• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2012년도 학술발표회
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• pp.405-405
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• 2012

기후변화에 따른 태풍, 집중호우 등에 의해 설계홍수량을 능가하는 크기의 홍수가 발생하여 큰 피해를 입는 경우가 발생하고 있다. 따라서 기후변화를 고려하여 예측한 미래의 강우자료에 의한 홍수량의 설계가 필요하다. 본 연구의 목적은 기후변화를 고려해 예측한 미래의 강우자료에 기초한 설계 홍수량을 산정하고, 이를 기존의 설계 홍수량과 비교분석하는데 있다. 대상지구는 이동저수지 유역을 선정하였고, HEC-GeoHMS를 이용해 대상지구의 유역자료를 추출하였다. 설계홍수량 추정을 위한 과거 강우자료는 수원기상대의 1964년부터 2011년까지의 자료기간을 수집하여 사용하였으며, 미래의 강우자료는 기상청 국가표준 기후변화 시나리오에서 제공하는 자료를 사용하였다. 수집된 강우자료를 바탕으로 FARD2006의 Gumbel 분포와 모멘트법을 적용하여 빈도별 확률 강우량을 각각 산정하였다. 산정된 빈도별 확률강우량을 수원지역의 Huff 분포에 적용해 시간별 강우분포를 구한 후 HEC-HMS의 Clark 단위도법을 이용하여 빈도별 홍수량을 각각 산정하여 그 결과를 비교 분석하였다. 본 연구를 통해 미래 강우자료에 의한 홍수량 설계의 필요성을 입증하고, 이를 바탕으로 다른 대상 지구에 대해서도 적용하여 미래의 홍수량 예측에 따른 설계빈도 설정에 활용할 수 있을 것으로 기대된다.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2008년도 학술발표회 논문집
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• pp.164-168
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• 2008

일반적으로 확률강우량은 관측지점에서 관측된 연최대 강우량자료를 바탕으로 빈도해석을 적용하여 산정한다. 그러나 국내에서는 매시각별로 관측된 자료가 대부분이기 때문에 단기간 혹은 장기간의 지속기간에 대한 확률강우량을 산정하는 것은 쉽지 않다. 따라서 본 연구에서는 매시각단위의 지속기간 강우자료를 바탕으로 다양한 지속기간에 대한 확률 강우량을 산정할 수 있는 스케일 성질을 적용하여 확률강우량을 산정하여 정확성을 판단하였다. 강우자료는 비교적 신뢰성이 높고 자료기간이 긴 기상청 지점 22개 자료를 사용하였으며, 2003년까지의 관측된 자료를 이용하여 확률강우량을 산정한 후 지점빈도해석 프로그램인 FARD2006과 비교하여 지점빈도해석의 결과 값을 참값으로 절대상대오차를 산정하여 비교하였다. 산정한 방법은 기준이 되는 확률강우량을 산정한 후 그보다 긴 지속기간에 대한 확률강우량을 산정하는 방법인 상향스케일링 (Up-scaling)과 그 보다 짧은 지속기간에 대한 확률강우량을 산정하는 방법인 하향스케일링(Down-scaling)의 두 가지 방법으로 확률강우량을 산정하였다. 두 방법 모두 1시간$\sim$24시간의 지속기간에 대한 확률강우량을 2년$\sim$500년의 재현기간에 대하여 확률강우량을 산정하였으며, 빈도해석으로 산정한 FARD2006의 결과값과 비교하여 절대상대오차를 산정하였다. 그 결과, 시간단위자료를 사용할 경우 대부분 절대상대오차가 10% 미만인 결과를 얻을 수 있었으며, 14개의 재현기간 중에서 8개 이상의 재현기간에 대해 적용이 가능한 것으로 나타났다. 지속기간 1시간 강우자료를 기준 지속기간으로 1시간 미만의 지속기간에 대한 확률강우량을 추정한 결과 10분을 제외하고는 대부분 절대상대오차가 10% 내외의 정확도를 가지는 것으로 나타났다. 따라서 스케일 성질을 이용하여 미계측 강우지속기간의 확률강우량을 추정할 수 있을 것으로 판단된다.

• Structural Engineering and Mechanics
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• 제49권5호
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• pp.537-554
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• 2014

In this paper, free vibration of a sandwich curved beam with a functionally graded (FG) core was investigated. Closed-form formulations of two-dimensional (2D) refined higher order beam theory (RHOBT) without neglecting the amount of z/R was derived and used. The present RHOBT analysis incorporated a trapezoidal shape factor that arose due to the fact that stresses through the beam thickness were integrated over a curved surface. The solutions presented herein were compared with the available numerical and analytical solutions in the related literature and excellent agreement was obtained. Effects of some dimensionless parameters on the structural response were investigated to show their effects on fundamental natural frequency of the curved beam. In all the cases, variations of the material constant number were calculated and presented. Effect of changing ratio of core to beam thickness on the fundamental natural frequency depended on the amount of the material constant number.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2003년도 ICCAS
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• pp.1504-1508
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• 2003

The functional behavior of each body segments were investigated with respect to human standing posture when they were exposed to the horizontal vibration in the sagittal plane. This study is processed by experimental approach. The data is analyzed, both in the time domain and in the frequency domain. Random and multisinusoidal vibration was used as input. The ankle, hip, and head were employed as the significant body segments. High relative movements were present between hip and head, and there was no significant relationship between ankle and head. Variations of visual input produced a significant postural effect.

• Asian Pacific Journal of Cancer Prevention
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• 제15권19호
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• pp.8019-8026
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• 2014

The promyelocytic leukemia (PML) gene is a gene known to be a tumor suppressor, although recent data suggest that it has a dual function in tumorigenesis. It was initially discovered in acute promyelocytic leukemia (APL) in which a t(15; 17) chromosomal translocation fused it to the retinoic acid receptor alpha ($RAR{\alpha}$). It has been shown to be involved in various types of cancer. It has at least 6 nuclear isoforms and a cytoplasmic type with different characteristics. Its multiple functions in growth inhibition, apoptosis induction, replicative senescence, inhibition of oncogenic transformation, and suppression of migration and angiogenesis have made it a therapeutic target for cancer therapy. However, its dual role in the process of tumorigenesis has made this field challenging. In this review, we discuss PML structure, functions and expression in tumors.

• Asian Pacific Journal of Cancer Prevention
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• 제15권3호
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• pp.1453-1457
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• 2014

Background: The association of colorectal cancer with human cytomegalovirus (HCMV) is a controversial issue in cancer research. This study aimed to identify the HCMV virus in colorectal cancer tissues and to investigate the association of HCMV with colorectal cancer. In this study, 50 cancer tissue samples and 50 samples without colon cancer were studied in order to identify the HCMV virus through nested-polymerase chain reaction. The virus was identified in 15 cases of colorectal cancer tissues (15/50) and in 5 cases of normal tissues (5/50). Eight cases of adenocarcinoma tissues were in a moderately differentiated stage, and 7 cases had well-differentiated stage tissues that were positive for viral DNA. The findings were statistically evaluated at a significance level of p<0.05. The HCMV virus could playa role in creating malignancy and the progress of cancer through the process of oncomodulation.

• Asian Pacific Journal of Cancer Prevention
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• 제15권6호
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• pp.2395-2403
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• 2014

As the recurrence and mortality rates of bladder cancer are high, research is needed to find suitable biomarkers for early detection, evaluation of prognosis, and surveillance of drug responses. We performed a computerized search of the Medline/PubMed databases with the key words bladder cancer, biomarker, early detection, prognosis and drug response. Several markers were identified at DNA, RNA and protein levels with different sensitivities and specificities. Only a few of the potential bladder cancer biomarkers have been approved for clinical use. Efforts now should be concentrated on finding a panel of markers with acceptable sensitivity and specificity for early detection of bladder cancer.

• 유통과학연구
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• 제11권3호
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• pp.5-11
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• 2013

Purpose - Going concern is one of fundamental concepts in accounting and auditing and sometimes the assessment of a company's going concern status that is a tough process. Various going concern prediction models' based on statistical and data mining methods help auditors and stakeholders suggested in the previous literature. Research design - This paper employs a data mining approach to prediction of going concern status of Iranian firms listed in Tehran Stock Exchange using Particle Swarm Optimization. To reach this goal, at the first step, we used the stepwise discriminant analysis it is selected the final variables from among of 42 variables and in the second stage; we applied a grid-search technique using 10-fold cross-validation to find out the optimal model. Results - The empirical tests show that the particle swarm optimization (PSO) model reached 99.92% and 99.28% accuracy rates for training and holdout data. Conclusions - The authors conclude that PSO model is applicable for prediction going concern of Iranian listed companies.

• Asian Pacific Journal of Cancer Prevention
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• 제16권7호
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• pp.3079-3081
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• 2015

Cancer-testis antigens (CTAs) are a group of tumor associated antigens with a restricted expression pattern in normal gametogenic tissues but expression in a broad range of malignancies. Their expression pattern has made them potential targets for immunotherapy. However, expression of some of these antigens has been demonstrated in normal stem cells as well as cancer stem cells (CSCs). As CSCs have been shown to be sources of metastasis and tumor recurrence, novel therapies are being focused on their eradication. On the other hand, CTA expression in normal stem cells raises the possibility that CTA based immunotherapies cause side effects in normal tissues.

• Journal of Power Electronics
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• 제10권1호
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• pp.34-42
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• 2010

Reliability is an important issue in cascaded H-bridge converters (CHB converters) because they use a high number of power semiconductors. A faulty power cell in a CHB converter can potentially lead to expensive downtime and great losses on the consumer side. With a fault-tolerant control strategy, operation can continue with the undamaged cells; thus increasing the reliability of the system. In this paper, the operating principles and the control method for a CHB multilevel rectifier are introduced. The influence of various faults on the CHB converter is investigated. The method of fault diagnosis and the bypassing of failed cells are explained. A fault-tolerant protection strategy is proposed to achieve redundancy in the CHB rectifier. The redundant H-bridge concept helps to deal with device failures and to increase system reliability. Simulation results verify the performance of the proposed strategy.