• Korean Journal of Pharmacognosy
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• v.54 no.2
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• pp.72-79
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• 2023

MRSA is Staphylococcus aureus resistant to β-lactam antibiotics, and is a worldwide infectious disease. Even with the discovery of new antibiotics, resistance develops rapidly, so new alternatives are needed. Jakyakgamcho-tang (JGT) is a combination of Jakyak and Gamcho, and has been mainly used as an antispasmodic and analgesic in oriental medicine. This study was conducted to find out whether there is an effect on MRSA in relation to the anti-inflammatory effect of JGT and the antibacterial effect of Jakyak and Gamcho found in previous studies. In this study, in order to investigate the antibacterial activity of JGT and the combined effect of existing antibiotics, after extracting JGT with 70% EtoH, the disc diffusion method, minimum inhibitory concentration (MIC), drug combination effect (FICI), and time-kill analysis (Time-kill assay), metabolic inhibition, Western blot and qRT-PCR analysis were used to confirm the antibacterial activity mechanism of MRSA of JGT. As a result of the experiment, all of MRSA showed antibacterial activity in JGT's disc diffusion method, and the MIC was 250-1000 ㎍/mL. When existing antibiotics and JGT were combined with drugs, most had synergy or partial synergy. In addition, it was confirmed that the degree of bacterial growth was suppressed over time when simultaneous administration for 24 hours. JGT showed a synergistic effect when administered together with the ATPase-inhibitor DCCD, suggesting that it affected the inhibition of ATPase. As a result of observing the expression of PBP2a, and hla protein in the JGT-treated group and the untreated control group through wstern blot, it was confirmed that the protein expression of the JGT-treated group was significantly suppressed, and the expression levels of mecA, mecR1 and hla genes were also suppressed during JGT treatment. was observed by qRT-PCR. Combining the results of the experiment, it can be seen that JGT has antibacterial activity in MRSA, and when combined with existing antibiotics, the effect was increased compared to treatment with the drug alone. This suggests that JGT can be an alternative to treatment for antibiotic resistance of MRSA.

• Information Systems Review
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• v.24 no.4
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• pp.97-118
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• 2022

As generative adversarial network (GAN) based oversampling techniques have achieved impressive results in class imbalance of unstructured dataset such as image, many studies have begun to apply it to solving the problem of imbalance in structured dataset. However, these studies have failed to reflect the characteristics of structured data due to changing the data structure into an unstructured data format. In order to overcome the limitation, this study adapted CycleGAN to reflect the characteristics of structured data, and proposed hybridization of synthetic minority oversampling technique (SMOTE) and the adapted CycleGAN. In particular, this study tried to overcome the limitations of existing studies by using a one-dimensional convolutional neural network unlike previous studies that used two-dimensional convolutional neural network. Oversampling based on the method proposed have been experimented using various datasets and compared the performance of the method with existing oversampling methods such as SMOTE and adaptive synthetic sampling (ADASYN). The results indicated the proposed hybrid oversampling method showed superior performance compared to the existing methods when data have more dimensions or higher degree of imbalance. This study implied that the classification performance of oversampling structured data can be improved using the proposed hybrid oversampling method that considers the characteristic of structured data.

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.29 no.3
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• pp.22-32
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• 2011

This study explored the architectural nature, the thought reflected in the place and the 'meaning-landscape' characteristic of a place, to where a retired scholar had lived. The object of the study is the Maechun-Byulup Toesu-jeong wonlim, which consists of a summer house and a garden forest. The results of the study are as following. Toesu-jeong wonlim is located at Daejeong-ri, Sannae-myeon, Namwon-si. It had been built by Maechun Park Chi-Gi in 1870 for his residence after retirement. It is a villa type pavilion and a garden forest which have Banseondaegi(伴仙臺記), Banseondae-10-yeong, Toesu-jeong(退修亭) Sangryangmun, a writing dedicated when putting up the ridge beam of a wooden house), Toesu-jeong Wonwun Byeongsoseo, hanging boards and tablets with poems written on them. In the Toesu-jeong wonlim, there are various 'meaning-landscapes' such as the Maechun-Byulup, Banseondae, Yabakdam and Simjinam together with engraved calligraphy related to the landscaping culture. It is also possible to find the remains of beautiful engraving on the stones and woods at Goksoo Yoogeo(曲水流渠) that suggest the banquets they had while discussing the elegant tastes and appreciating the landscape. The Toesu-jeong wonlim consists of the Toesu-jeong area(a pavilion), the Gwanseon-jae area(a shrine) area and the Gyejeong area(a garden with a brook) area. The pedantic 'meaning-landscape' elements, as the residence of retired scholar who spent his remaining life with elegant tastes, and the expertise of Maechun Park Chi-Gi, as a landscaping architect who built a villa and a garden forest in the motif of a Taoist hermit, can be extracted through the Banseondae-10yeong. The Banseondae-10yeong is the first Toesu-jeong poem and consisting of the Samseon-dae, Sejin-dae, Samcheong-dam, Yabak-dam, Samseo, Takgeum-dam, flat stones, caves, stone sculptures and harvest. The existing vegetation and plants in the Toesu-jeong wonlim are; natural pine forest in the rear garden, zelkova trees, wild cherry trees, apricot trees and pine trees bent to the waterfront direction. Except some ornament-species and shielding-species such as the poplars, most of current trees and vegetation keep the shape of the original Toesu-jeong wonlim landscape.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.14 no.2
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• pp.307-316
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• 1994

The rainfall forecasting model of the short term is improved at the point where meterological data is not gaged. In this study, the adopted model is based on the assumptions for simulation model of rainfall process, meteorological homogeneousness, prediction and estimation of meteorological data. A Kalman Filter technique is used for rainfall forecasting. In the existing models, the equation of the model is non-linear type with regard to rainfall rate, because hydrometer size distribution (HSD) depends on rainfall intensity. The equation is linearized about rainfall rate as HSD is formulated by the function of the water storage in the cloud. And meteorological input variables are predicted by emprical model. It is applied to the storm events over Taech'ong Dam area. The results show that root mean square error between the forecasted and the observed rainfall intensity is varing from 0.3 to 1.01 mm/hr. It is suggested that the assumptions of this study be reasonable and our model is useful for the short term rainfall forecasting at the ungaged point of the meteorological data.

• Journal of the Korean Chemical Society
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• v.55 no.5
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• pp.857-874
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• 2011

The purposes of this study were to develop teaching strategy enhancing creative problem solving skills and to examine the instructional influences on studints' creative thinking skills, critical thinking skills, creative personality and academic self-regulation. In this study, a model using inter-disciplinary analogies(PDCA model) was designed and applied to the existing 'Teaching model for the enhancement of the creative problem solving skills'. And it was implemented to preservice science teachers for the one semester. Results indicated that the experimental group presented statistically meaningful improvement in creative thinking skills, especially in the originality of identifying a problem, making hypothesis, and controlling variables (p<.05). In addition, the strategy contributed to improving critical thinking skills, especially in inquiry process of recognizing problems, making hypothesis, interpreting and transforming of data (p<.05). This strategy also helped students' academic self-regulation (p<.05). But there was no significant improvement in creative personality(p<.05).

• Journal of Haehwa Medicine
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• v.15 no.1
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• pp.41-45
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• 2006

Aims: This overview summarizes the existing evidence on acupuncture for cancer-related pain. Methods: Literature searches were conducted in 7 databases. All clinical studies of acupuncture, electroacupuncture, ear acupuncture and transcutaneous electrical nerve stimulation (TENS) in cancer patients with the main outcome measure of pain were included. Results: Of the 8 studies included, one high quality randomized clinical trial (RCT) of ear acupuncture showed statistically significant pain relief in comparison with placebo ear acupuncture. All the other studies were either non-blinded (n = 2) or uncontrolled clinical trials (n = 5). Most investigations suffered from methodological flaws such as inadequate study design, poor reporting of results, small sample size and overestimation of the results. Conclusions: The current evidence does not support the use of acupuncture as an adjunctive analgesic method for cancer patients. Only one high quality RCT showed promising results thus warranting further investigation into this under-researched area.

• Proceedings of the Korea Water Resources Association Conference
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• 2006.05a
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• pp.1444-1449
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• 2006

Korea is about 70% of all country to mountain, and basin is consisted of various terrain, soil, vegetation, land use etc. because use land as intensive. Also, need basin hydrologic model that can analysis base outflow as well as outflow directly for calculation of discharge to establish irrigation plan. Inconvenient in use method and user interface offer side is causing by way that existing USGS WEASEL runs in PC Arc/Info, and ArcGIS with development of present GIS technology is applied in many fields offering convenience in analysis that use GIS. In this research, wished to develop suitable outflow parameter extraction system, For this, develop pre-processor and post-processor that effectively draw of hydrologic model input data from water resources DB through van example benchimarking, and developed input/output component of GIS base applicable to various hydrologic and water quality model.

• Journal of Korea Water Resources Association
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• v.42 no.4
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• pp.271-279
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• 2009

The objective of this study is to develop the scheme to apply one-dimensional finite volume method (FVM) to natural river with complex geometry. In the previous study, FVM using the Riemann approximate solver was performed successfully in the various cases of dam-break, flood propagation, etc. with simple and rectangular cross-sections. We introduced the transform the natural into equivalent rectangular cross-sections. As a result of this way, the momentum equation was modified. The accuracy and applicability of newly developed scheme are demonstrated by means of a test example with exact solution, which uses triangular cross-sections. Secondly, this model is applied to natural river with irregular cross-sections and non-uniform lengths between cross-sections. The results shows that the aspect of flood propagation, location and height of hydraulic jump, and numerical solutions of maximum water level are in good agreement with the measured data. Using the developed scheme in this study, existing numerical schemes conducted in simple cross-sections can be directly applied to natural river without complicated numerical treatment.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.21 no.7
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• pp.1429-1434
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• 2017

In automatic defect detection problem for spectacle lenses, it is important to extract lens area accurately. Many existing detection methods fail to do it due to insufficient minute noise removal. In this paper, we propose an automatic defect detection method using Bresenham algorithm and adaptive binarization strategy. After usual average binarization, we apply Bresenham algorithm that has the power in extracting ellipse shape from image. Then, adaptive binarization strategy is applied to the critical minute noise removal inside the lens area. After noise removal, We can also compute the influence factor of the defect based on the fuzzy logic with two membership functions such as the size of the defect and the distance of the defect from the center of the lens. In experiment, our method successfully extracts defects in 10 out of 12 example images that include CHEMI, MID, HL, HM type lenses.

• Korean Journal of Agricultural Science
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• v.32 no.2
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• pp.107-126
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• 2005

The most limited production resource in Korea is land. During the period from 1995 to 2002, annual farm land area of 17,600ha have been converted to urban and industrial land. The self-sufficiency rate of rice, Korean staple food, is expected to be decreased from 97.5% in 2003 to 60-70% in 2020. Under such conditions, this study is aimed at first identifying multi-functional benefits of the reclamation projects such as agricultural production, industrial water supply, urban land supply, transportation effects, sightseeing effects and environmental values with and without the projects. To carry out the objectives, three existing tideland reclamation projects such as Daeho, Kumgang and Yongsangang irrigation project stage II were evaluated and Saemangeum tideland reclamation project which was jointly revaluated by environmental NGO and Govn't appointed specialists in 2000 was reviewed. According to this study results, tide land reclamation projects were showed financially and economically feasible and environmentally sustainable. The joint cost like estuary dam should be allocated based on the multi-functional benefits of the projects. To allocate the joint cost, legal and institutional improvement should adapt the joint cost allocation method as the specific cost-remaining benefit method. Korea has more than 402,000 ha of tidal flat of which 76,396ha have been reclaimed in 2003. To meet food security and to cope with shortage of land, phil-environmental reclamation projects should be continuously implemented and necessary tidal flats for protecting environmental ecosystem should be remained according to the detail survey results of reclaimable resources.