• Journal of the Korean Society of Clothing and Textiles
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• v.28 no.1
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• pp.100-111
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• 2004

The purpose of this study is to investigate fashion advertisements portraying ambiguous sex phenomena, including homosexuality codes and to analyze the meaning of these advertisements in order to develop effective fashion advertisements strategies. The method of this study was to observe the readings about ambiguous sex theory, including homosexuality, and analyze fashion advertisements that express this through the Internet and fashion journals. The ambiguous sex expression seen in fashion advertisements meet various consumers' needs which is what the latest advertisement market requires, and offer competitive brand image by fresh appeal. In the background, there are various complex factors like the change of contemporary spirit, and designers' tastes and values about homosexuality. The kinds of ambiguous sex expression techniques portrayed in fashion advertisements can be divided as the ambiguity of physical codes and the ambiguity of sex role identity. These advertisements do play a role as a public campaign for a change in society from the sociocultural point of view. And, from the economical viewpoint, they approach the consumer as a fresh marketing strategy. From the esthetic viewpoint, they express new esthetic sense named “edge” And seen from the designers' viewpoints, they express designers' private sexual identities.

• The Research Journal of the Costume Culture
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• v.22 no.2
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• pp.258-272
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• 2014

This study aims at comprehending the characteristics of fashion communications through case study about an art marketing that Prada develops in the field of modern fashion and providing theoretical materials on creativity-based art marketing and communication spread as expression strategy for brand philosophy and personality. For its research method, theoretical study was reviewed about art marketing and Prada's fashion philosophy and then cases on Prada's art marketing were analyzed according to their types. Prada's types in their art marketing are classified into several groups: support of art foundation and artists, differentiation via flagship store, application of image fashion, exhibition project, and cooperative work with different realms. From the above marketing strategies, we can find the values in that the brand image imbedded in enterprises with culture and art was contributable to set up the brand identity, that they were much beneficial to continuous activation for fashion culture and art fields, and that fashion communications of artistic emotion based on challenge and innovation were proposed. This fashion communication in Prada via way of art marketing is not just expression of Prada's luxury fashion brand but willingness to make their unique style from different facades. This also suggests the orientation that modern fashion should look forward to in finding a new way through cooperative relationship with other fields.

• Journal of Ginseng Research
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• v.33 no.2
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• pp.99-103
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• 2009

The in-vitro immunomodulatory function of murine natural-killer (NK) cells induced by red-ginseng acidic polysaccharide (RGAP) in ovariectomized (OVX) rats was examined in this study. The IL-2-induced NK cell activity was significantly decreased in the OVX rats compared to the sham groups, but the normally induced NK cell activity was not. RGAP, however, increased the NK cell activity in both groups, and this effect involved iNOS expression. The inhibition of iNOS activity did not increase the NK cell cytotoxicity by RGAP in the OVX rats. The data that were obtained also demonstrated that the expression of iNOS was increased in the spleen of the OVX rats. These results indicate that RGAP increases the tumoricidal activity of the NK cell in the OVX rats, which is a primed or activated state of innate immune cells resulting from the changes in cytokine production induced by estrogen-deficient stress. Therefore, RGAP has a synergistic effect on the NK cell activities, which are regulated by the iNOS signals in OVX rats. This suggests that RGAP is useful for potential therapeutic strategies as a nutrient in regulating the NK cells in OVX rats.

• Korean Parent-Child Health Journal
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• v.5 no.1
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• pp.62-74
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• 2002

The purpose of this study was to explore bringing-up process of mothers with first baby in the context of Korean culture. The field survey was performed with four primiparae during four months from September, 2000 and grounded theory approach was used for data analysis. The results indicated that there were 27 primary categories and 12 secondary categories. Unclearness was extracted as an expression of the core category of bringing-up process. The subjects was faced with care of their baby after delivery and experienced formation and deepening of unclearness. After that, they also went through expression and disentanglement of complication caused by unclearness. It is found that the core concept of this study, the unclereness("Magmagham" in Korean) means a confusion, a burden, a helplessness and a hardness. New mothers make an effort to resolve this situation with strong motherhood in their mind. By supports from significant others, they are empowered and some mothers get depressive feelings. The findings of this study are contributed for nurses to understand new mothers in developmental crisis. We suggested that the nursing intervention strategies including learning baby care skills and preparing emotionally a motherhood must be given new mother during pregnancy period.

• YAKHAK HOEJI
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• v.49 no.2
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• pp.151-155
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• 2005

For decades, the demand for new antiviral strategies, especially in hepatitis, has increased markedly due to its devastating pathogenic outcome, In the present study, we examin ed the antiviral effect of the combination of amantadine and biphenyl dimethyl dicarboxylate (DDB) in HepG2 2.2.15, which is transfected with HBV DNA. The study demonstrated that the combination not the single treatment may have an anti-HBV effect through a synergism of antiviral, anti-inflammatory and cytoprotective activities in STAT1 ${\alpha}$, 6-16 gene, and pro-inflammatory components such as nitric oxide and IL-1${\beta}$ expression. In addition, hepatitis B surface and core gene expression were examined as a final end point for the anti-HBV activities, which was also significantly suppressed comparing to normal control (p<0.01).

• Journal of Fashion Business
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• v.13 no.3
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• pp.99-108
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• 2009

The purpose of this study is to analyze the middle-aged British women's apparel purchase behavior. The results of this study can be used to present the tendency of Korean middle-aged women's apparel purchase behavior when they become the old-aged by comparing and analyzing the British women's purchase behavior. We found that they prefer to choose and purchase their clothes by their own decision-making and search for actively the new brands for old age. Strong willingness was showed that their level of consumption amounts for clothing would be the same level between middle-aged and old-aged. It was also presented that they like to see a old-aged fashion model for fashion advertisement rather than a younger one and prefer to use the expression of 'mature' rather than a stereotypical expression such as a silver, gray and gold. The segmentation of fashion market by age can not be simply standardized. We expect that the propensity for clothing purchase behavior pattern of middle-aged women will not be changed and keep the same tendency by the time of their old-aged. We expect that this research results can be used as a basic material for another study and setting up the product developments and marketing strategies.

• Journal of Microbiology and Biotechnology
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• v.29 no.4
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• pp.571-576
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• 2019

Microenvironmental stress, which is naturally observed in solid tumors, has been implicated in anticancer drug resistance. This tumor-specific stress causes the degradation of topoisomerase $II{\alpha}$, rendering cells resistant to topoisomerase $II{\alpha}$-targeted anticancer agents. In addition, microenvironmental stress can induce the overexpression of 78kDa glucose regulated protein (GRP78), which can subsequently block the activation of apoptosis induced by treatment with anticancer agents. Therefore, inhibition of topoisomerase $II{\alpha}$ degradation and reduction in GRP78 expression may be effective strategies for inhibiting anticancer drug resistance. In this study, we investigated the active compound arctigenin, which inhibited microenvironmental stress-induced etoposide resistance in HT-29 cells. Arctigenin was also highly toxic to etoposide-resistant HT-29 cells, with an $IC_{50}$ value of $10{\mu}M$ for colony formation. We further showed that arctigenin inhibited the degradation of topoisomerase $II{\alpha}$ and reduced the expression of GRP78. Thus, these results suggest that arctigenin is a novel therapeutic agent that inhibits resistance to etoposide associated with microenvironmental stress conditions.

• BMB Reports
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• v.52 no.2
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• pp.119-126
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• 2019

The tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) initiates the extrinsic apoptotic pathway through formation of the death-inducing signaling complex (DISC), followed by activation of effector caspases. TRAIL receptors are composed of death receptors (DR4 and DR5), decoy receptors (DcR1 and DcR2), and osteoprotegerin. Among them, only DRs activate apoptotic signaling by TRAIL. Since the levels of DR expressions are higher in cancer cells than in normal cells, TRAIL selectively activates apoptotic signaling pathway in cancer cells. However, multiple mechanisms, including down-regulation of DR expression and pro-apoptotic proteins, and up-regulation of anti-apoptotic proteins, make cancer cells TRAIL-resistant. Therefore, many researchers have investigated strategies to overcome TRAIL resistance. In this review, we focus on protein regulation in relation to extrinsic apoptotic signaling pathways via ubiquitination. The ubiquitin proteasome system (UPS) is an important process in control of protein degradation and stabilization, and regulates proliferation and apoptosis in cancer cells. The level of ubiquitination of proteins is determined by the balance of E3 ubiquitin ligases and deubiquitinases (DUBs), which determine protein stability. Regulation of the UPS may be an attractive target for enhancement of TRAIL-induced apoptosis. Our review provides insight to increasing sensitivity to TRAIL-mediated apoptosis through control of post-translational protein expression.

• Mycobiology
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• v.49 no.4
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• pp.421-433
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• 2021

Morchella is a genus of fungi with the ability to concentrate Cd both in the fruit-body and mycelium. However, the molecular mechanisms conferring resistance to Cd stress in Morchella are unknown. Here, RNA-based transcriptomic sequencing was used to identify the genes and pathways involved in Cd tolerance in Morchella spongiola. 7444 differentially expressed genes (DEGs) were identified by cultivating M. spongiola in media containing 0.15, 0.90, or 1.50 mg/L Cd²⁺. The DEGs were divided into six sub-clusters based on their global expression profiles. GO enrichment analysis indicated that numerous DEGs were associated with catalytic activity, cell cycle control, and the ribosome. KEGG enrichment analysis showed that the main pathways under Cd stress were MAPK signaling, oxidative phosphorylation, pyruvate metabolism, and propanoate metabolism. In addition, several DEGs encoding ion transporters, enzymatic/non-enzymatic antioxidants, and transcription factors were identified. Based on these results, a preliminary gene regulatory network was firstly proposed to illustrate the molecular mechanisms of Cd detoxification in M. spongiola. These results provide valuable insights into the Cd tolerance mechanism of M. spongiola and constitute a robust foundation for further studies on detoxification mechanisms in macrofungi that could potentially lead to the development of new and improved fungal bioremediation strategies.

• Journal of Microbiology and Biotechnology
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• v.31 no.11
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• pp.1568-1575
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• 2021

Obesity and related metabolic diseases are major problems worldwide. Some probiotics are currently considered potential therapeutic strategies for obesity. We aimed to investigate the anti-obesity efficacy of Latilactobacillus sakei WIKIM31 in obese mice induced by a high fat diet. The administration of a high-fat diet with L. sakei WIKIM31 reduced body weight gain, epididymal fat mass, triglyceride and total cholesterol levels in the blood, and remarkably decreased the expression of lipogenesis-related genes in the epididymal adipose tissue and liver. Interestingly, intake of L. sakei WIKIM31 improved gut barrier function by increasing the gene expression of tight junction proteins and suppressing the inflammatory responses. Additionally, L. sakei WIKIM31 enhanced the production of short-chain fatty acids, such as butyrate and propionate, in the intestinal tract. These results showed that L. sakei WIKIM31 can be used as a potential therapeutic probiotic for obesity.