• KSII Transactions on Internet and Information Systems (TIIS)
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• 제15권11호
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• pp.3935-3949
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• 2021

With the rapid development of Internet and big data technology, various online social network platforms have been established, producing massive information every day. Hot topic discovery aims to dig out meaningful content that users commonly concern about from the massive information on the Internet. Most of the existing hot topic discovery methods focus on a single network data source, and can hardly grasp hot spots as a whole, nor meet the challenges of text sparsity and topic hotness evaluation in cross-network scenarios. This paper proposes a novel hot topic discovery method across social network based on an im-proved LDA model, which first integrates the text information from multiple social network platforms into a unified data set, then obtains the potential topic distribution in the text through the improved LDA model. Finally, it adopts a heat evaluation method based on the word frequency of topic label words to take the latent topic with the highest heat value as a hot topic. This paper obtains data from the online social networks and constructs a cross-network topic discovery data set. The experimental results demonstrate the superiority of the proposed method compared to baseline methods.

• 자동차안전학회지
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• 제10권4호
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• pp.54-59
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• 2018

While the advanced trffic environment systems are developed recently, the traffic systems for transportation vulnerable are still under development and their social life are limited as well. In order to the secure their mobility rights, it had been required to set up the particular system for the traffic welfare. One of the significant items is the express bus operation for wheelchair users. Thus, the research of development and operation for express buses with wheelchair users was funded by the Korean government. Before the express bus development for wheelchair users based on the current bus model, this study set up the evaluation method for the bus rollover characteristics to ensure occupant safety using the finite element method. The partial bus model was developed corresponding to the full bus model response under rollover event and the evaluation method based on two model (full bus model and partial bus model) responses is planned to apply the model development of express bus modification for wheelchair users.

• 정보보호학회논문지
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• 제16권3호
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• pp.115-127
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• 2006

본 논문의 목적은 다중 생체 인식을 위하여 사용되는 다양한 정규화함수와 결합 및 패턴 분류 알고리즘들의 성능을 비교 평가하는 것이다. 이를 위하여 NIST에서 제공하는 유사도 집합인 BSSR(Biometric from Set-Releasel) 데이터베이스와 다양한 정규화함수, 결합 및 패턴 분류 알고리즘을 이용하여 실험을 수행하였으며, HTER(Half Total Error Rate)을 이용한 평가 결과를 제시하고 있다. 본 연구는 단일 데이터베이스와 평가 항목을 이용한 평가 결과를 제시함으로써 다중 생체 인식시스템의 성능 개선 연구를 위한 토대가 될 수 있다.

• Genomics & Informatics
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• 제21권4호
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• pp.45.1-45.11
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• 2023

Nonalcoholic fatty liver disease (NAFLD) is a common type of chronic liver disease, with severity levels ranging from nonalcoholic fatty liver to nonalcoholic steatohepatitis (NASH). The extent of liver fibrosis indicates the severity of NASH and the risk of liver cancer. However, the mechanism underlying NASH development, which is important for early screening and intervention, remains unclear. Weighted gene co-expression network analysis (WGCNA) is a useful method for identifying hub genes and screening specific targets for diseases. In this study, we utilized an mRNA dataset of the liver tissues of patients with NASH and conducted WGCNA for various stages of liver fibrosis. Subsequently, we employed two additional mRNA datasets for validation purposes. Gene set enrichment analysis (GSEA) was conducted to analyze gene function enrichment. Through WGCNA and subsequent analyses, complemented by validation using two additional datasets, we identified five genes (BICC1, C7, EFEMP1, LUM, and STMN2) as hub genes. GSEA analysis indicated that gene sets associated with liver metabolism and cholesterol homeostasis were uniformly downregulated. BICC1, C7, EFEMP1, LUM, and STMN2 were identified as hub genes of NASH, and were all related to liver metabolism, NAFLD, NASH, and related diseases. These hub genes might serve as potential targets for the early screening and treatment of NASH.

• 한국산학기술학회논문지
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• 제13권6호
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• pp.2751-2756
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• 2012

위성영상을 이용한 감독분류에서 훈련집단의 선택은 분류정확도에 많은 영향을 미친다. 일반적으로 훈련집단의 특징이 명확한 순수화소를 선택할 경우 전체 정확도가 높은 반면, 저해상도 영상이거나 식별이 불분명하여 혼합화소를 선택하면 정확도는 저하된다. 그러나 실제 영상분류를 수행할 때 순수화소만을 훈련집단으로 선택하는 것은 매우 어렵다. 이에 본 연구에서는 혼합화소를 훈련집단으로 선택하였을 경우 적합한 분류기법을 제시하고자 하였다. 이를 위해 소수의 순수화소를 훈련집단으로 선정하여 분류정확도를 산출하고 같은 수의 혼합화소를 이용한 분류결과와 정확도를 비교하였다. 연구 결과, 혼합화소를 사용한 분류기법들 중 SVM의 정확도가 가장 높았으며, 순수화소를 이용한 분류결과와도 가장 작은 차이를 보였다. 따라서 훈련집단으로 혼합화소를 선택할 가능성이 높은 건물 및 녹지혼합지역에서는 SVM을 이용한 영상분류가 가장 적합할 것으로 판단된다.

• 정보처리학회논문지C
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• 제17C권5호
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• pp.407-414
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• 2010

CAS란 정당한 사용자만이 방송 콘텐츠에 접근할 수 있도록 하는 하드웨어 기반 시스템이다. CAS의 경우에는, 방송사업자 교체 시 셋탑 박스를 교체해야 한다는 점, 스마트카드에 의한 빈번한 오작동과 같은 문제점이 있었다. 이러한 문제점을 해결하기 위해 2009년에 XCAS가 개발되었다. 그러나 XCAS에 대한 평가체계는 현재까지 정해진 것이 없다. 기존의 평가체계는 XCAS에 그대로 적용하기에는 평가기준, 비용과 효율성 등이 떨어진다. 따라서 XCAS의 안전성 및 적합성을 검증 평가하는 체계가 필요하다. 본 논문에서는 기존에 존재하는 평가체계를 분석하고, XCAS에 적합한 평가체계를 제안한다. 제안하는 평가체계는 평가목적 및 대상, 평가주체, 평가절차, 평가제출물, 평가비용으로 구성되어 있다.

• Genomics & Informatics
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• 제8권1호
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• pp.50-57
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• 2010

Mercuric chloride, a model nephrotoxicant was used to elucidate time- and dose- dependent global gene expression changes associated with proximal tubular toxicity. Rat kidney cell lines NRK-52E cells were exposed for 2, 6 and 12 hours and with 3 different doses of mercuric chloride. Cell viability assay showed that mercuric chloride had toxic effects on NRK-52E cells causing 20% cell death (IC20) at $40{\mu}M$ concentration. We set this IC20 as high dose concentration and 1/5 and 1/25 concentration of LC20 were used as mid and low concentration, respectively. Analyses of microarray data revealed that 738 genes were differentially expressed (more than two-fold change and p<0.05) by low concentration of mercuric chloride at least one time point in NRK-52E cells. 317 and 2,499 genes were differentially expressed at mid and high concentration of mercuric chloride, respectively. These deregulated genes showed a primary involvement with protein trafficking (CAV2, CANX, CORO1B), detoxification (GSTs) and immunity and defense (HMOX1, NQO1). Several of these genes were previously reported to be up-regulated in proximal tubule cells treated with nephrotoxicants and might be aid in promoting the predictive biomarkers for nephrotoxicity.

• 품질경영학회지
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• 제49권2호
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• pp.127-143
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• 2021

Purpose: Smart Safety Living Lab is a Living Lab facility, constructed and operated by KITECH in Korea, to support the user experience(UX) evaluation, planning and certification of smart safety products and services. The purpose of this study is to develop a UX evaluation methodology that accommodates the characteristics of the Living Lab and smart safety products and services for a systematic and efficient UX evaluation in the Smart Safety Living Lab. Methods: A generic model of UX evaluation was first derived based on a review of related literature. Then, the generic model is revised to accommodate the characteristics of the Smart Safety Living Lab and smart safety products and services, resulting in the UX Evaluation Methodology for Smart Safety Living Lab (SSLL-UXEM). Results: The developed SSLL-UXEM consists of a structured process for UX evaluation, a guideline for conducting each step of the process, and a set of forms for recording the major evaluation results in each step. Conclusion: SSLL-UXEM can help to enhance the efficiency of the UX evaluation process and the consistency of the UX evaluation results. SSLL-UXEM is also expected to serve as a basis for UX evaluation in various living lab environments in the future.

• 한국환경보건학회지
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• 제41권6호
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• pp.405-411
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• 2015

Objectives: The purpose of this study is to evaluate the optimum conditions for oral mucosal irritation testing using the buccal pouch of hamsters. Methods: Test materials were applied to the buccal pouch of seven-week old male Syrian hamsters (SLC, Japan) four times at one-hour intervals and macroscopic changes were examined at 24 hours after final treatment. After sacrifice, the buccal pouches were removed and prepared for histopathological evaluation. In order to set the exposure time, we performed exposure tests of 5, 12, 18 and 23 minutes using sodium lauryl sulfate (SLS) 1% and set the treatment volume from the test results at 2, 3, or 4 ml treatment using SLS 1%, Triton X-100 1% and ethanol. After setting the experimental conditions, seven groups of materials [sodium lauryl sulfate (SLS) (1%), Triton X-100 (1%), hydrogen peroxide (3%), ethanol (100%), chlorhexidine (0.2%, 2%), phosphate buffer saline (PBS)] were assessed. Results: Experimental conditions of material exposure time were fixed as 18 minutes from the exposure tests of 5, 12, 18 or 23 min using sodium lauryl sulfate (SLS) 1%. Treated volume was set as 4 ml per each pouch from the test results of 2, 3, or 4 ml treatments using SLS 1%, Triton X-100 1% and ethanol. The results in terms of irritation degree were in the order of sodium lauryl sulfate (SLS) (1%) > Triton X-100 (1%) ${\fallingdotseq}$ hydrogen peroxide (3%) > ethanol (100%) ${\fallingdotseq}$ chlorhexidine (0.2%, 2%) > phosphate buffer saline (PBS). Conclusion: From this study, suitable conditions for hamster mucosal irritation testing were suggested and this method was verified through materials commonly used on oral mucosal membranes.

• Journal of Microbiology
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• 제44권1호
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• pp.29-34
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• 2006

The purpose of this study was to develop molecular identification method for medical mushrooms and their preparations based on the nucleotide sequences of nuclear large subunit (LSD) rDNA. Four specimens were collected of each of the three representative medicinal mushrooms used in Korea: Ganoderma Incidum, Coriolus versicolor, and Fomes fomentarius. Fungal material used in these experiments included two different mycelial cultures and two different fruiting bodies from wild or cultivated mushrooms. The genomic DNA of mushrooms were extracted and 3 nuclear LSU rDNA fragments were amplified: set 1 for the 1.1-kb DNA fragment in the upstream region, set 2 for the 1.2-kb fragment in the middle, and set 3 for the 1.3-kb fragment downstream. The amplified gene products of nuclear large subunit rDNA from 3 different mushrooms were cloned into E. coli vector and subjected to nucleotide sequence determination. The sequence thus determined revealed that the gene sequences of the same medicinal mushroom species were more than $99.48\%$ homologous, and the consensus sequences of 3 different medicinal mushrooms were more than $97.80\%$ homologous. Restriction analysis revealed no useful restriction sites for 6-bp recognition enzymes for distinguishing the 3 sequences from one another, but some distinctive restriction patterns were recognized by the 4-bp recognition enzymes AccII and HhaI. This analysis was also confirmed by PCR-RFLP experiments on medicinal mushrooms.