• Title/Summary/Keyword: Evidence Analysis

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A Multicenter Study to Identify the Respiratory Pathogens Associated with Exacerbation of Chronic Obstructive Pulmonary Disease in Korea

  • Lee, Hyun Woo;Sim, Yun Su;Jung, Ji Ye;Seo, Hyewon;Park, Jeong-Woong;Min, Kyung Hoon;Lee, Jae Ha;Kim, Byung-Keun;Lee, Myung Goo;Oh, Yeon-Mok;Ra, Seung Won;Kim, Tae-Hyung;Hwang, Yong Il;Rhee, Chin Kook;Joo, Hyonsoo;Lee, Eung Gu;Lee, Jin Hwa;Park, Hye Yun;Kim, Woo Jin;Um, Soo-Jung;Choi, Joon Young;Lee, Chang-Hoon;An, Tai Joon;Park, Yeonhee;Yoon, Young-Soon;Park, Joo Hun;Yoo, Kwang Ha;Kim, Deog Kyeom
    • Tuberculosis and Respiratory Diseases
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    • v.85 no.1
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    • pp.37-46
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    • 2022
  • Background: Although respiratory tract infection is one of the most important factors triggering acute exacerbation of chronic obstructive pulmonary disease (AE-COPD), limited data are available to suggest an epidemiologic pattern of microbiology in South Korea. Methods: A multicenter observational study was conducted between January 2015 and December 2018 across 28 hospitals in South Korea. Adult patients with moderate-to-severe acute exacerbations of COPD were eligible to participate in the present study. The participants underwent all conventional tests to identify etiology of microbial pathogenesis. The primary outcome was the percentage of different microbiological pathogens causing AE-COPD. A comparative microbiological analysis of the patients with overlapping asthma-COPD (ACO) and pure COPD was performed. Results: We included 1,186 patients with AE-COPD. Patients with pure COPD constituted 87.9% and those with ACO accounted for 12.1%. Nearly half of the patients used an inhaled corticosteroid-containing regimen and one-fifth used systemic corticosteroids. Respiratory pathogens were found in 55.3% of all such patients. Bacteria and viruses were detected in 33% and 33.2%, respectively. Bacterial and viral coinfections were found in 10.9%. The most frequently detected bacteria were Pseudomonas aeruginosa (9.8%), and the most frequently detected virus was influenza A (10.4%). Multiple bacterial infections were more likely to appear in ACO than in pure COPD (8.3% vs. 3.6%, p=0.016). Conclusion: Distinct microbiological patterns were identified in patients with moderate-to-severe AE-COPD in South Korea. These findings may improve evidence-based management of patients with AE-COPD and represent the basis for further studies investigating infectious pathogens in patients with COPD.

A Study on Calculation of Air Pollutant Emissions from ships at Incheon Port and the Effects of Eco-Friendly Policies (인천항 선박 대기오염물질 배출량 산정 및 친환경 정책 효과에 대한 연구)

  • Lee, Jungwook;Lee, Hyangsook
    • Journal of Korea Port Economic Association
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    • v.38 no.1
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    • pp.129-142
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    • 2022
  • In the past, interest in air pollution was concentrated on greenhouse gases, but in recent years, interest in fine dust has been increasing. The media and environmental organizations continue to emphasize air pollution caused by fine dust. The awareness of fine dust is increasing, and air pollution generated at ports is analyzed to be serious as a domestic factor excluding foreign inflows. Recognizing this, in order to reduce air pollution generated at ports, special laws on improving air quality, such as port areas, have been enacted in Korea, and attempts are being made to curb air pollution caused by ports. In this law, it is a policy that regulates air pollutants generated not only by ships but also throughout ports such as vehicles and unloading machines, and representative are ECA, VSR, and AMP. This study attempted to analyze the effects of these eco-friendly policies at Incheon Port. First of all, a study was conducted to calculate emissions assuming that there was no policy, analyze each policy, and finally calculate and compare actual emissions reflecting all policies. The methodology presented by the European Environmental Administration and the U.S. Environmental Protection Agency was used, and pollutants to be analyzed were analyzed for sulfur oxides (SOX), carbon monoxide (CO), nitrogen oxides (NOX), total floating substances (TSP), fine dust and ultrafine dust (PM10, PM2.5) and ammonia (NH3). As a result of the analysis, it was analyzed that the actual emission reflecting all policies was about 4,097 tons/year, which had an emission reduction effect of about 760 tons/year compared to about 4,857 tons/year when the policy was not reflected. When the effects of each policy were analyzed individually, it was found that ECA 4,111 tons/year, VSR 4,854 tons/year, and AMP 4,843 tons of air pollutant emissions occurred The results of this study can be used as basic data and evidence for policy establishment related to the atmospheric environment at Incheon Port.

Effects of Traffic Volume and Air Quality on the Characteristic of Urban Park Soil (교통량과 대기질이 도시 공원 토양 특성에 미치는 영향)

  • Joo, Sunyoung;Lee, Hyunjin;Jeon, Juhui;Seo, Inhye;Yoo, Gayoung
    • Ecology and Resilient Infrastructure
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    • v.9 no.1
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    • pp.77-82
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    • 2022
  • This study aims to understand how mobile and stationary air pollution sources affect the air quality and soil properties in urban parks. We selected three sites of urban parks in Seoul as follows: Ha-neul Park in Mapo-gu (Site_M), Ill-won Eco-Park in Gangnam-gu (Site_G), and Yangjae Citizen's Forest in Seocho-gu (Site_Y), and compared the results of each site's traffic volume, air quality concentration, and soil analysis. Traffic volume was high in Site_M, followed by Site_G and Y; Site_M and G were closer to the resource recovery facility than Site_Y. Hence, we hypothesized that PM and NO2 concentrations in the atmosphere were higher in Site_M than Site_G and Y, causing different soil nitrogen content among sites due to different atmospheric deposition. Consistent with our hypothesis, the concentrations of PM2.5 and NO2 were higher in Site_M and G than Site_Y, while Site_Y had higher PM10 than other sites. The soil NO3- contents showed no significant difference among three sites, whereas the soil NH4+ content was extremely high in Site_Y. This high content of soil NH4+ is thought to be due to acidification from excessive fertilization. Lower soil pH of Site_Y further supported the evidence of heavy fertilization in this site. Overall nitrogen dynamics implies that soil nitrogen status is more influenced by park management such as fertilization rather than atmospheric deposition. Despite of lower soil NH4+ content of Site_M and G than Y, vegetation vitality looked similar among three sites. This indirectly indicates that excessive fertilizer input in urban park management needs to be reconsidered. This study showed that even if the air quality was different due to mobile and stationary sources, it did not directly affect the soil nitrogen nutrient status of the adjacent urban park.

Characteristics of Environmental Factors and Vegetation Community of Zabelia tyaihyonii (Nakai) Hisauti & H.Hara among the Target Plant Species for Conservation in Baekdudaegan (백두대간 중점보전종인 댕강나무의 식생 군집 및 환경인자 특성)

  • Kim, Ji-Dong;Lee, Hye-Jeong;Lee, Dong-Hyuk;Byeon, Jun Gi;Park, Byeong Joo;Heo, Tae-Im
    • Journal of Korean Society of Forest Science
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    • v.111 no.2
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    • pp.201-223
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    • 2022
  • Currently, species extinctions are increasing due to climate change and continued anthropogenic impact. We selected 300 species for conservation with emphasis on plants co-occurring in the Baekdudaegan area, which is a large ecological axis of Korea. We aimed to investigate the vegetation community and environmental characteristics of Zabelia tyaihyonii in the limestone habitat among the target plant species in the Baekdudaegan region to derive effective conservation strategies. In Danyang-gun, Yeongwol-gun, and Jecheon-si, we selected 36 investigation sites where Z. tyaihyonii was present. We investigated the vegetation, flora, soil and physical environment. We also found notable plants such as Thalictrum petaloideum, Sillaphyton podagraria, and Neillia uekii at the investigation sites. We classified forest vegetation community types into 4 vegetation units and 7 species group types. With canonical correspondence analysis (CCA) of the vegetation community and habitat factors, we determined the overall explanatory power to be 75.2%, and we classified the environmental characteristics of the habitat of Z. tyaihyonii into a grouping of three. Among these, we detected a relationship between the environmental factors elevation, slope, organic matter, rock ratio, pH, potassium, and sodium. We identified numerous rare and endemic plants, including Thalictrum petaloideum, in the investigation site, and determined that these groups needed to be preserved at the habitat level. In the classification of the vegetation units analyzed based on the emerging plants and the CCA, we reaffirmed the uniqueness and specificity of the vegetation community in the habitat of Z. tyaihyonii. We anticipate that our results will be used as scientific evidence for the empirical conservation of the native habitats of Z. tyaihyonii.

Raman Spectroscopic Study for Investigating the Spatial Distribution and Structural Characteristics of Mn-bearing Minerals in Non-spherical Ferromanganese Nodule from the Shallow Arctic Ocean (북극해 천해저 비구형 망가니즈단괴 내 광물종 분포 및 구조적 특성 규명을 위한 라만 분광분석 연구)

  • Sangmi, Lee;Hyo-Jin, Koo;Hyen-Goo, Cho; Hyo-Im, Kim
    • Korean Journal of Mineralogy and Petrology
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    • v.35 no.4
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    • pp.409-421
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    • 2022
  • Achieving a highly resolved spatial distribution of Mn-bearing minerals and elements in the natural ferromanganese nodules can provide detailed knowledge of the temporal variations of geochemical conditions affecting the formation processes of nodules. While a recent study utilizing Raman spectroscopy has reported the changes in the manganate mineral phases with growth for spherical nodules from the Arctic Sea, the distributions of minerals and elements in the nodules from the shallow Arctic Sea with non-spherical forms have not yet fully elucidated. Here, we reported the micro-laser Raman spectra with varying data acquisition points along three different profiles from the center to the outermost rim of the non-spherical ferromanganese nodules collected from the East Siberian Sea (~73 m). The elemental distributions in the nodule (such as Mn, Fe, etc.) were also investigated by energy dispersive X-ray spectroscopy (EDS) analysis to observe the internal structure and mineralogical details. Based on the microscopic observation, the internal structures of a non-spherical nodule can be divided into three different regions, which are sediment-rich core, iron-rich substrate, and Mn-Fe layers. The Raman results show that the Mn-bearing mineral phases vary with the data acquisition points in the Mn-Fe layer, suggesting the changes in the geochemical conditions during nodule formation. In addition, we also observe that the mineral composition and structural characteristics depend on the profile direction from the core to the rim. Particularly, the Raman spectra obtained along one profile show the lack of Fe-(oxy)hydroxides and the noticeably high crystallinity of Mn-bearing minerals such as birnessite and todorokite. On the other hand, the spectra obtained along the other two profiles present the presence of significant amount of amorphous or poorly-ordered Fe-bearing minerals and the low crystallinity of Mn-bearing minerals. These results suggest that the diagenetic conditions varied with the different growth directions. We also observed the presence of halite in several layers in the nodule, which can be evidence of the alteration of seawater after nodule formation. The current results can provide the opportunity to obtain detailed knowledge of the formation process and geochemical environments recorded in the natural non-spherical ferromanganese nodule.

Initial Evaluation using Geochemical Data to infer Tectonic Setting of Mt. Baekdu/Changbaishan Volcano (백두산 화산의 지체구조 추론을 위한 지구화학적 데이터를 이용한 기초 평가)

  • Yun, Sung-Hyo;Chang, Cheolwoo;Pan, Bo
    • Journal of the Korean earth science society
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    • v.43 no.1
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    • pp.128-139
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    • 2022
  • This study aimed to investigate the tectonic setting of the volcanic edifice at Mt. Baekdu by analyzing petrochemical characteristics of Holocene felsic volcanic rocks distributed in the Baekdusan stratovolcano edifice and summit of the Cheonji caldera rim, as well as Pleistocene mafic rocks of the Gaema lava plateau and Changbaishan shield volcano edifice. During the early eruption phases, mafic eruption materials, with composition ranging from alkali basalt to trachybasalt, or from subalkaline (tholeiitic) basalt to basaltic andesite formed the Gaema lava plateau and Changbaishan shield volcanic edifice, whereas the Baekdusan stratovolcano edifice and Holocene tephra deposits near the summit of the Cheonji caldera comprises trachytic and rhyolitic compositions. Analysis results revealed bimodal compositions with a lack of 54-62 SiO2, between the felsic and mafic volcanic rocks. This suggested that magmatic processes occurred at the locations of extensional tectonic settings in the crust. Mafic volcanic rocks were plotted in the field of within-plate volcanic zones or between within-plate alkaline and tholeiite zones on the tectonic discrimination diagram, and it was in good agreement with the results of the TAS diagram. Felsic volcanic rocks were plotted in the field of within-plate granite tectonic settings on discrimination diagrams of granitic rocks. None of the results were plotted in the field of arc islands or continental margin arcs. The primitive mantle-normalized spider diagram did not show negative (-) anomalies of Nb and Ti, which are distinctive characteristics of subduction-related volcanic rocks, but exhibited similar patterns of ocean island basalt. Trace element compositions showed no evidence of, magmatic processes related to subduction zones, indicating that the magmatic processes forming the Baekdusan volcanic field occurred in an intraplate environment. The distribution of shallow earthquakes in this region supports the results. The volcanic rocks of the Baekdusan volcanic field are interpreted as the result of intraplate volcanism originating from the upwelling of mantle material during the Cenozoic era.

A Study on Cultural Planning Based on the Characteristics of Domestic Cultural Archetypes: Focusing on the Jeju Folktale 'Seolmundae Halmang and Obaek General' (국내 문화원형 특징을 기반으로 한 문화 기획 연구: 제주 설화 '설문대 할망과 오백장군'을 중심으로)

  • Lee, Ji-Hun
    • Journal of Korea Entertainment Industry Association
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    • v.15 no.7
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    • pp.259-269
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    • 2021
  • This study examines the legend of 'Grandmother Seolmundae and Five Hundred Generals', the cultural archetypes of Jeju, and analyzes the characteristics of its contents. After analyzing the feasibility of using the analyzed cultural prototype as cultural contents such as games and animations, based on this analysis, we tried to suggest a cultural planning approach based on the cultural prototype to the cultural agency. Therefore, the implications of this study are as follows. First, among the cultural prototypes in Korea, 'Grandmother Seolmundae and Five Hundred Generals', which represent the legends of Jeju Island, are being organized centered on many historical researchers and Chaerokga, but there is no precise establishment of the exact timing of the legend and how it arose. Therefore, when planning and developing content based on the cultural prototype, it is most important for cultural agencies to develop a story after researching historical evidence and opinions of local residents to identify a consistent point of view. Second, although the contents of the cultural archetype are arranged slightly differently by historians and recorders, the main contents and characteristics of the story are found to have a similar form. Therefore, cultural agencies should focus on finding the point of view and characteristics of a story, even if a story is written differently by different people when doing a cultural prototype. Third, when planning a game based on the cultural prototype, the main elements such as the elements to be expressed in the game and the fun elements should be found and presented. In particular, because fun and rules are the most important parts of games, if this part cannot be derived from the story of the cultural archetype or cannot be made, it is difficult to transform the cultural archetype into a game. Therefore, it can be seen that it is important for cultural agencies to set their game plan intentions in consideration of story expression and fun, even if it is the core or non-core of the entire story of the cultural archetype. Lastly, although the cultural prototype 'Grandmother Seolmundae and Five Hundred Generals' was presented as animation content, it is important to develop it considering the story, characters, media, and audience. Therefore, cultural agencies should be able to derive the elements such as stories, representative and auxiliary characters, and viewers that can be adapted from the cultural prototype as much as possible. It will be an important part of raising.

An exploration of the relationship between crime/victim characteristics and the victim's criminal damages: Variable selection based on random forest algorithm (범죄 및 피해자 특성과 범죄피해 내용의 관계 탐색: 랜덤포레스트 알고리즘에 기초한 변인선택)

  • Han, Yuhwa;Lee, Wooyeol
    • Korean Journal of Forensic Psychology
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    • v.13 no.2
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    • pp.121-145
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    • 2022
  • The current study applied the random forest algorithm to Korean crime victim survey data collected biennially between 2010 and 2018 to explore the relationship between crime/victim characteristics and the victim's criminal damages. A total of 3,080 cases including gender, age (life cycle stage), type of crime, perpetrator acquisition, repeated victimization, psychological damage (depression, isolation, extreme fear, somatic symptoms, interpersonal problems, moving out to avoid people, suicidal impulses, suicide attempts), and emotional changes after victimization (changes in self-protection confidence, self-esteem, confidence in others, confidence in legal institutions, and respect for Korean legal system/law) were analyzed. Considering the features of data that are difficult to apply traditional statistical techniques, this study implemented random forest algorithms to predict crime and victim characteristics using the victim's criminal damages (psychological damage and emotional change) and selected good predictors using VSURF function in VSURF package for R. As a result of the analysis, it was confirmed that the relationship between the type of crime and depression, extreme fear, somatic symptoms, and interpersonal problems, between perpetrator acquisition and somatic symptoms and interpersonal problems, and between repeated victimization and changes in respect for Korean legal system/law. Gender and life cycle stage (youth/adult/elderly) were found to be related to extreme fear and changes in self-protection confidence, respectively. However, more empirical evidence should be aggregated to explain the results as meaningful. The results of this study suggest that it is necessary to enhance the experts' knowledge and educate them on cases about the relationship between crime/victim characteristics and criminal damage. Strengthening their interview strategy and knowledge about law/rules were also needed to increase the effectiveness of the Korean victim assessment system.

Anti-inflammatory Activity of Sorghum bicolor (L.) Moench var. Hwanggeumchal Grains in Lipopolysaccharide-stimulated RAW264.7 Murine Macrophage Cell Line (지질다당류-자극된 마우스 대식세포주 RAW264.7에서 황금찰수수 종자의 항염증 활성)

  • Jun, Do Youn;Woo, Hyun Joo;Ko, Jee Youn;Kim, Young Ho
    • Journal of Life Science
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    • v.32 no.12
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    • pp.929-937
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    • 2022
  • To investigate the anti-inflammatory activity of the grains of sorghum, three Sorghum bicolor (L.) Moench variants (Hwanggeumchal, Huinchal, and Chal) being cultivated in Korea, the 80% ethanol (EtOH) extracts of individual sorghum grains were compared for their inhibitory activity against nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 murine macrophage cell line. Among them, the EtOH extract of sorghum Hwanggeumchal grains could exert the highest inhibitory effect on the LPS-induced NO production. However, under these conditions, the viability of RAW264.7 cells was not affected. When the EtOH extract of sorghum Hwanggeumchal grains was sequentially fractionated with n-hexane, methylene chloride (MC), ethyl acetate (EtOAc), and n-butanol, the anti-NO production activity was predominantly detected in both MC and EtOAc fractions. In particular, treatment with the MC fraction reduced dose-dependently the expression levels of iNOS, COX-2 and pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) in LPS-stimulated RAW264.7 cells. Simultaneously, the MC fraction could prevent LPS-induced activating phosphorylation of p38 mitogen-activated protein kinase (MAPK), c-Jun N-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK). HPLC analysis of the MC fraction showed gentisic acid and naringenin as the major phenolic components. Both gentisic acid and naringenin commonly exhibited a potent inhibitory activity against LPS-induced NO production in RAW264.7 cells. Together, these results provide the evidence of the inhibitory activity of Hwanggeumchal grains on LPS-induce inflammatory responses in RAW264.7 murine macrophage cells and also suggest that sorghum grains possess beneficial health effects which can be applicable in development of the grain-based functional foods.

The Analysis of Scientific Attitude in the Government-designated and Authorized Teacher's Guides of Elementary School Science for the 3rd~4th Grades (초등 3~4학년군 국정 및 검정 과학 교사용지도서의 과학적 태도 분석: '지구와 우주' 영역을 중심으로)

  • Jang, Myoung-Duk
    • Journal of the Korean Society of Earth Science Education
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    • v.15 no.2
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    • pp.192-212
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    • 2022
  • The purpose of this study is to analyze scientific attitude and its components in the general remarks and in the particulars of one government-designated and seven authorized elementary school science teacher's guides for the 3rd~4th grades which were developed according to the 2015 national science curriculum, and to derive implications for future development of teacher's guide. The results of the study are as follows: First, in their general remarks, five of eight teacher's guides (62.5%) give a very brief explanation on the components of scientific attitude, and the remaining three teacher's guides give a relatively detailed explanation on the components but they lack practical information on teaching and assessing of the components; Second, in the case of unit objective in the four units of the area of 'Earth and Universe', five of eight teacher's guides (62.5%) contain 3~4 components among 'curiosity', 'cooperation', 'objectivity', 'critical mindedness', or 'respect for evidence', and one of the remaining three teacher's guides contains only the component of 'curiosity', another guide doesn't have any component, and the other guide doesn't have unit objective itself; Third, in the case of unit assessment, only one of eight teacher's guide (12.5%) has independent unit assessment, includes several components of scientific attitude in the unit assessment, and is broadly consistent between the components of scientific attitude in unit objective and in unit assessment; Fourth, in case of lesson objective, three teacher's guide (37.5%) contain 3~4 components among 'curiosity', 'cooperation', 'objectivity' and 'critical mindedness', and the remaining five teacher's guide (62.5%) include only 'curiosity'; Fifth, in the case of lesson assessment, among eight teacher's guides, five (62.5%) evaluate 3~4 components of scientific attitudes, two (25.0%) evaluate only 'curiosity' and 'cooperation', and one (12.5%) does not evaluate anything.