• BMB Reports
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• 제44권5호
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• pp.298-305
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• 2011

Most intracellular reactive oxygen species (ROS), especially superoxide anion ($O_2^{{\bullet}_-}$) that is converted from oxygen, are overproduced by excessive electron leakage from the mitochondrial respiratory chain. Intracellular oxidative stress that damages cellular components can contribute to lifestyle-related diseases such as diabetes and arteriosclerosis, and age-related diseases such as cancer and neuronal degenerative diseases. We have previously demonstrated that the excessive mitochondrial $O_2^{{\bullet}_-}$ production caused by SDHC mutations (G71E in C. elegans, I71E in Drosophila and V69E in mouse) results in premature death in C. elegans and Drosophila, cancer in mouse embryonic fibroblast cells and infertility in transgenic mice. SDHC is a subunit of mitochondrial complex II. In humans, it has been reported that mutations in SDHB, SDHC or SDHD often result in inherited head and neck paragangliomas (PGLs). Recently, we established Tet-mev-1 conditional transgenic mice using our uniquely developed Tet-On/Off system, which equilibrates transgene expression to endogenous levels. These mice experienced mitochondrial respiratory chain dysfunction that resulted in $O_2^{{\bullet}_-}$ overproduction. The mitochondrial oxidative stress caused excessive apoptosis leading to low birth weight and growth retardation in the neonatal developmental phase in Tet-mev-1 mice. Here, we briefly describe the relationships between mitochondrial $O_2^{{\bullet}_-}$ and aging phenomena in mev-1 animal models

• Journal of Dental Anesthesia and Pain Medicine
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• 제24권3호
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• pp.173-185
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• 2024

Background: Excessive fear of dental procedures leads to disruptive behavior during dental examinations and treatments. Dental examinations and treatments of these patients usually require additional techniques, such as sedation. The most commonly used techniques are inhalation of nitrous oxide, infusion of propofol with fentanyl, and premedication and infusion of midazolam. Methods: A prospective observational epidemiological study was conducted on patients who required sedoanalgesia techniques for dental exploration and procedures. The reasons for the inability of patients to cooperate (excessive fear or intellectual disability), age, sex, weight, systemic pathology, oral pathology, treatment performed, time of intervention, anesthetic technique performed, and occurrence of complications were recorded. Results: In total, 218 patients were studied. Sixty-five patients came for fear of dental treatment and 153 for presenting with a diagnosis of intellectual disability and not collaborating in the treatment with local anesthesia. The average age of all patients was 30.54±17.30 years. The most frequent oral pathologies found in patients with excessive fear were tartar (6.8%) and wisdom teeth (6.4%), followed by missing teeth (5%). In patients with disabilities, a combination of tartar and cavities appeared most frequently (41.3%), followed by cavities (15.6%). The most frequently used sedoanalgesia technique was the infusion of propofol with fentanyl in both groups of patients, followed by nitrous oxide. Conclusion: The combination of propofol and fentanyl was the most frequently used alternative in patients who were unable to collaborate because of intellectual disability or carry out longer or more complex treatments. Inhaled nitrous oxide and midazolam were the sedative techniques of choice for simpler oral treatments, such as tartrectomies, shallow obturations, and shorter interventions, or in younger patients.

• 정보처리학회논문지C
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• 제12C권4호
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• pp.519-524
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• 2005

동하중 측정 데이터에 추가되는 여러 가지 종류의 오차로 인하여, 신뢰할 수 있는 하중을 구하기 위해 측정 오차를 감소시키는 적절한 방법이 필요하다. 과도한 진동으로 인해 발생하는 측정 오류는 쉽게 제거하기 어렵다. 이러한 오류를 최소화하기 위하여 측정 장치 혹은 측정 대상의 수직 운동과 상호 관계가 전혀 없는 광 센서 시스템을 이용한다. 여러 가지 시료들의 흐름률을 광 센서를 이용하여 측정함으로써 로드셀을 이용한 부정확한 측정 부분을 보완한다. 동하중 측정시 발생하는 잡음 감소를 확인하기 위하여 모형 트레일러 시스템을 사용하며, 제안된 방법이 효과적임을 확인한다.

• Food Science and Biotechnology
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• 제16권2호
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• pp.311-314
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• 2007

Citrus sunki Hort. ex Tanaka is one of several Jeju-native citrus fruits. A number of biological properties for citrus fruits have been suggested, however little is known about those of C. sunki. The present study tested whether fermented product of C. sunki peel (FSP) might affect the activities of enzymes regulating ethanol metabolism. Effects on body weight gain as well as on fatty liver formation were also investigated. The activities of alcohol dehydrogenase and aldehyde dehydrogenase were stimulated remarkably by FSP. Excessive ethanol-induced cytotoxicity was also prevented by FSP in HepG2 cells. FSP decreased the weight gain and fatty liver formation induced by a high-fat diet in mice. From these results, FSP might be a potent source of neutraceuticals useful for preventing ethanol-induced health problems.

• 대한조선학회논문집
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• 제40권6호
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• pp.12-19
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• 2003

Corrugated bulkheads for a bulk carrier are divided into watertight bulkheads and deep tank bulkheads. Design of the watertight bulkheads is principally determined by the permissible limit of Classification and IACS requirements. But, the verification of strength through finite element analysis is indispensable for design of the deep tank bulkheads. A stage for stress evaluation of corrugated part is required for optimum structural design of the deep tank bulkheads. Since the finite element analysis for real model requires excessive amount of calculation time, in this study one corrugated structure is replaced with beam element and is idealized as 2 dimensional frame structure connected to upper and lower stool Minimum weight design of the deep tank bulkheads is performed through generalized sloped deflection method(GSDM) as direct calculation method. The purpose of this study is the development of design system for the minimization of steel weight of deep tank bulkheads as well as watertight bulkheads. Discrete variables are used as design variables for the practical design. Evolution strategies(ES) is used as an optimization technique.

• 한국컴퓨터정보학회논문지
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• 제21권2호
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• pp.105-112
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• 2016

In this paper, we propose a technique that can be mapped to the most appropriate type of health patterns, depending on the health status of health promotion measures to establish a body mass index (BMI). When used as a mapping scheme proposed in this paper it is possible to contribute to effective healthcare and health promotion. BMI is widely used as a simple way to assess obesity because body fat increases the status and relevance. Despite normal weight determined by this and because of the social atmosphere has increased prefer the skinny tend to try to excessive weight loss. Since health can affect the health maintenance and promotion of the rest of your life, depending on whether and how much weight perception and health can be considered as very important. Therefore, this paper identifies the differences in perception and in this respect for the body mass index (BMI). And physical, mental and map the appropriate type of pattern in the relationship between body mass index (BMI) in order to facilitate the social and health conditions. Proposal to give such a mapping technique provides the opportunity to increase the efficiency of health care and health promotion.

• Journal of Community Nutrition
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• 제2권2호
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• pp.105-109
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• 2000

To investigate the correlation between college women's energy intake and body fat percentage, this study was undertaken with 116 college women aged 19-24 years. The subjects were 20.9 years old on the average, and mean height and weight was 161.3 cm, 51.2 kg. Blood pressures were 112.4 mm Hg(systolic pressure), 70.2 mmHg(diastolic pressure). The number of pulse was 75.5 count/min. The energy intake and percent body fat were examined. The average intake of energy was 7652kcal/day(82.3% of RDA), which was lower than the recommended amount. It was similar to the level of energy intake of Korean women. BMI was 19.7 and body fat percent was 24.4%, so they appeared plump. According to BMI, 43.1% of subjects was grouped into normal, 56.9% was thin ; there was no difference between groups in age and stature. Also, normal group(27.1%) shoed significantly higher body fat percent(27.1%) than thin group(22.3%). But, body fat percent of thin group according to BMI was shown normal. Therefore, it may be thought that BMI is unsuitable indicator in this study. As a result of analyzing the correlation between body-measuring value and food intake, body fat percent against body weight and BMI was significant at the level p<0.001, but thee was no significant correlation with food intake. Therefore, it is desirable to recommend a healthful dietary lifestyle and activities for young women who want to reduce body weight due to excessive concerns regarding their outward figure.

• 한국연소학회지
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• 제19권3호
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• pp.18-25
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• 2014

Bottom ash from a coal-fired power plant is usually landfilled to a nearby site, which causes a growing environmental concern and increased operating costs. One way of recycling the bottom ash is to produce light-weight aggregate (LWA) using a rotary kiln. This study investigated the temperature profiles of raw LWA particles in a rotary kiln to identify the range of operating conditions appropriate for ideal bloating. For this purpose, a new simulation method was developed to integrate a 1-dimensional model for the bed of LWA particles and the computational fluid dynamics (CFD) for the fuel combustion and gas flow. The temperature of LWA particles was found very sensitive to the changes in the air preheating temperature and excess air ratio. Therefore, an accurate control of the operation parameters was essential to achieve the bloating of LWA particles without excessive sintering or melting.

• 펄프종이기술
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• 제42권5호
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• pp.31-36
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• 2010

When corrugated board is folded at the severely low humidity condition, crack can occur along the scored (or creased) lines of linerboard. This phenomenon is called as score (or crease) crack. It is mainly resulted from the excessive concentration of stress on the outer layer of linerboard. To overcome score crack, many approaches including the installation of constant temperature and humidity system, displacement of low grade raw material by long and strong fibers, or application of water have been tried. We examined the effect of the weight fraction of top layer in two-ply sheet, freeness of top layer stock and wet pressing on strain and elastic modulus of sheet to prevent score crack. Lower freeness and higher press load increased the density and elastic modulus of sheet. Pressing load over the $50kgf/cm^2$, however, decreased the strain of sheet. The weight fraction of top layer had positive effect on strain as well as elastic modulus without increasing the density of sheet.

• 한국식품영양학회지
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• 제30권4호
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• pp.830-840
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• 2017

Excessive body weight gain during the growth period of early life may predispose individuals towards obesity and metabolic disorder in later life. We investigated the possibility of using the food efficiency ratio as an early indicator for predicting susceptibility to diet-induced obesity and insulin resistance. Four-week-old, prepubertal, male Sprague Dawley rats were divided into obesity-prone and obesity-resistant groups based on food efficiency ratio values after five days on a high-fat diet. Metabolic parameters measured after 2, 6, and 10 weeks, and specific phenotypes were compared with each group. Obesity-prone rats had higher increases in body weight and fat mass compared to obesity-resistant rats over the study period. Obesity-prone rats became glucose intolerant early in this study and remained so throughout the experimental period, with increases in fat weight and leptin levels occurring first, followed by increases in insulin level. Gluconeogenesis and insulin resistance significantly increased in obesity-prone groups in which activities of glucose-6-phosphatase and phosphoenolpyruvate carboxykinase were increased and glucokinase activity decreased. Higher food efficiency ratio at an early age was closely correlated with body fat accumulation, hyperleptinemia, and hyperinsulinemia of middle and elderly age. We suggest a high food efficiency ratio in prepubertal subjects may be a useful predictor of future obesity and insulin resistance.