• Journal of Sensor Science and Technology
• /
• v.32 no.6
• /
• pp.418-424
• /
• 2023

Natural killer (NK) cells play a crucial role in combating infections and tumors. However, their therapeutic application in solid tumors is hindered by challenges, such as limited lifespan, tumor penetration, and delivery precision. Our research introduces a novel ultrasonic actuation technique to navigate NK cells more effectively in the vascular system, particularly at vessel bifurcations where targeted delivery is most problematic. We use a hemispherical ultrasonic transducer array that generates phase-modulated traveling waves, focusing on an ultrasound beam to steer NK cells using blood-flow dynamics and a focused acoustic field. This method enables the precise obstruction of non-target vessels and efficiently directs NK cells toward the tumor site. The simulation results offer insights into the behavior of NK cells under various conditions of cell size, radiation pressure, and fluid velocity, which inform the optimization of their trajectories and increase targeting efficiency. The experimental results demonstrate the feasibility of this ultrasonic approach for enhancing NK cell targeting, suggesting a potential leap forward in solid tumor immunotherapy. This study represents a significant step in NK cell therapeutic strategies, offering a viable solution to the existing limitations and promising enhancement of the efficacy of cancer treatments.

• The Korean Journal of Air & Space Law and Policy
• /
• v.18
• /
• pp.135-183
• /
• 2003

Aerospace force is a determining factor in a modem war. The combat field is expanding to space. Thus, the legitimacy of establishing aerospace force is no longer an debating issue, but "how should we establish aerospace force" has become an issue to the military. The standard limiting on the military use of space should be non-aggressive use as asserted by the U.S., rather than non-military use as asserted by the former Soviet Union. The former Soviet Union's argument is not even strongly supported by the current Russia government, and realistically is hard to be applied. Thus, the multi-purpose satellite used for military surveillance or a commercial satellite employed for military communication are allowed under the U.S. principle of peaceful use of space. In this regard, Air Force may be free to develop a military surveillance satellite and a communication satellite with civilian research institute. Although MTCR, entered into with the U.S., restricts the development of space-launching vehicle for the export purpose, the development of space-launching vehicle by the Korea Air Force or Korea Aerospace Research Institute is beyond the scope of application of MTCR, and Air Force may just operate a satellite in the orbit for the military purpose. The primary task for multi-purpose satellite is a remote sensing; SAR sensor with high resolution is mainly employed for military use. Therefore, a system that enables Air Force, the Korea Aerospace Research Institute, and Agency for Defense Development to conduct joint-research and development should be instituted. U.S. Air Force has dismantled its own space-launching vehicle step by step, and, instead, has increased using private space launching vehicle. In addition, Military communication has been operated separately from civil communication services or broadcasting services due to the special circumstances unique to the military setting. However, joint-operation of communication facility by the military and civil users is preferred because this reduces financial burden resulting from separate operation of military satellite. During the Gulf War, U.S. armed forces employed commercial satellites for its military communication. Korea's participation in space technology research is a little bit behind in time, considering its economic scale. In terms of budget, Korea is to spend 5 trillion won for 15 years for the space activities. However, Japan has 2 trillion won annul budget for the same activities. Because the development of space industry during initial fostering period does not apply to profit-making business, government supports are inevitable. All space development programs of other foreign countries are entirely supported by each government, and, only recently, private industry started participating in limited area such as a communication satellite and broadcasting satellite, Particularly, Korea's space industry is in an infant stage, which largely demands government supports. Government support should be in the form of investment or financial contribution, rather than in the form of loan or borrowing. Compared to other advanced countries in space industry, Korea needs more budget and professional research staff. Naturally, for the efficient and systemic space development and for the prevention of overlapping and distraction of power, it is necessary to enact space-related statutes, which would provide dear vision for the Korea space development. Furthermore, the fact that a variety of departments are running their own space development program requires a centralized and single space-industry development system. Prior to discussing how to coordinate or integrate space programs between Agency for Defense Development and the Korea Aerospace Research Institute, it is a prerequisite to establish, namely, "Space Operations Center"in the Air Force, which would determine policy and strategy in operating space forces. For the establishment of "Space Operations Center," policy determinations by the Ministry of National Defense and the Joint Chief of Staff are required. Especially, space surveillance system through using a military surveillance satellite and communication satellite, which would lay foundation for independent defense, shall be established with reference to Japan's space force plan. In order to resolve issues related to MTCR, Air Force would use space-launching vehicle of the Korea Aerospace Research Institute. Moreover, defense budge should be appropriated for using multi-purpose satellite and communication satellite. The Ministry of National Defense needs to appropriate 2.5 trillion won budget for space operations, which amounts to Japan's surveillance satellite operating budges.

• Physical Therapy Korea
• /
• v.12 no.2
• /
• pp.1-10
• /
• 2005

Pressure ulcers are serious complications of tissue damage that can develop in patients with diminished pain sensation and diminished mobility. Pressure ulcers can result in irreversible tissue damage caused by ischemia resulting from external loading. There are many intrinsic and extrinsic contributors to the problem, including interface tissue pressure, shear, temperature, moisture, hygiene, nutrition, tissue tolerance, sensory and motor dysfunction, disease and infection, posture, and body support systems. The purposes of this study were to investigate the relationship between buttock interface pressure and seating position, wheelchair propulsion speed. Seated-interface pressure was measured using the Force Sensing Array pressure mapping system. Twenty subjects propelled wheelchair handrim on a motor-driven treadmill at different velocities (40, 60, 80 m/min) and seating position used recline ($100^{\circ}$, $110^{\circ}$, $120^{\circ}$) with a wheelchair simulator. Interface pressure consists of average (mean of the pressure sensor values) and maximum pressure (highest individual sensor value). The results of this study were as follows; No significant correlation in maximum/average pressure was found between a static position and a 40 m/min wheelchair propulsion (p>.05). However, a significant increase in maximum/average pressure were identified between conditions of a static position and 60 m/min, and 80 m/min wheelchair propulsion (p<.05). No significant correlation in maximum pressure were found between a $90^{\circ}$ recline (neutral position) and a $100^{\circ}$, $110^{\circ}$, or $120^{\circ}$ recline of the wheelchair back (p>.05). No significant difference in average pressure was found between conditions of a $90^{\circ}$ recline and both a $100^{\circ}$ and $110^{\circ}$ recline of wheelchair back. However, a significant reduction in average pressure was identified between conditions of a $90^{\circ}$ and $120^{\circ}$ recline of wheelchair back (p<.05). This study has shown some interesting results that reclining the seat by $120^{\circ}$ reduced average interface pressure, including the reduction or prevention in edema. And interface pressure was greater during dynamic wheelchair propulsion compared with static seating. Therefore, the optimal seating position and seating system ought to provide postural control and pressure relief. We need an education on optimal seating position and a suitable propulsion speeds for wheelchair users.

• Transactions of the Korean Society of Mechanical Engineers A
• /
• v.38 no.9
• /
• pp.925-932
• /
• 2014

If a rotor possesses a high gyroscopic coupling or the running speed is high, the dynamical changes in the rotor become prominent. When active magnetic bearings are used to support such rotors, it is necessary for the bearing controller to take these dynamical changes into consideration. Independent-axis controllers, which are the most commonly used, modulate the bearing force solely based on the sensor output of the same axis. However, this type of controller has difficulties in overcoming the dynamical changes. On the other hand, mixed-axis controllers transform the sensor output into components corresponding to the vibrational modes. A separate controller can then be designed for each vibrational mode. In this way, the controller can be designed based on the dynamics of the rotor. In this paper, we describe a design process for a mixed-axis controller that uses a detailed mathematical model of the system. The performance of the controller is evaluated based on the ISO sensitivity requirements and unbalance response, while considering the change in the system dynamics due to the running speed.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.19 no.7
• /
• pp.493-503
• /
• 2018

Recently, as living standards have improved, many people are becoming more interested in health, and self-training is increasing through exercise to prevent and manage pre-illness. In general, an imbalance of muscles causes asymmetry of posture, which can cause various diseases by accompanying an adjustment force, circulation action, displacement of internal organs, etc.. In this study, the development of fitness software that can be self - training among smart wears has attracted considerable attention in recent years. In this study, a technology was proposed for the commercialization of self - trainer fitness wear by a simulation through Android - based applications. Self - trainer fitness software was developed by combining a conductive polymer, fashion design, sewing, and electric and electronic technology to monitor the unbalance of the muscles during exercise and make smart wear that can calibrate the asymmetry by oneself. In particular, a polymer sensor was fabricated by deriving the optimal MWCNT concentration, and the electrode signal was collected by attaching the electrode to the optimal position, where the electrode signal line using the conductive fiber was designed and attached to collect the signal. A signal module that converts the bio-signals collected through electrical signal conversion and transmits them using Bluetooth communication was designed and manufactured. Self-trainer fitness software that can be commercialized was developed by combining noise cancellation with Android-based self-training application using a software algorithm method.

• Journal of Sensor Science and Technology
• /
• v.10 no.5
• /
• pp.292-303
• /
• 2001

This work reports the tunneling effects of the lateral field emitters. Tunneling effect is applicable to the VMFS(vacuum magnetic field sensors). VMFS uses the fact that the trajectory of the emitted electrons are curved by the magnetic field due to Lorentz force. Polysilicon was used as field emitters and anode materials. Thickness of the emitter and the anode were $2\;{\mu}m$, respectively. PSG(phospho-silicate-glass) was used as a sacrificial layer and it was etched by HF at a releasing step. Cantilevers were doped with $POCl_3(10^{20}cm^{-3})$. $2{\mu}m$-thick cantilevers were fabricated onto PSG($2{\mu}m$-thick). Sublimation drying method was used at releasing step to avoid stiction. Then, device was vacuum sealed. Device was fixed to a sodalime-glass #1 with silver paste and it was wire bonded. Glass #1 has a predefined hole and a sputtered silicon-film at backside. The front-side of the device was sealed with sodalime-glass #2 using the glass frit. After getter insertion via the hole, backside of the glass #1 was bonded electrostatically with the sodalime-glass #3 at $10^{-6}\;torr$. After sealing, getter was activated. Sealing was successful to operate the tunneling device. The packaged VMFS showed very small reduced emission current compared with the chamber test prior to sealing. The emission currents were changed when the magnetic field was induced. The sensitivity of the device was about 3%/T at about 1 Tesla magnetic field.

• Journal of Digital Convergence
• /
• v.17 no.11
• /
• pp.207-213
• /
• 2019

The fuel-cut coast-down driving mode is activated when the acceleration pedal is released with transmission gear engaged, and it's a default function for electronic-controlled engine of vehicles. The fuel economy becomes better because fuel injection stops during fuel-cut driving mode. A fuel-cut detection method is suggested in the study and it's based on the speed, acceleration and road gradient data from GPS sensor. It detects fuel-cut driving mode by comparing calculated acceleration and realtime acceleration value. The one is estimated with driving resistance in the condition of fuel-cut driving and the other is from GPS sensor. The detection accuracy is about 80% when the method is verified with road driving data. The result is estimated with 9,600 data set of vehicle speed, acceleration, fuel consumption and road gradient from test driving on the road of 12km during 16 minutes, and the road slope is rather high. It's easy to detect fuel-cut without injector signal obtained by connecting wire. The detection error is from the fact that the variation range of speed, acceleration and road gradient data, used for road resistance force, is larger than the value of fuel consumption data.

• KIPS Transactions on Computer and Communication Systems
• /
• v.6 no.11
• /
• pp.437-444
• /
• 2017

Electric Pole is a supporting beam used for power transmission/distribution which is sensitive to external force change of environmental factors. Therefore, power facilities have many difficulties in terms of maintenance/conservation from external environmental changes and natural disasters that cause a great economic impact. The aerial wire cause elasticity due to the influence of temperature, or factors such as wind speed and wind direction, that weakens the electric pole. The situation may lead to many safety risk in day-to-day life. But, the safety assessment of the pole is carried out at the design stage, and aftermath is not considered. For the safety and maintenance purposes, it is very important to analyze the influence of weather factors on external forces periodically. In this paper, we analyze the acceleration data of the sensor nodes installed in electric pole for maintenance/safety purpose and use Kalman filter as noise compensation method. Fast Fourier Transform (FFT) is performed to analyze the influence of each meteorological factor, along with the meteorological factors on frequency components. The result of the analysis shows that the temperature, humidity, solar radiation, hour of daylight, air pressure, wind direction and wind speed were influential factors. In this paper, the influences of meteorological factors on frequency components are different, and it is thought that it can be an important factor in achieving the purpose of safety and maintenance.

• KIPS Transactions on Computer and Communication Systems
• /
• v.6 no.11
• /
• pp.445-452
• /
• 2017

Electric pole is a supporting beam used for power transmission/distribution which accelerometer are used for measuring a external force. The meteorological condition has various effects on the external forces of electric pole. One of them is the elasticity change of the aerial wire. It is very important to perform modelling. The acceleration sensor is converted into a pitch and a roll angle. The meteorological condition has a high correlation between variables, and selecting significant explanatory variables for modeling may result in the problem of over-fitting. We constructed high deviance explained model considering multicollinearity using the Generalized Additive Model which is one of the machine learning methods. As a result of the Variation Inflation Factor Test, we selected and fitted the significant variable as temperature, precipitation, wind speed, wind direction, air pressure, dewpoint, hours of daylight and cloud cover. It was noted that the Hours of daylight, cloud cover and air pressure has high explained value in explonatory variable. The average coefficient of determination (R-Squared) of the Generalized Additive Model was 0.69. The constructed model can help to predict the influence on the external forces of electric pole, and contribute to the purpose of securing safety on utility pole.

• Journal of Korean Society of Transportation
• /
• v.22 no.5
• /
• pp.75-87
• /
• 2004

Along the seashore regions in Korea, though strong winds with very large strength are frequently witnessed, no system which can provide appropriate speed information for driving vehicle has been introduced. The driving against strong winds could be very dangerous because of the high possibility of accidents such as rollover and collision. These accidents usually resulted from driver's forced driving try even in difficult situation for steering vehicle, and sometimes overspeed without consideration of wind impact to the vehicles. To reduce accident caused by strong winds, it is important to inform drivers of appropriate driving speeds by perceiving strong winds. By setting up WIS at the main points where strong winds frequently appear and using the variable message sign(VMS) connected to the on-line whether information system, it tis possible to provide desired speed information, which can maintain vehicles' tractive force and maximum running resistance. The case study is conducted on the case of Mokpo-Big-Bridge, which is under construction at Mokpo city. The result show that in case the annual average direction of wind is South and the wind speed is over 8m/hr, the desired speed, which is required in order for vehicles running to South direction to maintain the marginal driving power, is 60km/hr. In addition, for the case of a typhoon such as Memi generated in 2003 year, if wind speed had been 18m/sec in Mokpo city at that time, the running resistance at the speed of 40km/hr is calculated as 1131N. This resistance can not be overcome at the 4th gear(1054N) level, therefore, the gear of vehicles should be reduced down to the 3rd level. In this case, the appropriate speed is 40km/h, and at this point the biggest difference between running resistance and tractive force is generated.