• Journal of Gastric Cancer
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• v.9 no.3
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• pp.88-95
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• 2009

Purpose: p53 and bcl-2 are important markers of apoptosis. The expression of p53 and bcl-2 in gastric adenocarcinoma was examined in relation to prognosis and survival rate. Materials and Methods: The clinicopathologic data from 238 patients who underwent gastrectomies for gastric adenocarcinoma between December 1999 and July 2007 were reviewed. Immunohistochemical staining of gastric adenocarcinoma tissues embedded in paraffin blocks was performed using an Envision kit (DAKO, Glostrup, Denmark). Statistical comparisons were made between age, gender, tumor invasion, lymph node metastasis, TNM stage, Lauren's classification, cell differentiation, and the relationship with p53 and bcl-2. Results: The expression of p53 was related to cell differentiation (P=0.028) and UICC TNM stage (P<0.001). The expression of bcl-2 was related to UICC TNM stage (P=0.005). The co-expression of p53 and bcl-2 was related to UICC TNM stage (P=0.002). The co-expression group exhibited a greater reduction in the survival rate (P=0.001). Conclusion: The expression of p53 and bcl-2 nuclear proteins has significant relationships with other conventional prognostic factors and the survival rate. bcl-2 will be characterized through analysis of a greater number of patients and comparison with survival data over a longer period of time.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.24 no.9B
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• pp.1643-1651
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• 1999

Video-On-Demand (VOD) is expected to provide the user with interactive operations such as VCR functions. In particular, fast scan functions like “Fast Forward” of “Fast Backward” for a certain speedup playback are required. Since they require a significant amount of system resources, schemes to reduce bandwidth requirements for the network or disk are needed. In MPEG standard, Group-of-Pictures (GoP) is a random access unit which can be decoded independently. Since storing and transmitting a video stream based on GoP is efficient, it is practical to support fast scan functions based on GoP. In this paper, we present a dynamic transmission scheduling scheme to support fast scan functions with m-times normal playback rate for a stored video. The proposed scheme writes a transmission schedule whenever user requests a fast scan function. That is, the scheme constructs the data set to be smoothed by skipping GoPs according to a given speedup factor, and then writes the transmission schedule by applying a bandwidth smoothing. Finally, the scheme restarts the transmission of video data to a client according to the new schedule. The proposed scheme results in speeding up the playback rate by utilizing “GoP skipping”, and then reduces the computational overhead by applying a bandwidth smoothing based on GoP.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.14 no.9
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• pp.904-911
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• 2003

A new method to reduce the size of microwave amplifiers spiral-shaped defected ground structure(Spiral-DGS) is proposed. A microstrip line having Spiral-DGS on the ground plane produces increased slow-wave factor and electrical length for the fixed physical length. In addition, it provides an excellent rejection characteristic for a finite frequency band like band rejection filters. The rejection band is used for rejecting harmonic components of amplifiers. The reduced microstrip line lengths in matching networks by Spiral-DGS are 39 % and 44 % of the original ones in input and output matching networks, respectively. It is shown that the measured S-parameters of the reduced amplifier agree well with those of the original amplifier. The measured second harmonic of the reduced amplifier is much less than that of the original amplifier by at least 10 dB. The same technique is applied to reject the third harmonic using the proper Spiral-DGS for the third harmonic frequency. The measured third harmonic is smaller than that of the original amplifier by 25 dB.

• Journal of the Economic Geographical Society of Korea
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• v.9 no.3
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• pp.358-378
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• 2006

This study aims to examine seven factors and forty-two selection attributes of Seoul as an Exhibition and Convention Destination Site through the Importance-Performance Analysis(IPA) from the Exhibition and Convention Planner. The result of this study shows these three conclusions. First, according to the result of the Importance-Performance Analysis(IPA) of the forty-two selection attributes of an Exhibition and Convention Destination Site, thirteen attributes were placed on the right top area(Keep Up the Good Work), four attributes were placed on the right bottom area(Possible Overkill), five attributes were located on the left top area(Concentrate Here), and the other twenty attributes were located on the left bottom area(Low Priority). Second, the Importance-Performance Analysis(IPA) of seven factors in an Exhibition and Convention Destination Site reveals that the factors in the right top area(Keep Up the Good Work) of high importance and high performance were "Exhibition and Convention Center Facilities", "Exhibition and Convention Fee", and "Exhibition and Convention Center Accommodation Capacity". And the one factor located on the left top area(Concentrate Here) of high importance and low performance was "Exhibition and Convention Destination Regional Space", while the other factors of "Exhibition and Convention Center Management", "Exhibition and Convention Destination Tourism Space" and "Exhibition and Convention Destination Leisure Activity Space" were placed on the left bottom area(Low Priority) of low importance and low performance. Third, the difference of the mean value of the Importance and Performance on Seoul as an Exhibition and Convention Destination Site has been revealed that the performance of the attributes was lower than the importance of the attributes because forty attributes have described all plus(+) except two attributes.

• Journal of the Korean Society of Food Science and Nutrition
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• v.41 no.12
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• pp.1671-1676
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• 2012

In this study, the immuno-enhancing activity of seed extracts were studied on the macrophage cell lines. We examined the effect of nine seed extracts on nitric oxide (NO) production in RAW 264.7 cells and selected four highly-effective seed candidates (Fagopyrum esculentum, Taraxacum platycarpum, Impatiens balsamina, Helianthus annuus) for further immune-related studies. The effects of the four seed extracts on the production of immune-related cytokines in the RAW 264.7 macrophage cell line and proliferation of Molt-4 as a T cell line were investigated. The secretion of NO from the RAW 264.7 cells was increased up to 39 ${\mu}M$ by adding the seed extracts (25 ${\mu}g/mL$) compared to the control. Also, the secretion of tumor necrosis factor-alpha (TNF-${\alpha}$) was also increased up to 32 times by adding the seed extracts (25 ${\mu}g/mL$). Secretion of cytokines such as interleukin-1 beta (IL-$1{\beta}$), interleukin-6 (IL-6), and interleukin-10 (IL-10) was also increased and induced the proliferation of T cells compared to the control. In conclusion, these results suggest that four seed extracts provide beneficial immuno-enhancing effects for human health.

• International Journal of Oral Biology
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• v.30 no.1
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• pp.9-15
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• 2005

Recently, we reported that high extracellular calcium increased receptor activator of nuclear factor-${\kappa}B$ ligand (RANKL) expression via p44/42 mitogen-activated protein kinase (p44/42 MAPK) activation in mouse osteoblasts. However, the mechanism for p44/42 MAPK activation by high extracellular calcium is unclear. In this study, we examined the role of intracellular calcium increase in high extracellular calcium-induced RANKL induction and p44/42 MAPK activation. Primary cultured mouse calvarial osteoblasts were used. RANKL expression was highly induced by 10 mM calcium treatment. Ionomycin, a calcium ionophore, also increased RANKL expression and activated p44/42 MAPK. U0126, an inhibitor of MEK1/2, an upstream activator of p44/42 MAPK, blocked the RANKL induction by both high extracellular calcium and ionomycin. High extracellular calcium increased the phosphorylation of proline-rich tyrosine kinase 2 (Pyk2), one of the known upstream regulators of p44/42 MAPK activation. Bisindolylmaleimide, an inhibitor of protein kinase C, did not block RANKL induction and p44/42 MAPK activation induced by high extracellular calcium. 2-Aminoethoxydiphenyl borate, an inhibitor of inositol 1,4,5-trisphosphate (IP3) receptor, blocked the RANKL induction by high extracellular calcium. It also partially suppressed the activation of Pyk2 and p44/42 MAPK. Cyclosporin A, an inhibitor of calcineurin, also inhibited high calcium-induced RANKL expression in dose dependent manner. However, cyclosporin A did not affect the activation of Pyk2 and p44/42 MAPK by high extracellular calcium treatment. These results suggest that 1) the increase in intracellular calcium via IP3-mediated calcium release is necessary for RANKL induction by high extracellular calcium treatment, 2) Pyk2 activation, but not protein kinase C, following the increase in intracellular calcium might be involved in p44/42 MAPK activation, and 3) calcineurin-NFAT activation by the increase in intracellular calcium is involved in RANKL induction by high extracellular calcium treatment.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.5 no.2
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• pp.237-256
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• 1998

Death and dying of human being is a comprehensive system, and death orientation, the subjective meaning related to every component of the death system is developed throughout life. This study was designed and carried out to identify, describe and classify the orientations of Korean adult towards the death system. In an attempt to measure the subjective meaning of death and dying, unstructured Q-methodology was used. The 65 Q-statements developed by Kim(1994), used by Kim(1994) and Park(1996) were adopted as Q-population and 39 Q-statements were selected by the three researchers for Q-items for this study. Thirty-three P-samples were sampled from P-population of literate Korean men and women, 35 and 55 years of age, lived in urban Korea for the last 10 years. Sortings of the 39 Q-items according to the level of personal agreement, and a forced normal distribution into the 9 levels were carried out by the P-samples. The Z-scores of the Q-sort data were computed, and the principal components factor analysis by PC-QUANL Program were carried out. The demographic, socio-cultural and health-related attributes of the P-samples were descriptively analysed. Eight types of death orientation were identified ; Type I ; 'naturalist'. Six P-samples. Death is a natural phenomena, to be accepted as it is and to follow its natural course. Prefer to be informed of all facts and possibilities concernig the course of dying and death to occur to self. Type II ; 'life-after-life negator'. Three P-samples. Time and process of death is the destiny of each person. Death means 'darkness' and 'end to every thing, the absolute end'. Yet, wish physical integrity at the dying and after death. Type III ; 'life-after-life believer'. Six P-samples. Men are travellers passing by this life bound to the life-after-life. Priority concerns are on the activities to prepare self for the eternal life ahead. Disregard premature and sudden death. Type IV ; 'here-now believer' Five P-samples. Positive regard to the cremation of the body and donation of the organs on death. Regard religious and customary post-motem rituals meaningless. Negate life-after life. Type V; 'believer of rituals'. Five P-samples. Death being accepted as a part of, a natural end to, and destiny of human life. Concerned to ensure a dignified end to personal life and dignified post-mortem rituals. Type VI ; 'Realist'(derived from Type I). Two P-samples. Life and death as universal reality. The abrupt death at golden age at the peak of happiness is favored to avoid inevitable physical and mental distress of self and the family. Agreed to the cremation of the body. Disregard rituals. Type VII : 'Fatalist' (derived from Type II). Five P-samples. Not favored, yet, all man are destined to death, the inevitable end of all living beings. To ensure dignified end by personal consummation, information on one's dying and imminent death are to be shared. Type VIII ; 'reality avoider'(derived from Type III). One P-sample. Negative to longevity, artificial prolongation of, meaningless and distressful life. Highly positive to postmortem organ donation.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2008.11a
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• pp.32-32
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• 2008

Microstructure and positive temperature coefficient of resistivity (PTCR) characteristics of $0.9BaTiO_3-0.1(Bi_{0.5}Na_{0.5})TiO_3$ [BaBiNT] ceramics doped with $Nb_2O_5$ were investigated in order to develop the Pb-free high Curie temperature ($T_c$)(>$160^{\circ}C$) PTC thermistor. The BaBiNT ceramics showed a tetragonal perovskite structure, irrespective of the added amount of $Nb_2O_5$. They also have a homogeneous microstructure. The resistivity of BaBiNT ceramics was gradually decreased by doping $Nb_2O_5$, which might be due to $Nb^{+5}$ ions substituting for $Ti^{+4}$ sites. The PTCR characteristics of BaBiNT ceramics appeared when the amount of doped $Nb_2O_5$ exceeded 0.0025mol%. Moreover, the abrupt grain growth was observed for the 0.03mol% $Nb_2O_5$added BaBiNT ceramics. It showed an especially high $T_c$ of approximately $172^{\circ}C$ and good PTCR characteristics of a high $\rho_{max}/\rho_{min}$ ratio ($2.96\times10^3$), a high resistivity temperature factor (11.40/$^{\circ}C$) along with a relatively low resistivity ($3.5\times10^4\Omega{\cdot}cm$).

• The Korean Journal of Ecology
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• v.25 no.3 s.107
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• pp.153-161
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• 2002

This study was carried out to classify forest vegetation of the Mt. Naeyeon with phytosociological analysis of ZM school and to explain ordination of communities with CCA. The research sites were located between the northern part of Pohang-si area and the southern part of Yeongdeok-gun area. The 70 plots consisted of 253 species were investigated. The forest vegetation was classified into Quercus mongolica community, Q. variabilis community, Pinus densiflora community, Carpinus laxiflora community and Zelkova serrata community. Q. mongolica community was divided into 2 groups such as Rhododendron schlippenbachii group and Euonymus oxyphyllus group and Q. variabilis community was divided into 3 groups such as Syneilesis palmata group, Lespedeza$\times$tomentilia group and Tilia mandshurica group, and Z. serrata community was divided into 2 groups such as Carpinus cordata group and Diospyros lotus group. According to the results of CCA ordination, Q. mongolica community showed high positive correlation to altitude and topography, whereas it showed negative correlation to bare rock. But Z. serrata community showed the opposite tendency to Q. mongolica community, Altitude was considered as the most important factor among 5 environmental variables in the correlation with axes.

• Journal of The Korean Association For Science Education
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• v.9 no.1
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• pp.19-37
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• 1989

The purpose of this study was to investigate the development of logical thinking and scientific reasoning pattern of Korean high school students. To carry out this study subjects were selected about 2,000 Junior high school students, and about 4,100 senior high school students throughout the nation. They were identified as concrete, transitional or formal operational stage with the use of TOLT(the Test of Logical Thinking) by Tobin and Capie(1980), and TOSR(the Test of Scientific Reasoning) by W.A Farmer(1986). This study turned out that more than 76% of Junior high school students were classified as the concrete operational stage and about 44% of senior high school students were classified as the formal operational stage, while about 26% of them were still in the concrete operational level. This study showed that the main factor of the intellectual development of students is learning by the gradual advancement of their grades and especially entrance into the senior high school rather than by the physical growth. This study also showed that there are the take-off stage of the development of logical thinking between fourteen and fifteen years of their ages. Less than 25% of junior high school students were in the formal operational stages which are capable of control of variables, probabilistic, correlation and combinational logic in problem-solving situation, while 33-54% of senior high school students were in the formal operational levels. 38% of junior high school students were in the formal operational stage which is capable of proportional logic, while about 55% of senior high school students were in the formal operational stage. Less than 20% of senior high school students were classified as group of highly capable of scientific reasoning, while more than 23% of them were classified as group of poor capability. It also turned out that there are differences or no differences between male and female students of each school in problem-solving situation regarding each logic approach. These differences were proved to be fluctuating depending on the situations and their grades. The other results of this study is similar to those of other researches such as Tomlinson-Keasey 1972, Coleman 1973, Lawson 1973, Lawson and Renner 1974, Neimark 1975, Han 1982, and Kim 1989.