• Journal of Veterinary Science
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• v.22 no.5
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• pp.47.1-47.10
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• 2021

Background: Due to multiple similarities in the structure and physiology of human and pig skin, the pig model is extremely useful for biological drug testing after subcutaneous administration. Knowledge of the differences between subcutaneous injection sites could have a significant impact on the absorption phase and pharmacokinetic profiles of biological drugs. Objectives: This study aimed to analyze the impact of administration site on pharmacokinetics and selected biochemical and hematological parameters after a single subcutaneous administration of ustekinumab in pigs. Drug concentrations in blood plasma were analyzed by enzyme-linked immunosorbent assay. Pharmacokinetic analyses were performed based on raw data using Phoenix WinNonlin 8.1 software and ThothPro v 4.1. Methods: The study included 12 healthy, female, large white piglets. Each group received a single dose of ustekinumab given as a 1 mg/kg subcutaneous injection into the internal part of the inguinal fold or the external part of the inguinal fold. Results: The differences in absorption rate between the internal and external parts of the inguinal fold were not significant. However, the time of maximal concentration, clearance, area under the curve calculated between zero and mean residence time and mean residence time between groups were substantially different (p > 0.05). The relative bioavailability after administration of ustekinumab into the external part of the inguinal fold was 40.36% lower than after administration of ustekinumab into the internal part of the inguinal fold. Conclusions: Healthy breeding pigs are a relevant model to study the pharmacokinetic profile of subcutaneously administered ustekinumab.

• Korea Trade Review
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• v.42 no.6
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• pp.131-154
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• 2017

In international trade, transportation generally has the largest and direct impact on freight costs. However, it is also sensitive to external factors such as global economic conditions, global trade volume and exchange rate. Therefore, it is necessary to examine the relationship and influence of international trade in terms of external factors that affect the change of imports and exports by marine and air transportation through empirical analysis. In particular, the analysis of the impact of these external factors on marine and air transportation is an important topic when recent exchange rate changes are significant, and it is also necessary to analyze what transportation means are more sensitive to exchange rate changes. In this study, we use the Vector Error Correction Model to analyze the dynamic effects of changes in exchange rate and domestic and international economic conditions on marine and air transportation from January 2000 to March 2017. Respectively. Alos, Impulse response function and variance decomposition were examined.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.40 no.2
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• pp.99-103
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• 2017

Productivity improvement is one of the important goals which firms' technology developments aim at. Firms' improved productivity from technology development means that their inputs can produce more outputs through technology development, which makes firms' productivity improvement from technology development more and more important in the age of technology advance and convergence like today. This research empirically analyzes the influence of the external technology collaboration network diversity on the productivity improvement of the small and medium-sized enterprises (SMEs) from technology development and the moderating effect of the chief technology officer (CTO)-driven technology development on this influence. This study constructs the research model reflecting the moderating impact of the CTO-driven technology development and tests it with the ordinary least squares regression through the IBM SPSS version 23 by using the 2,000 data about South Korean SMEs. This research empirically reveals two points. One is that SMEs' external technology collaboration network diversity has a positive influence on their productivity improvement from technology development. The other is that the positive effect of SMEs' external technology collaboration network diversity on their productivity improvement from technology development is moderated by the CTO-driven technology development. The two points revealed in this study present two meaningful implications in not only the practical but also academic point of view. The practical implication is that it is effective for SMEs to use CTOs in increasing their productivity improvement from technology development. The academic implication is that making technology collaboration with more diverse external partners can increase SMEs' productivity improvement from technology development.

• Journal of the Korean Institute of Rural Architecture
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• v.26 no.1
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• pp.1-9
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• 2024

This study was motivated by the need to identify the characteristics of professionals involved in planning exterior spaces in urban development projects and to provide guidelines for maintaining the identity of urban images. Urban development's impact on external spaces can alter the image of the urban structure, especially due to the many boundaries between urban and rural areas. Therefore, there is a need for public standards for external spaces in such projects. This study collects and analyzes experts' opinions to understand the characteristics of each professional, selects the relative importance of each, and uses this as a guideline for step-by-step deliberation in planning external spaces. The research scope includes analyzing each expert's characteristics based on the external space evaluation items from Lee Limjeong's 2023 study, which builds upon existing research, and presenting the importance and priority of each expert. As a methodology, a questionnaire was conducted for each expert group using the indicators established in Lee Lim Jung's 2023 study for external spaces in urban development projects. An in-depth analysis was performed using the Analytic Hierarchy Process (AHP) for each expert. Using AHP analysis, the composite weight for each of the 17 detailed items was first adjusted by the number of item weights to account for the classification level of the large and detailed items. Then, the composite importance was calculated by multiplying the importance of the large, medium, and detailed classifications. The calculated composite importance was finally adjusted by applying the number of item weights again, ensuring the sum of the 17 importance values equals 1. The final importance calculated through this process was then presented by occupation.

• Journal of the Korean Institute of Intelligent Systems
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• v.22 no.4
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• pp.521-526
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• 2012

The performance of arrow from a manufacturing process depends on arrow's trajectory(archer's paradox) and intensity of an impact points. Especially, when conducting a shooting experiment over and over in the same experiment condition, the intensity of impact point is an objective standard to judge the performance of the arrow. However, the analysis method for the impact point is not enough, a previous research of the arrow's performance has been focused on a skill to optimize a manufacturing variables(feathers of an arrow, barb of an arrow, arrow's shaft, weight, external diameter, spine). In this paper, We propose measurement system of arrow's impact point with Mamdani fuzzy inference system and similarity of polygon for automation of impact point's measurement. Measuring the impact point data of the arrow moving with a high speed(approximately 275km/h) by using line laser and photo diode array, then the measured data are mapped to arrow's impact point with fuzzy inference and similarity of polygon.

• Korean Journal of Applied Biomechanics
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• v.15 no.4
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• pp.117-129
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• 2005

The purpose of this study was to characterize the impact shock wave and its attenuation, and the kinematic response of the lower extremity's joints to the impact shock during downhill running in which the lower extremity's extensor acts dominantly. For this study, fifteen subjects(mean age:$27.08{\pm}4.39$; mass:$76.30{\pm}6.60$; height:$177.25{\pm}4.11$) were required to run on the 0% grade treadmill and downhill grades of 7%, and 15% in random at speed of their preference. When the participant run, acceleration at the tibia and the sacrum and kinematic data of the lower extremity were collected for 20s so as to provide at least 5 strides for analysis at each grade. Peak impact accelerations were used to calculate shock attenuation between the tibia and sacrum in time domain at each grade. Fast Fourier transformation(FFT) and power spectral density(PSD) techniques were used to analyze impact shock factors and its attenuation in the frequency domain. Joint coordinate system technique was used to compute angular displacement of the ankle and knee joint in three dimension. The conclusions were drawn as fellows: 1. Peak impact accelerations of the tibia and sacrum in downhill run were greater than that of 0% grade run, but no significant between conditions. Peak shock of PSD resembled also in pattern of peak impact acceleration. The wave of impact shock attenuation between the tibia and sacrum decreased with increasing grade, but didn't find a significant difference between grade conditions. 2. Adduction/abduction, flexion/extention, and internal/external rotation of the ankle and knee joints at support phase between grade conditions didn't make much difference. 3. At grade of 7% and 15%, there were relationship between the knee of the flexion/extension movement and peak impact acceleration during heel strike and found also it in the ankle of plantar/dorsiflexion at grade of 15%.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.7
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• pp.166-172
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• 2019

A case study was performed in order to develop well-designed of thin plate door impact beam. The conventional impact beam was consisted of steel-pipe welded two brackets on the both side, which causes low productivity and high cost. In order to overcome those disadvantage, it is necessary to develop a new type of door impact; thin plate impact beam. The thin plate impact beam was not needed a welding procedure, which can lead low cost and high productivity. In order to maximally resist from an external force, the cross-section design should be well designed. 6 different cross-section design were proposed based on engineer's experience. Three point bending test was simulated those 6 different impact beam and compared the reaction forces. Among them, one case was chosen and redesigned for detail design.

• Wind and Structures
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• v.37 no.4
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• pp.255-274
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• 2023

The aim of this paper is to enhance the accuracy of predicting time-averaged external surface pressures on low-rise buildings by utilizing Computational Fluid Dynamics (CFD) simulations. To achieve this, benchmark studies of the Silsoe cube and the Texas Tech University (TTU) experimental building are employed for comparison with simulation results. The paper is structured into three main sections. In the initial part, an appropriate domain size is selected based on the precision of mean pressure coefficients on the windward face of the cube, utilizing Reynolds Averaged Navier-Stokes (RANS) turbulence models. Subsequently, recommendations regarding the optimal computational domain size for an isolated building are provided based on revised findings. Moving on to the second part, the Silsoe cube model is examined within a horizontally homogeneous computational domain using more accurate turbulence models, such as Large Eddy Simulation (LES) and hybrid RANS-LES models. For computational efficiency, transient simulation settings are employed, building upon previous studies by the authors at the Windstorm Impact, Science, and Engineering (WISE) Lab, Louisiana State University (LSU). An optimal meshing strategy is determined for LES based on a grid convergence study. Three hybrid RANS-LES cases are investigated to achieve desired enhancements in the distribution of mean pressure coefficients on the Silsoe cube. In the final part, a 1:10 scale model of the TTU building is studied, incorporating the insights gained from the second part. The generated flow characteristics, including vertical profiles of mean velocity, turbulence intensity, and velocity spectra (small and large eddies), exhibit good agreement with full-scale (TTU) measurements. The results indicate promising roof pressures achieved through the careful consideration of meshing strategy, time step, domain size, inflow turbulence, near-wall treatment, and turbulence models. Moreover, this paper demonstrates an improvement in mean roof pressures compared to other state-of-the-art studies, thus highlighting the significance of CFD simulations in building aerodynamics.

• Korean Journal of Applied Biomechanics
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• v.15 no.4
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• pp.85-95
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• 2005

The purpose of this study was to investigate the relations between the segments of the body, the three dimensional anatomical angle during One Hand Backhand Stroke and Two Hand Backhand in tennis. For the movement analysis three dimensional cinematographical method(APAS) was used and for the calculation of the kinematic variables a self developed program was used with the LabVIEW 6.1 graphical programming(Johnson, 1999) program. By using Eular's equations the three dimensional anatomical Cardan angles of the joint and racket head direction were defined. 1. In three dimensional maximum linear velocity of racket head the X axis and Y axis(horizontal direction) showed $-11.04{\pm}2.69m/sec$, $-9.31{\pm}0.49m/sec$ before impact, the z axis(vertical direction) maximum linear velocity of racket head did not show at impact but after impact this will resulted influence upon hitting ball. It could be suggest that Y axis velocity of racket head influence on ball direction and z axis velocity influence on ball spin after impact. The stance distance between right foot and left foot was mean $75.4{\pm}5.86cm$ during one hand backhand stroke and $72.6{\pm}4.67cm$ during two hand backhand stroke. 2. The three dimensional anatomical angular displacement of trunk in interna rotation-external rotation showed most important role in backhand stroke. and is follwed by flexion-extension. the three dimensional anatomical angular displacement of trunk did not show significant difference between one hand backhand stroke and two hand backhand stroke but the three dimensional anatomical angular displacement of trunk was bigger than one hand backhand stroke. 3. while backhand stroke, the flexion-extension and adduction-abduction of right shoulder joint showed significant different between one hand backhand stroke and two hand backhand stroke. the three dimensional anatomical angular displacement of right shoulder joint showed more flex and abduct in one hand backhand stroke. 4. The three dimensional anatomical angular displacement of left shoulder showed flexion, adduction, and external rotation at impact. after impact, The angular displacement as adduction-abduction of left shoulder changed motion direction as abduction. angular displacement of left shoulder as flexion-extension showed bigger than the right shoulder.

• The Journal of the Korea Contents Association
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• v.18 no.1
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• pp.132-142
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• 2018

This study attempts to identify the external and internal factors which affect collaboration motives and investigates their respective impacts from the perspective of foreign direct investment(FDI). Although there has been much research on collaboration motives, so far, few studies have associated collaboration motives with FDI. The findings suggest that while price competitiveness and cost structure uncertainty have a positive and significant impact on collaboration motives, the gross added value to property as well as plant and equipment have a significant negative impact. Furthermore, in the case of gross added value to both property and plant and equipment, managers tend to collaborate with others to enhance the value of these factors. For both FDI and non-FDI firms, internal factors such as price competitiveness and investment within three years are significant determinants for the decision to collaborate. The difference between FDI and non-FDI firms is that for the former, the gross added value to property, an internal factor, is a critical factor, while for the latter, the cost structure uncertainty, an external factor, is critical for collaboration. To summarize, this study suggests the following managerial implication: the enhancement of the internal competency of a firm broadens the window of opportunity for collaboration with others, and consequently provides a chance to boost management efficiency.