• 대한기관식도과학회:학술대회논문집
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• 대한기관식도과학회 1977년도 제11차 학술대회연제 순서 및 초록
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• pp.4.1-4
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• 1977

신생아 및 유아에서의 청력의 진단에 지금까지 수많은 방법이 연구 발표되어 왔으며, 그 중에서도 소리에 대한 신생아, 및 유아의 구체적인 반응을 평가하는 것은 매우 중요하다. 저자들은 1977년 1월부터 동년 4월까지 서울대학교 소아과신생아실에 입원한 100명(남아 54명, 여아 46명)을 대상으로 하여 beltone audiometer model 10d(Ansi 1969)를 사용해서 피검자로 부터 4인치의 거리에서 3,000 Hz, 90dB의 순음으로 2초동안 자극하여 신생아에서 나타나는 반응을 조사하여 다음과 같은 결론을 얻었다. 1. 피검아의 연령은 2시간 내지 3.5시간이었으며(평균연령 2.4시간), 안검반사가 39%, (안검을 폐쇄시키는 반응이 10%, 안검을 개대시키는 반응이 29%), Moro refbex가 35%로 가장 많았으며, 그 외에 손가락을 빠는 반응이 14%, 동작을 갑자기 정지하는 반응이 6%, 머리를 소리자극의 방향으로 움직이는 반응이 2%, 아무 반응도 나타나지 않는 례가 4%의 순서였다. 2. 소리자극에 대한 신생아의 반응시간은 2초 내지 5초(평균 3.3초)이었다.

• 대한영양사협회학술지
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• 제23권1호
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• pp.27-38
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• 2017

Maintaining adequate fluid balance is essential for all biological functions in the body. The purpose of this study was to evaluate vulnerability to dehydration by analyzing age, gender, body mass index (BMI), and blood lipid parameters in health checkup examinees who visited Sahmyook Seoul Hospital for comprehensive health checkups. In a binary logistic regression analysis stratified by age and body mass index the odd ratio for dehydration was as high as 3.317 (95% CI: 1.666~6.605) in the 50s age group, 4.224 (95% CI: 2.038~ 8.755) in the 60s age group, and 4.610 (95% CI: 1.943~10.940) in the above 70s age group compared to 20s reference age group. Aged females showed greater vulnerability to dehydration with significance levels of P<0.01 and P<0.001. Compared to a normal weight (BMI: 18.5~22.9) the odd ratio was higher in males with an under weight (BMI: less than 18.5) (5.130 [95% CI: 1.631~16.132]) and in females with an over weight (BMI: 23.0~24.9) (1.500 [95% CI: 1.065~2.114]). In conclusion, our results showed that vulnerability to dehydration increased with age and was higher in under weight males and over weight females than that in normal weight.

• 한국산학기술학회논문지
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• 제14권9호
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• pp.4335-4341
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• 2013

본 연구는 검진센터에서 대장내시경을 실시한 무증상 성인들을 중심으로 대장암의 전구병변인 대장용종의 유병률 및 위험인자를 알아보고 무증상의 건강한 성인들에게 대장암 관리를 위한 기초자료를 제공하고자 시행하였다. 2010년 1월부터 12월까지 일개 대학병원 검진센터에서 대장내시경검사를 받은 995명을 대상으로 자기기입식 설문지, 의료기록지, 임상검사 결과지들을 이용하여 후향적으로 시행하였으며, 자료의 분석은 SPSS18.0을 이용하였다. 무증상 성인들의 대장용종 유병률은 남성에서 높았고, 연령대가 높을수록 증가하였다. 남성, 고령, 운동을 하지 않은 경우 독립적인 위험인자로서 대장용종과 밀접한 관련이 있는 것으로 나타났다. 따라서 40대 이상 성인에서는 대장내시경 검사를 통한 대장용종의 조기 발견이 중요하며, 대장암 전구병변인 대장용종의 일차 예방을 위한 지속적인 생활습관 교정 및 운동프로그램 개발이 필요하다.

• 한국산업보건학회지
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• 제31권4호
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• pp.540-548
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• 2021

Introduction: Preplacement health examination (PHE) is performed when a worker starts a certain work task which is designated as having occupational risks by the Ministry of Employment and Labor (MOEL). All data related to health examination except PHE are reported to the MOEL by the law. This study has been performed to understand the status of PHE at certain workplaces. Methods: PHE data gathered in a university hospital were analyzed and they were followed with results of the special health examination (SHE) in 2019 and 2020. Those who were evaluated as unfit to work as it was, were interviewed directly or indirectly through an occupational health manager to follow up the management status of their recognized health problems. Results: The unfit to work (unFTW) rate of PHE was 2.8%, and was not different according to the size of workplace or having occupational health service. The major cause of unfit to work was the uncontrolled life-style diseases such as hypertension and diabetes. The rate of SHE followed by PHE was 31.1%. It was not different by the unFTW rates, however, they were different according to having a full time in-house occupational health manager. Thirty-one among 71 examinees who were evaluated as unFTW underwent SHE after controlling their health condition and were finally evaluated as fit to work. Nineteen among 31 started to take medicine and eight have been placed in the work without designated risks. Conclusion: PHE can be used for new workers, who may have unknown or uncontrolled life-style diseases, to be asked to manage life-style diseases as well as work-related risks such as shift work. In order to have a better tracking system for work-related risks, the information of PHE should be analyzed together with other data from health examination.

• Journal of Preventive Medicine and Public Health
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• 제51권6호
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• pp.298-309
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• 2018

Objectives: The objective of this study was to assess the relationship between systolic and diastolic blood pressure (SBP, DBP) and the risk of death from specific causes other than cardiovascular diseases. Methods: We calculated the risk of specific death by SBP and DBP categories for 506 508 health examinees in 2002-2003 using hazard ratios (HRs) and 95% confidence intervals (CIs) in a Cox proportional hazards model. Results: Compared to normal levels (SBP <120 or DBP <90 mmHg), stage I systolic and diastolic hypertension (SBP 140-159, DBP 85-89 mmHg, respectively) were associated with an increased risk of death from diabetes mellitus, alcoholic liver disease, and renal failure (HR, 1.83; 95% CI, 1.51 to 2.22; HR, 1.24; 95% CI, 1.06 to 1.46; HR, 2.30; 95% CI, 1.64 to 3.21; HR, 1.67; 95% CI, 1.27 to 2.20; HR, 1.99; 95% CI, 1.41 to 2.81; HR, 1.31; 95% CI, 0.99 to 1.73, respectively), but a decreased risk of death from intestinal pneumonia (HR, 0.64; 95% CI, 0.42 to 0.98; HR, 0.59; 95% CI, 0.39 to 0.91). Only stage II systolic hypertension (SBP ${\geq}160mmHg$) was associated with an increased risk of death from pneumonia, liver cirrhosis, and intestinal ischemia (HR, 1.54; 95% CI, 1.19 to 1.98; HR, 1.46; 95% CI, 1.00 to 2.15; HR, 3.77; 95% CI, 1.24 to 11.40, respectively), and stage I and II diastolic hypertension (SBP 140-159 and ${\geq}160mmHg$) were associated with an increased risk of death from intestinal ischemia (HR, 3.07; 95% CI, 1.27 to 7.38; HR, 4.39; 95% CI, 1.62 to 11.88, respectively). Conclusions: An increase in blood pressure levels may alter the risk of death from certain causes other than cardiovascular diseases, a well-known outcome of hypertension, although the mechanism of these associations is not well documented.

• 산업융합연구
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• 제19권1호
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• pp.1-6
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• 2021

본 연구는 국가건강검진에 대한 현 상황을 제시하여 수검률을 높이기 위한 방안을 찾는 것을 목적으로 한다. 이를 위해 인구적 요인(성별, 연령, 소득수준, 교육수준), 건강 요인(흡연, 음주, 비만, 주관적 건강상태)을 각각 선정하고, 선정된 요인이 집단별 차이가 있는지 여부와, 병원 수·소득수준에 따른 수검자를 시각화했다. 그 결과 주관적 건강상태를 제외한 건강 요인, 인구적 요인, 병원 개수 모두 검진 여부와 관련이 있었다. 또한 인구적 요인의 연령 중 20대와 소득수준이 낮은 집단과, 건강적 요인의 비만여부 중 저체중이 미수검률이 높았다. 따라서 이러한 집단들의 미수검자에 대한 홍보와 지원, 교육 등이 필요하다고 여겨진다.

• 대한의생명과학회지
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• 제26권4호
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• pp.368-375
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• 2020

Metabolic syndrome (MetS) is a disease that is accompanied by various metabolic related problems and refers to a disease in which various adult diseases occur along with obesity. These metabolic syndromes appear according to the individual's genetic background. APOA5-ZPR1-BUD13, a gene cluster belonging to chromosome 11q23.3, is well known for its risk of plasma triglycerides and coronary artery disease. Recently, the GWAS results for metabolic syndrome were published in Koreans. The results included the APOA5-ZPR1-BUD13, and the SNPs that first appeared in Koreans in the ZPR1 and BUD13 were also discovered. In this study, the reproducibility was investigated for the newly discovered ZPR1 (rs964184) and BUD13 (rs2075295, rs1558861) using The Health Examinees (HEXA) cohort and showed significance. In addition, BUD13 (rs117548857, rs10488698, rs149527022, rs10790162), ZPR1 (rs2075290, rs145796806, rs201247587), APOA5 (rs12791103, rs1263173, rs7396835, rs17520254) were additionally discovered and significant results were obtained. For the SNPs that showed significant results, the effect on protein expression and the effect of expression quantitative trait loci (eQTL) were also confirmed. This study is expected to contribute to the prevention and treatment of diseases with differences in onset based on individual genetic patterns as well as presenting the effect of genetic mutations in the APOA5-ZPR1-BUD13 on metabolic syndrome and blood lipid levels.

• Safety and Health at Work
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• 제14권3호
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• pp.279-286
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• 2023

Background: This study aimed to evaluate the association between exposure to occupational hazards and the metabolic syndrome. A secondary objective was to analyze the additive and multiplicative effects of exposure to risk factors. Methods: This retrospective cohort was based on 31,615 health examinees at the Pusan National University Yangsan Hospital in Republic of Korea from 2012-2021. Demographic and behavior-related risk factors were treated as confounding factors, whereas three physical factors, 19 organic solvents and aerosols, and 13 metals and dust were considered occupational risk factors. Time-dependent Cox regression analysis was used to calculate hazard ratios. Results: The risk of metabolic syndrome was significantly higher in night shift workers (hazard ratio = 1.45: 95% confidence interval = 1.36-1.54) and workers who were exposed to noise (1.15:1.07-1.24). Exposure to some other risk factors was also significantly associated with a higher risk of metabolic syndrome. They were dimethylformamide, acetonitrile, trichloroethylene, xylene, styrene, toluene, dichloromethane, copper, antimony, lead, copper, iron, welding fume, and manganese. Among the 28 significant pairs, 19 exhibited both positive additive and multiplicative effects. Conclusions: Exposure to single or combined occupational risk factors may increase the risk of developing metabolic syndrome. Working conditions should be monitored and improved to reduce exposure to occupational hazards and prevent the development of the metabolic syndrome.

• 정보처리학회논문지:소프트웨어 및 데이터공학
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• 제11권6호
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• pp.267-272
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• 2022

온라인 시험은 시간과 공간에 제약이 없다. 수험자의 시험 장소가 별도로 필요하지 않고, 시험 장소로의 이동에 필요한 시간과 비용이 들지 않는다는 장점이 있다. 그러나 온라인 시험은 개별적 환경에서 시험을 진행하기 때문에 다양한 부정행위가 가능하다는 단점이 있다. 그리고 시험 감독 방법이 부족하여 부정행위 탐지에 어려움이 있다. 또 시험 과정과 결과 데이터가 디지털 데이터로만 존재하여 시험 결과 위조 여부 확인을 위해 매건 해당 시험 결과가 저장된 서버에서 직접 확인해야 하는 번거로움이 있고 악의적으로 시험과 관련 데이터를 변경한 경우 진위 확인이 불가하다. 본 연구에서는 부정행위 탐지를 위해 시험 진행 관련 데이터를 블록체인에 저장하는 블록체인 기반 온라인 시험 부정행위 탐지 시스템을 개발하여 온라인 시험의 신뢰도를 높이고자 하였다. 실험을 통해 시험 결과 위변조 부정행위가 탐지됨을 확인하였다.

• 핵의학기술
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• 제27권2호
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• pp.133-136
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• 2023

Purpose: Prolactin in the blood is separated into three types, and over 90% of prolactin presents as a double monomer (23 KDa). Rarely, it can exist in the size of big prolactin (150 KDa), which is called macroprolactin and is known as an autoantibody complex. When macroprolactin accounts for more than 60% of prolactin in the blood, it is called macroprolactinemia. The presence of such macroprolactin was first reported in a patient with hyperprolactinemia but without typical symptoms. Macroprolactinemia is emerging as an important cause of idiopathic hyperprolactinemia. The polyethylene glycol (PEG) precipitation method using the property of precipitating large-molecular-weight proteins is simple and recently has been widely used as a screening test. The results are in good agreement with the results of gel chromatography. The purpose of this study was to confirm the measurement method and reference value verification of monomeric prolactin in blood prolactin using the PEG precipitation method. Materials and Methods: For 40 examinees who visited the Gangnam Center of Seoul National University Hospital in 2021, the prolactin level was verified using radioimmunoassay (RIA). For macroprolactinemia PEG precipitation method, 25% PEG (molecular weight 6000kDa) solution and serum were mixed in equal amounts in a test tube, then left at room temperature for 20 minutes and centrifuged at 4℃ for 30 minutes (1500g). The prolactin level was measured in the supernatant. Results : After confirming that more than 90% of the 40 tested samples within the reference range <25 ng/mL, the same value as the reference value for prolactin was applied. Since the concentration of monomeric prolactin in serum from which macroprolactin has been removed from blood is diluted 1:1 with PEG, our laboratory is currently reporting the result by multiplying the result by a dilution factor of 2. Conclusion: Radioimmunoassay using PEG precipitation method using the property of precipitating large molecular weight proteins is simple and effective for quantitative measurement of monomeric prolactin in blood prolactin.