• Proceedings of the Korean Vacuum Society Conference
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• 2013.08a
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• pp.91-91
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• 2013

Imagine a world where we could biomanufacture hybrid nanomaterials having atomic-scale resolution over functionality and architecture. Toward this vision, a fundamental challenge in materials science is how to design and synthesize protein-like material that can be fully self-assembled and exhibit information-specific process. In an ongoing effort to extend the fundamental understanding of protein structure to non-natural systems, we have designed a class of short peptides to fold like proteins and assemble into defined nanostructures. In this talk, I will talk about new strategies to drive the self-assembled structures designing sequence of peptide. I will also discuss about the specific interaction between proteins and inorganics that can be used for the development of new hybrid solar energy devices. Splitting water into hydrogen and oxygen is one of the promising pathways for solar to energy convertsion and storage system. The oxygen evolution reaction (OER) has been regarded as a major bottleneck in the overall water splitting process due to the slow transfer rate of four electrons and the high activation energy barrier for O-O bond formation. In nature, there is a water oxidation complex (WOC) in photosystem II (PSII) comprised of the earthabundant elements Mn and Ca. The WOC in photosystem II, in the form of a cubical CaMn4O5 cluster, efficiently catalyzes water oxidation under neutral conditions with extremely low overpotential (~160 mV) and a high TOF number. The cluster is stabilized by a surrounding redox-active peptide ligand, and undergo successive changes in oxidation state by PCET (proton-coupled electron transfer) reaction with the peptide ligand. It is fundamental challenge to achieve a level of structural complexity and functionality that rivals that seen in the cubane Mn4CaO5 cluster and surrounding peptide in nature. In this presentation, I will present a new strategy to mimic the natural photosystem. The approach is based on the atomically defined assembly based on the short redox-active peptide sequences. Additionally, I will show a newly identified manganese based compound that is very close to manganese clusters in photosystem II.

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.28 no.2
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• pp.98-108
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• 2010

The purpose of this study was to analyze the monumental expression of Korean War Memorials(KWM) in Korea(KWMK). Through site survey and internet searching, the researcher selected 17 KWMK and analyzed four analysis categories: contents, spatial form, landscape elements, sculptures and architectural elements. The results are as follows: 1. The analysis revealed that main contents of KWMK were to cherish victims of the Korean War, honor military merit, and explain Korean War. 2. Most KWMK built battlefield had the form of symmetry and spatial axis arranged monuments and sculptures for solemnity and heroism. Though the sites were terraced by traditional spatial order, spatial sequence wasn't seen except Yang-gu KWMK and Chumomyeongbi in United Nations Memorial Cemetery in Korea. 3. Stone monument-like towers, tablets, podium, monoliths, cenotaphs, and exhibit halls to explain Korean War and combat history were used as main elements of KWMK and also, war weapons were often displayed the flags of countries taking part in Korean War were raised with Taegeukgi and the United Nations flag. 4. Most sculptures were used as important media to represent the Korean War and assumed realistically the form of heroic combat. But a few architectural memorial built in recent were designed in contemporary style to have spatial sequence and represent Korean War symbolically and narratively. 5. In memorial culture, KWMK were strongly influenced by ideology and patriotism, impacted by conventional value, and designed by some sculptors and designers in a certain circle. Further study will be required to analyze the characteristics of KWMK in the point of design style and diachronic.

• Journal of the Korea institute for structural maintenance and inspection
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• v.25 no.4
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• pp.83-91
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• 2021

In this study, to improve the connection performance between the existing reinforced concrete (R/C) frame and the strengthening member, we proposed a new H-section steel frame with elastic pad (HSFEP) system for seismic rehabilitation of existing medium-to-low-rise reinforced concrete (R/C) buildings. This HSFEP strengthening system exhibits an excellent connection performance because an elastic pad is installed between the existing structure and reinforcing frame. The method shows a strength design approach implemented via retrofitting, to easily increase the ultimate lateral load capacity of R/C buildings lacking seismic data, which exhibit shear failure mechanism. Two full-size two-story R/C frame specimens were designed based on an existing R/C building in Korea lacking seismic data, and then strengthened using the HSFEP system; thus, one control specimen and one specimen strengthened with the HSFEP system were used. Pseudodynamic tests were conducted to verify the effects of seismic retrofitting, and the earthquake response behavior with use of the proposed method, in terms of the maximum response strength, response displacement, and degree of earthquake damage compared with the control R/C frame. Test results revealed that the proposed HSFEP strengthening method, internally applied to the R/C frame, effectively increased the lateral ultimate strength, resulting in reduced response displacement of R/C structures under large scale earthquake conditions.

• Journal of the Korea institute for structural maintenance and inspection
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• v.25 no.5
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• pp.60-67
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• 2021

According to the 「Guidelines of Structural Design for Piloti Building」 of the Ministry of Land, Infrastructure and Transport (2018), the natural period of middle and low rise building of upper-walled lower frame type, such as the domestic multiplex house in piloti style, is suggested for safety to apply the existing code formula of the wall structure. However, the current code formula of the wall structure was provided based on actual measurement of high-rise wall-type structures that mainly exhibit bending behavior. So it is considered that it is not suitable for a piloti-type house with four stories or less, where the wall behaves in shear. See also Park et al. (2000) confirmed that the effect of the lower frame part is greater than that of the upper wall part in the natural period of complex structures with 10 or more floors through analytical studies. Therefore, in this study, in order to examine the effect of the lower frame on the natural period of the middle and low-rise piloti structure, the estimation of natural period by the finite element analysis, approximation formula and ccurrent code formula was performed for the target structures with the shear and flexural stiffness of the upper wall and the shear stiffness of the lower frame as variables. As result, it was found that the change in the shear stiffness of the lower frame had a greater effect on the natural period of the whole building than the change in the bending or shear stiffness of the upper wall.

• Biomolecules & Therapeutics
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• v.27 no.5
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• pp.492-501
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• 2019

Nitrogen-containing heterocycles such as quinoline, quinazolinones and indole are scaffolds of natural products and have broad biological effects. During the last years those structures have been intensively synthesized and modified to yield new synthetic molecules that can specifically inhibit the activity of dysregulated protein kinases in cancer cells. Herein, a series of newly synthesized isoquinolinamine (FX-1 to 8) and isoindoloquinazolinone (FX-9, FX-42, FX-43) compounds were evaluated in regards to their anti-leukemic potential on human B- and T- acute lymphoblastic leukemia (ALL) cells. Several biological effects were observed. B-ALL cells (SEM, RS4;11) were more sensitive against isoquinolinamine compounds than T-ALL cells (Jurkat, CEM). In SEM cells, metabolic activity decreased with $10{\mu}M$ up to 26.7% (FX-3), 25.2% (FX-7) and 14.5% (FX-8). The 3-(p-Tolyl) isoquinolin-1-amine FX-9 was the most effective agent against B- and T-ALL cells with IC50 values ranging from 0.54 to $1.94{\mu}M$. None of the tested compounds displayed hemolysis on erythrocytes or cytotoxicity against healthy leukocytes. Anti-proliferative effect of FX-9 was associated with changes in cell morphology and apoptosis induction. Further, influence of FX-9 on PI3K/AKT, MAPK and JAK/STAT signaling was detected but was heterogeneous. Functional inhibition testing of 58 kinases revealed no specific inhibitory activity among cancer-related kinases. In conclusion, FX-9 displays significant antileukemic activity in B- and T-ALL cells and should be further evaluated in regards to the mechanisms of action. Further compounds of the current series might serve as templates for the design of new compounds and as basic structures for modification approaches.

• Tunnel and Underground Space
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• v.33 no.3
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• pp.150-168
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• 2023

The anisotropic behavior of rocks is primarily attributed to the directional arrangement of rock-forming minerals and the distribution characteristics of microcracks. Notably, sedimentary and metamorphic rocks often exhibit distinct transverse isotropy in terms of their strength and deformation characteristics. Consequently, it is crucial to gain accurate insights into the deformation and failure characteristics of transversely isotropic rocks during rock mechanics design processes. The deformation of such rocks is described by five independent elastic constants, which are determined through laboratory testing. In this study, the characteristics of the directional variation of apparent elastic constants in transversely isotropic rocks were investigated using experimental data reported in the literature. To achieve this, the constitutive equation proposed by Mehrabadi & Cowin was introduced to calculate the apparent elastic constants more efficiently and systematically in a rotated Cartesian coordinate system. Four transversely isotropic rock types from the literature were selected, and the influence of changes in the orientation of the weak plane on the variations of the apparent elastic modulus, apparent shear modulus, and apparent Poisson's ratio was analyzed. Based on the investigation, a new constraint on the elastic constants has been proposed. If the proposed constraint is satisfied, the directional variation of the apparent elastic constants in transversely isotropic rocks aligns with intuitive predictions of their tendencies.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.23 no.2
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• pp.173-188
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• 2024

With the advancement of autonomous vehicle (AV) technology, autonomous driving on real roads has become feasible. However, there are challenges in achieving complete autonomy due to perceptual blind areas, which occur when the AV's sensory range or capabilities are limited or impaired by surrounding objects or environmental factors. This study aims to analyze AV accident patterns and safety issues of perceptual blind area that may occur in urban areas, with the goal of developing test scenarios for Level 4+ autonomous driving. It utilized AV accident data from the California Department of Motor Vehicles (DMV) to compare accident patterns and characteristics between AVs and conventional vehicles based on activation status of autonomous mode. It also categorized AV disengagement data to identify types and real-world cases of disengagements caused by perceptual blind areas. The analysis revealed that AVs exhibit different accident types due to their safe driving maneuvers, and three types of perceptual blind area scenarios were identified. The findings of this study serve as crucial foundational data for developing Level 4+ autonomous driving test scenarios, enabling the design of efficient strategies to mitigate perceptual blind areas in various scenarios. This, in turn, is expected to contribute to the effective evaluation and enhancement of AV driving safety on real roads.

• Nuclear Engineering and Technology
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• v.56 no.1
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• pp.106-113
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• 2024

Understanding the tritium release and retention behavior of candidate tritium breeder materials is crucial for breeder blanket design. Recently, a melt spraying process was developed to prepare Li₄SiO₄ pebbles, which were subsequently subjected to the in-pile tritium production and extraction platform in China Mianyang Research Reactor (CMRR) to investigate their in-situ tritium release behavior and irradiation performance. The results demonstrate that HT is the main tritium release form, and adding hydrogen to the purge gas reduces tritium retention while increasing the HT percent in the purge gas. Post-irradiation experiments reveal that the irradiated pebbles darken in color and their grains swell, but the mechanical properties remain largely unchanged. It is concluded that the tritium residence time of Li₄SiO₄ made by melt spraying method at 467 ℃ is approximately 23.34 h. High-density Li₄SiO₄ pebbles exhibit tritium release at relatively low temperatures (<600 ℃) that is mainly controlled by bulk diffusion. The diffusion coefficient at 525 ℃ and 550 ℃ is 1.19 × 10^-11 cm²/s and 5.34 × 10^-11 cm²/s, respectively, with corresponding tritium residence times of 21.3 hours and 4.7 hours.

• Journal of Korean Tunnelling and Underground Space Association
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• v.26 no.4
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• pp.327-344
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• 2024

In general tunnel design and analysis, rock masses are often assumed to be isotropic. Under isotropic conditions, material properties are uniform in all directions, leading to a higher evaluation of tunnel stability. However, actual rock masses exhibit anisotropic characteristics due to discontinuities such as joints, bedding planes, and faults, which cause material properties to vary with direction. This anisotropy significantly affects the stress distribution during tunnel excavation, leading to non-uniform deformation and increased risk of damage. Therefore, thorough pre-analysis is essential. This study analyzes the displacement and stress changes occurring during tunnel excavation based on rock anisotropy. A three-dimensional numerical analysis was performed, selecting anisotropy index and dip angles as variables. The results showed that as the anisotropy index increased, the displacement in the tunnel increased, and stress concentration became more pronounced. The maximum displacement and shear stress were observed where the dip planes met the tunnel.

• Korea Science and Art Forum
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• v.23
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• pp.111-122
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• 2016

The purpose of this multi-disciplinary convergent study is to establish Image Copyright Archive Model for Museums to protect image copyright and vitalize the use of images out of necessity of research and development on copyright services over the life cycle of art contents created by the museums and out of the necessity to vitalize distribution market of image copyright contents in creative industry and to formulate management system of copyright services. This study made various suggestions for enhancement of transparency and efficiency of art contents ecosystem through vitalization of use and recycling of image copyright materials by proposing standard system for calculation, distribution, settlement and monitoring of copyright royalty of 1,000 domestic museums, galleries and exhibit halls. First, this study proposed contents and structure design of image copyright archive model and, by proposing art contents distribution service platform for prototype simulation, execution simulation and model operation simulation, established art contents copyright royalty process model. As billing system and technological development for image contents are still in incipient stage, this study used the existing contents billing framework as basic model for the development of billing technology for distribution of museum collections and artworks and automatic division and calculation engine for copyright royalty. Ultimately, study suggested image copyright archive model which can be used by artists, curators and distributors. In business strategy, study suggested niche market penetration of museum image copyright archive model. In sales expansion strategy, study established a business model in which effective process of image transaction can be conducted in the form of B2B, B2G, B2C and C2B through flexible connection of museum archive system and controllable management of image copyright materials can be possible. This study is expected to minimize disputes between copyright holder of artwork images and their owners and enhance manageability of copyrighted artworks through prevention of such disputes and provision of information on distribution and utilization of art contents (of collections and new creations) owned by the museums. In addition, by providing a guideline for archives of collections of museums and new creations, this study is expected to increase registration of image copyright and to make various convergent businesses possible such as billing, division and settlement of copyright royalty for image copyright distribution service.