• 한방안이비인후피부과학회지
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• 제16권1호
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• pp.179-190
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• 2003

Atopic dermatitis is a chronic, inflammatory skin disease characterized by intense pruritus and the course marked by exacerbation and remission. It has the characteristic symptoms of dry, itchy, scaly skin with cracks by typical distribution of lesions. Even though the etiology of atopic dermatitis is not fully understood, it is considered an allergic reaction whose onset is frequently and strongly associated with both hereditary and environmental factors. In the present clinical study, we studied the efficacy of internal herb-medicine, external herb medicine - ex. dermal oints, aqueous solutions, etc -, and steam therapy. The patient's SCORAD index was lowered 55.8 than before of which the SCORAD index was 74.8. On the basis of this study, it should be considered that the treatment of atopic dermatitis should be focused on the external therapy as steam therapy, dermal oint, a aqueous solution etc.

• Clinical Psychopharmacology and Neuroscience
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• 제16권4호
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• pp.497-500
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• 2018

Prader-Willi syndrome (PWS) is a quite rare multi-systemic genetic disorder strongly associated with psychiatric illness in adults, especially psychosis. This report presents a 16-year-old female with PWS and symptoms of brief psychotic disorder with a complete resolution of symptoms under aripiprazole medication. However, an exacerbation occurred after aripiprazole reduction. Apart from a weight gain of about 2 kg over the course of two years, no adverse effects could be found. This first report on the use of aripiprazole in a subject with PWS and psychosis suggests that aripiprazole might be a promising treatment approach in this distinct group of patients.

• Perinatology
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• 제29권4호
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• pp.175-179
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• 2018

Pneumatocele (PC) is a thin-walled cyst of the lung that can occur at all ages and with various etiologies. However, there is no fully accepted consensus for the management of PC in a neonatal intensive care unit. Although the management of PC is generally expectant, it is difficult to decide how long conservative management should be maintained, especially under Korea's medical care environment and the parents' worry and anxiety. We report a male neonate, born at $27^{+5}weeks$ gestation, weighing 1,000 g, who had a post infectious PC caused by methicillin-resistant Staphylococcus aureus sepsis. We treated conservatively for about 100 days (roughly 14 weeks), but unfortunately after a few days of chest retraction, acute exacerbation occurred, video assisted thoracoscopic surgery (VATS) was deemed necessary and performed. The purpose of this publication is to describe the clinical course, aggravation and relief after VATS management with a review of the literature.

• Clinical and Experimental Pediatrics
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• 제62권1호
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• pp.22-29
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• 2019

Particulate matter (PM) is a ubiquitous air pollutant that is a growing public health concern. Previous studies have suggested that PM is associated with asthma development and exacerbation of asthma symptoms. Although several studies have suggested increased risks of atopic dermatitis, allergic rhinitis, and allergic sensitization in relation to PM exposure, the evidence remains inconsistent. The plausible mechanisms underlying these effects are related to oxidative stress, enhancement of sensitization to allergens, inflammatory and immunological responses, and epigenetics. This review discusses the effect of PM on childhood allergic diseases, along with plausible mechanisms. Further studies are required to understand the role of PM exposure on childhood allergic diseases, to reduce these diseases in children.

• 대한두개안면성형외과학회지
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• 제22권3호
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• pp.131-134
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• 2021

Morbihan disease (MD) is a rare condition that involves rosaceous lymphedema or erythematous lymphedema of the middle and upper thirds of the face. It typically affects the periorbital region, forehead, glabella, nose, and cheeks. The etiology of MD remains unclear, and its diagnosis is challenging. MD often tends to be unresponsive to therapies commonly used to treat rosacea, including corticosteroids, isotretinoin, and antibiotics. Surgical treatments have therefore been attempted, but most cases showed unsatisfactory responses. These problems could have resulted from an incorrect recognition and interpretation of the pathophysiology of MD and inaccurate planning of the operation, resulting in recurrence or exacerbation of edema.

• Tuberculosis and Respiratory Diseases
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• 제85권4호
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• pp.283-288
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• 2022

Asthma is a chronic inflammatory disease of the airways characterized by varying and recurrent symptoms, reversible airway obstruction, and bronchospasm. In this paper, clinical important studies on asthma published between March 2021 and February 2022 were reviewed. A study on the relationship between asthma and chronic rhinosinusitis, bronchiectasis, and hormone replacement therapy was published. A journal on the usefulness of fractional exhaled nitric oxide for the prediction of severe acute exacerbation was also introduced. Studies on the effect of inhaler, one of the most important treatments for asthma, were published. Studies on the control of severe asthma continued. Phase 2 and 3 studies of new biologics were also published. As the coronavirus disease 2019 (COVID-19) pandemic has been prolonged, many studies have explored the prevalence and mortality of COVID-19 infection in asthma patients.

• Tuberculosis and Respiratory Diseases
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• 제86권3호
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• pp.151-157
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• 2023

The introduction of inhaled corticosteroids (ICS) for the management of asthma has led to a decrease in acute exacerbation of asthma. However, there are concerns regarding the safety of long-term ICS use, particularly pneumonia. Growing evidence indicates that ICS use is associated with an increased risk of pneumonia in patients with chronic obstructive pulmonary disease, whereas the risk in patients with asthma remains unclear. This review discusses the effect of ICS on pneumonia among patients with asthma to update the existing literature. Asthma is associated with an increased risk of pneumonia. Several hypotheses have been proposed to explain this association, including that asthma impairs the clearance of bacteria owing to chronic inflammation. Therefore, controlling airway inflammation with ICS may prevent the occurrence of pneumonia in asthma. In addition, two meta-analyses investigating randomized control trials showed that ICS use was associated with a protective effect against pneumonia in asthma.

• International journal of advanced smart convergence
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• 제13권2호
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• pp.214-221
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• 2024

This study explores the relationship between childhood abuse experiences and subsequent mental disorders in adults, with a particular focus on the moderating role of spiritual well-being. Using self-reported data from 210 graduate students in the Daejeon and Chungcheong regions, the findings demonstrate that spiritual well-being significantly moderate how childhood abuse impacts adult mental health. Specifically, individuals with lower levels of spiritual well-being experience a greater exacerbation of metnal disorders related to past abuse, while those with higher levels show a buffering effect. These results suggest that enhancing spiritual well-being could be a vital component of therapeutic interventions aimed at preventing mental disorders in adults who have experienced childhood abuse. We highlight the potential benefits of incorporating spiritual well-being into mental health strategies and call for additional research to substantiate these findings across broader populations. This unique contribution underscores the importance of considering spiritual factors int the therpeutic process, offering a new and valuable perspective in the field of mental health research.

• Journal of Digestive Cancer Research
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• 제11권2호
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• pp.108-113
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• 2023

Dyspnea is a common symptom among patients with gastrointestinal cancer, and a comprehensive evaluation of their respiratory function is essential. Self-reporting aids in the assessment of the degree of dyspnea, while objective examination methods are performed to identify the potential underlying causes when subjective symptoms are present. Standard treatment protocols should be followed for potentially reversible and common causes of dyspnea, such as pleural effusion, pneumonia, airway obstruction, anemia, asthma, exacerbation of chronic obstructive pulmonary disease, pulmonary thromboembolism, or drug-induced interstitial lung disease. Careful and close monitoring is required due to the high frequency of pulmonary thromboembolism and the risk of cardiovascular accidents, drug-induced interstitial lung disease, or other complications from some anticancer drugs. In case of hypoxemia with an oxygen saturation of 90% or less, palliative treatment should comprise standard oxygen therapy such as nasal cannula, mask, or high-flow nasal cannula. If non-pharmacological oxygen therapy is not effective, pain control through systemic narcotic analgesics and anti-anxiety therapy with benzodiazepines may be helpful.

• Tuberculosis and Respiratory Diseases
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• 제51권1호
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• pp.35-43
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• 2001

연구배경 : Eotaxin은 chemokine으로서 호산구를 기도의 염증부위로 동원하는 기능을 한다. Eotaxin이 호산구에 대한 주화작용이 있다는 점, 그리고 호산구가 천식의 중증도와 관련이 있다는 점을 생각할 때 eotaxin은 천식의 급성 악화시에 증가될 것으로 생각되었다. 본 연구에서는 혈청 eotaxin의 양과 천식의 급성악화 및 중증도와 관계를 연구하기로 하였다. 방 법 : 천식의 급성악화로 내원한 환자 100명과 대조군으로 안정상태의 천식환자 48명을 대상으로 하여, 폐기능, 천식의 중증도, 기관지확장제 투여 전후의 PEFR의 측정, 치료약제 및 입원여부를 조사하였고, 호산구수, IgE, 혈장 eotaxin을 측정 하였다. 결 과 : 천식악화군($233{\pm}175\;pg/mL$)에서 안정상태의 천식환자($169{\pm}74\;pg/mL$)에 비해 유의하게 혈장 eotaxin양이 높았다(p<0.01). 기관지확장제에 반응이 있는 경우가 그렇지 않은 경우에 비해 혈장 eotaxin이 낮은 경향이 있었다. 천식악화로 입원을 하였던 환자들이 퇴원하거나 외래 치료를 하였던 환자들에 비해 혈장 eotaxin이 높았고, 치료약제로 전신적인 스테로이드를 사용하였던 환자들이 스테로이드를 쓰지 않았던 환자들에 비해 혈청 eotaxin이 높았다. 혈장 eotaxin 양과 $FEV_1$은 유의한 역상관관계가 있었다(상관계수 -0.251, p<0.01). 그리고, 천식의 중증도에 따른 eotaxin의 양은 경증간헐성($160{\pm}60\;pg/mL$)에 비해 중등증 지속성($323{\pm}256\;pg/mL$) 및 중중 지속성($276{\pm}170\;pg/mL$) 군에서 유의하게 eotaxin이 높았다(p<0.01). 결 론 : 혈장 eotaxin은 천식의 급성악화시 증가하여 급성악화의 매개하는 인자중 하나로 생각되며, 폐기능 저하 및 천식의 중증도와 연관이 있었다. eotaxin은 표적세포인 호산구의 동원에 관여함으로서 폐기능 저하에 기여하는 것으로 생각된다.