• Transactions of the Korean Society of Automotive Engineers
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• v.5 no.3
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• pp.220-228
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• 1997

We discuss finite element approximation and use a Mindlin plate element based upon uniformly reduced numerical integration. The finite element selected for use in this work is a four-node, bilinear displacement element based upon the Mindlin theory of plates. Such elements show good accuracy for laminated composite plates when reduced numerical integration is used to evaluate the element marices. This study presents both the experimental and F.E. results for the natural frequencies of CFRPURETHANE-CFRP Composite plate. Good agreement between experimental and calculated frequencies is achived.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.57 no.4
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• pp.603-609
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• 2008

Slotless linear brushless DC motor are widely used in precision machine applications because of their advantages such as low of detent force, negligible iron loss. But they have a disadvantage such as low thrust density, thrust ripple, and excessive use of permanent magnet materials. These lead to undesirable performance and high production cost. In this paper, we deal with the design and characteristics investigation of a air-core tubular linear brushless DC(TLBLDC) motor with air-core stator and permanent magnet mover. And to investigate the static and dynamic characteristics of air-core TLBLDC motor, the prototype machine is manufactured and analyzed by F.E.M. and Matlab simulink simulations. Especially, dynamic characteristics of air-core TLBLDC motor driven with 6 step inverter are simulated by F.E.M.coupling with external circuit and Matlab simulink program, and measured for the prototype motor. The simulation results are compared to the experimental results such as current waves, thrust and speed curve.

• Journal of the Korean Society for Precision Engineering
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• v.16 no.11
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• pp.166-173
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• 1999

Al forged parts are many cases with rib-web section which is difficult to manufacture precisely. Therefore, process conditions must be optimized for precision forging of Al alloys. In this study, various process parameters such as die design, lubricant, ram speed, forging temperature have been investigated using the experiment, upper bound theory and F.E.M. simulation to develop the precision forging technology for rib-web shape component. When lubricant is applied to both material and die, shear friction factor is 0.1 which shows best effect of lubricant. It is specific corner radius of die that minimized forging load regarding process conditions, especially according to the ratio of the width of rib and web. In conclusion, optimum corner radius is 2~3mm when the width of rib and web is 3mm and 20mm respectively.

• Journal of the Korean Society of Visualization
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• v.22 no.3
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• pp.60-69
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• 2024

A sloshing motion of highly viscous fluid in a rigid rectangular box with free surface is considered. The flow is generated by the motion of container being in harmonic motion in time along the horizontal axis normal to gravity, where the container velocity externally imposed is u=cos(2πt). Matched asymptotic method is invoked to elucidate flow visualization results such as linear profile of free surface and thin film flow on the vertical sidewall. Theoretical solution and physical reasoning are given to confirm that no-slip condition could be satisfied through near wall boundary layer of the thickness of l~O($F_r\sqrt{R_e}$), where F_r and R_e denotes, respectively, Froude and Reynolds number.

• Animal cells and systems
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• v.9 no.2
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• pp.87-94
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• 2005

Spindle position checkpoint monitors the orientation of mitotic spindle for proper segregation of replicated chromosomes into mother cell and the daughter, and prohibits mitotic exit when mitotic spindle is misaligned. BUB2 forms one of the key upstream element of spindle position checkpoint in budding yeast, but its functional homologues have not been identified in higher eukaryotes. Here, we analyzed the functions of two putative BUB2 homologues of C. elegans in the spindle orientation checkpoint. From the C. elegans genome database, we found that two open reading frames (ORFs), F35H12_2 and C33F10_2, showed high sequence homology with BUB2. We obtained the expressed sequence tag (EST) clones for F35H12_2 (yk221d4) and C33F10_2 (yk14e10) and verified the full cDNA for each ORF by sequencing and 5' RACE with SL1 primer. The functional complementation assays of yk221d4 and yk14e10 in ${\Delta}bub2$ of S. cerevisiae revealed that these putative BUB2 homologues of C. elegans could not replace the function of BUB2 in spindle position checkpoint and mitotic exit. Our attempt to document the component of spindle position checkpoint in metazoans using sequence homology was not successful. This suggests that structural information about its components might be required to identify functional homologues of the spindle position checkpoint in higher eukaryotes.

• Korean Journal of Ecology and Environment
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• v.41 no.3
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• pp.331-337
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• 2008

Polycyclic aromatic hydrocarbons (PAHs) derived from leakage of fossil fuels and incomplete combustion of organic materials have been considered as harmful contaminants in environments. This study evaluated the effect of benzo[k]fluoranthene (BkF), one of the PAHs, using the multiple biomarkers and applied the integration model with those biomarker responses. After 10 days of the exposure at the measured concentrations of BkF (6, 25, and 45 ${\mu}g\;L^{-1}$), the changes of the four biomarkers, that is, 7-ethoxyresorufin-O-deethylase (EROD), DNA single-strand breaks (Comet), acetylcholinesterase (AChE) and vitellogenin (VTG) in the common carp (Cyprinus carpio) were observed. The standardized values of four biomarker responses were computed and integrated as star plots, representing Integrated Biomarker Respnse (IBR) values. DNA damage was induced in a dose-dependent manner, and increased significantly compared with that in the control. EROD and VTG levels were significantly elevated at low concentrations of BkF. On the other hand, AChE activities were not altered by BkF. IBR values increased as the exposure concentrations increased. Thus, the metabolic, endocrine and genetic changes of the biomarker responses in the common carp exposed to BkF should be considered in the case of the ecological risk assessment of the BkF in fish and it can be used as a biomonitoring tool in aquatic ecosystems. In addition, star plots can be used as a useful analysis tool in multibiomarker integration approach.

• Proceedings of the Korea Water Resources Association Conference
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• 2006.05a
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• pp.1772-1776
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• 2006

The Ministry of Environment is determining reference flows and goal water qualities in many stations over all around riverbasin to control TMDL. Reference flow is now defined to 10 years averaged 275th minimum flow$(Q_{275})$. Dam operation takes direct effect on flows downstream. The Yongdam mutipurposed dam was constructed in 2002 and TMDL managing stations between the Daecheong dam and the Yongdam dam are the Geumbon B, C, D, E, and F in main stream of the Geum river. Geumbon F is the Daecheong dam site. Observed flows are ideal to be used to set reference flows, but simulated flows are more practical to be used to set reference flows from the cause of the Yongdam dam's operation. A system for simulating daily storages of the Yongdam dam was constructed and the DAWAST model was selected to simulate daily streamflows. Analysis period was selected for 10 years from 1996 to 2005. Scenario was set as follows; Firstly, observed outflows from the Yongdam dam are used from 2002 to 2005 and the Yongdam dam does not exist from 1995 to 2001. Secondly, the Yongdam dam existed also from 1995 to 2001 and simulated outflows from the Yongdam dam are used from 1996 to 2005 with provision of constant outflow of $7.0m^3/s$ and water supply to the Jeonju region outsided watershed of $900,000m^3/day$. In case of scenario 1 reference flows at the Geumbon B, C, D, E, F are 4.52, 6.69, 7.96, 11.17, and $13.21m^3/s$, respectively. And in case of scenario 2 reference flows at the Geumbon B, C, D, E, F are 6.27, 8.48, 9.58, 12.73, and $15.12m^3/s$, respectively.

• Environmental Analysis Health and Toxicology
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• v.4 no.3_4
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• pp.7-14
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• 1989

Amygdalin has been used for a long time as an anticancer agent. But because of its toxicity, it is difficult to administer continuously for treatment of cancer. This paper was attempted to reduce the side effect and toxicity of amygdalin. That is, effects of cysteine and streptomycin on the toxicity of amygdalin were investigated in rats orally administered amygdalin. 1. The group administered only amygdalin 400 mg/kg was effected on the lung and body weight, hematocrit, hemoglobin, clotting time, SGOT and albumin value. That is, lung and body weight, hematocrit hemoglobin and albumin value were significantly decreased. SGOT and clotting time were significantly increased compared with those of normal group. 2. Weight of lung was significantly increased in the C group (administred amygdalin 400 mg/kg and cysteine 300 mg/kg), D group (amygdalin 400 mg/kg and streptomycin 10 mg/kg), E group (amygdalin 400 mg/kg, streptomycin 10 mg/kg and cysteine 200 mg/kg)and F group (amygdalin 400 mg/kg, streptomycin 10 mg/kg and cysteine 300 mg/kg). 3. Values of hematocrit and hemoglobin were significantly increased, and clotting time was significantly decreased, in the I group and F group compared with those of A group. 4. SGOT was significantly decreased in the C group, E group and F group compared with that of A group. 5. The blood cyanide concentration was significantly decreased in the E group and F group compared with that fo A group. 6. In short, coadministration of cysteine and streptomycin are considered to reduce the toxicity of amygdalin in rats orally administered.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.12
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• pp.5139-5145
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• 2016

There has been an increment in the number of studies focused on marine bioactive materials. Many peptides and other biomaterials with anticancer potential have been extracted from various marine animals. Artemia extracts have found uses in sun-light protection cosmetics and anti-aging products. However, contents of biochemical compounds in Artemia spp. and molecular mechanisms of have not been clearly studied in leukemic cells in vitro. In this work, we isolated and purified proteins of Artemia Urmiana. Six clear fractions (A-F) observed on DEAE-cellulose chromatography were assayed for effects on cell growth, differentiation and apoptosis using the human leukemic HL-60 cell line. Cell proliferation analysis by MTT and BrdU assays indicated that did not affect cells, growth. Cells treated with crude extract and fractions A, B and C, but not E and F (up to $100{\mu}g/mL$), exhibited increase of cell growth in a dose dependent manner. Stimulatory effects of fraction D were observed at concentrations of $10{\mu}g/mL$ and above. In nitro blue tetrazolium (NBT) reduction assays, treatment with $100{\mu}g/mL$ of fraction E or F for 96 hr increased the fraction of differentiated cells up to $14.8{\pm}3.56%$ and $16.5{\pm}2.08%$ respectively. Combination of those fractions with retinoic acid had significant synergistic effects on the differentiation of cells ($56.8{\pm}3.7%$ and $67.4{\pm}4.2%$, $p{\leq}0.01$). Annexin-V FITC staining for apoptosis and flow cytometric assays indicated induction of apoptosis by fractions E and F up to 23.8 and 31.8% of cells.

• Korean Journal of Exercise Nutrition
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• v.25 no.1
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• pp.23-29
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• 2021

[Purpose] This preliminary study aimed to develop a regression model to estimate the non-exercise activity thermogenesis (NEAT) of Korean adults using various easy-to-measure dependent variables. [Methods] NEAT was measured in 71 healthy adults (male n = 29; female n = 42). Statistical analysis was performed to develop a NEAT estimation regression model using the stepwise regression method. [Results] We confirmed that age^A, weight^B, heart rate (HR)_average^C, weight × HR_average^D, weight × HR_sum^E, systolic blood pressure (SBP) × HR_rest^F, fat mass ÷ height^2G, gender × HR_average^H, and gender × weight × HR_sum^I were important variables in various NEAT activity regression models. There was no significant difference between the measured NEAT values obtained using a metabolic gas analyzer and the predicted NEAT. [Conclusion] This preliminary study developed a regression model to estimate the NEAT in healthy Korean adults. The regression model was as follows: sitting = 1.431 - 0.013 × (A) + 0.00014 × (D) - 0.00005 × (F) + 0.006 × (H); leg jiggling = 1.102 - 0.011 × (A) + 0.013 × (B) + 0.005 × (H); standing = 1.713 - 0.013 × (A) + 0.0000017 × (I); 4.5 km/h walking = 0.864 + 0.035 × (B) + 0.0000041 × (E); 6.0 km/h walking = 4.029 - 0.024 × (C) + 0.00071 × (D); climbing up 1 stair = 1.308 - 0.016 × (A) + 0.00035 × (D) - 0.000085 × (F) - 0.098 × (G); and climbing up 2 stairs = 1.442 - 0.023 × (A) - 0.000093 × (F) - 0.121 × (G) + 0.0000624 × (E).