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A case of 17 alpha-hydroxylase deficiency

  • Kim, Sung Mee;Rhee, Jeong Ho
    • Clinical and Experimental Reproductive Medicine
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    • v.42 no.2
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    • pp.72-76
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    • 2015
  • $17{\alpha}$-hydroxylase and 17,20-lyase are enzymes encoded by the CYP17A1 gene and are required for the synthesis of sex steroids and cortisol. In $17{\alpha}$-hydroxylase deficiency, there are low blood levels of estrogens, androgens, and cortisol, and resultant compensatory increases in adrenocorticotrophic hormone that stimulate the production of 11-deoxycorticosterone and corticosterone. In turn, the excessive levels of mineralocorticoids lead to volume expansion and hypertension. Females with $17{\alpha}$-hydroxylase deficiency are characterized by primary amenorrhea and delayed puberty, with accompanying hypertension. Affected males usually have female external genitalia, a blind vagina, and intra-abdominal testes. The treatment of this disorder is centered on glucocorticoid and sex steroid replacement. In patients with $17{\alpha}$-hydroxylase deficiency who are being raised as females, estrogen should be supplemented, while genetically female patients with a uterus should also receive progesterone supplementation. Here, we report a case of a 21-year-old female with $17{\alpha}$-hydroxylase deficiency who had received inadequate treatment for a prolonged period of time. We also include a brief review of the recent literature on this disorder.

A Case Study on Thermal Performance for Transparent Glazing Space Considering Solar Radiation in Summer (여름철 일사를 고려한 투명 투과체 공간의 열환경 특성에 관한 사례연구)

  • Ryu, Young-Hee;Seo, Hye-Soo;Lee, Min-Jung;Nam, Ji-yeon;Song, Mi-Na;Chun, Chung-Yoon
    • KIEAE Journal
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    • v.3 no.1
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    • pp.31-36
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    • 2003
  • Recently, buildings with transparent glazing on exterior walls have increased. The transparent glazing on exterior walls gives an impression of opening through introducing external environment's elements to inside of the building, and has various merits and so on, but has defects in controling indoor environments. Especially, the excess of solar radiation in summer increases cooling load causing discomforts to occupants providing radiant environment with high temperature. Cooling load mainly depends on electricity comparing to heating load and intents to centralize specific time. So it is necessary to work out a countermeasure. In this study, showed P building with transparent glazing on exterior walls as a case, investigated indoor thermal performance, numerical analysis of P building in summer through comparing dry-sauna which is represented as radiant environment with high temperature. In the results of this study, transparent glazing space has radiant environment with high temperature such as dry-sauna because of the excess of solar radiation. Accordingly countermeasures are considered in building planning. As concrete methods, there are adiabatic effects using double glazing, use of sunscreen, blind, ventilation facilitation using natural draft, decrease of surface temperature through evaporation cooling and cooling coils.

The Effect of Auricular Acupuncture on the Pulse Rate (이침 요법이 맥박의 변화에 미치는 영향)

  • Jang, Jun-hyouk;Kim, Ji-young
    • Journal of Acupuncture Research
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    • v.20 no.1
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    • pp.97-103
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    • 2003
  • Objective : Auricular acupuncture is a method of treatment that involves needling the ear in order to produce relief of symptoms. This concept was first developed by P.Nogier, french doctor and referred to as somatotopic representation. Many authors have commented the fact that the vagus nerve supplies the external auditory and the concha. The aim of this randomised, single blind study was to investigate whether auricular acupuncture of the ear produced changes in the pulse rate, an indicator of vagal tone. Methods: 10 healthy man volunteers were divided into normal and epinephrine stimulation group. Then each group was divided into vagus area acupuncture and control area acupuncture group again. Epinephrine stimulation group was injected by epinephrine 0.3cc twice, first. All of them were needled in either the vagus area or control area of the ear, and pulse rate changes were measured by patient monitor over 1 hour. Results : In the epinephrine stimulation group, there was significant differences in the pulse rate change between vagus area acupuncture and control area acupuncture group. After injection of epinephrine, the basal pulse rate was increased 1.3~1.4 times in the control group. However, in the vagus area acupuncture group the basal pulse rate was increased only 1.1~1.2 times.

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English as an Instructional Medium in Korean Higher Education: Focusing on the Perspectives of Professors

  • Choi, Soo Joung
    • English Language & Literature Teaching
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    • v.18 no.3
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    • pp.25-51
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    • 2012
  • The study explores the way professors working in a private university in Korea perceive the recent English-medium instruction (EMI) frenzy in Korean higher education (HE) and the way they respond to its manifestation at their institution. Working within a qualitative research paradigm (Merriam, 2009), I gathered data primarily via one-time semi-structured interviews with ten participants who have offered or are offering EMI at the time of data collection and used a qualitative data analysis method. The findings illustrate that the professors view external factors residing outside individual universities, such as the college rankings and the university evaluation parameters, as the principal drive behind the current EMI boom in Korean tertiary education. Acknowledging the importance of strengthening the international competitive edge of Korean HE in the global era, the professors perceive the EMI policy positively expecting it to be beneficial for both students and institutions. They, however, problematize the blind acceptance of EMI policy and externally forced EMI expansion movement in Korean HE, which they believe will lower the standard of the academic experience of students. Experiencing first-hand the inadequate manifestation of the EMI policy at their university, the professors claim that a systematic long-term implementation plan and context-suitable approaches should be taken at both the national and institutional level for successful future EMI implementation and expansion efforts.

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The Effects of Vibration Exercise after Modified Bröstrom Operation in Soccer Players with Ankle Instability

  • Kim, Sanghoon;Kim, Yangrae;Kim, Yongyoun
    • Journal of International Academy of Physical Therapy Research
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    • v.10 no.2
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    • pp.1791-1796
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    • 2019
  • Background: Vibration exercise after ankle surgery improves proprioception and ankle muscle strength through vibration stimulation. Objective: To examine the effects of vibration exercise on the ankle stability. Design: Randomized controlled clinical trial (single blind) Methods: Twenty soccer players were randomly divided into experimental group and control group. The Vibration exercise program was conducted 12 weeks and 3 times a week. Ankle joint proprioceptive sensory test and Isokinetic muscle strength test were performed using Biodex system pro III to measure plantar flexion / dorsiflexion and eversion / inversion motion. Results: The result of isokinetic test of ankle joint is showed significant improvement in all measurement items, such as leg flexion, lateral flexion, external and internal muscle forces, compared to previous ones by performing vibration movements for 12 weeks. However, in the comparison group, plantar flexor ($30^{\circ}$), eversion muscle ($120^{\circ}$), inversion ($30^{\circ}$) of limb muscle strength were significantly improved compared with the previous phase; was no significant difference in dorsi-flexion. There was no significant difference between groups in all the items. Conclusions: In this study, we analyzed the effects of rehabilitation exercise on soccer players who had reconstructed with an ankle joint ligament injury through vibration exercise device. As a result, we could propose an effective exercise method to improve the ability, and confirmed the applicability as an appropriate exercise program to prevent ankle injuries and help quick return.

Analysis on Dimming Control Effect by Algorithm Variation for Direct/Indirect Lighting in a Small Office (알고리듬 변화에 따른 직/간접 조명시스템에 대한 디밍제어 효과분석)

  • Kim, Soo-Young
    • Journal of the Korean Solar Energy Society
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    • v.28 no.5
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    • pp.36-48
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    • 2008
  • This study examines the influence of control algorithms on dimming performance to determine appropriate control setting when direct/indirect lighting is controlled by a daylight dimming system. Computer simulation were performed for a small office with double skin envelope under various daylight conditions. A retractable fabric shading and Venetian blind were applied for internal and external envelopes under three CIE standard sky conditions. Unshielded and partially-shielded photosensors were used, and three control algorithms were applied for the sensors. In general, dimming level was too excessive due to the direct impact of light from lighting fixture to the photosensor. Providing insufficient lighting output, the unshielded photosensor completely failed to secure required illuminance under any daylight condition. When a partially-shielded photosensor was applied under clear sky, three setting points functioned effectively. Less sensitivity for the partially-shielded photosensor was effective to control the dimming system optimally with reasonable energy saving. However, the daylight dimming control system for direct/indirect lighting does not appear to be energy effective when photosensors without enough shielded area is installed on ceiling where light from fixtures reaches directly.

Rear Vehicle Detection Method in Harsh Environment Using Improved Image Information (개선된 영상 정보를 이용한 가혹한 환경에서의 후방 차량 감지 방법)

  • Jeong, Jin-Seong;Kim, Hyun-Tae;Jang, Young-Min;Cho, Sang-Bok
    • Journal of the Institute of Electronics and Information Engineers
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    • v.54 no.1
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    • pp.96-110
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    • 2017
  • Most of vehicle detection studies using the existing general lens or wide-angle lens have a blind spot in the rear detection situation, the image is vulnerable to noise and a variety of external environments. In this paper, we propose a method that is detection in harsh external environment with noise, blind spots, etc. First, using a fish-eye lens will help minimize blind spots compared to the wide-angle lens. When angle of the lens is growing because nonlinear radial distortion also increase, calibration was used after initializing and optimizing the distortion constant in order to ensure accuracy. In addition, the original image was analyzed along with calibration to remove fog and calibrate brightness and thereby enable detection even when visibility is obstructed due to light and dark adaptations from foggy situations or sudden changes in illumination. Fog removal generally takes a considerably significant amount of time to calculate. Thus in order to reduce the calculation time, remove the fog used the major fog removal algorithm Dark Channel Prior. While Gamma Correction was used to calibrate brightness, a brightness and contrast evaluation was conducted on the image in order to determine the Gamma Value needed for correction. The evaluation used only a part instead of the entirety of the image in order to reduce the time allotted to calculation. When the brightness and contrast values were calculated, those values were used to decided Gamma value and to correct the entire image. The brightness correction and fog removal were processed in parallel, and the images were registered as a single image to minimize the calculation time needed for all the processes. Then the feature extraction method HOG was used to detect the vehicle in the corrected image. As a result, it took 0.064 seconds per frame to detect the vehicle using image correction as proposed herein, which showed a 7.5% improvement in detection rate compared to the existing vehicle detection method.

FPGA-based One-Chip Architecture and Design of Real-time Video CODEC with Embedded Blind Watermarking (블라인드 워터마킹을 내장한 실시간 비디오 코덱의 FPGA기반 단일 칩 구조 및 설계)

  • 서영호;김대경;유지상;김동욱
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.29 no.8C
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    • pp.1113-1124
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    • 2004
  • In this paper, we proposed a hardware(H/W) structure which can compress and recontruct the input image in real time operation and implemented it into a FPGA platform using VHDL(VHSIC Hardware Description Language). All the image processing element to process both compression and reconstruction in a FPGA were considered each of them was mapped into H/W with the efficient structure for FPGA. We used the DWT(discrete wavelet transform) which transforms the data from spatial domain to the frequency domain, because use considered the motion JPEG2000 as the application. The implemented H/W is separated to both the data path part and the control part. The data path part consisted of the image processing blocks and the data processing blocks. The image processing blocks consisted of the DWT Kernel fur the filtering by DWT, Quantizer/Huffman Encoder, Inverse Adder/Buffer for adding the low frequency coefficient to the high frequency one in the inverse DWT operation, and Huffman Decoder. Also there existed the interface blocks for communicating with the external application environments and the timing blocks for buffering between the internal blocks The global operations of the designed H/W are the image compression and the reconstruction, and it is operated by the unit of a field synchronized with the A/D converter. The implemented H/W used the 69%(16980) LAB(Logic Array Block) and 9%(28352) ESB(Embedded System Block) in the APEX20KC EP20K600CB652-7 FPGA chip of ALTERA, and stably operated in the 70MHz clock frequency. So we verified the real time operation of 60 fields/sec(30 frames/sec).

Does Single Blind Anterior Glenohumeral Steroid Injection Performed by Short Experienced Clinicians Could Provide Clinical Efficacy in Patients with Frozen Shoulder?

  • Hong, Jin Ho;Ryu, Ho Young;Park, Yong Bok;Jeon, Sang Jun;Park, Won Ha;Yoo, Jae Chul
    • Clinics in Shoulder and Elbow
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    • v.17 no.3
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    • pp.102-106
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    • 2014
  • Background: The purpose of this study was to evaluate the effect of single blinded anterior intra-articular corticosteroid injection to the glenohumeral joint performed by short experienced clinicians in frozen state adhesive capsulitis patients. Methods: From March to June of 2013, among the patients who visited the shoulder outpatient clinic due to shoulder pain for 5-6 months and those patient diagnosed as frozen state adhesive capsulitis was selected. The diagnosis were based on base, first the global limitation of range of motion, defined as forward elevation <100, external rotation at side <10, internal rotation less than buttock, and abduction <70. Second, the patients had additional radiologic evaluations showing no major pathologies for such stiffness. Clinical outcome, were performed with pain visual analog scale (PVAS) and functional visual analog scale (FVAS), American Shoulder and Elbow Surgeons Shoulder score (ASES), preinjection and postinjection after 2-4 weeks. Finally 82-patients were enrolled. Mean age of the patients was 55.1 years and mean follow-up duration was 25.17 days. Results: The mean preinjection PVAS was 6.91 and postinjection was 3.11, there was 3.8 decreases from preinjection status (p < 0.001). The mean FVAS score showed 4.26 at preinjection and 6.63 afterwards (p < 0.001). The ASES score showed 27.89 increases after injection (p < 0.001). There were 64-patients (78.04%) who reported more than 3 points of decrease of PVAS, who could be judged as effective treatment. Conclusions: Single anterior glenohumeral steroid injection by short experienced clinicians to the patients with frozen state adhesive capsulitis has shown relatively high efficacy in clinical result evaluated by means of PVAS.

Effects of Auricular Acupressure on Female College Students with Functional Constipation (이압요법이 기능성 변비를 가진 여대생의 변비 완화에 미치는 영향)

  • Min, Juyon;Park, Hyojung
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.21 no.7
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    • pp.487-495
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    • 2020
  • This study examined the effects of auricular acupressure on female college students with functional constipation to propose auricular acupressure as an effective and evidence-based nursing intervention. This is an experimental study designed with randomization and single-blind in a Sham-control approach. The subjects included 44 female college students with functional constipation whose symptoms met the Rome IV criteria. In this study, five different acupressure sites were applied to each group; the experimental group (n=23) received auricular acupressure on rectum, large intestine, lung, san jiao, and shenmen, whereas the Sham control group (n=21) received acupressure on ankle, helix, tooth, jaw, and external ear. The intervention was implemented once a week for a total of six weeks. After six weeks, the severity of constipation, stool form, and quality of life regarding constipation in the experimental group significantly improved compared to that of the Sham control group (p<.001). Consequently, the study showed that auricular acupressure can be used as an effective nursing intervention to alleviate constipation in female college students.