• Molecules and Cells
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• 제42권10호
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• pp.693-701
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• 2019

Plants monitor changes in day length to coordinate their flowering time with appropriate seasons. In Arabidopsis, the diel and seasonal regulation of CONSTANS (CO) protein stability is crucial for the induction of FLOWERING LOCUS T (FT) gene in long days. FLAVIN-BINDING, KELCH REPEAT, F-BOX 1 (FKF1) and ZEITLUPE (ZTL) proteins control the shape of CO expression profile antagonistically, although regulation mechanisms remain unknown. In this study, we show that GIGANTEA (GI) protein modulates the stability and nuclear function of FKF1, which is closely related to the stabilization of CO in the afternoon of long days. The abundance of FKF1 protein is decreased by the gi mutation, but increased by GI overexpression throughout the day. Unlike the previous report, the translocation of FKF1 to the nucleus was not prevented by ZTL overexpression. In addition, the FKF1-ZTL complex formation is higher in the nucleus than in the cytosol. GI interacts with ZTL in the nucleus, implicating the attenuation of ZTL activity by the GI binding and, in turn, the sequestration of FKF1 from ZTL in the nucleus. We also found that the CO-ZTL complex presents in the nucleus, and CO protein abundance is largely reduced in the afternoon by ZTL overexpression, indicating that ZTL promotes CO degradation by capturing FKF1 in the nucleus under these conditions. Collectively, our findings suggest that GI plays a pivotal role in CO stability for the precise control of flowering by coordinating balanced functional properties of FKF1 and ZTL.

• Smart Structures and Systems
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• 제15권1호
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• pp.99-117
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• 2015

The Stonecutters Bridge (SCB) in Hong Kong is the third-longest cable-stayed bridge in the world with a main span stretching 1,018 m between two 298 m high single-leg tapering composite towers. A Wind and Structural Health Monitoring System (WASHMS) is being implemented on SCB by the Highways Department of The Hong Kong SAR Government, and the SCB-WASHMS is composed of more than 1,300 sensors in 15 types. In order to establish a linkage between structural health monitoring and maintenance management, a Structural Health Rating System (SHRS) with relevant rating tools and indices is devised. On the basis of a 3D space frame finite element model (FEM) of SCB and model updating, this paper presents the development of an SHR-oriented 3D multi-scale FEM for the purpose of load-resistance analysis and damage evaluation in structural element level, including modeling, refinement and validation of the multi-scale FEM. The refined 3D structural segments at deck and towers are established in critical segment positions corresponding to maximum cable forces. The components in the critical segment region are modeled as a full 3D FEM and fitted into the 3D space frame FEM. The boundary conditions between beam and shell elements are performed conforming to equivalent stiffness, effective mass and compatibility of deformation. The 3D multi-scale FEM is verified by the in-situ measured dynamic characteristics and static response. A good agreement between the FEM and measurement results indicates that the 3D multi-scale FEM is precise and efficient for WASHMS and SHRS of SCB. In addition, stress distribution and concentration of the critical segments in the 3D multi-scale FEM under temperature loads, static wind loads and equivalent seismic loads are investigated. Stress concentration elements under equivalent seismic loads exist in the anchor zone in steel/concrete beam and the anchor plate edge in steel anchor box of the towers.

• BMB Reports
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• 제52권3호
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• pp.208-213
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• 2019

Chemoresistance is the primary obstacle in the treatment of locally advanced and metastatic nasopharyngeal carcinoma (NPC). Recent evidence suggests that the transcription factor forkhead box M1 (FoxM1) is involved in chemoresistance. Our group previously confirmed that FoxM1 is overexpressed in NPC. In this study, we investigated the role of FoxM1 in cisplatin resistance of the cell lines 5-8F and HONE-1 and explored its possible mechanism. Our results showed that FoxM1 and NBS1 were both overexpressed in NPC tissues based on data from the GSE cohort (GSE12452). Then, we measured FoxM1 levels in NPC cells and found FoxM1 was overexpressed in NPC cell lines and could be stimulated by cisplatin. MTT and clonogenic assays, flow cytometry, ${\gamma}H2AX$ immunofluorescence, qRT-PCR, and western blotting revealed that downregulation of FoxM1 sensitized NPC cells to cisplatin and reduced the repair of cisplatin-induced DNA double-strand breaks via inhibition of the MRN (MRE11-RAD50-NBS1)-ATM axis, which might be related to the ability of FoxM1 to regulate NBS1. Subsequently, we demonstrated that enhanced sensitivity of FoxM1 knockdown cells could be reduced by overexpression of NBS1. Taken together, our data demonstrate that downregulation of FoxM1 could improve the sensitivity of NPC cells to cisplatin through inhibition of MRN-ATM-mediated DNA repair, which could be related to FoxM1-dependent regulation of NBS1.

• Ocean Systems Engineering
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• 제12권2호
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• pp.225-245
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• 2022

More and more shipping containers are falling into the sea due to bad weather. Containers lost at sea negatively affect the shipping line, the trader and the consumer, and the environment. The question of locating and recovering dropped containers is a challenging engineering problem. Model-testing of small-scaled container models is proposed as an efficient way to investigate their falling trajectories to salvage them. In this study, we first build a standard 20-ft container model in SOLIDWORKS. Then, a three-dimensional (3D) geometric model in the STL (Standard Tessellation Language) format is exported to a Stratasys F170 Fused Deposition Modeling (FDM) printer. In total, six models were made of acrylonitrile styrene acrylate (ASA) and printed for the purpose of testing. They represent three different loading conditions with different densities and center of gravity (COG). Two samples for each condition were tested. The physical models were dropped into the towing tank of University of New Orleans (UNO). From the experimental tests, it is found that the impact of the initial position after sinking can cause a certain initial rolling velocity, which may have a great impact on the lateral displacement, and subsequently affect the final landing position. This series of model tests not only provide experimental data for the study of the trajectory of box-shape objects but also provide a valuable reference for maritime salvage operations and for the pipeline layout design.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2023년도 학술발표회
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• pp.137-137
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• 2023

해양쓰레기는 해안의 심미적 가치 저하뿐만 아니라 생태계 파괴, 유령 어업에 따른 수산업 피해 등의 사회적·환경적 문제를 발생시키며, 그중 70% 이상은 육상 기인으로 플라스틱 및 기타 쓰레기가 주를 이루는 해외와 달리 국내의 경우 다량의 초목류를 포함하고 있다. 다양한 부유쓰레기에 대한 기존의 해양쓰레기량 추정의 한계와 하천·하구 쓰레기 수거의 효율화를 위해 해양으로 유입되는 부유쓰레기 방지를 위한 실효성 있는 대책 수립이 필요한 실정이다. 본 연구는 해양 유입 전 하천의 차단시설에 차집된 부유쓰레기의 수거 효율화 및 지속가능한 해양쓰레기 데이터 구축을 위해 AI기반의 기술을 통해 부유쓰레기 성상 분석 기법(Object Detection)과 차집량 분석 기법(Semantic Segmentation)을 활용하였다. 실제와 유사한 데이터 수집을 위해 다양한 하천 환경(정수조, 소하천, 급경사수로)에 대해 탁도(녹조, 유사), 광량, 쓰레기형상, 초목류 함량, 날씨(소하천), 유속(급경사수로) 등의 실험조건에 대하여 해양쓰레기 분류 기준 및 통계를 바탕으로 부유쓰레기 종류 선정하여 학습을 위한 데이터를 수집하였다. 학습 목적에 따라 구분하여 라벨링(Bounding box, Polygon)을 수행하고, 각 분석 기법별 전이학습을 통해 Phase 1(정수조), Phase 2(소하천), Phase 3(급경사수로) 순서로 모델을 고도화하였다. 성상 분석을 위해 YOLO v4를 활용하여 Train, Test DataSet(9:1)을 구성하고 학습 및 평가는 Iteration마다의 mAP, loss 값을 통해 비교하였으며, 학습 Phase에 따라 모델 고도화로 Test Set의 mAP 값이 성상별로 높아짐을 확인하였으며, 차집량 분석을 위해 Unet을 활용하여 Train, Test, Validation DataSet(8.5:1:0.5)을 구성하고 epoch별 IoU(intersection over Union), F1-score, loss 값을 비교하여 정성적, 정량적 평가 모두 Phase 3에서 가장 높은 성능을 확인하였다. 향후 하천 환경에서의 다양한 영양인자별 분석을 통해 주요 영향인자 도출 및 Hyper Parameter 최적화를 통한 모델 고도화로 인해 활용성이 높아질 것으로 판단된다.

• 한국지반공학회논문집
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• 제24권8호
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• pp.13-23
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• 2008

다양한 토목 건축 구조물의 하부구조로 많이 사용되는 콘크리트 말뚝기초는 상부 토목 건축 구조물의 안전에 있어 매우 중요한 요소이다. 본 논문에서는 이러한 말뚝의 비파괴적인 건전성 평가를 위하여, 범용적인 파의 위상 그룹속도 결정법인 HWAW(Harmonic Wavelet Analysis of Wave)방법을 말뚝의 비파괴 시험에 적용하였다. 제안된 방법은 말뚝자체의 건전성 평가와 선단지지말뚝의 거동에 매우 중요한 말뚝 선단부 상태(경계조건)를 자동적으로 결정할 수 있다. 제안된 방법을 검증하기 위하여 ABAQUS를 사용한 수치모의 실험을 수행하였으며, 실제 모형말뚝을 제작하여 공기중 실험과 실제 지반조건을 모사하기 위한 토조내 실험을 수행하였다. 이러한 수치모의 실험과 실제 모의 실험을 통하여 말뚝의 비파괴 건전성 평가에 있어서의 제안된 방법의 타당성을 확인하였다.

• 천문학회보
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• 제45권1호
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• pp.38.2-38.2
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• 2020

Horizon Run 5 (HR5) is a cosmological hydrodynamical simulation which captures the properties of the Universe on a Gpc scale while achieving a resolution of 1 kpc. This enormous dynamic range allows us to simultaneously capture the physics of the cosmic web on very large scales and account for the formation and evolution of dwarf galaxies on much smaller scales. Inside the simulation box. we zoom-in on a high-resolution cuboid region with a volume of 1049 × 114 × 114 Mpc3. The subgrid physics chosen to model galaxy formation includes radiative heating/cooling, reionization, star formation, supernova feedback, chemical evolution tracking the enrichment of oxygen and iron, the growth of supermassive black holes and feedback from active galactic nuclei (AGN) in the form of a dual jet-heating mode. For this simulation we implemented a hybrid MPI-OpenMP version of the RAMSES code, specifically targeted for modern many-core many thread parallel architectures. For the post-processing, we extended the Friends-of-Friend (FoF) algorithm and developed a new galaxy finder to analyse the large outputs of HR5. The simulation successfully reproduces many observations, such as the cosmic star formation history, connectivity of galaxy distribution and stellar mass functions. The simulation also indicates that hydrodynamical effects on small scales impact galaxy clustering up to very large scales near and beyond the baryonic acoustic oscillation (BAO) scale. Hence, caution should be taken when using that scale as a cosmic standard ruler: one needs to carefully understand the corresponding biases. The simulation is expected to be an invaluable asset for the interpretation of upcoming deep surveys of the Universe.

• 한국전기전자재료학회논문지
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• 제37권3호
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• pp.261-273
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• 2024

This paper is an experimental study on the improvement of smoke and flame detection from different materials with YOLO. For the study, images of fires occurring in various materials were collected through an open dataset, and experiments were conducted by changing the main factors affecting the performance of the fire object detection model, such as the bounding box, polygon, and data augmentation of the collected image open dataset during data preprocessing. To evaluate the model performance, we calculated the values of precision, recall, F1Score, mAP, and FPS for each condition, and compared the performance of each model based on these values. We also analyzed the changes in model performance due to the data preprocessing method to derive the conditions that have the greatest impact on improving the performance of the fire object detection model. The experimental results showed that for the fire object detection model using the YOLOv5s6.0 model, data augmentation that can change the color of the flame, such as saturation, brightness, and exposure, is most effective in improving the performance of the fire object detection model. The real-time fire object detection model developed in this study can be applied to equipment such as existing CCTV, and it is believed that it can contribute to minimizing fire damage by enabling early detection of fires occurring in various materials.

• 한국전자거래학회지
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• 제19권3호
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• pp.125-141
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• 2014

인터넷에서 매 순간 발생하는 데이터의 홍수는 사용자가 필요로 하는 유용한 정보를 검색하는데 어려움을 초래한다. 그래서 많은 사용자들이 자신이 원하는 정보를 쉽게 찾기 위한 기법을 고안하고 이를 지원하는 도구를 개발하게 되었다. 이런 유용한 도구 중 하나인 추천시스템은 기존의 사용자 정보를 분석하여 사용자가 원하는 제품이나 정보를 추천하는 것이다. 본 논문에서는 추천시스템을 활용하여 원하는 정보를 제안하는데 인구통계학적인 기법을 사용한다. 인구통계학 기반 추천시스템은 나이, 성별과 같은 인구통계학적인 특성을 사용하여 유용한 정보를 추출한다. 본 연구는 영화 선택 시 중요한 요소인 사용자 평점을 분석하고 이를 활용할 수 있는 방법을 제시하였다. 이를 위해 Internet Movie Database(IMDB) 웹 사이트에 있는 영화의 사용자 평점을 인구통계학적 요인으로 분석하였다. 본 논문에서는 인구통계학적 분석을 위해 사용자를 성별과 연령대로 분류하였고, 각 영화를 22개 장르로 나눈 IMDB 기준에 따라 사용자 평점을 분석하였다. 각 장르별 영화에 대해 사용자 그룹의 평균 평점을 F-테스트와 T-테스트를 수행하여 그 장르 영화 평점과 동일한 결과를 나타내는 대표 그룹을 찾아내었다. 인구통계학적 분석 결과인 대표 그룹은 새로운 영화가 개봉될 때 대표 그룹에 대한 프로모션과 추천을 통해 영화 홍보를 할 수 있는 대상을 찾아내는데 유용하다.

• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 2003년도 제27회 추계학술대회
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• pp.78-78
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• 2003

Purpose: This event related fMRI study was to further our understanding about how different brain regions could contribute to effective access of specific information stored in long term memory. This experiment has allowed us to determine the brain regions involved in recognition of familiar faces among non familiar faces. Materials and Methods: Twelve right handed normal, healthy volunteer adults participated in face recognition experiment. The paradigm consists of two 40 familiar faces, 40 unfamiliar faces and control base with scrambled faces in a randomized order, with null events. Volunteers were instructed to press on one of two possible buttons of a response box to indicate whether a face was familiar or not. Incorrect answers were ignored. A 1.5T MRI system(GMENS) was employed to evaluate brain activity by using blood oxygen level dependent (BOLD) contrast. Gradient Echo EPI sequence with TR/TE= 2250/40 msec was used for 17 contiguous axial slices of 7mm thickness, covering the whole brain volume (240mm Field of view, 64 ${\times}$ 64 in plane resolution). The acquired data were applied to SPM99 for the processing such as realignment, normalization, smoothing, statistical ANOVA and statistical preference. Results/Disscusion: The comparison of familiar faces vs unfamiliar faces yielded significant activations in the medial temporal regions, the occipito temporal regions and in frontal regions. These results suggest that when volunteers are asked to recognize familiar faces among unfamiliar faces they tend to activate several regions frequently involved in face perception. The medial temporal regions are also activated for familiar and unfamiliar faces. This interesting result suggests a contribution of this structure in the attempt to match perceived faces with pre existing semantic representations stored in long term memory.