• Journal of the Society of Cosmetic Scientists of Korea
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• v.46 no.2
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• pp.105-117
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• 2020

Agaricus blazei Murill (Almond mushroom) has many beneficial effects, such as anti-cancer, immuneenhancement, and anti-obesity. Also, its skin benefits have been reported for antioxidant, anti-inflammatory, and whitening. In order to elucidate these effects, many studies have been conducted. In this study, we reconfirmed the skin efficacy of the extract of the mushrooms mushrooms. The Agaricus blazei extract showed inhibition of melanin synthesis, enhancement of collagen synthesis, and up-regulation of gene expression (hyaluronan syntahase-2, 3 and aquaporin-3) at 100 ㎍/mL. and identified the ingredients from the extract. We further investigated them to find an applicability as cosmetic ingredients. The ingredients were confirmed comparison of their spectroscopic data with literature values. They were identified as being ergosterol (1), 5-dihydroergosterol (2), cerevisterol (3), cerebroside B (4), cerebroside D (5), adenosine (6), and benzoic acid (7). Among these compounds, we evaluated skin efficacy for two cerebrosides and three ergosterol derivatives that have not been reported its efficacy. As a result, 5-dihydroergosterol (2) inhibited melanogenesis in B16F10 and promoted collagen biosynthesis in human dermal fibroblast. In addition, cerevisterol (3), cerebroside B (4), and cerebroside D (5) inhibited NO production in RAW 264.7 cell. In particular, cerebroside D (5) increased the expression of hyaluronan synthase-2 and aquaporin-3 genes in HaCaT. These results suggest that Agaricus blazei extract and isolated compounds can be used as cosmetic ingredients.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.36 no.2
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• pp.137-143
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• 2010

Yuza (Citrus junos Sieb ex TANAKA) is a citrus fruit that is cultivated in northeast Asia. Citron is known for containing abundant antioxidants such as vitamin C, flavonoids, for example hesperidin and hesperetin, and terpenoids such as limononin. When mature citron is processed for tea or other beverage food products in Korea, massive amounts of seeds and pericarp are remained as waste. This study aimed to exploit the processed remnant of Citron for developing functional cosmetic applications. Ethanol extracts of Yuza seed and pericarp did not show significant radical scavenging activities measured by DPPH (2,2-diphenyl-1-picrylhydrazyl) method. But they contained significantly high phenolic compounds. Cultured human dermal fibroblasts and HaCaT keratinocytes were irradiated with 25 mJ UVB and the citron extracts were added to the medium of each culture. Cellular damages caused by UVB irradiation were prevented by the addition of the Yuza extract. In addition, the reduction of the enhanced MMP-1 expression after irradiation of UVB in human dermal fibroblasts was observed. Also the increased level of pro-inflammtory TNF-$\alpha$ in the UVB irradiated HaCaT cells was decreased. The collagen expression was enhanced by the extract. Yuza extract markedly inhibited melanin production from $\alpha$-MSH treated B16F1 melanoma cells. Melanin assay, tyrosinase zymography results indicated that Yuza extract had strong depigmenting activity. In conclusion, Yuza ethanol extracts have good anti-photoaging and strong anti-melanogenic efficacies.

• Korean Journal of Plant Resources
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• v.21 no.5
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• pp.374-387
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• 2008

This study was carried out to investigate the distribution of the useful resources plants and the flora of the sand dune on South Coast and Jeju Island. The flora of sand dune on South Coast and Jeju Island was investigated from February to November in 2006. Vascular plants of this area consist of total 171 taxa; 1 forma, 18 varieties, 152 species, 130 genera, 51 families. The dominant species in the vegetations of the south coast sand dune were Calystegia soldanella, Ischaemum anthephoroides, Vitex rotundifolia, Carex pumila, Carex kobomugi. It corresponds to 11.1 % of totally 4,071 taxa appeared in Korea. Useful plants of this area were investigated 113 taxa. It corresponds to 66% of collected plants in this area under our study. Among the useful plants, there are 73 taxa of edible source, 61 taxa of medicinal source, 22 taxa of pasture source, 16 taxa of ornamental source, 7 taxa of fiber source, 1 taxa of timber source. Korean endemic plants were composed 1 taxa.

• Journal of The Korean Society of Grassland and Forage Science
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• v.23 no.4
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• pp.271-276
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• 2003

A Jeju local variety of Italian millet (Setaria italica Beauvois) was grown at five seeding rates (6, 9, 12, 15 and 15 kg/ha) from May 1 to August 25, 2003 at Jeju to determine influence of seeding rate on agronomic characters, forage yield and quality. Days to flowering increased from 89 to 96 days as seeding rate increased from 6 to 18 kg/ha. The plant height increased from 128 to 148cm as seeding rate was increased from 6 to 12 kg/ha and then decreased to 131cm at a rate of 18 kg/ha. With increasing seeding rate, stem diameter, number of leaves, number of nodes, leaf width and weight per plant decreased but leaf length had the same trend with plant height. As seeding rate increased from 6 to 12 kg/ha, fresh furage, dry matter, crude protein, and total digestible nutrients (TDN) yield increased from 35.93 to 54.83 MT/ha, 10.49 to 17.43 MT/ha, 0.94 to 1.79 MT/ha and 5.33 to 9.27 MT/ha, respectively, and then decreased with further increased seeding rates. Crude protein, either extract, nitrogen free extract, and TDN content increased 9.0 to 12.01％, 1.3 to 1.8%, 45.6 to 47.8% and 50.8 to 55.0%, respectively, but crude fiber content decreased 35.2 to 30.0% and crude ash declined 5.8 to 8.4% as seeding rate increased from f to 18 kg/ha. The optimum seeding rate to obtain the highest forage yield was estimated to be 12 kg/ha.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2019.04a
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• pp.70-70
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• 2019

본 연구는 인천시 강화군 퇴모산(338m) 일원을 중심으로 식물상을 조사하였다. 관속식물은 76과 210속 268종 3아종 27변종 3품종으로 총 301분류군으로 조사되었다. 분류군별로 양치식물이 4과 5분류군, 나자식물 2과 4분류군, 쌍자엽식물이 61과 226분류군, 단자엽식물이 9과 66분류군이 확인되었다. 주요 식물로 특산식물은 할미밀망(Clematis trichotoma), 백운산원추리(Hemerocallis hakuunensis), 늦둥굴레(Polygonatum infundiflorum)로 3분류군, 희귀식물은 관심대상종(Least Concern)인 두루미천남성(Arisaema heterophyllum), 정보부족종(Data Deficient)인 늦둥굴레(Polygonatum infundiflorum)로 2분류군이 확인되었다. 침입 외래식물은 돼지풀(Ambrosia artemisiifolia), 미국자리공(Phytolacca americana), 좀명아주(Chenopodium ficifolium), 달맞이꽃(Oenothera biennis L.), 털별꽃아재비(Galinsoga ciliata (Raf.) S.F.Blake) 등 10과 20분류군이 조사되었다. 유용식물로는 용도를 모르는 49분류군(16.3%)을 제외하면 252분류군(83.7%)이 자원식물로 이용가치가 있는 것으로 나타났다. 이들을 용도에 따라 구분해보면 식용 130분류군(29.4%), 섬유용 3분류군(0.7%), 약용 106분류군(24.0%), 관상용 34분류군(7.7%), 사료용 141분류군(31.9%), 산업용 3분류군(0.7%), 염료용 10분류군(2.3%), 목재용 15분류군(3.4%)으로 조사되었다.

• Economic Analysis
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• v.25 no.2
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• pp.54-95
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• 2019

The purpose of this study is to analyze quantitatively and qualitatively the effects of the increase in online shopping and its effects on real-world commercial outlets. The empirical analysis of this study is based on the results of "Census on Establishments" and "Online Shopping Survey" that cover 15 years, from 2002 to 2016. According to the results of this study, the increase in the number of online transactions affects the decrease in the number of stores in the real-world retail sector. However, non-specialized large stores and chain convenience stores showed an increase in the number of stores. In addition, the number of F&B stores increased the most in line with the increase in online transactions. This is because the increase in online transactions and in internet users led to the use of more delivery applications and the introduction of popular places on blogs or through social media. Street-level rents for medium and large-sized locations increased. In other words, it is seen that the demand for differentiated real-world stores that provide a good user experience increases, even though online transactions also increase. These results suggest that real-world stores should provide good user experiences in their physical locations with a certain size and assortment of goods.

• The korean journal of orthodontics
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• v.36 no.4
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• pp.284-294
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• 2006

Objective: Activating mutations in the fibroblast growth factor receptor-2 (FGFR2) have been shown to cause syndromic craniosynostosis such as Apert and Crouzon syndromes. The purpose of this pilot study was to investigate the resultant phenotypes induced by the two distinctive bone-targeted gene constructs of FGFR2, Pro253Arg and Cys278Phe, corresponding to human Apert and Crouzon syndromes respectively. Methods: Wild type and a transgenic mouse model with normal FGFR2 were used as controls to examine the validity of the microinjection. Micro-CT and morphometric analysis on the skull revealed the following results. Results: Both Apert and Crouzon mutants of FGFR2 induced fusion of calvarial sutures and anteroposteriorly constricted facial dimension, with anterior crossbite present only in Apert mice. Apert mice differed from Crouzon mice and transgenic mice with normal FGFR2 in the anterior cranial base flexure and calvarial flexure angle which implies a possible difference in the pathogenesis of the two mutations. In contrast, the transgenic mice with normal FGFR2 displayed normal craniofacial phenotype. Conclusion: Apert and Crouzon mutations appear to lead to genotype-specific phenotypes, possibly causing the distinctive sites and sequence of synostosis in the calvaria and cranial base. The exact function of the altered FGFR2 at each suture needs further investigation.

• Tuberculosis and Respiratory Diseases
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• v.43 no.1
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• pp.69-74
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• 1996

Background: The diagnosis of pulmonary embolism (PE) based on clinical findings is often elusive and therefore requires confirmative diagnostic method. Pulmonary angiography, though the gold standard for the diagnosis of pulmonary embolism, is an invasive method and requires trained personnel and special equipment. Lung V/Q scan, on the other hand, is a noninvasive method but the diagnostic specificity and sensitivity arc not satisfactory in case that the results are either intermediate or low probability scan. Plasma D-dimer is generated when a thrombus is fibrinolysed by plasmin and is known to be increased in various thrombotic disorders. The aim of this study was to investigate the value of the determination of plasma D-dimer level in the diagnosis of pulmonary embolism. Methods: Pulmonary angiography was performed in 17 patients who were clinically suspected to have pulmonary embolism. 9 patients(PE, $56{\pm}13.4$ yrs, M:F=8:1) were diagnosed to have pulmonary embolism by pulmonary angiography. The control group were the 8 patients with negative pulmonary angiography and 13 orthopedic patients with no evidence of pulmonary embolism on scintigraphic and impedance plethysmographic studies(n=21) (non-PE, $54.5{\pm}11.1$ yrs, M:F=11:10). Plasma D-dimer was measured by latex agglutination method in study subjects and the results were analyzed according to the presence or absence of pulmonary embolism. Results: 1) The increased level of plasma D-dimer was more frequently observed in the patients with pulmonary embolism than in the controls(>0.5 mg/L, 8 in PE, 10 in non-PE; <0.5 mg/L, 1 in PE, 11 in non-PE, p=0.049). 2) The diagnostic value of plasma D-dimer level higher than 0.5 mg/L were as follows: sensitivity 88.9%(8/9), specificity 52.4%(11/21), positive predictive value 44.4%(8/18), and negative predictive value 91.7%(11/12). Conclusion: Plasma D-dimer determination showed high sensitivity and negative predictive value in the diagnosis of pulmonary embolism and is therefore thought to be useful in excluding the possibility of pulmonary embolism.

• Journal of Sericultural and Entomological Science
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• v.2
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• pp.1-31
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• 1962

The purpose of this treatise is to prove the presence of cystine in silk fiber through wide sampling throughout all the sericultural processes of Bombyx mori.; also to show that disulfide cross linkages exist in the silk fiber. The conclusions reached were as follows: 1. Crystalline cystine was obtained from silk fibroin using Folin's Method. 2. Analytical data showing the cystine content of silk fiber and its related materials were obtained using Sullvan's Method as follows: Material Percent Cystine A. Mulberry leaf protein 0.175 B. Silkworm egg 0.33 C. Silkworm Body, matured, fat extracted, without silk gland 0.41 D. Silk gland, matured 1.23 E. Silkworm feces none F. Silkworm pupa, fat extracted 0.30 G. Silkworm moth, fat extracted 0.60 H. Raw Silk 0.22 I. Fibroin 0.175 J. Sericin 0.30 3. The presence of cystine in the silkworm was substantiated the existence of 0.175 % methionine in mulberry leaves and 0.12% methionine in the silk gland. 4. Part of the sulfhydryl compounds in the silk gland is believed to transfer to serine and methionine, with the former being secreted into the liquid silk finally as silk fiber and the latter used for nutritive purposes in the growing of silk gland tissue. 5. The cystine content is variable by mulberry species, silkworm species, sex, breeding process, and other culturing environments. 6. Hybrid silkworms require more nutritive amino acids for effective growth than the original parents, and secrete less of them as silk fiber. 7. From such an observation, the amino acid composition of silk fiber is believed to be fairly flexible. Cystine if included in the amorphous part of the fiber, especially in sericin. 8. The result from enriching the silkworm diet with pure cystine or wool cystine did not result in any advantage, therefore it is believed that the natural cystine and methionine contents in the mulberry leafaregoodenoughforsilkwormnutrition. 9. The disulfide cross linkage in silk fiber was verified by using the Harris Method. Contraction took place following the treatment of the fiber with various salts and acids. Comparisons were made with wool fiber. 10. During these experiments, the fibrious structure of silk fiber and the net-globular liquid form were photographed microscopically. It is believed that the globules of liquid silk are net-formed by the inter attraction of the OH ion of the globular peptide and the H ion of water as shown by the hair cracking behavior of the film. The net-globular protein precipitation from the mulberry protein solution showed that mulberry is a proper diet for the formation of fibrous protein in the silk fiber. 11. The significance of the presence of cystine in silk fiber as emphasized in this paper should result in modification of the general conception that cystine is absent from this fiber. NOTICE: A part of this treatise was presented at the annual Korea Sericultural Society meeting held in 1961.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.3 no.2
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• pp.1-15
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• 1983

This paper has concentrated on estimating the possibility and mathematical analysis for the application of BFB to the treatment of nightsoil with low dilution rate. The experiment for the study of this purpose was conducted by continuous type reactor at $20^{\circ}C$, varying F/M ratio from 0.12 to 0.37 and dilution ratio from 2 to 10, and in it provided matted reticulated polypropylene sheets for the solid supports. The obtained results showed that the application of BFB to the treatment of nightsoil would be more effective than any other biological treatment process. Also, it has observed that the optimum dilution ratio was about 5 times and the optimum HRT was about 17 hours, and then it was estimated that the reactor volume and the quantity of weak water could be reduced to the extent of 70 percent and 80 percent. The experimental results of BFB could be analysed by the mathematical models applied to complete mixing activated sludge process. The substrate removal rates which were obtained by McKinney's($K_m$) and EcKenfelder's($K_e$) equation was 1.784/hr and $2.0{\times}10l/mg{\cdot}day$, and substrate was removed very rapidly compared to those of conventional type biological treatment processes. The biomass yield coefficient($a_5$), the endogeneous respiration rate(b), the synthesis oxygen demand rate($a{_5}^{\prime}$), and the endogeneous respiration oxygen demand rate(b') were 0.349, 0.0237/day, 0.495 and 0.0336, respectively.