• Asian Pacific Journal of Cancer Prevention
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• v.14 no.3
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• pp.2127-2130
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• 2013

Cancer, despite all the efforts, still causes one in five deaths worldwide. Surgery, chemotherapy and radiotherapy provide inadequate protection and instead affect normal cells along with cancer cells. The search for cancer cures from natural products (plants and animals) has been practice for over a decade and the use of purified chemical to treat cancer still continues. Several studies have been undertaken during last three decades to find the anti-cancerous property of various plant extract and toxins secreted by animals and micro-organism. These lead to the discovery of several promising molecule having anticancer activity, some of which are in clinical trial and may emerged to be a potential future drug in cancer therapy. In this study we have used penicillin to evaluate its anti-cancer activity. It shown significant effects at cellular and molecular levels against growth of HeLa and K562 cell lines.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.1977-1981
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• 2012

Houttuynia cordata Thunb (HCT) is a native herb found in Southeast Asia which features various pharmacological activities against allergy, inflammation, viral and bacterial infection, and cancer. The aims of this study were to determine the cytotoxic effect of 6 fractions obtained from silica gel column chromatography of alcoholic HCT extract on human leukemic Molt-4 cells and demonstrate mechanisms of cell death. Six HCT fractions were cytotoxic to human lymphoblastic leukemic Molt-4 cells in a dose-dependent manner by MTT assay, fraction 4 exerting the greatest effects. Treatment with $IC_{50}$ of HCT fraction 4 significantly induced Molt-4 apoptosis detected by annexinV-FITC/propidium iodide for externalization of phosphatidylserine to the outer layer of cell membrane. The mitochondrial transmembrane potential was reduced in HCT fraction 4-treated Molt-4 cells. Moreover, decreased expression of Bcl-xl and increased levels of Smac/Diablo, Bax and GRP78 proteins were noted on immunoblotting. In conclusion, HCT fraction 4 induces Molt-4 apoptosis cell through an endoplasmic reticulum stress pathway.

• Journal of the Korean Society for Library and Information Science
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• v.12
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• pp.121-147
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• 1985

In the modern communicative age, the standards of the school libraries are the qualitative guarantee on the services of school libraries or school library media programs, as the guidline, the active guide, the policy documentation and criteria for the professional excellence. The standards of SLMP were revised the sixth time by the school library profession(ALA) with the members or agency of NEA in the U.S. There are the first standard was a quantitative; 'the Certain Report'(by A.L.A., 1920) appearing that the school library is the heart of the school, 2nd 1925; turning up the teaching material source and personel, 'School Libraries for today and tomorrow' (by AASL, 1945) incluseing the instructional materials and the 7th educational ideas in the quantitative feature, 'Standards for School Library Programs' (by AASL, 1960) expressing the instructional material center, communicative environment, learning and teaching laboratory, 'Standards for school media programs' (by DAVI & AASL, 1969) implicating the instructional resource, learning and teaching laboratory, the condition precedent of qualitative education for excellence, 'Standards for media programs; District/school (by AASL & AECT, 1975) containing the improving user's educational experience and personal freedom on the use of SLMP's services. Through changing the standards of SLMP in the US, We have known that the main educational idea in the standards are; (1) SLMP is the instructional force and resource for qualitative, excellence education by learning and teaching laboratory, instructional resource, communicative environment (2) SLMP is the actualizing force and resource for user's self-realization by intellectual and personal excellence, individualizing, humanizing and personalizing education.

• Journal of Microbiology and Biotechnology
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• v.20 no.12
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• pp.1696-1701
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• 2010

The ${\alpha}$-amylases activity was improved by random mutagenesis and screening. A region comprising residues from the position 34-281 was randomly mutated in B. licheniformis ${\alpha}$-amylase (AmyL), and the library with mutations ranging from low, medium, and high frequencies was generated. The library was screened using an effective liquid-phase screening method to isolate mutants with an altered pH profile. The sequencing of improved variants indicated 2-5 amino acid changes. Among them, mutant TP8H5 showed an altered pH profile as compared with that of wild type. The sequencing of variant TP8H5 indicated 2 amino acid changes, Ile157Ser and Trp193Arg, which were located in the solvent accessible flexible loop region in domain B.

• The Journal of Asian Finance, Economics and Business
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• v.7 no.8
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• pp.309-321
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• 2020

This study aims to examine the effects of strategic management accounting on firm performance of finance businesses in Thailand. Strategic management accounting comprises of environmental scanning, competitor orientation and forward-looking information. In this study, 175 finance businesses in Thailand are the samples of the study. A mail survey procedure was used for data collection. The hierarchical multiple regression analysis is employed to test the research relationships. Firstly, environmental scanning positively affects operational excellence, organizational effectiveness and firm performance. Secondly, competitor orientation is positively related to managerial efficiency and organizational effectiveness. Thirdly, forward-looking information has a positive influence on operational excellence, managerial efficiency, organizational effectiveness, and firm performance. In addition, operational excellence, managerial efficiency and organizational effectiveness have positive impact on firm performance. Finally, to verify the mediating effects, operational excellence, managerial efficiency and organizational effectiveness are the mediators of the research relationships. This study confirms that all dimensions of strategic management accounting play a significant role in determining business outcome as being congruent with the theory of resource-based views of the firms. Executives of firms need to provide valuable resources and capabilities to support the strategic management accounting implementation in order to achieve good business outcome in highly competitive environments.

• BMB Reports
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• v.40 no.1
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• pp.1-6
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• 2007

Apoptosis signal-regulating kinase 1 (ASK1) is a mitogenactivated protein kinase (MAPK) kinase kinase that activates JNK and p38 kinases. ASK1 is activated by various stresses, such as reactive oxygen species (ROS), endoplasmic reticulum (ER) stress, lipopolysaccharide (LPS) and calcium influx which are thought to be responsible for the pathogenesis or exacerbations of various human diseases. Recent studies revealed the involvement of ASK1 in ROS- or ER stressrelated diseases, suggesting that ASK1 may be a potential therapeutic target of various human diseases. In this review, we focus on the current findings for the relationship between pathogenesis and ASK1-MAPK pathways.

• International Journal of Control, Automation, and Systems
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• v.5 no.3
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• pp.251-268
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• 2007

A Gaussian sum filter (GSF) is proposed in this paper on simultaneous localization and mapping (SLAM) for mobile robot navigation. In particular, the SLAM problem is tackled here for cases when only bearing measurements are available. Within the stochastic mapping framework using an extended Kalman filter (EKF), a Gaussian probability density function (pdf) is assumed to describe the range-and-bearing sensor noise. In the case of a bearing-only sensor, a sum of weighted Gaussians is used to represent the non-Gaussian robot-landmark range uncertainty, resulting in a bank of EKFs for estimation of the robot and landmark locations. In our approach, the Gaussian parameters are designed on the basis of minimizing the representation error. The computational complexity of the GSF is reduced by applying the sequential probability ratio test (SPRT) to remove under-performing EKFs. Extensive experimental results are included to demonstrate the effectiveness and efficiency of the proposed techniques.

• International Journal of Naval Architecture and Ocean Engineering
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• v.5 no.1
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• pp.47-61
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• 2013

This study compares the Residual ultimate longitudinal strength - grounding Damage index (R-D) diagrams produced by two analysis methods: the ALPS/HULL Intelligent Supersize Finite Element Method (ISFEM) and the design formula (modified Paik and Mansour) method - used to assess the safety of damaged ships. The comparison includes four types of double-hull oil tankers: Panamax, Aframax, Suezmax and VLCC. The R-D diagrams were calculated for a series of 50 grounding scenarios. The diagrams were efficiently sampled using the Latin Hypercube Sampling (LHS) technique and comprehensively analysed based on ship size. Finally, the two methods were compared by statistically analysing the differences between their grounding damage indices and ultimate longitudinal strength predictions. The findings provide a useful example of how to apply the ultimate longitudinal strength analysis method to grounded ships.

• Polymer(Korea)
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• v.37 no.6
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• pp.794-801
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• 2013

Novel microgels of N-isopropylacrylamide (NIPAM)-co-methacrylic acid (MAA) (NIPAM-co-MAA) with different contents of N,N-methylene bis acrylamide (MBA) were prepared by emulsion polymerization technique and were studied by Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS) and zeta potential measurement. Effect of pH, temperature and different salts concentration on the microgel particles was investigated. DLS results have shown that the hydrodynamic radius of the microgel increased upon increasing pH and decreased upon increasing temperature. The swelling/deswelling behaviors as determined by DLS showed the ionic repulsions of the carboxyl group of the methacrylic acid and hydrophobic interaction of NIPAM. The effect of various salts on volume phase transition temperature (VPTT) was also investigated. Upon increasing salt concentration, VPTT became broad and shifted to a lower temperature. Electrophoretic mobility measurements showed an increase with increasing pH and temperature at a constant ionic strength.

• Structural Engineering and Mechanics
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• v.47 no.1
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• pp.119-129
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• 2013

Nonlinear Static Procedures (NSPs) have been developed as a practical tool to estimate the seismic demand of structures. Several researches have accomplished to minimize errors of NSPs, namely pushover procedures, in the Nonlinear Time History Analysis (NTHA), as the most exact method. The most important issue in a typical pushover procedure is the pattern and technique of loading which are extracted based on structural dynamic fundamentals. In this paper, the coefficients of modal force combination is focused involving a meta-heuristic optimization algorithm to find the optimum load pattern which results in a response with minimum amount of errors in comparison to the NTHA counterpart. Other parameters of the problem are based on the FEMA recommendations for pushover analysis of building structures. The proposed approach is implemented on a high-rise 20 storey concrete moment resisting frame under three earthquake records. In order to demonstrate the effectiveness and robustness of the studied procedure the results are presented beside other well-known pushover methods such as MPA and the FEMA procedures, and the results show the efficiency of the proposed load patterns.