• Biomolecules & Therapeutics
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• 제26권1호
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• pp.45-56
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• 2018

Cancer is the leading cause of human deaths worldwide. Understanding the biology underlying the evolution of cancer is important for reducing the economic and social burden of cancer. In addition to genetic aberrations, recent studies demonstrate metabolic rewiring, such as aerobic glycolysis, glutamine dependency, accumulation of intermediates of glycolysis, and upregulation of lipid and amino acid synthesis, in several types of cancer to support their high demands on nutrients for building blocks and energy production. Moreover, oncogenic mutations are known to be associated with metabolic reprogramming in cancer, and these overall changes collectively influence tumor-microenvironment interactions and cancer progression. Accordingly, several agents targeting metabolic alterations in cancer have been extensively evaluated in preclinical and clinical settings. Additionally, metabolic reprogramming is considered a novel target to control cancers harboring un-targetable oncogenic alterations such as KRAS. Focusing on lung cancer, here, we highlight recent findings regarding metabolic rewiring in cancer, its association with oncogenic alterations, and therapeutic strategies to control deregulated metabolism in cancer.

• 대한산업공학회지
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• 제31권3호
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• pp.180-193
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• 2005

This paper deals with a multiobjective process planning problem of flexible assembly systems(FASs). The FAS planning problem addressed in this paper is an integrated one of the assignment of assembly tasks to stations and the determination of assembly routing, while satisfying precedence relations among the tasks and flexibility capacity for each station. In this research, we consider two objectives: minimizing transfer time of the products among stations and absolute deviation of workstation workload(ADWW). We place emphasis on finding a set of diverse near Pareto or true Pareto optimal solutions. To achieve this, we present a new multiobjective coevolutionary algorithm for the integrated problem here, named a multiobjective symbiotic evolutionary algorithm(MOSEA). The structure of the algorithm and the strategies of evolution are devised in this paper to enhance the search ability. Extensive computational experiments are carried out to demonstrate the performance of the proposed algorithm. The experimental results show that the proposed algorithm is a promising method for the integrated and multiobjective problem.

• 토지주택연구
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• 제9권2호
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• pp.21-31
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• 2018

The purpose of this study is to introduce the design and early implementation results of Choice Neighborhoods(Choice) initiative, which is the most recent version of public housing policies in the United States designed and implemented under the Obama administration. The Choice initiative aims to support a wide range of strategies locally driven to address problems in disadvantaged neighborhoods with an emphasis on a comprehensive approach to transforming those neighborhoods. In this study, first, I briefly review the history of public housing policies since 1937, particularly focusing on limitations of HOPE VI(Housing Opportunity for People Everywhere) projects to understand the context behind the advent of the program. Second, I introduce the overall design of the Choice program and point out how this programs' design differs from previous public housing programs by reviewing the literature on federal guidelines for the Choice program. This study particularly focuses on introducing social services given to existing residents in public housing and their neighborhoods in redevelopment processes. These social services are intended to address poverty-related problems that public housing residents often confront, to help them break out of the cycle of poverty, and to minimize the negative impacts of relocation triggered by redevelopment. Third, to examine how this program has been implemented and has revealed limitations so far, I review an interim evaluation report based on five cities. This study ends with discussing policy implications for public housing providers and housing policy-makers in South Korea.

• 한국시스템다이내믹스연구
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• 제17권2호
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• pp.5-32
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• 2016

Purpose of this paper is to review series of Limits to Growth studies from its original Rome Club Report published in 1972 to the most recent one in 2012 by Jorgen Randers and finds its implications on concept and strategy of sustainable development. For this purpose first, this paper reviewed series of Limits to Growth studies in details with focus on scenarios used in simulation of world model. Second, response to the original Limit to Growth was reviewed and to see validity of its scenario based simulations, simulated results of interest variables and actual historical data up to the year 2010 was compared. Third, structure and key arguments in both studies, Limit to Growth studies and Our Common Future was explained and compared. Finally, implications of the Limit to Growth studies on concept and strategy for sustainable development was discussed. Based on the comparison, this paper argued that even if the term sustainable development was not used in the Limit to Growth at all, concept and strategies for sustainable development implied in the Limit to Growth are more clear and specific than those of Our Common Future. Since Limit to Growth studies were simulation based ones that produce detailed behaviors on interest variables, it clarifies more clearly the abstract concept of sustainable development and thus, provides specific guidelines for the direction of sustainable policy which has been suffering long from vagueness of concept of sustainable development.

• Journal of Preventive Medicine and Public Health
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• 제42권4호
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• pp.209-214
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• 2009

Objectives : The aim of this study was to develop search filters able to retrieve the South Korean scientific output and relating the fields of public health, preventive medicine, and physical education, activity, fitness, exercise and sport in MEDLINE between 2000 and 2007. Methods : The search filters were constructed and applied in MEDLINE accessed through PubMed according to the affiliation and subject. The language and place of publication were identified and the evaluation of the geographical filter performance was done. Results : The search format was successfully elaborated and applied, and the articles originated, published in Korea and/or abroad focusing on the fields of public health, preventive medicine, physical education, activity, fitness, exercise and sport, added to MEDLINE between 2000 and 2007 were retrieved. Publications in six languages originated in South Korea were detected. Conclusions : A geographic search filter determined the South Korean research output, and combined with additional filters focused on specific areas. The dynamics of the scientific output followed an increased evolution in all categories. Articles were written mainly in English/Korean. Further research is recommended on developing search strategies in order to retrieve precise and reliable information.

• Journal of Communications and Networks
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• 제15권3호
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• pp.292-300
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• 2013

Nowadays, energy saving has become a hot topic and information and communication technology has become a major power consumer. In long term evolution advanced (LTE-A) networks, heterogeneous deployments of low-power nodes and conventional macrocells provide some new features, such as coverage extension, throughput enhancement, and load balancing. However, a large-scale deployment of low-power nodes brings substantial energy consumption and interference problems. In this paper, we propose a novel switching strategy (NS), which adaptively switches on or off some low-power nodes based on the instantaneous load of the system. It is compatible with the microcells' load balancing feature and can be easily implemented on the basis of existing LTE-A specifications. Moreover, we develop an analytical model for analyzing the performance of system energy consumption, block rate, throughput, and energy efficiency. The performance of NS is evaluated by comparison with existing strategies. Theoretical analysis and simulation results show that NS not only has a low block rate, but also achieves a high energy efficiency.

• 기술혁신학회지
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• 제6권2호
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• pp.213-227
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• 2003

초고속 인터넷 서비스는 사용자수의 증가와 더불어 고객의 다양한 욕구 즉 인터넷 방송, 주문형비디오(VOD)서비스, 원격교육, 고화질 TV 등 대용량의 멀티미디어 서비스에 대한 욕구가 폭발적으로 증가하고 있다. 이러한 욕구를 충족하기 위해서는 현재의 초고속 인터넷서비스로서는 속도에 대한 한계에 부딪치게 되어 통신사업자들은 새로운 기술 또는 여러 가지 기술적 대안들을 추구하고 있다. 2002년부터 시작하여 2003년 이후에는 멀티미디어 수요의 증가에 따라 ADSL을 대체하는 기술로 VDSL이 등장하여 매년 꾸준한 신규가입자 수요가 발생하고 있으나, 통신사업자들은 각각의 망 특성, 시장위치, 전략적 필요성 둥에 의해 상용화를 적극 검토,추진하고 있으나 각각 전개하는 방식은 조금씩 다르다. 따라서 본 연구에서는 통신사업자들의 가입자망 진화 전략에 대해 살펴 본 다음 Lot3n-Volterra Competition (LVC) 모델을 이용 ADSL 과 VDSL 두 기술간의 상호 경쟁 및 대체를 통해 어떻게 진화 되어가는지를 살펴보았다. 대표적인 통신사업자인 KT는 막강한 자금력을 바탕으로 시장 확대 및 경쟁사와의 차별화를 위해 VDSL 서비스 조기도입을 서두르고 있고, 하나로는 자금의 열세로 인한 ADSL 투자비를 회수 할때까지 VDSL 서비스를 연기하고 있는 실정이다. ADSL과 VDSL 두 기술의 관계는 Lotka-Volterra Competition (LVC) 모델을 이용한 시뮬레이션 결과를 통해 빠른 속도와 비슷한 가격대의 VDSL이 침략자(predator)로 기존 시장 지배자인 ADSL을 사냥감(prey)으로 빠른 속도로 대체해 나가는 것을 알 수 있었다.

• 한국지능시스템학회논문지
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• 제12권1호
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• pp.61-66
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• 2002

본 논문에서는 Flexible Manipulator의 제어를 위해 퍼지제어의 제약인 멤버쉽 함수, 퍼지규clr을 유전알고리즘으로 조정, 최적화 하는 새로운 제어기를 설계하였다. 사용된 유전알고리즘은 Steady State Genetic 알고리즘과 Adaptive 유전 알고리즘의 합성이다. 제안한 제어기는 Flexible Manipulator의 끝점 무게 0.8kmg, 최대속도 1m/s의 경우, 퍼지제어에 비해 오차가 90.8% 감소하고 신경회로망을 이용한 퍼지제어에 비하여는 31.8% 감소하였으며 진화전략과 퍼지제어합성에 의한 제어기보다는 오차가 31.3% 감소하는 통 제어성능과 그 유용성이 우수함을 확인하였다.

• ETRI Journal
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• 제42권2호
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• pp.205-216
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• 2020

An arbiter physical unclonable function (APUF) has exponential challenge-response pairs and is easy to implement on field-programmable gate arrays (FPGAs). However, modeling attacks based on machine learning have become a serious threat to APUFs. Although the modeling-attack resistance of an MA-APUF has been improved considerably by architecture modifications, the response generation method of an MA-APUF results in low uniqueness. In this study, we demonstrate three design problems regarding the low uniqueness that APUF-based strong PUFs may exhibit, and we present several foundational principles to improve the uniqueness of APUF-based strong PUFs. In particular, an improved MA-APUF design is implemented in an FPGA and evaluated using a well-established experimental setup. Two types of evaluation metrics are used for evaluation and comparison. Furthermore, evolution strategies, logistic regression, and K-junta functions are used to evaluate the security of our design. The experiment results reveal that the uniqueness of our improved MA-APUF is 81.29% (compared with that of the MA-APUF, 13.12%), and the prediction rate is approximately 56% (compared with that of the MA-APUF (60%-80%).

• 대한가정학회지
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• 제39권6호
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• pp.109-122
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• 2001

This study was performed to identify the roles of residents for the environmentally sound and sustainable development, taco-polis(kologisches Bauen), eco-village and Symbiotic Housing. These buildings will achieve energy efficiency through design strategies such as passive solar heating system, natural cooling and day lighting. Their infrastructure will feature parking on the periphery, extensive pedestrian paths, outdoor ground lights that preserve stellar visibility, and environmentally sensitive technologies such as low writer use fixtures. And they will restore biodiversity while protecting the wildlife, wetlands, forests, soil, air and water. Their houses wile be designed to support home-based occupations, offering high-speed Internet access and other options to promote a localized, sustainable economy. To support and encourage the evolution of sustainable settlements, it is necessary to prepare constructing the physical facilities and the social functions relating with residents. The roles of residents are important to provide a high Quality lifestyle and to integrate a supportive social environment with a low-impact way of life. This study concluded the four main roles of residents for the sustainable of Eco-polis and Ecovillage. 1. Residents assist transition towards a sustainable society as eco-conscious consumers in the planning stage. 2. Residents live in a ecological way for the sustainable ecovillage. 3. Residents exchange information and education for increasing the community glue as a communication network. 4. Residents support and transmit their cultural vitality and tradition for the next generation. So, users are expected to encourage resident's participation in the planning, design, ongoing management and maintenance of the sustainable ecovillage.