• Food Science of Animal Resources
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• v.44 no.1
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• pp.204-215
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• 2024

This study was designed to examine the effect of Lactilactobacillus curvatus LB-P9 on hair regeneration. The treatment of LB-P9 conditioned medium increased the proliferation of both hair follicle dermal papilla cells and hair germinal matrix cells (hGMCs). Moreover, the expression levels of hair growth factors such as vascular endothelial growth factor (VEGF) and fibroblast growth factor 7 were significantly elevated in hGMCs co-cultured with LB-P9. After time-synchronized depilation, mice were orally administered with either 4×10⁷ colony forming unit (CFU) of LB-P9 (low dose) or 4×10⁸ CFU of LB-P9 (high dose), once daily for 4 weeks. Compared with the vehicle (phosphate-buffered saline)-administrated group, the LB-P9-treated groups exhibited accelerated hair regrowth rate and enhanced hair thickness in a dose-dependent manner. Supporting this observation, both hair follicle numbers and the dermal thickness in skin tissues of the LB-P9-treated groups were increased, compared to those of the vehicle-treated group. These results might be explained by the increased level of β-catenin and number of hair follicle stem cells (CD34⁺ CD49f⁺ cells) in the skin tissues of mice administered with LB-P9, compared to the vehicle-treated mice. Also, increased serum levels of hair growth factors such as VEGF and insulin-like growth factor-1, and superoxide dismutase were found in the LB-P9-treated groups, compared to those of the vehicle-treated group. Taken together, these results might demonstrate that the oral administration of LB-P9 promotes hair regeneration by the enhancement of dermal papilla proliferation through the stimulation of hair growth factor production.

• Clinical and Experimental Reproductive Medicine
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• v.38 no.4
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• pp.210-215
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• 2011

Objective: This study was performed to identify whether growth and differentiation factor-9 (GDF-9) and transforming growth factor-${\beta}1$ (TGF-${\beta}1$) expressions would be lower in the follicular fluid (FF) of those over age 35 who underwent IVF than under age 35. Methods: A total of 24 IVF cycles (20 patients) were included in this study. All of patients were stimulated for IVF by the GnRH short protocol and divided into two groups for analysis, according to their age: <35 group (14 cycles, 11 patients) vs. ${\geq}35$ group (10 cycles, 9 patients). The expression levels of GDF-9 and TGF-${\beta}1$ were determined by western blotting and quantitative enzyme-linked immunosorbent assay. Results: The numbers of retrieved oocytes and metaphase II oocytes were significantly lower in the ${\geq}35$ group. Lower expression of GDF-9 and TGF-${\beta}1$ by western blotting in the ${\geq}35$ group were observed as well. The mean GDF-9 and TGF-${\beta}1$ levels by enzyme-linked immunosorbent assay were lower in the ${\geq}35$ group. The values were $6,850.5{\pm}928.4$ ng/L vs. $3,333.3{\pm}1,089.2$ ng/L of GDF-9 ($p$ <0.05) and $3,844.1{\pm}571.1$ ng/L vs. $2,187.7{\pm}754.0$ ng/L of TGF-${\beta}1$ ($p$ <0.05). A negative correlation between GDF-9 and age was observed (r=-0.546, $p$=0.006). Conclusion: GDF-9 and TGF-${\beta}1$ production from stimulated ovaries during IVF appears to decrease with age.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.16 no.1
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• pp.50-63
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• 2017

While transit is inconvenient, it is also inevitable for the efficient public transportation. Reducing the number of transfers as much as possible is most important in providing the convenience of public transportation and facilitating the public transportation. As for the public transportation card data, 61,986 items on weekdays and 69,100 items on weekends were collected. Pattern analysis and traffic influence factors were analyzed using traffic data card. Trip chain results revealed that people have more transit transfers for shopping and leasure than commuting purposes on weekends and that commuting distance and time increase by 10 km and 9.9 minutes, respectively. Besides, results of the structural equation model showed that factor 1(total travel time, total travel distance), factor 2(number of people getting on and off), factor 3(transit time), and factor 4(number of bus connections, number of operations) were found to have significant effects on the number of transfers.

• Journal of the Korean Society of Costume
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• v.58 no.2
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• pp.162-180
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• 2008

The purpose of this study is to find the basic design factors that affect the changes in body surface lines caused by lower limb movements, thereby resulting in slacks that fit well regardless of whether the human form is static or in motion. Using unmarried female university students aged 18-24 as subjects, a total of 32 body surface lines (15 body surface total lines and 17 body surface segment lines) were measured in one static and 9 movement poses, The analysis first involved the calculation of the expansion and contraction rates per body part in body surface line in 9 lower limb movements, Second, a factor analysis was conducted using the expansion and contraction rates of these changes in body surface line. The results of this study are as follows, According to the factor analysis, basic design factors that affect changes in body surface lines comprised 8 types of factors as illustrated in fig, 2-fig, 9, which explained 79.2% of total variate for the variables studied, Factor 1, comprising the lower segment of center back leg line, center front leg line and inner leg line, and lower limb girth except midway thigh girth and ankle girth below hip girth, accounted for 30.3% of total variance, Factor 2, comprising waist girth, the total and upper segment of center back leg line and center tront leg line, and front and back segment of crotch length, explained 17.4% of total variance, Factor 3, the total and upper segment of lateral leg line at the center, accounted for 56.5% of total variance in accordance with Factors 1, 2, and 3, Factor 4 was the contracting upper part of lower leg between legscye girth and midway thigh girth, Factor 5 comprised the total and upper segment of inner leg line and posterior knee girth, Factor 6 was the total crotch length, Factor 7 was the ankle girth, Factor 8 was the abdomen girth.

• Korean Parent-Child Health Journal
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• v.17 no.1
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• pp.37-45
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• 2014

Purpose: This study aimed to review measurements of environmental health behavior and assess the construct validity of Environmental Health Engagement Profile (EHEP) through confirmatory factor analysis. Methods: The literature review was performed for selection of measurements. Confirmatory factor analysis with AMOS 19.0 was used for validation of EHEP. Results: The model fitness was not appropriate in the one-factor model; $x^2=91.11$ (df=5, p<.001), Comparative Fit Index (CFI)=8.19, Non Normed Fit Index (NNFI)=6.39, and Root Mean Square Error of Approximation (RMSEA)=0.20. The model fitness was appropriate in the two-factor model; $x^2=3.19$ (df=1, p=.074), CFI=9.95, NNFI= 9.71, RMSEA=0.07. A modification of scale was found to be the most suitable for use in the investigation of environmental health behavior. Conclusion: This study confirms that a two-factor model underlies the concept of environmental health behavior. The review of measurements can help nurses and researchers to assess the environmental health behaviors.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.12 no.2
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• pp.1-6
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• 1998

It is required to determine proper values for the maintenance factor according to traffic volume in the freeway lighting design. This paper presents a simple method to seperate of the effect of surrounding environment and that of traffic volume, which is based on the IESNA treatment with additional assumptions on their effects. Furthermore, it is found that prevailing concept for the maintenance factor does not necessarily yield a proper value for light loss factor, so that an additional factor of 0.9 should be included as an equipment factor.factor.

• Biomedical Science Letters
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• v.10 no.2
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• pp.143-151
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• 2004

Matrix metalloproteinases (MMPs) are capable of degrading extracellular matrix, a process that is necessary for angiogenesis, tumor invasion and metastasis. Platelet-activating factor (PAP) increases angiogenesis, tumor growth and metastasis through nuclear factor (NF)-$\kappa$B activation. Based on these facts, the involvement of MMPs in PAF-induced pulmonary metastasis was investigated in murine sarcoma cells, MMSV-BALB/3T3. Messenger RNA expression and enzymatic activity of MMP-9 were assessed by RT-PCR and zymography, and cell migration and metastasis were done for the detection of MMP-9 functional activity. PAP induced mRNA expression and enzymatic activity of MMP-9, and its effects were either inhibited by the PAP antagonist, WEB 2170 or by the NF-$\kappa$B inhibitor, parthenolide, or p65 antisense oligonucleotide in a dose-dependent manner. In addition, PAF induced promoter activity of MMP-9, which was inhibited by WEB 2170, phenanthroline, NAC, PDTC. These results indicate that PAF induces mRNA expression and enzymatic activity of MMP-9 in NF-$\kappa$B dependent manner. Cell migration assay showed that PAF induced MMSV-BALB/3T3 migration, and its effect was significantly inhibited by treatment with phenanthroline. PAF enhanced pulmonary metastasis of murine sarcoma cells, MMSV-BALB/3T3 was also reduced by phenanthroline. These results suggest that PAF-enhanced cell migration and pulmonary metastasis is mediated through the expression of MMP. In conclusion, It is suggested that PAF enhances pulmonary metastasis by inducing MMP-9 expression via the activation of NF-$\kappa$B.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.20 no.9
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• pp.2792-2799
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• 1996

It was shown in the previous study that the numerically derived elastic work factor for CLS specimen was independent of fiber direction for a unidirectional case. Also, it was proposed the elastic work factor could be used to determine energy release rate from a single test record. In the present study, elastic work factor was derived from a simple beam theory to investigate its dependence on material property and geometric condition. Also, the elastic work factor of CLS specimen was applied experimentally to determine critical energy release rate in order to prove its validity determining critical energy release rate from a single specimen. For this purpose, critical energy release rate determined using the elastic work factor was compared with that determined by the compliance method. The results showed that while elastic work factor is affected by $t_2/t_1$ and $L_2/L_1$ it is independent of fiber angle for a unidirectional case. It was also found that critical energy release rates determined by both methods are comparable each other, thus elastic work factor approach can be used to determine energy release rate from a single test specimen.

• Journal of Electrical Engineering and Technology
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• v.9 no.5
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• pp.1592-1601
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• 2014

In this study, a novel single phase soft switched power factor correction (PFC) converter is developed with active snubber cell. The active snubber cell provides boost switch both to turn on with zero voltage transition (ZVT) and to turn off with zero current transition (ZCT). As the switching losses in the proposed converter are too low, L and C size can be reduced by increasing the operating frequency. Also, all the semiconductor devices operate with soft switching. There is no additional voltage stress in the boost switch and diode. The proposed converter has a simple structure, low cost and ease of control as well. It has a simple control loop to achieve near unity power factor with the aid of the UC3854. In this study, detailed steady state analysis of the proposed converter is presented and this theoretical analysis is verified by a prototype of 100 kHz and 500 W converter. The measured power factor and efficiency are 0.99 and 97.9% at full load.

• Bulletin of the Korean Chemical Society
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• v.27 no.9
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• pp.1456-1458
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• 2006