• Title/Summary/Keyword: FOUNDATION

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A Study on Brand Selection Property of Preliminary Business Founder In Food Service Franchise Foundation (외식 프랜차이즈 가맹점창업 시 예비 창업자의 브랜드 선택 속성에 관한 연구)

  • Sung, Daw-kwon;Wu, Jong-phil;Lee, Hyung-gun
    • The Korean Journal of Franchise Management
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    • v.3 no.1
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    • pp.92-110
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    • 2012
  • Due to the social problems including recent economic crisis and unemployment rate increase, the demand of business foundation market has been increased and, in the meantime, on the basis of the business foundation support policy of the government including youth foundation support policy and Small & Medium Business Administration foundation planning, business foundation market has been showing steady growth trend. With this enlargement of foundation market, as the accompanied increase of franchise market is expected, it is considered that the importance of more realistic and concrete research about franchise market be larger than before. This study considered brand image, main office support, foundation cost, information search activity as the advanced variable of effect on brand selection and established the cause of effect on brand selection by improving the existing advanced research, and its result is as follows. First, according to foundation business kind, age, sex, yes or no of marriage, there is some difference III the thought about brand image and foundation possibility. Second, Second, the most important factor of franchise contract intention is economical specificity. It is difficult to consider brand image, franchise support and information search activity as the property having a big effect on preliminary founder, and it was shown that the cost for franchise management(Consistency with initial foundation cost and self-capital, promotion cost, management fund, facility/equipment reinvestment, etc.) is an important property. Specially, it was shown that consistency with initial foundation cost and self-capital is the most important factor for preliminary founder.

Efficacy and Safety of Trastuzumab Deruxtecan and Nivolumab as Third- or Later-Line Treatment for HER2-Positive Advanced Gastric Cancer: A Single-Institution Retrospective Study

  • Keitaro Shimozaki;Izuma Nakayama ;Daisuke Takahari;Kengo Nagashima;Koichiro Yoshino ;Koshiro Fukuda;Shota Fukuoka ;Hiroki Osumi ;Mariko Ogura ;Takeru Wakatsuki;Akira Ooki ;Eiji Shinozaki;Keisho Chin ;Kensei Yamaguchi
    • Journal of Gastric Cancer
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    • v.23 no.4
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    • pp.609-621
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    • 2023
  • Purpose: Determination of optimal treatment strategies for HER2-positive advanced gastric cancer (AGC) in randomized trials is necessary despite difficulties in direct comparison between trastuzumab deruxtecan (T-DXd) and nivolumab as third or later-line treatments. Materials and Methods: This single-institution, retrospective study aimed to describe the real-world efficacy and safety of T-DXd and nivolumab as ≥ third line treatments for HER2-positive AGC between March 2016 and May 2022. Overall, 58 patients (median age, 64 years; 69% male) were eligible for the study (T-DXd group, n=20; nivolumab group, n=38). Results: Most patients exhibited a HER2 3+ status (72%) and presented metastatic disease at diagnosis (66%). The response rates of 41 patients with measurable lesions in the T-DXd and nivolumab groups were 50% and 15%, respectively. The T-DXd and nivolumab groups had a median progression-free survival of 4.8 months (95% confidence interval [CI], 3.3, 7.0) and 2.3 months (95% CI, 1.5, 3.5), median overall survival (OS) of 10.8 months (95% CI, 6.9, 23.8) and 11.7 months (95% CI, 7.6, 17.1), and grade 3 or greater adverse event rates of 50% and 2%, respectively. Overall, 64% patients received subsequent treatment. Among 23 patients who received both regimens, the T-DXd-nivolumab and nivolumab-T-DXd groups had a median OS of 14.0 months (95% CI, 5.0, not reached) and 19.3 months (95% CI, 9.5, 25.1), respectively. Conclusions: T-DXd and nivolumab showed distinct efficacy and toxicity profiles as ≥ third line treatments for HER2-positive AGC. Considering the distinct features of each regimen, they may help clinicians personalize optimal treatment approaches for these patients.

Effects of Nonlinear Soil Characteristics on the Dynamic Stiffnesses of a Foundation-Soil System Excited with the Horizontal Motion (비선형 지반특성이 수평 방향운동을 받는 기초지반체계의 동적강성에 미치는 영향)

  • 김용석
    • Proceedings of the Earthquake Engineering Society of Korea Conference
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    • 2000.04a
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    • pp.120-129
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    • 2000
  • As structure-soil interaction analysis for the seismic analysis of structures requires a nonlinear analysis of a structure-soil system considering the inelastic characteristics of soil layers nonlinear analyses of the foundation-soil system with the horizontal excitation were performed considering the nonlinear soil conditions for the nonlinear seismic analysis of structures. Stiff soil profile of SD and soft soil profile of SE specified in UBC were considered for the soil layers of a foundation and Ramberg-Osgood model was assumed for the nonlinear characteristics of soil layers. Studies on the changes of dynamci stiffnesses and damping rations of surface and embedded foundations depending on foundation size soil layer depth and piles were performed to investigate the effects of the nonlinear soil layer on the horizontal and rotational dynamic stiffnesses and damping ratios of the foundation-soil system According to the study results nonlinear prperties of a soil laryer decreeased horizontal and rotational linear stiffnesses and increased damping ratios largely Effects of foundation size soil layer depth and piles were also significant suggesting the necessity of nonlinear seismic analyses of structures.

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Laboratory Test of Piled-Raft Foundation Improved by Gravel Mat (Gravel Mat로 보강된 말뚝지지 전면기초의 실내모형실험)

  • Seo, Young-Kyo;Lee, Jeong-Hoon
    • Journal of Ocean Engineering and Technology
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    • v.25 no.2
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    • pp.47-54
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    • 2011
  • A piled raft foundation is one of the systems used to reduce the settlement of structures. However, the general design method for a piled raft foundation system assumes that the piles only support external loads, which exclude the bearing capacity of the raft itself. In this study, an experimental model test was performed to evaluate the raft capacity for the external load on the sand. Additionally, a part of the sandy ground under the raft was replaced with a gravel mat to reinforce the piled raft foundation system and increase the bearing capacity. Then, parametric studies of the reinforced ground were performed to determine the displacement and load-sharing ratio of the piled raft foundation system.

Numerical Analysis of the Mechanical Impedance and Transmitted Vibration of the Foundation for the Equipment in a Naval Vessel (수치해석을 이용한 함정용 장비 받침대의 기계적 임피던스 및 전달 진동 분석)

  • Han, Hyung-Suk;Son, Yoon-Jun
    • Transactions of the Korean Society for Noise and Vibration Engineering
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    • v.19 no.5
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    • pp.462-467
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    • 2009
  • Reduction of the structure-borne noise of the naval vessel is very important in order to reduce the underwater radiated noise of it. One of the important factors to reduce the structure-borne noise of the installed machine in a ship is the design of the foundation having sufficiently high mechanical impedance. In this paper, the mechanical impedance of the foundation for the fan-coil unit in a naval vessel is evaluated numerically according to variation of the thickness of the foundation. And also, the forced vibration analysis is conducted considering the dynamic property of the anti-vibration mount. Through the analysis results, it can be known that the dynamic property of the anti-vibration mount should be considered when the minimum level of the mechanical impedance of the foundation is set.

A Consideration of Volume and Installation Method of Concrete-Embedded Foundation Earthed an Electrode (콘크리트에 매입된 기초접지극의 크기 및 설치방법에 관한 고찰)

  • Lee, Ju-Cheol;Lee, Young-Chul;Kim, Jae-Chul
    • Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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    • v.27 no.7
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    • pp.82-88
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    • 2013
  • IEC standards do not require to limit the earthing resistance of the concrete-embedded foundation earthing electrode which is installed to a specific value. However, in Korea the value of $5{\Omega}$ and below applies to the earthing resistance for a domestic customer whose receiving voltage is 22.9kV. This paper calculates the minimum area and volume of the concrete-embedded foundation earthing electrode in order to obtain a specific value of the earthing resistance when the electrode of the building's lightning protection system and that of its power system are interconnected. It also suggested the most appropriate method of installing the foundation earthing electrode, taking the electric characteristics of concrete into account.

Model Test and Deformation Analysis of the Improved Soft Foundation( Il) (개량연약지반의 모형실험과 변형해석 (II))

  • 이진수;이문수
    • Magazine of the Korean Society of Agricultural Engineers
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    • v.36 no.4
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    • pp.73-86
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    • 1994
  • Ths paper was aimed to investigate the effect of reinforcement for the deformation characteristics of clayey foundation. Among numerous improvement method of foundation, only geotextil-reinforced foundation and foundation with both geotextile and sand mat which were 2-dimensional model clayey foundations were selected for load test in order to obtain fundamental results in analizing the behavior of the foundation with geotextile. To scrutinize the behavior characteristics and effect of reinforcement, the model foundations were constructed with various conditions on the location of layout of geotextile, the number of layouts and the depth of sand mat As for the technique of the numerical analysis elasto-plastic constitutive model for clayey soil, beam element for geotextile and elastic model for sand were respectively employed. Interface element was introduced for the block between materials with different rigidity. Observed values and numerical results were compared with satisfactory correspondence, which proved that the numercial technique developed in this paper was available.

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Vibration attenuation in periodic composite Timoshenko beams on Pasternak foundation

  • Xiang, Hong-Jun;Shi, Zhi-Fei
    • Structural Engineering and Mechanics
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    • v.40 no.3
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    • pp.373-392
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    • 2011
  • Periodic and quasi-periodic Timoshenko beams on Pasternak foundation are investigated using the differential quadrature method. Not only band gaps in the beams but also the dynamic response of them is analyzed. Numerical results show that vibration in periodic beams can be dramatically attenuated when the exciting frequency falls into band gaps. Different from the band structures of periodic beams without foundation, the so-called critical frequency was found because of the Pasternak foundation. Its physical meaning was explained in detail and a useful formula was given to calculate the critical frequency. Additionally, a comprehensive parameter study is conducted to highlight the influence of foundation modulus on the band gaps.

The Numerical analysis of Top-Base Foundation in Siwha Marine Clay (시화 해성점토 지반에서의 팽이기초의 수치해석연구)

  • Kim, Hyun-Soo;Kim, Hak-Moon;Kim, Chan-Kook
    • Proceedings of the Korean Geotechical Society Conference
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    • 2008.03a
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    • pp.1155-1165
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    • 2008
  • Full scale size model tests of the top-base foundation was performed in siwha marine clay and the site measurement results were compared with the analytical results from finite different programs, FLAC-2D to investigate the behavior of top-base foundation. The stress distribution obtained from the numerical analysis for the various types of foundation were compared and analysed during the application of allowable load as well as yield load. It was found that the top-base foundation prevents the lateral deformation of soft ground and stress dispersion effect to reduce the surface settlement, and that the foundation creates uniform stress distribution around it, therefore increasing bearing capacity.

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Foundation Design of Apartment Buildings considering Upper Structure Stiffness (상부구조물강성을 고려한 아파트 건축물의 기초판 설계 방법)

  • Lee, Kyung-Koo;Park, Hong-Gun;Noh, Jung-Tae;Lee, Sang-Hyun;Chung, Lan
    • Proceedings of the Korea Concrete Institute Conference
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    • 2009.05a
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    • pp.113-114
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    • 2009
  • The efficient foundation design of apartment buildings needs to include the effect of upper structure on foundation behavior. In this study, a foundation design method effectively considering upper structure stiffness using finite element analysis program is proposed. The analytical study showed that the proposed method reduces the allowable soil pressure under foundation and the amount of reinforcement as well as concrete for foundation.

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