variables as the factors influencing the implementation performance in the ERP systems. The data have been collected from the 164 enterprises which implemented ERP systems at least one year ago. The respondents were person in charge of ERP system of each corporation. The results of hypothesis testing through multiple regression analysis are summarized as follows. Firstly, standardization of work, concentration of decision making, top management concern and support, real user participation, project support goodness, ease of use, and system usefulness have positive influence upon non-financial performance. Secondly, market uncertainty, industrial competition, project support goodness, and customization minimization have positive influence upon financial performance. From the analysis, this research have identified important characteristics for the successful implementation of ERP systems. Consequently, this research ends with managerial and theoretical implications of the study results, as well as limitations and future research directions.

• 한국임상약학회지
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• 제28권3호
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• pp.216-223
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• 2018

Objective: This study aimed to assess treatment persistence in Korean children and adolescents with attention deficit hyperactivity disorder (ADHD) and the factors influencing their adherence to ADHD pharmacotherapy. Methods: The study included patients between 6 and 18 years of age with ADHD who were taking various formulations of methylphenidate and atomoxetine on June 1, 2014. Patients were dichotomized as "persistent" or "non-persistent", depending on whether they continued ADHD therapy for 6 months (therapy persistence). We also investigated if the patients were taking the same medication(s) as before and also classified the patients as "medication persistent" or "non-persistent". Patient' characteristics were correlated with therapy persistence and medication persistence. Multiple logistic regression analyses were performed to assess potential risk factors for treatment persistence. Results: Overall, 3,317 patients were included in the analysis. A majority of patients were taking stimulants (82.0%), 16.2% were taking non-stimulants and 1.8% were taking a combination therapy of stimulants and non-stimulants. After 6 months, 2,290 patients (69.0%) continued to take medication for ADHD with 1,953 patients taking the same medication(s) as 6 months previously. Common positive factors for therapy persistence and medication persistence were identified as younger age, retardation, and developmental delay, and long-acting formulations of methylphenidate as either monotherapy or in a combination therapy may be used. Conclusion: ADHD medications were proven to improve academic performance and social skills of children. Collaboration between patients, parents, school staffs, and prescribers is required to improve the persistent use of ADHD medications.

• 경영정보학연구
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• 제24권2호
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• pp.67-88
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• 2022

본 연구는 SOR(Stimulus-Organism-Response) 모델을 기반으로 퍼스널 모빌리티의 성능적 측면과 외부 환경적 요인을 고려해 이용자들과 비이용자들의 사용 의도를 설명할 수 있는 연구 모형을 제안하였다. 국내 사용자들과 비사용자들을 대상으로 설문조사를 진행하였고 부분최소자승법(Partial Least Square, PLS)과 인공신경망 분석(Artificial Neural Network, ANN)을 통해 연구모형 및 가설들을 검증하였다. 분석결과, 사용자들은 지각된 만족도와 지각된 신뢰도가 사용 의도에 긍정적인 영향을 미치고, 지각된 위험성과 환경적 가치가 지각된 만족도와 지각된 신뢰도와 유의한 관계가 있음이 확인되었다. 반면, 비사용자들은 지각된 만족도와 사용의도 간에 양의 상관관계가 있음이 밝혀졌고, 사용자들과 마찬가지로 지각된 위험성과 환경적 가치가 지각된 만족도와 지각된 신뢰도의 유의한 선행변수임이 검증되었다. 나머지 변수들 중에서는 사용자들의 지각된 이동성과 비사용자들의 지각된 이용 용이성이 각각 지각된 만족도의 중요한 영향요인으로 파악되었다.

• Journal of Preventive Medicine and Public Health
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• 제32권2호
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• pp.147-154
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• 1999

Objectives: To construct basic data to develop strategies for achieving higher Pap test coverage rate by evaluating factors associated with the use of Pap test through population-based survey. Methods: 16.4%(671) of the 4,090 women, who were eligible population for this study, in 3 Myens of Chung-ju City participated in this study voluntarily from July 21 to 26, 1997. After basic physical examination by trained doctors, they were interviewed with structured questionnaire by well-educated interviewers. Results: It shows that only 54.3% of study participants experienced Pap test. The strongest factor which is related with the use of Pap test was the history of having breast screening tests(aOR=8.71, 95% CI=4.25-17.84). Probability of ever having Pap test was also higher in married women(aOR of single=0.46, 95% CI=0.29-0.72), younger(Ptrend<0,051, more educated (Ptrend<0.001), non-smoker (aOR of smoker=0.25, 95% CI=0.12-0.55), women of ever having Hepatitis test(aOR=2.60, 95% CI=1.73-3.88) in multiple lineal logistic analysis. Conclusions : This study suggests that several factors significantly associated with the use of Pap test, and especially, high-risk population for cervical cancer such as women of older ages, less educated, living alone are less likely to have the Pap test. We should concentrate on encouraging high-risk women in the use of Pap test to improve Pap test coverage rate.

• International Journal of Computer Science & Network Security
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• 제22권7호
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• pp.332-346
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• 2022

Digital transformation represents one of the main obstacles facing several government, private, and non-profit sectors that help stabilize digital transformation in the Arabic region. One of the helpful ways to improve the level of freedom, productivity, and flexibility among employees to accept the BYOD approach is using their own devices to perform their work both in and outside the workplace. This study focuses to present the differences between the main three economic sectors, which represent the most important pillars of the economy in Saudi Arabia within the Kingdom's Vision 2030. BYOD also has great importance to the stakeholders for raising their awareness by expressing the implications, if the concept of BYOD is widely and correctly adopted. The study uses the diffusion of innovation (DOI) framework and quantitative analysis data to determine the main dimensions and important factors that help increase the awareness of the target audience. The number of participants in this study was 830, and the participants are mixing between the government, private, and non-profit sectors. The main findings showed a significant impact of several factors such as the importance of knowledge, ease of use, employee satisfaction, risk awareness, and attention to increase the level of acceptance in three main sectors study for using the BYOD approach widespread and professional use.