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Crystal Structure of Nalidixic Acid (Nalidixic Acid의 결정구조)

  • 김문집;신준철
    • Korean Journal of Crystallography
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    • v.6 no.2
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    • pp.98-102
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    • 1995
  • The crystal structure of -Ethyl-1,4-dihydro-7-methyl-1,8-naphthyridin-4-one-3-carboxylic acid [Nalicixic Acid] has been determined from single crystal X-ray diffraction study; C12H12N2O3, monoclinic, P21/c, a=8.910(2)Å, b=13.145(3)Å, c=9.370(3)Å, β =100.06(2)°, V=1080.6Å, T=293K, Z=4, CuKα(λ=1.5418Å). The molecular structure was solved by direct method and refined by full-matrix least squares to a final R=0.055 for 1555 unique observed [F0>4σ(F0)] reflections and 166 parameters. The conformation of the molecule is stabilized by an intramolecular O(17)-H(17)…O(14) hydrogen bond [2.525(2)Å, 144.3(10)°].

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Knowledge and Attitude about Smoking in Middle School Students (중학생의 흡연에 대한 지식 및 태도)

  • Kim Shin-Jeong;Yang Soon-Ok
    • Child Health Nursing Research
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    • v.8 no.2
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    • pp.152-163
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    • 2002
  • This study was done to provide basic data to develop smoking prevention and non-smoking education program. Questionnaire were collected from 438 male, 474 female middle school students at Chunchon, Kwangwon-do from Sep 2, 2000 to Feb 28, 2001. The Questionnaire used to measure subjects' knowledge and attitude about smoking was Guideline for the content of tobacco smoking surveys of the general population by WHO. The collected data were analyzed by SPSS-Win program. The results were as follows. 1.The average score of knowledge about smoking of subjects was 57.01 on the basis of 100. 2. The average score of attitude about smoking of subjects was 63.54 on the basis of 100. 3. In knowledge about smoking, there were statistically significant difference according to subjects' grade(F=3.218, p=.041), thinking about smoking behavior(F=3.424, p=.017), harmfulness of smoking(F=17.202, p=.000), present drinking(F=3.555, p=.029) and in attitude about smoking, there were statisti cally significant difference according to subjects' grade(F=20.520, p=.000), sex(t= -5.073, p=.000), mother's smoking(t= -2.405, p=.035), brother's smoking(t= -5.022, p=.000), mother's schooling(F= 3.730, p=.024), having smoking friend or not (t=-9.357, p=.000), subjects' smoking experience (t=-12.363, p=.000), present smoking(F= 76.643, p=.000), quantity of smoking(F= 6.808, p=.001), period of stop smoking(F= 4.685, p=.004), beginning time of smoking (F=2.286, p=.049), thinking about smoking behavior(F=17.933, p=.000), harmfulness of smoking(F=58.360, p=.000), present drinking (F=58.071, p=.000). 4. There were significant relationship between subjects' knowledge and attitude about smoking(r=.469, p=.000).

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The Relationship between Knowledge and Attitude about Smoking of College Student Smokers (흡연대학생의 흡연지식과 태도와의 관계)

  • Jeong Mi-Hyeon;Shin Mi-A
    • Journal of Korean Public Health Nursing
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    • v.20 no.1
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    • pp.69-78
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    • 2006
  • Purpose: This study investigated the relationship between knowledge and attitude about smoking of college student smokers. Methods: The data were collected from the 6th to 27th of April 2005, from 411 college student smokers in Jeollabuk-Do area. The collected data were analysed by using the SPSS WIN 11.0. Results: 1) The focus group showed mean $17.40{\pm}12.45$ in the knowledge about smoking. The knowledge about smoking was significantly different among general subject characteristics of age(F=4.84, p=.008), grade(t=2.96, p=.003), major(F=5.93, p=.001), and religion(t=2.96, p=.003). 2) The focus group showed mean $23.69{\pm}16.19$ in their attitude about smoking. The attitude about smoking was significantly different among general subject characteristics of age(F=8.15, p=.000), grade(t=-2.33, p=.020), major(F=8.35, p=.000), and residence(t=3.08, p=.010). 3) The correlations between knowledge and attitude about smoking were positively correlated(p<0.01). Conclusion: The subjects knowledge about smoking was correlated with their attitude about smoking. Therefore, we need to develop various differential smoking prevention programs and extend the role of experts.

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A Study on Occupational Diseases of Fire Officials (소방공무원의 직무질환에 관한 연구)

  • Cho, Kwang-Rae
    • Korean Security Journal
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    • no.61
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    • pp.109-135
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    • 2019
  • The purpose of this study is to investigate the occupational diseases(the number of medical treatment) of fire officials by using time-series analysis. The results of the study are as follows. First, the average rates of the occupational diseases of fire officials were as follows: ① internal diseases were the highest at 9.24% in December, the lowest at 7.76% in February, ② otolaryngologic diseases were the highest at 9.29% in December, the lowest at 6.74% in August, ③ dermatological diseases were the highest at 10.03% in July, the lowest at 7.35% in January and February, ④ surgical diseases were the highest at 10.38% in November, the lowest at 5.62% in February, ⑤ orthopedic diseases were the highest at 9.69% in March, the lowest at 7.52% in November, ⑥ neurosurgical diseases were the highest at 9.33% in April, the lowest at 6.82% in February, ⑦ neurological diseases were the highest at 9.47% in December, the lowest at 7.06% in October, and ⑧ mental health diseases were the highest at 9.93% in December, the lowest at 6.51% in May. Second, the seasonal decomposition of the disease occurrence of fire officials were described by assigning seasonal factor(S), trend factor(T), circulation factor(C) and irregular factor(R): ① internal diseases were 1.075(S) × 189.355(T·C) × 1.174(R) = 238.975(F), ② otolaryngologic diseases were 1.023(S) × 69.605(T·C) × 1.040(R) = 74.000(F), ③ dermatological diseases were 1.002(S) × 73.088(T·C) × 0.874(R) = 64.000(F), ④ surgical diseases were 1.099(S) × 27.229(T·C) × 0.669(R) = 20.000(F), ⑤ orthopedic diseases were 1.115(S) × 73.182(T·C) × 1.213(R) = 99.000(F), ⑥ neurosurgical diseases were 0.993(S) × 27.836(T·C) × 1.303(R) = 36.000(F), ⑦ neurological diseases were 1.029(S) × 62.417(T·C) × 1.152(R) = 74.000(F), and ⑧ mental health diseases were 1.210(S) × 8.781(T·C) × 1.035(R) = 11.000(F).

Comparison of Batch Assay and Random Assay Using Automatic Dispenser in Radioimmunoassay (핵의학 체외 검사에서 자동분주기를 이용한 Random Assay 가능성평가)

  • Moon, Seung-Hwan;Lee, Ho-Young;Shin, Sun-Young;Min, Gyeong-Sun;Lee, Hyun-Joo;Jang, Su-Jin;Kang, Ji-Yeon;Lee, Dong-Soo;Chung, June-Key;Lee, Myung-Chul
    • Nuclear Medicine and Molecular Imaging
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    • v.43 no.4
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    • pp.323-329
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    • 2009
  • Purpose: Radioimmunoassay (RIA) was usually performed by the batch assay. To improve the efficiency of RIA without increase of the cost and time, random assay could be a choice. We investigated the possibility of the random assay using automatic dispenser by assessing the agreement between batch assay and random assay. Materials and Methods: The experiments were performed with four items; Triiodothyronine (T3), free thyroxine (fT4), Prostate specific antigen (PSA), Carcinoembryonic antigen (CEA). In each item, the sera of twenty patients, the standard, and the control samples were used. The measurements were done 4 times with 3 hour time intervals by random assay and batch assay. The coefficient of variation (CV) of the standard samples and patients' data in T3, fT4, PSA, and CEA were assessed. ICC (Intraclass correlation coefficient) and coefficient of correlation were measured to assessing the agreement between two methods. Results: The CVs (%) of T3, fT4, PSA, and CEA measured by batch assay were 3.2$\pm$1.7%, 3.9$\pm$2.1%, 7.1$\pm$6.2%, 11.2$\pm$7.2%. The CVs by random assay were 2.1$\pm$1.7%, 4.8$\pm$3.1%, 3.6$\pm$4.8%, and 7.4$\pm$6.2%. The ICC between the batch assay and random assay were 0.9968 (T3), 0.9973 (fT4), 0.9996 (PSA), and 0.9901 (CEA). The coefficient of correlation between the batch assay and random assay were 0.9924(T3), 0.9974 (fT4), 0.9994 (PSA), and 0.9989 (CEA) (p<0.05). Conclusion: The results of random assay showed strong agreement with the batch assay in a day. These results suggest that random assay using automatic dispenser could be used in radioimmunoassay.

The optical and structural properties by ZrO2 and Y2O3 compositional ratio of Co- and Ce-doped cubic zirconia (YSZ) single crystals (ZrO2와 Y2O3 조성비에 따른 Co와 Ce 첨가 큐빅지르코니아(YSZ) 단결정의 광학적 및 구조적 특성)

  • Moon, So-I.;Park, Hee-Yul;Seok, Jeong-Won
    • Journal of the Korean Crystal Growth and Crystal Technology
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    • v.22 no.2
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    • pp.73-77
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    • 2012
  • Co-(0.8 wt%) and Ce-(0.4 wt%) doped cubic zirconia ($ZrO_2$ : $Y_2O_3$ = 80 : 20, 70 : 30, 60 : 40, 50 : 50 wt%) single crystals grown by a skull melting method were heat-treated in $N_2$ at $1000^{\circ}C$ for 5 hrs. The orange, yellowish brown and brown colored as-grown single crystals were changed into either brownish red, yellow and green color after the heat treatment. Before and after the heat treatment, the YSZ (yttria-stabilized zirconia) single crystals were cut for wafer form (${\phi}6.5mm{\times}t2mm$). The optical and structural properties were examined by UV-VIS spectrophotometer and X-ray diffraction. Absorption by $Ce^{3+}(^2F_{5/2,7/2}(4f){\rightarrow}^2T_g(5d^1))$, $Co^{2+}(^4A_2(^4F){\rightarrow}^4T_1(^4F)$ or $^4T_1(^4P))$ and $Co^{3+}$, change of ionization energy and lattice parameter were confirmed.

Production of ${\alpha}$1,3-Galactosyltransferase (GalT) Double Knock-out (-/-) Transgenic Pigs for Xenotransplantation (${\alpha}$1,3-Galactosyltransferase(GalT) 유전자가 완전 Knock-out(-/-)된 바이오장기용 형질 전환 돼지 생산)

  • Hwang, Seong-Soo;Oh, Keun-Bong;Kim, Dong-Hoon;Woo, Jea-Seok;Shim, Ho-Sup;Yun, Ik-Jin;Park, Jin-Ki;Im, Gi-Sun
    • Journal of Embryo Transfer
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    • v.27 no.1
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    • pp.9-14
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    • 2012
  • This study was conducted to analyze the transgenic efficiency and sex ratio in ${\alpha}$-1,3-galactosyltransferase (GalT) knock-out (KO) transgenic pigs according to generation. GalT KO piglets were produced by artificial insemination or natural mating. The transgenic confirmation of GalT KO was evaluated by PCR amplification using specific primers. After electrophoresis, three types of bands were detected such as 2.3 kb single band (Wild), 2.3 and 3.6kb double bands (GalT KO -/+; heterozygote), and 3.6kb single band (GalT KO -/-; homozygote). Transgenic efficiency in F1 generation was 64.5% (23/35) of GalT KO (-/+). In F2 generation, GalT KO transgenic efficiency was 36.4% (21/57, Wild), 47.5% (28/57, GalT KO -/+), and 16.1% (8/57, GalT KO -/-), respectively. Interestingly, no homozygote piglets were born in 6 deliveries among total 11 deliveries, although they were pregnant between male (M) and female (F) $F_1$ heterozygote. In the 5 litters including at least one GalT KO -/- piglet, the transgenic efficiency was 13.3% (2/24, Wild), 51.3% (14/24, GalT KO -/+), and 35.3% (8/24, GalT KO -/-), respectively. The sex ratio of M and F was 40:60 in $F_1$ and 49:51 in $F_2$ generation, respectively. Based on these results, GalT KO transgenic pigs have had a reproductive ability with a normal range of transgenic efficiency and sex ratio.

Effect of $N_2$-backflushing Time in Carbon Ceramic UF & MF System for Paper Wastewater Treatment

  • Park, Jin-Yong
    • Korean Membrane Journal
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    • v.7 no.1
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    • pp.34-41
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    • 2005
  • The wastewater discharged from a paper plant was filtrated by 3 kinds of tubular carbon ceramic UF and MF membranes with $N_2$-backflushing. The filtration time (FT) was fixed at 8 min or 16 min, and $N_2$-backflushing time (BT) was changed in 0${\~}$60 sec. The optimal condition was discussed in the viewpoints of total permeate volume ($V_T$), dimensionless permeate flux (J/Jo) and resistance of membrane fouling ($R_f$). In the viewpoints of $V_T$, J/Jo and $R_f$, the optimal $N_2$-BT was 40 sec at both FT for M9 (MWCO: 300,000 Daltons) and C005 ($0.05{\mu}m$) membranes. However, for C010 ($0.1{\mu}m$) it was 10 sec at FT=8 min, and 20 sec at FT=16 min in the viewpoints of J/Jo and $R_f$, and 5 sec at both FT in the viewpoints of $V_T$. It means that the short $N_2$-BT could reduce the membrane fouling and recover the permeate flux sufficiently for MF membrane having a large pore size as C010. Average rejection rates of pollutants were higher than $99.0\%$ for turbidity and $22.8{\~}59.6\%$ for $COD_{cr}$, but rejection rates of total dissolved solid (TDS) were lower than $8.9\%$. Therefore, the low turbidity water purified in our system could be reused for paper process.

HYERS-ULAM STABILITY OF HOMOGENEOUS FUNCTIONAL EQUATIONS

  • Park, Kyoo-Hong;Kim, Gwang-Hui;Lee, Young-Whan;Choi, Chang-Ho
    • Journal of applied mathematics & informatics
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    • v.8 no.2
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    • pp.569-580
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    • 2001
  • In this paper, we obtain some results on the Hyers-Ulam stability for the family of the functional equation f(xоy) = $H(f(x)^{1/t},f(y)^{1/t}$) (x, $y{\in}S$), where H is a homogeneous function of degree t and о is a square-symmetric operation on the set S.

Study about PR-VEP Characteristics on Perception Function and Judgement Function of MBTI (MBTI의 인식기능(S/N), 판단기능(T/F)에 대한 PR-VEP 특성연구)

  • Seol, Jee-Yong;Park, Pyong-Woon
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.16 no.8
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    • pp.5485-5491
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    • 2015
  • The purpose of this study is to investigate PR-VEP characteristics on the perception function(S/N) and the judgement function(T/F) of MBTI. The 136 study participants, over 20 years old adults, were examined by PR-VEP and MBTI test for two months in July and August in 2013. PR-VEP was conducted in O1 and O2 by 32 channels EEG system and MBTI test was measured by Form-M online. We found that the time interval(Duration) between N75 and P100 of PR-VEP was 5.49 ms significantly shorter in the group preferring S indicator. And the latency until N75 was 4.83 ms significantly shorter in O1 and 4.27 ms shorter in O2 in the group preferring F indicator. According to these, the characteristics of groups preferring S and F indicator have influence on visual cognitive function, which is meaningful that the interpretation of brain-science can be used with recognition/judgement function of MBTI.