• Journal of the Korea Institute of Information and Communication Engineering
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• v.20 no.4
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• pp.683-690
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• 2016

In modern society, disasters frequently occur, and the effect is getting more massive. Also, unpredictable future increases anxiety about social security. Accordingly, in order to prevent national-scale emergency from happening, it is highly required governments' role as ICT power nation and transition to disaster management system using big data applied service. Thus, e-gov necessarily acquires disaster response system in order to predict and manage disasters. Disasters are linked with some attributes of modern society in diversity, complexity and unpredictability, so various approach and remedies of them will appease the nation's anxiety upon them. For this reason, this manuscript suggests epidemics preactive warning algorithm model as a mean of reduce national anxiety on disaster using big data for social security. Also, by recognizing the importance of e-gov and analyzing problems in weak disaster management system, it suggests political implication for disaster response.

• Archives of Craniofacial Surgery
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• v.14 no.1
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• pp.11-15
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• 2013

Background: In cleft lip patients, the necessity of a thorough preoperative analysis of facial deformities before reconstruction is unquestioned. The surgical plan of cleft lip patient is based on the information gained from our preoperative anthropometric evaluation. A variety of commercially available three-dimensional (3D) surface imaging systems are currently introduced to us in plastic surgery for these use. However, few studies have been published on the soft tissue morphology of unrepaired cleft infants described by these 3D surface imaging systems. Methods: The purpose of this study is to determine the accuracy of facial anthropometric measurements obtained through digital 3D photogrammetry and to compare with direct anthropometry for measurement in unilateral cleft lip patients. We compared our patients with three measurements of dimension made on both sides: heminasal width, labial height, and transverse lip length. Results: The preoperative measurements were not significantly different in both side of labial height and left side of heminasal width. Statistically significant differences were found on both side of transverse lip length and right side of heminasal width. Although the half of preoperative measurements were significantly different, trends of results showed average results were comparable. Conclusion: This is the first study in Korea to simultaneously compare digital 3D photogrammetry with traditional direct anthropometry in unilateral cleft lip patients. We desire this study could contribute the methodological choice of the many researchers for proper surgical planning in cleft lip reconstruction field.

• Journal of the Korean Data and Information Science Society
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• v.27 no.3
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• pp.599-607
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• 2016

The first patient of Middle East respiratory syndrome caused by a novel coronavirus infection in Korea was confirmed on May 20, 2015. After that, MERS spread over the country. In recent years, patients of MERS have been found around the Arabian Peninsula and the case fatality ratio of MERS in those area was been reported to range from 30 to 40%. In this paper, we estimate the case fatality ratio of MERS of Korea using data of 186 infections until December 1, 2015. In this study we propose a novel estimator of the case fatality ratio using information of the patients severity condition as well as records on the days of confirmation and death or recovery of the patient. By using publicly available data of the Department of Health and Human Services Centers for Disease Control, we evaluate a performance of the estimator and demonstrate a stability of the estimator from the early stage of the epidemic.

• Herbal Formula Science
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• v.17 no.1
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• pp.29-43
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• 2009

This report carried out to study 59 prescriptions related to the use of Pueraria thunbergiana bentham in Dongueibogam This study is based on Dongueibogam which has been widely used for herbal clinic in Korea. And this study is investigated to make sure of the range of treatment, nature of disease, the pathology and the dosage of Pueraria thunbergiana bentham in Dongueibogam. The following conclusions were reached through investigations on the prescriptions that used in Dongueibogam as a various role. 1. The prescriptions that Pueraria thunbergiana bentham was taken as a 15 for monarchy, 15 for attendant, 11 for assistance and valet herb are utilized for therapeutic treatments such as cough, fever etc, mainly Sanghan syndromes in the chapter of Wind. 2. The Pueraria thunbergiana bentham was also utilized as a key ingradients in the chapter of Eye and Onyeok epidemic. 3. The most frequent mass of the Pueraria thunbergiana bentham when used as a monarchy herb is 2jeon, and the standard limited range of adding Pueraria thunbergiana bentham to medical prescription is 7pun$\sim$5jeon per dose. But, when used as a attendant herb, an typical and regular adding dose is the range of 3pun5ri$\sim$1yang2.5jeon,and 3pun$\sim$1.5jun in the case of assistant. 4. The phathogenic factors and phathology of Pueraria thunbergiana bentham in the prescription are based on the chapter of Cold when used as a monarchy herb and on the chapter of Wind in the case of attendant herb. 5. The Seungmagalgeontang is the most useful base prescription which use the Pueraria thunbergiana bentham as the main ingredient.

• The Journal of Korean Medical History
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• v.22 no.1
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• pp.31-45
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• 2009

Eui Bang Shin Gam("醫方新鑑") is a classic on oriental medicines written by Shin Oh (新塢) Han Byung Lyun (韓秉璉) in 1913. It was written under the base of the writer's own experience as well as in the light of 36 other classics on oriental medicines such as Dong Eui Bo Gam ("東醫寶監"), Eui Hak Yip Mun ("醫學入門"), and Kyung Ak Jeon Seo ("景岳全書"). In an attempt to avoid difficult theories and list only the essential informations and formulas for clinical purposes, it attained its own characteristics of not only reorganizing Dong Eui Bo Gam in a pragmatic way but also explaining diseases classified in western medicines in oriental medicines' point of view as well as suggesting medicine formulas regarding such explanations. As a result, it is a complete and efficient medical classic through which one can gain knowledge in both classic oriental medicines and combination of western and oriental medicines. Its special features are making a separate chapter for cholera and Lao Zhai (勞瘵), which is also a contagious disease, and trying in the chapter to explain the diseases in words of oriental medicines; listing details of nine major epidemic and matching them with the diseases known in oriental medicines; and recording a case of enforcing sterilization and preventive injection against contagious diseases. The basic medical theory in Eui Bang Shin Gam are the yin-yang theory, the thesis of fire and water, the thesis of the exterior and the interior, Yun Qi Lun (運氣論), and four institutions of human body. In explaining the basic theories, the writer emphasized strengthening the yang of the body, under the influence of the thoughts of Zhang Ga Bin (張介賓). Since he put the importance of diagnosis first, the first chapter is about diagnosis. There are five different ways of diagnosing a patient mentioned in the book, and acupuncture, pulse, and medicines was considered crucial.

• Nutrition Research and Practice
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• v.8 no.1
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• pp.20-26
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• 2014

Obesity is an epidemic disease characterized by an increased inflammatory state and chronic oxidative stress with high levels of pro-inflammatory cytokines and lipid peroxidation. Moreover, obesity alters cholesterol metabolism with increases in low-density lipoprotein (LDL) cholesterols and triglycerides and decreases in high-density lipoprotein (HDL) cholesterols. It has been shown that mulberry leaf and fruit ameliorated hyperglycemic and hyperlipidemic conditions in obese and diabetic subjects. We hypothesized that supplementation with mulberry leaf combined with mulberry fruit (MLFE) ameliorate cholesterol transfer proteins accompanied by reduction of oxidative stress in the high fat diet induced obesity. Mice were fed control diet (CON) or high fat diet (HF) for 9 weeks. After obesity was induced, the mice were administered either the HF or the HF with combination of equal amount of mulberry leaf and fruit extract (MLFE) at 500mg/kg/day by gavage for 12 weeks. MLFE treatment ameliorated HF induced oxidative stress demonstrated by 4-hydroxynonenal (4-HNE) and modulated the expression of 2 key proteins involved in cholesterol transfer such as scavenger receptor class B type 1 (SR-B1) and ATP-binding cassette transporter A1 (ABCA1) in the HF treated animals. This effect was mainly noted in liver tissue rather than in cutaneous tissue. Collectively, this study demonstrated that MLFE treatment has beneficial effects on the modulation of high fat diet-induced oxidative stress and on the regulation of cholesterol transporters. These results suggest that MLFE might be a beneficial substance for conventional therapies to treat obesity and its complications.

• Journal of environmental and Sanitary engineering
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• v.17 no.3
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• pp.60-66
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• 2002

Iksan city is planning to construct a waste incinerator on the site of about $110,000\textrm{m}^2$ in size that will be selected from a public bid(Oct.~Nov.2002)in the wake of expiration by June 2003 of use for Hamyeol fill-up ground. Science it has usually been difficult to find sites for filling-up or incinerating facilities owing to NIMBY phenomenon, it is badly requested to employ up-to-date technology for processing wastes without environmental pollution. The conflicts between the administrative authorities and community people with regard to construction of incineration facilities, fill-up ground and facilities for waste processing or recycling are not the matters of just today but are increasingly deepening and spreading countrywide. There seems to be no prospect for these conflicts to be amicably settled through dialogues. They rather become a social disease inflicting the whole country like an epidemic. It is therefore believed to be necessary to introduce measures to design and build environment-friendly facilities that may be accepted by residents as not abominable ones but be used as amusing place while they watch the daily operation of them as watchdogs. Iksan city's plan to construct environment-friendly waste incineration facilities of pyrolysis type without chimney has undergone the process of public hearings and explanatory gatherings from every class of Iksan citizens to get consensus but is still delayed due mainly to be the failure of inducing foreign investments. Pyrolysis technology has two advantages ; first, environment-friendly due to less emission of second pollutants ; second, production of by-products highly valuable as resources. It Is known that Germany has recently begun installation and operation of pyrolysis facility urban wastes, an evidence indicating that pyrolysis method will be widely applied to cope with the tightened regulation to preserve environment worldwide.

• Journal of Preventive Medicine and Public Health
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• v.53 no.3
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• pp.151-157
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• 2020

Objectives: The outbreak of coronavirus disease 2019 (COVID-19) is one of the main public health challenges currently facing the world. Because of its high transmissibility, COVID-19 has already caused extensive morbidity and mortality in many countries throughout the world. An accurate estimation of the basic reproduction number (R₀) of COVID-19 would be beneficial for prevention programs. In light of discrepancies in original research on this issue, this systematic review and meta-analysis aimed to estimate the pooled R₀ for COVID-19 in the current outbreak. Methods: International databases (including Google Scholar, Science Direct, PubMed, and Scopus) were searched to identify studies conducted regarding the R₀ of COVID-19. Articles were searched using the following keywords: "COVID-19" and "basic reproduction number" or "R₀." The heterogeneity among studies was assessed using the I² index, the Cochran Q test, and T². A random-effects model was used to estimate R₀ in this study. Results: The mean reported R₀ in the identified articles was 3.38±1.40, with a range of 1.90 to 6.49. According to the results of the random-effects model, the pooled R₀ for COVID-19 was estimated as 3.32 (95% confidence interval, 2.81 to 3.82). According to the results of the meta-regression analysis, the type of model used to estimate R₀ did not have a significant effect on heterogeneity among studies (p=0.81). Conclusions: Considering the estimated R₀ for COVID-19, reducing the number of contacts within the population is a necessary step to control the epidemic. The estimated overall R₀ was higher than the World Health Organization estimate.

• Korean Journal of Veterinary Research
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• v.34 no.2
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• pp.381-386
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• 1994

Evidence is presented for the isolation and characterization of Anaplasma avis in both indigenous (Korean) and exotic goats imported from Australia. These studies were carried out in response to epidemic scenario whereby farmers reported noticing what was described as a mysterious disease characterized by anemia, anorexia, general malaise and a significant morbidity and mortality rate in both types of goat breeds. The syndrome consistent with caprine anaplasmosis was associated with an intraerythrocytic agent occuring in single initial bodies characteristically surrounded by a single-layered membrane whereas the marginal body was typically surrounded by a double-layered membrane. The identity of the etiologic agent was confirmed as Anaplasma avis by light and ultrastructural microscopy.

• Genomics & Informatics
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• v.9 no.4
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• pp.143-151
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• 2011

In this study, we propose a novel, intuitive method of constructing an expression quantitative trait (eQT) network that is related to the metabolic syndrome using LOD scores and peak loci for selected eQTs, based on the concept of gene-gene interactions. We selected 49 eQTs that were related to insulin resistance. A variance component linkage analysis was performed to explore the expression loci of each of the eQTs. The linkage peak loci were investigated, and the "support zone" was defined within boundaries of an LOD score of 0.5 from the peak. If one gene was located within the "support zone" of the peak loci for the eQT of another gene, the relationship was considered as a potential "directed causal pathway" from the former to the latter gene. SNP markers under the linkage peaks or within the support zone were searched for in the database to identify the genes at the loci. Two groups of gene networks were formed separately around the genes IRS2 and UGCGL2. The findings indicated evidence of networks between genes that were related to the metabolic syndrome. The use of linkage analysis enabled the construction of directed causal networks. This methodology showed that characterizing and locating eQTs can provide an effective means of constructing a genetic network.