• Journal of Genetic Medicine
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• v.2 no.2
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• pp.65-70
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• 1998

Lysosomal acid lipase (LAL) plays a central role in the intracellular degradation of neutral lipids derived from plasma lipoproteins. In this study, we investigated the missense mutation within exon 2 of human LAL gene changing of codon -6 of prepeptide from threonine to proline. The Thr-6Pro mutation was detected by the HaeIII restriction fragment length polymorphism (RFLP) and single-strand conformation polymorphism (SSCP). We analyzed the mutation in subjects with 221 unrelated randomly selected control samples and 86 patients with familial hypercholesterolemia (FH) in Korea. We observed that mutation is present with high frequency in Korea compared to other populations studied previously. The frequency of PP homozygote in the FH group was observed considerably higher than that of control. However, there was no significant difference of genotype frequency between two groups. These results, together with the fact that plasma lipids and lipoproteins levels between genotypes showed no statistical difference, suggest that the Thr-6Pro mutation in the LAL gene may have no association with the increased risk of FH development.

• The korean journal of orthodontics
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• v.44 no.2
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• pp.77-87
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• 2014

Objectives: This study was designed to define the Korean norm values for the Ricketts analysis. Methods: In this longitudinal study, lateral cephalograms of 31 subjects with normal occlusion were taken biennially from ages 9-19 years. Cephalometric measurements were performed. Parameters for which the 10-year change did not exceed one standard deviation were defined as unchanged. The means and standard deviations for the measured parameters were determined for each age group. Results: No significant changes in growth were observed in the molar relationship, incisor overjet, incisor overbite, mandibular incisor extrusion, interincisor angle, lower incisor tip (B1) to A point-Pogonion (A-PO) plane, upper incisor tip (A1) to A-PO plane, B1 inclination to A-PO, A1 inclination to A-PO, B1 inclination to Frankfurt plane (FH), convexity, lower facial height, facial axis, maxillary depth, maxillary height, palatal plane to FH, cranial deflection, ramus Xi position, or porion location. Continual changes over the 10 years of growth were observed in the maxillary first molar distal position to pterygoid true vertical plane, facial depth, mandibular plane to FH, anterior cranial length, mandibular arc, and corpus length. Conclusions: Clinicians can apply the Korean norms at age 9 as determined in this study when using the Ricketts analysis. The patient's age at the beginning of treatment and their sex should be taken into consideration when drawing visual treatment objectives.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.33 no.2A
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• pp.159-166
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• 2008

In this paper, we proposed an algorithm to solve the problem that can't maintain hop synchronization using only early-late gate tracking loop due to the drift of geo-stationary satellite in frequency hopping satellite communication system. When the signal is transferred to downlink through DRT(Dehop-Rebop Transponder), the problem with synchronization loss is occurred periodically when using only early-late gate tracking loop, because of energy loss in each side portion of hop due to orbital variation of the satellite. To solve this problem, we have developed Anti-Shrink synchronization tracking algorithm which uses the prediction value of transmission timing and the structure of inner-outer gate instead of early-late gate with the ranging information. Through simulations, we showed that the performance of the Anti-Shrink algorithm is better than that of simple inner-outer energy ratio algorithm and similar to that of conventional early-late tracking loop algorithm with ranging information. No synchronization failure in the proposed algorithm was occurred because of less energy loss and robustness without the ranging information.

• The korean journal of orthodontics
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• v.51 no.3
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• pp.166-178
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• 2021

Objective: To investigate dimensional changes in regional pharyngeal airway spaces after premolar extraction in bimaxillary skeletal protrusion (BSP) patients according to vertical skeletal pattern, and to further identify dentoskeletal risk factors to predict posttreatment pharyngeal changes. Methods: Fifty-five adults showing BSP treated with microimplant anchorage after four premolar extractions were included in this retrospective study. The subjects were divided into two groups according to the mandibular plane steepness: hyperdivergent (Frankfort horizontal plane to mandibular plane [FH-MP] ≥ 30) and nonhyperdivergent groups (FH-MP < 30). The control group consisted of 20 untreated adults with skeletal Class I normodivergent pattern and favorable profile. Treatment changes in cephalometric variables were evaluated and compared. The association between posttreatment changes in the dentoskeletal and upper airway variables were analyzed using linear regression analysis. Results: The BSP patients showed no significant decrease in the pharyngeal dimensions to the lower level in comparison with controls, except for middle airway space (MAS, p < 0.01). The upper airway variable representing greater decrease in the hyperdivergent group than in the nonhyperdivergent group was the MAS (p < 0.01). Posttreatment changes in FH-MP had negative correlation with changes in MAS (β = -0.42, p < 0.01) and inferior airway space (β = -0.52, p < 0.01) as a result of multivariable regression analysis adjusted for sagittal skeletal relationship. Conclusions: Decreased pharyngeal dimensions after treatment in BSP patients showed no significant difference from the normal range of pharyngeal dimensions. However, the glossopharyngeal airway space may be susceptible to treatment when vertical dimension increased in hyperdivergent BSP patients.

• The korean journal of orthodontics
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• v.27 no.3 s.62
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• pp.359-372
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• 1997

This study was conducted to discern differences of craniofacial, dentoalveolar structure and model measurements between sex and between class n openbite group and non-openbite group. The sample consisted of 49 adult patients with class Il malocclusion. 24 linear measurements, 22 angular measurements and 12 ratios were selected in lateral cephalometry. Also, arch width, length, anterior crowding, average molar relation were measured or calculated in diagnostic model. The data were evaluated by t-test and multiple discriminant analysis. The results were as follows, 1. Most linear measurements, with the exception of MnBL and AUDH, were significantly larger in male(p<0.05). but, intermaxillary relations and spatial position of maxilla and mandible relative to cranial base were not different for both sex. 2. With the exception of upper and lower anterior crowding, lower arch width, upper arch length, AMR, male exhibited significantly larger measurements in model analysis (p<0.05). 3. Size differences of maxilla and mandible between openbite and non-openbite group were not significant(p>0.05). but openbite group showed significantly increased genial angle(p<0.05), FH-CoGo(p<0.01), FH-NA(p<0.01) and FH-NB, FH-NPog (p<0.05). 4. ALFH and PUDH were larger(p<0.05) in openbite group. this result served as compensation for the spatial position of mandible relative to cranial base. AUPUDH (p<0.001) and ALPLDH(p<0.05) were lower in openbite group. upper anterior crowding was the only measurement which showed difference between openbite and non-openbite group(p<0.05). 5. For the purpose of classifying adult class n openbite and non-openbite group, multiple discriminant analysis was done genial angle, ALPLDH, AUPUDH, FH-NA were included in multiple discriminant equation. 39 cases($92.86\%$) were correctly classified when applied to the sample used in this study.

• The korean journal of orthodontics
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• v.39 no.5
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• pp.300-309
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• 2009

Objective: The purpose of this study was to evaluate the correlation between menton deviation and dental compensation in facial asymmetry. Methods: Tooth axis and distance of first molar and canine to the reference plane were investigated by cone-beam computerized tomography. The subjects consisted of 50 patients with asymmetric mandibles (male 21, female 29, mean age 24.3 years). Control groups were also assessed (male 11, female 9, mean age 25.6 years). Nine measurements (5 linear measurements and 4 angular measurements) were measured in order to evaluate the correlation between menton deviation and the linear and angular difference of first molar and canine in the deviated and none-deviated sides using the defined MPR images. The differences between deviated and non-deviated side, according to menton deviation, were statistically analyzed using stepwise multiple regression analysis. Results: From the result, Menton deviation was negatively correlated with mandibular first molar's angular measurement (${\Delta\angle}LM6$-Mn plane (dev.-ndev.)) and positively with maxillary fist molar's angular measurement (${\Delta\angle}UM6$-FH plane (dev.-ndev.)) (p < 0.01). Two angular measurements (${\Delta\angle}LM6$-Mn plane (dev.-ndev.), ${\Delta\angle}UM6$-FH plane (dev.-ndev.)) explained the variability in menton deviation with a significant $r^2$ value of 0.589. Conclusions: This study suggests that the tooth axis of upper and lower first molars leans towards the deviated side of Menton when there is mandibular asymmetry with Menton deviation.

• Reproductive and Developmental Biology
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• v.36 no.4
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• pp.243-248
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• 2012

This study was conducted to find a useful marker for gene polymorphism analysis using Microsatellite marker (MS marker) in Gyeongju Donggyeong dog. Twenty three MS marker analyzed the genetic features of DNA using 100 Gyeongju Donggyeong dogs in Gyeongju area. It was performed multiplex PCR with 3 set primer divided 9, 10 and 4 by analysis of conditions among MS markers. The results were calculated heterozygosity, polymorphic information content (PIC), allele frequency and number of allele at each locus using Microsatellite Toolkit software and Cervus 3.0 program. Total 148 alleles were genotyped to determine and average 6.43 alleles was detected. FH3381 had the highest of 15 alleles and FH2834 had the lowest of 2 alleles. Expected heterozygosity had a wide range from 0.282 to 0.876 and had average value of 0.6496. Also, Observed heterozygosity had a more wide range from 0.200 to 0.950 and had average value of 0.6404. PIC had range from 0.262 to 0.859 and average PIC was calculated 0.606. Especially, FH2998 represented the highest rate of observed heterozygosity of 0.950 and FH3381 represented the highest rate of expected heterozygosity of 0.876 and PIC of 0.859. The use of these markers was considered to be useful to study genetic traits of Gyeongju Donggyeong dog.

• The korean journal of orthodontics
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• v.28 no.5 s.70
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• pp.791-802
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• 1998

The purpose of this study was to obtain the angulation and inclination of FACC of all teeth to FH plane. Study models of 31 persons with normal occlusion were selected and mounted on the semiadjustable articulator for this study. Using T.A.R.G. with a little modified method, the angulation and inclination of FACC of all teeth to FH plane were measured and then the measurements were analyzed statistically. The obtained results were as follows. Mean, standard deviation, maximum value, and minimum value of the angulation and inclination of FACC of upper and lower teeth were obtained. $\cdot$The FACC in both upper and lower arch was progressively lingually-inclined from anterior teeth to posterior teeth. $\cdot$In the angulations of FACC of upper teeth, central and lateral incisor showed similar value. Yet, the FACC of the rest was progressively distally-angulated from the canine to posterior teeth. The FACC in lower arch was progressively mesially-angulated from anterior teeth to posterior teeth. $\cdot$The angulation and inclination of FACC of any tooth in both upper and lower teeth correlated strongly and positively with the angulation and inclination of FACC of adjacent tooth.

• Journal of Dental Rehabilitation and Applied Science
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• v.25 no.2
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• pp.171-181
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• 2009

The objective of this study was to analyse stress distribution of maxillary complex by use of face mask. The construction of the three-dimensional FEM model was based on the computed tomography(CT) scans of 13.5 years-old male subject. The CT image were digitized and converted to the finite element model by using the mimics program, with PATRAN. An anteriorly directed force of 500g was applied at the first premolar 45 degrees downwards to the FH plane and at the first molar 20 degrees downwards to the FH plane. When 45 degrees force was applied at maxillary first premolar, there were observed expansion at molar part and constriction at premolar part. The largest displacement was 0.00011mm in the x-axis. In the y-axis, anterior displacement observed generally 0.00030mm at maximum. In the z-axis, maxillary complex was displaced 0.00036 mm forward and downward. When 20 degrees force was applied at maxilla first molar, there were observed expansion at lateral nasal wall and constriction at molar part. The largest displacement was 0.001mm in the X-axis. In the Y-axis, anterior displacement observed generally 0.004mm at maximum. In the Z-axis, ANS was displaced upward and pterygoid complex was displaced downward. The largest displacement was 0.002mm.

• The KIPS Transactions:PartC
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• v.19C no.2
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• pp.99-118
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• 2012

In PMIPv6-based network, mobile nodes can be made smaller and lighter because the network nodes perform the mobility management-related functions on behalf of the mobile nodes. The one of the protocols, Fast Handovers for Proxy Mobile IPv6(FPMIPv6)[1] has studied by the Internet Engineering Task Force(IETF). Since FPMIPv6 adopts the entities and the concepts of Fast Handovers for Mobile IPv6(FMIPv6) in Proxy Mobile IPv6(PMIPv6), it reduces the packet loss. Conventional scheme has proposed that it cooperated with an Authentication, Authorization and Accounting(AAA) infrastructure for authentication of a mobile node in PMIPv6, Despite the best efficiency, without begin secured of signaling messages, PMIPv6 is vulnerable to various security threats such as the DoS or redirect attAcks and it can not support global mobility between PMIPv. In this paper, we analyze Kang-Park & ESS-FH scheme, and then propose an Enhanced Security scheme for FPMIPv6(ESS-FP). Based on the CGA method and the pubilc key Cryptography, ESS-FP provides the strong key exchange and the key independence in addition to improving the weaknesses for FPMIPv6. The proposed scheme is formally verified based on Ban-logic, and its handover latency is analyzed and compared with that of Kang-Park scheme[3] & ESS-FH and this paper propose inter-domain fast handover sheme for PMIPv6 using proxy-based FMIPv6(FPMIPv6).