• Journal of Life Science
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• v.24 no.6
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• pp.677-685
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• 2014

The purpose of this study was to identify the effect on plasma levels of lipid and lipid peroxidation by administration of lactic acid bacteria (Lactobacillus bulgaricus, Streptococcus thermophilus, Lactobacillus acidophilus) fermented Orostachys malacophyllus (FOM) in alcohol fed rats. Male Sprague-dawley rats were randomly divided into seven groups: normal diet group (N), alcohol treated group (C), 2.5% (w/w) or 5% (w/w) OM treated group (2.5OM, 5OM), 2.5% (w/w) or 5% (w/w) fermented OM treated group (2.5FOM, 5FOM) and silymarin treated group (SM) as a positive control. As a result of measuring serum total lipid, C group were increased total lipid, free fatty acid content and were decreased HDL-cholesterol content, but 5FOM group were significantly decreased lipid content and were increased HDL-cholesterol content and accordingly reduced the incidence of atherosclerosis. Serum total protein content was similarly measured in all groups and serum albumin content was decreased in alcohol feeding groups compared to the N group. The 5FOM group had significantly decreased liver and serum triglycerides compared to the C group. The TBARS content in the liver, serum, testis, kidney, spleen, and heart were slightly decreased in the 5FOM group compared to the C group and the 5FOM group had an increased glutathione concentration. The 5FOM treatment was showed analogous results to those of the SM treatment, suggesting that FOM is can improve the lipid profiles of alcohol-fed rats.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.54 no.6
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• pp.1036-1044
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• 2021

A linear array acoustic transducer with 12 tonpilz elements mounted independently on a gradual wedge-shaped tail mass was fabricated, tested and analyzed. The compensated transducer, which is modified by including a series inductance of 137 µH in the developed linear array transducer, attained improved figure of merit (FOM) performance characteristics compared with the uncompensated transducer. The four resonant frequency bands were identified from the measured FOM curve. The FOM response patterns over the frequency ranges of 31 to 40 kHz and 50 to 60 kHz were relatively uniform, whereas sharp resonance peaks were observed at around 73 kHz and 84 kHz. These results indicate that the developed linear array transducer can be used as an enhanced broadband transducer of echo sounder, and the operating frequency can be selected for more effective echo surveys in the fishing ground.

• Journal of Life Science
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• v.25 no.8
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• pp.917-924
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• 2015

This study aimed to evaluate the protective effect of Orostachys malacophyllus (OM) and fermented O. malacophyllus (FOM) in Sprague-Dawley rats who had been intoxicated with 1% (w/w) orotic acid (OA) for 10 days. The activities of several hepatic enzymes, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and cholinesterase, were increased when OA was given, but these parameters were significantly decreased by FOM treatment. In addition, OA treatment resulted in an increased lipid peroxidative index (thiobarbituric acid-reactive substances, TBARS). A worsened antioxidant status (reduced glutathione) in the liver and serum was also observed. FOM treatment improved the antioxidant status of OA-induced fatty-liver rats, which was evaluated by decreased levels of the lipid peroxidative index and improved antioxidant status in the liver and serum. The contents of liver non-heme iron were increased with OA treatment and significantly decreased with FOM treatment, which suggested that the lipid peroxidation contents were inversely correlated with liver non-heme iron content. Based on these results, FOM is considered a material with significant potential for development into a functional health food that can improve fatty-liver conditions.

• Journal of Adhesion and Interface
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• v.19 no.3
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• pp.106-112
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• 2018

Recently, the hyperthermia treatment of malignant tissues has gained great attention as a biocompatible and benign method that facilitates successful cancer therapy compared to radiation and chemotherapy. In this study, superparamagnetic ($Fe_3O_4$) iron oxide nanoparticles (IONP) coated with biocompatible polymer (IONP@P(MPC/FOM)) for the purpose of hyperthermia treatment were prepared and related characterization were performed. IONPs with having 15 nm diameter were first prepared by coprecipitation and followed by surface modification with 4-cyanopentanoic acid dithiobenzoate (CTP) for reversible addition-fragmentation chain transfer (RAFT) copolymerization by using 2-methacryloyloxyethyl phosphorylcholine (MPC) and fluorescein O-methacrylate (FOM) to form corona layer of P(MPC/FOM) on the surface of the IONP. Transmission electron microscopy (TEM) and dynamic light scattering (DLS) confirmed the morphology and hydrodynamic size of the IONP@P(MPC/FOM) and thermogravimetric analysis (TGA) confirmed the formation of P(MPC/FOM) corona layer, respectively. Exposing IONP dispersion to alternating magnetic field suggests that the IONP@P(MPC/FOM) aqueous dispersion with 0.2 wt.% can be used for hyperthermia treatment.

• Bulletin of the Korean Mathematical Society
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• v.34 no.4
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• pp.667-678
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• 1997

This paper contains a convergence analysis of a flexible restarted FOM(k)(FFOM(k)), and its performance is compared with FGMRES(k). Performances of these two algorithms with variable preconditioners are also compared with those of preconditioned FOM(k) and GMRES(k). Numerical experiments show that FFOM(k) performs as well as, or better than for some problems, FGMRES(k).

• Journal of IKEEE
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• v.27 no.4
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• pp.567-572
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• 2023

In this paper, the breakdown voltage of Pi-LDMOS (Partial isolation lateral double diffused metal oxide semiconductor) was analyzed by simulation. Breakdown voltage variation is investigated under various settings of Parial buied oxide(P-BOX) parameters(length, thickness, location) and their mechanism is specified. In addition, the change in on-resistance in the breakdown voltage and trade-off relationship was analyzed according to the change in the P-BOX parameter, and the Figure-of-merit(FOM) was calculated and compared. In proposed structure, Lbox=5 ㎛, tbox=2 ㎛, and Lbc=2 ㎛ showed the highest breakdown voltage of 138V, and Lbox=5 ㎛, tbox=1.6 ㎛, and Lbc=2 ㎛ showed the highest FOM. Compared to conventional LDMOS, the breakdown voltage is 123% and FOM is 3.89 times improved. Therefore, Pi-LDMOS has a high breakdown voltage and FOM, which can contribute to the improvement of the stable operating range of the Power IC.

• Proceedings of the Materials Research Society of Korea Conference
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• 1995.11a
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• pp.29-29
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• 1995

• Proceedings of the Korea Information Processing Society Conference
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• 2011.11a
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• pp.1334-1337
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• 2011

HLA(High Level Architecture)는 분산 환경의 모델링 및 시뮬레이션(Modeling & Simulation)을 위한 공통 아키텍처를 제공하는 기술 표준이며, RTI(Run-Time Infrastructure)를 통해 HLA 서비스를 제공한다. HLA는 연동 객체 모델인 FOM(Federation Object Model)을 기반으로 시뮬레이션 환경을 구성하며, 시뮬레이션에 참여하는 모든 시뮬레이터는 동일한 FOM을 소유해야 한다. 따라서 시뮬레이션 체계 간 연동을 수행하기 위해서는 FOM을 통합하거나 FOM 간 연동을 위한 게이트웨이를 구현해야 한다. 한편, FOM을 통합하는 방법은 각 시뮬레이션의 연동 인터페이스 수정이 필요하기 때문에 게이트웨이를 구현하는 방법이 기존 시스템의 변경을 최소화할 수 있다. 따라서 본 논문은 HLA기반 시뮬레이션의 체계 간 연동을 제공할 수 있는 게이트웨이 구조를 제시한다. 특히, XML 형태의 객체 모델을 기반으로 교환 메시지를 정의하고, 메시지 처리 모듈을 게이트웨이에 플러그인 함으로써 시뮬레이션 체계 간 연동의 용이함을 보여준다.

• International Journal of Oral Biology
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• v.42 no.2
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• pp.63-70
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• 2017

Selecting an appropriate antigen with optimal immunogenicity and physicochemical properties is a pivotal factor to develop a protein based subunit vaccine. Despite rapid progress in modern molecular cloning and recombinant protein technology, there remains a huge challenge for purifying and using protein antigens rich in hydrophobic domains, such as membrane associated proteins. To overcome current limitations using hydrophobic proteins as vaccine antigens, we adopted in silico analyses which included bioinformatic prediction and sequence-based protein 3D structure modeling, to develop a novel periodontitis subunit vaccine against the outer membrane protein FomA of Fusobacterium nucleatum. To generate an optimal antigen candidate, we predicted hydrophilicity and B cell epitope parameter by querying to web-based databases, and designed a truncated FomA (tFomA) candidate with better solubility and preserved B cell epitopes. The truncated recombinant protein was engineered to expose epitopes on the surface through simulating amino acid sequence-based 3D folding in aqueous environment. The recombinant tFomA was further expressed and purified, and its immunological properties were evaluated. In the mice intranasal vaccination study, tFomA significantly induced antigen-specific IgG and sIgA responses in both systemic and oral-mucosal compartments, respectively. Our results testify that intelligent in silico designing of antigens provide amenable vaccine epitopes from hard-to-manufacture hydrophobic domain rich microbial antigens.

• Journal of Animal Science and Technology
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• v.64 no.1
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• pp.135-142
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• 2022

It is impossible to know the amount of pork primal cut by pig carcass grade which is determined only by carcass weight and backfat thickness in the Korean Pig Carcass System. The aim of this study was to investigate the correlation between the pig carcass grade and the amount of pork primal cut estimated with AutoFom III. A total of 419,321 Landrace, Yorkshire, and Duroc (LYD) pigs were graded with the Korean Pig Carcass Grade System. Amounts of belly, neck, loin, tenderloin, spare ribs, shoulder, and ham were estimated with AutoFom III. Regression equations for seven primal cuts according to each grade were derived. There were significant differences among the three carcass grades due to heteroscedasticity variance (p < 0.0001). Three regression equations were derived from AutoFom III estimation of primal cuts according to carcass grades. The coefficient of determination of the regression equation was 0.941 for grade 1⁺, 0.982 for grade 1, and 0.993 for grade 2. Regression equations obtained from this study are suitable for AutoFom III software, a useful tool for the analysis of each pig carcass grade in the Korean Pig Carcass Grade System. The high reliability of predicting the amount of primal cut with AutoFom III is advantageous for the management of slaughterhouses to optimize their product sorting in Korea.