• Journal of Life Science
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• v.17 no.7 s.87
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• pp.1019-1022
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• 2007

Thrombolytic therapy with tissue plasminogen activator (tPA) can improve the clinical outcome of ischemic stroke patients. However, its clinical application is limited by narrow therapeutic time windows and elevated risks of cerebral hemorrhage and brain injury. In part, these effects of tPA has been related to matrix metalloproteinase-9 (MMP-9) dysregulation. Here, we investigate that the effects of alteplase (tPA with short half-life) and pamiteplase (a modified tPA with long half-life) on the MMP-9 regulation in neurovascualr unit. The total levels of MMP-2 and MMP-9 in neuronal cells are lower than astrocytes. Alteplase (1-10 ${\mu}g/ml$) induced upregulation of MMP-2 and MMP-9 in rat cortical neurons and astrocytes, respectively. Whereas pamiteplase in a wide range of dose did not affect the MMP-2 and MMP-9 responses in both of cells. These results suggest that pamiteplase with long half-life can be provided as a agent that overcome the side effects of alteplase.

• Journal of the Korean Applied Science and Technology
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• v.37 no.3
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• pp.613-624
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• 2020

This study is a descriptive research to grasp the effects of nursing performance on emotional labor, job stress and resilience in general hospital nurses. Method: I surveyed them using a structured questionnaire for collecting data from Aug. 20, 2019 to Sep. 2, 2019. The collected data were analyzed by the frequency, the percentage, t-test, ANOVA, Scheffe's Test, Pearson's Correlation Coefficient, and Multiple Regression Analysis. Results: The factors affecting nursing performance of the subjects were resilience (β=0.58, p<.001), and current position is head nurse (β=0.21, p<.01), the number of working years at current working place (β=0.18, p<.05). The F statistics for the fit of the estimated regression model was very significant as 30.901(p<.001) and the explanatory power was 42.4%. Conclusion: The results of this study showed that resilience was the most influential factor to nursing performance of general hospital nurses, and the number of working years at current working place was the most influential factor to the performance of head nurses. Therefore, it is necessary to develop practical programs strengthening resilience of nurses for the improvement of nursing performance and to apply strategies on development.

• Korean journal of applied entomology
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• v.40 no.4
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• pp.337-344
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• 2001

The house fly (Musca domestica L.) strains were derived from the Yumenoshima III strain by selecting with cypermethrin and methomyl for 19 and 16 generations, respectively. The resulting strains, cypermethrin resistance strain (Cyp-R19) and methomyl resistance strain (Met-R16), showed high level of resistance by 12906 and 51 times, respectively, comparing with the susceptible SRS strain. The Cyp-R19 strain was resistant to synthetic pyrethroids such as deltamethrin, esfenvalerate, fenpropathrin, $\beta$-cyfluthrin, showing > 11000, 1231, 103, 292 times higher $LD_{50}$ values than the SRS strain, respectively. It was also resistant to 3 organophosphates and 2 carbamates such as fenitrothion, profenofos, pyridaphenthion, benfuracarb, methomyl, showing resistance ratios fo 51, 17, 49, 39 and 62 comparing to SRS strain. The Met-R16 strain was resistant to synthetic carbamate benfuracarb, showing 6 times higher $LD_{50}$ value than SRS strain. It was also resistant to 4 organophosphates such as acephate, fenitrothion, profenofos and pyridaphenthion, showing > 40, 103, 19, 60 times higher $LD_{50}$ value. It was also resistant to 5 pyrethroids and a pyrrole such as cypermethrin, deltamethrin, esfenvalerate, fenpropathrin, $\beta$-cyfluthrin and chlorfenapyr, showing 3030, 249, 4063, 34, 330 and 86 times higher $LD_{50}$ values than the SRS strain. Cyp-R14 strain which was selected for 14 generations by cypermethrin and developed 11014 times higher resistance to the SRS strain was used in the dominance and linkage group analysis. Cypermethrin resistance inheritance was incompletely dominant in house fly as judged by the reciprocal cross between the resistant and susceptible strains. The linkage group analysis for the major factors responsible for this resistance was carried out by the$ F_1$male-backcross method, using susceptible multi-chromosomal marker aabys strain. The major factors for cypermethrin resistance were located on the 1st, the 3rd and the 4th chromosomes, and the effect of the 3rd chromosome was most prominent.

• Journal of agricultural medicine and community health
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• v.39 no.2
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• pp.94-103
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• 2014

Objective: The purpose of this research was to define the factors influencing turnover intention of customized home health care nurses. Methods: Research participants were 237 nurses who worked in the customized home health care of 33 public health centers in Daegu city and Gyeong-Buk Province. The data were collected by self report questionnaires from July, 1 to August, 30, 2011. The data were analyzed by t-test, ANOVA, correlation coefficient, multiple stepwise regression using the SPSS program. Results: The average score for turnover intention was 3.12 (5 score) and job satisfaction was 2.41 (4 score). The scores for sub-categories of job satisfaction were operational factors, 1.99, personnel factors, 2.03, work factors, 2.64 and relationship factors, 3.04. Marital status, religion, visiting nurses career, employment status, work area were the significant factors related to turnover intention in these subjects. There was a significant negative correlation between job satisfaction and turnover intention (r=-0.354, p<0.001). Significant factors were job satisfaction, marital status, employment status (Cum $R^2$=0.198, F=17.179, p<0.001) that explained 19.8% of turnover intention. Conclusions: Customized home health care nurses management policy which includes job satisfaction and general characteristics of visiting nurses should be established to enhance of quality of customized home health care service.

• Child Health Nursing Research
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• v.20 no.1
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• pp.30-38
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• 2014

Purpose: The purpose of this study was to explore maternal physical activity support for preschool children. Methods: Survey methodology using a self-administered questionnaire was employed. Mothers with preschool children from a daycare center in Daejeon participated in the study. One hundred and fifty-six questionnaires were analyzed. Results: Mothers with preschool children showed a moderate level of physical activity support for their children. Significant factors affecting physical activity support of mothers were monthly household income (${\beta}$=.417, p=.002), maternal self-efficacy for physical activity support (${\beta}$=.231, p=.003), information for physical activity support (${\beta}$=.173, p=.022), and experience of education about physical activity support (${\beta}$=.237, p=.002). These variables explained 26.4% of the variance in physical activity support (F=7.628, p<.001). Conclusion: To improve maternal support for increasing physical activity of preschool children, maternal education and appropriate information should be provided to improve self-efficacy for physical activity support.

• Korean Journal of Plant Resources
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• v.21 no.5
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• pp.374-387
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• 2008

This study was carried out to investigate the distribution of the useful resources plants and the flora of the sand dune on South Coast and Jeju Island. The flora of sand dune on South Coast and Jeju Island was investigated from February to November in 2006. Vascular plants of this area consist of total 171 taxa; 1 forma, 18 varieties, 152 species, 130 genera, 51 families. The dominant species in the vegetations of the south coast sand dune were Calystegia soldanella, Ischaemum anthephoroides, Vitex rotundifolia, Carex pumila, Carex kobomugi. It corresponds to 11.1 % of totally 4,071 taxa appeared in Korea. Useful plants of this area were investigated 113 taxa. It corresponds to 66% of collected plants in this area under our study. Among the useful plants, there are 73 taxa of edible source, 61 taxa of medicinal source, 22 taxa of pasture source, 16 taxa of ornamental source, 7 taxa of fiber source, 1 taxa of timber source. Korean endemic plants were composed 1 taxa.

• Journal of Environmental Policy
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• v.4 no.1
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• pp.113-127
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• 2005

This study was aimed at developing an application method of biotope evaluation indexes to secure bird diversity on urban biotope that has high intensity of land use. The main purpose of the study was to plan the effective restoration method of sound urban biotope from the ecological aspects after evaluating the relationship between the biotope evaluation indexes. The biotope area, number of insect species, distance from adjacent road, biotope area index were surveyed on each designated site in order to analyze the evaluation indexes that influenced bird diversity in urban biotope. The analysis of the relationship between biotope evaluation. indexes showed the following results number of bird species and number of insect species > number of bird species and biotope area index > number of insect species and biotope area index, that is, the number of insect species and biotope area index had a specific effect on the bird diversity. The equation derived from the above result is 'number of bird species = 6.124 $\times$ biotope area index + 0.095 $\times$ number. of insect species - 1.197' ($R^2=0.716$, F=27.743, P<0.001). Therefore, even a small area can be helpful for promoting bird diversity in the urban area if the biotope area index and diversity of vertical landscape for insects are maintained.

• Journal of Intelligence and Information Systems
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• v.18 no.1
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• pp.91-107
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• 2012

As the Internet becomes more popular, many people use it to communicate. With the increasing number of personal homepages, blogs, and social network services, people often expose their personal information online. Although the necessity of those services cannot be denied, we should be concerned about the negative aspects such as personal information leakage. Because it is impossible to review all of the past records posted by all of the people, an automatic personal information detection method is strongly required. This study proposes a method to detect or classify online documents that contain personal information by analyzing features that are common to personal information related documents and learning that information based on the Na$\ddot{i}$ve Bayes algorithm. To select the document classification algorithm, the Na$\ddot{i}$ve Bayes classification algorithm was compared with the Vector Space classification algorithm. The result showed that Na$\ddot{i}$ve Bayes reveals more excellent precision, recall, F-measure, and accuracy than Vector Space does. However, the measurement level of the Na$\ddot{i}$ve Bayes classification algorithm is still insufficient to apply to the real world. Lewis, a learning algorithm researcher, states that it is important to improve the quality of category features while applying learning algorithms to some specific domain. He proposes a way to incrementally add features that are dependent on related documents and in a step-wise manner. In another experiment, the algorithm learns the additional dependent features thereby reducing the noise of the features. As a result, the latter experiment shows better performance in terms of measurement than the former experiment does.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.5
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• pp.332-338
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• 2016

This study examined the posttraumatic growth of North Korean defectors, the relation between their characteristics and posttraumatic growth and the factors influencing their posttraumatic growth, and explored methods of improving their mental health status. 145 North Korean defectors, who were trained in B city and G city, participated in the survey from February 1 to March 10, 2016. The posttraumatic growth, resilience, self-esteem, deliberate rumination, and impact of the (traumatic) event were measured using the PTGI (Posttraumatic Growth Inventory), RS (Rumination Scale, Resilience Scale), SES (Self-esteem Scale) and ISR (Impact of Event). The data were analyzed using the t-test, ANOVA, Pearson correlation coefficient and stepwise multiple regression. The mean scores were 29.64 for posttraumatic growth. There were significant positive correlations between posttraumatic growth and resilience and between posttraumatic growth and rumination. The influence of the independent variables on the total posttraumatic growth was examined using regression analysis. Models including the variables (resilience, positive self-esteem, and rumination) explained 54.2% of the variance for the posttraumatic growth. These findings demonstrate that it is essential for nurses to continuously intervene and help North Korean defectors so as to promote their posttraumatic growth and resilience. Furthermore, it is also necessary for nurses to find ways to develop ideal interventions in order to activate deliberate rumination.

• Journal of Chest Surgery
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• v.42 no.6
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• pp.704-709
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• 2009

Background: We assessed the efficacy of intraoperative intra-aortic balloon pump therapy for achieving hemodynamic instability during off-pump coronary artery bypass surgery. Material and Method: We studied seven hundred ninety-six patients who underwent off-pump coronary artery bypass between January 2000 and December 2006. The patient were divided into group I (n=39), which received intraoperative intra-aortic balloon pump therapy, and group II (n=757), which did not receive intraoperative intra-aortic balloon pump therapy. Result: There were no differences in the operative mortalities (2.6%, 1/39 vs 0.8%, 6/757; p=0.195) and morbidities such as atrial fibrillation (p=0.691), stroke (p=0.908) and mediastinitis (p=0.781) between the 2 groups, although the ventilator support time, the length of the intensive care unit stay and the length of the hospital stay were longer in group I than in group II (p<0.05). Multivariate analysis failed to prove that group I was a high risk group for operative mortality (p=0.549). There were 3 intraoperative intra-aortic balloon pump-related complications in group I (7.9%). However, no longer complications occurred after 2003, when the surgeons began using a smaller sized 8 F catheter that was inserted using a sheathless technique. Conclusion: Intraoperative intra-aortic balloon pump therapy for achieving hemodynamic instability during off-pump coronary artery bypass surgery can be performed safely and it showed comparable clinical results to that of not using intraoperative intra-aortic balloon pump therapy.