• 제목/요약/키워드: Epidemic Disease

검색결과 378건 처리시간 0.03초

1차 확산기 이후 코로나바이러스감염증-2019의 전파가 부모와 아동의 심리에 미치는 영향 (The Effect of the Transmission of Coronavirus Disease-2019 on the Mentality of Parents and Children After the First Wave of Infections)

  • 김정연;이고은;남옥형;이효설;최성철;김광철;김미선
    • 대한소아치과학회지
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    • 제48권3호
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    • pp.269-279
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    • 2021
  • 이 연구의 목적은 코로나바이러스감염증-2019의 전파가 학령기 아동과 부모의 심리에 미친 영향을 수면장애와 우울증의 측면에서 평가하는 것이었다. 2020년 4월 2일부터 2020년 4월 25일까지 강동 경희대학교 치과병원 소아치과를 방문한 123명의 부모와 108명의 학령기 아동을 대상으로 직접 기입 방식의 설문조사를 실시하였다. 참가자들은 Pittsburgh Sleep Quality Index, Generalized Anxiety Disorder (GAD) - 7, Center for Epidemiology Scale for Depression 로 평가되었다. 로지스틱 회기 분석은 유의 수준 5%로 시행되었다. 부모의 GAD, 우울증, 낮은 수면의 질은 각각 34.1%, 17.1%, 44.7%에서 나타났다. 아동의 GAD 유병률은 20.4%였다. 로지스틱 회기분석 결과 코로나바이러스 관련 안전재난문자로 인한 스트레스가 부모의 불안장애, 우울증과 관련이 있었다. 아동의 경우, 코로나바이러스감염증 발생 이후의 감정 변화 정도가 GAD와 연관성이 있었다. 이 연구를 통해 코로나바이러스감염증-2019의 유행으로 인한 어린이와 보호자들의 심리적 상태 변화가 있음을 확인하였고, 치과진료 시 이들의 심리상태를 고려해야 하겠다.

가축 전염병 발생에 따른 소와 닭 사체의 화학적 처리 방법의 적용 (Application of chemical treatment for cattle and chicken carcasses for the control of livestock infectious diseases)

  • 이택근;오연수;고영승;배다윤;탁동섭;임채광;조호성
    • 한국동물위생학회지
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    • 제45권2호
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    • pp.117-124
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    • 2022
  • In the event of an outbreak of a livestock epidemic, it has been considered that the existing burial-centered carcass disposal method should be improved ecofriendly for prevention of leachate and odors from burial basically in regard of pathogen inactivation. Therefore, the aim of this study is whether it was possible to treat the carcass of cattle and chickens using the chemical carcass treatment method. It was conducted to establish detailed treatment standards for the chemical treatment method of cattle and chicken carcasses based on the results of the proof of the absence of infectious diseases in cattle chickens. After inoculating cattle carcass with 10 pathogens (foot and mouth disease virus, bovine viral diarrhea virus, Mycobacterium bovis, Mycobacterium avium subsp. Paratuberculosis, Brucella abortus, Bacillus anthracis, Clostridium chauvoei, Clostridium perfringens, Escherichia coli, and Salmonella Typhimurium) and chicken carcasses with low pathogenic avian influenza virus, Clostridium perfringens type C, E. coli and Salmonella Typhimurium, these were treated at 90℃ for 5 hours in a potassium hydroxide liquid solution corresponding to 15% of the body weight. This method liquefies all cadaveric components and inactivates all inoculated pathogens by PCR and culture. Based on these results, it was possible to prove that chemical treatment of cattle and chicken carcasses is effective in killing pathogens and is a safe method without the risk of disease transmission. The chemical treatment method of livestock carcasses can be suggested as an alternative to the current domestic burial-centered livestock carcass treatment method, preventing environmental pollution, and contributing to public health.

신생아 중환자실에서의 아데노바이러스 8형에 의한 유행성 각결막염의 발생 (An Outbreak of Epidemic Keratoconjunctivitis by Adenovirus Type 8 in a Neonatal Intensive Care Unit)

  • 박나리미;나지윤;정경은;이진아;김이경;김한석;김성준;송정숙;오향순;이환종;최중환
    • Neonatal Medicine
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    • 제15권1호
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    • pp.44-53
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    • 2008
  • 목 적 : 아데노바이러스에 의한 유행성 각결막염은 안구 통증, 결막 충혈 및 분비물 증가 등을 특징으로 하는 전염성이 높은 질환으로, 주로 접촉으로 전파되며 4, 8, 19, 37형에 의해 발생하는 것으로 알려져 있다. 지역사회나 안과 병원에서의 유행성 각결막염이 성인에서 다수 보고되었으나 신생아 중환자실에서의 유행이 보고된 경우는 드물고, 국내에서는 아데노바이러스 8형에 의한 것으로 확인된 각결막염의 유행이 보고된 예가 없었다. 저자들은 신생아 중환자실에서 발생한 아데노바이러스 8형 유행성 각결막염의 전파 및 임상적 특징을 분석하고, PCR 기법이 진단과 감염 방지 대책의 수립에 기여할 수 있는가를 보고자, 본 연구를 실시하였다. 방 법 : 2005년 7월 12일부터 8월 1일까지 20일간, 신생아 중환자실에 입원 중인 미숙아 12명, 의료진 3명 및 보호자 1명에서 결막 충혈과 분비물 증가 등의 전형적인 결막염 증상이 발생하였다. 각결막염이 의심되는 환자의 결막 분비물 및 호흡기 검체에서 아데노바이러스에 대한 배양 검사와 PCR 검사를 시행하였고, PCR양성을 보인 검체에 대해서는 hexon 유전자 염기서열분석에 의해 혈청형을 결정하였다. 결 과 : 11명의 환아와 1명의 의료진에서 검사가 가능한 검체를 채취하였으며, 12명(100%) 모두에서 PCR 양성을 보였고, 검사 가능한 11명 중 6명(54.5%)에서 아데노바이러스가 배양되었다. 신생아 11명의 검체는 염기서열 분석에서 아데노바이러스 8형으로 확인되었다. 가장 먼저 결막염 증상이 발생한 4명의 환아는 유행 일주일 전 같은 날 미숙아 망막병증에 대한 정기 안과 검진을 받았다. 첫 증례가 발생한 후 10일째까지 10명의 환아와 각각 1명의 상근 의사, 간호사에서 증상이 발생하였고 이후 20일째까지 4명의 환자가 추가로 발생하였다. 감염이 의심되는 환아들은 코호트 격리 및 장갑, 가운을 포함한 접촉 격리를 시행하였고, 감염된 의료진은 증상이 호전될 때까지 1-2주간 병가를 받아 접촉이 차단되었다. 이환된 신생아들의 출생 당시 평균재태주령은 $28^{+5}$주, 평균 출생체중은 1,102 g이었고, 증상이 시작되었을 당시 연령 및 체중은 각각 평균 $35^{+6}$주, 1,745 g이었다. 환아들은 증상이 시작된 지 평균 16.7 (${\pm}$5.1)일이 지난 후에 합병증 없이 호전되었다. 이전의 보고에서 4주-4개월에 이르는 유행이 보고된바 있으나, 본원에서는 발병 3주 이후에는 더 이상 환자가 보고되지 않았다. 결 론 : 저자들은 신생아 중환자실에서 아데노바이러스 8형에 의한 각결막염이 있었던 미숙아들의 유행전파 경로와 임상적 특성을 분석하였다. 진단 시 PCR과 염기서열 분석을 이용한 아데노바이러스 혈청형의 결정법이 국내에서 처음으로 시도되어 높은 감수성을 보였으며, 이는 결막염 유행 시 빠른 실험실적 진단 방법으로 유용하리라 생각된다.

"삼국사기(三國史記)"에 기록된 의약내용(醫藥內容) 분석 (Study on Medical Records In ${\ulcorner}$the Historical Records of the Three Kingdoms${\lrcorner}$)

  • 신순식;최환수
    • 제3의학
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    • 제2권1호
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    • pp.35-54
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    • 1997
  • We tried to observe the features of ancient medical practice by analysing the records related to medicine in the book, ${\ulcorner}$the Historical Records of the Three Kingdom${\lrcorner}$ of which content includes the features of medicine in mythology, plague, delivery of twins, drugs, medical system, shamanism, constitutional medicine, psychiatry, forensic medicine, deformity, a spa, medical phrase, health and welfare work, religion, death. physiological anatomy, Taoist medicine, acupuncture, the occult af of transformation and etc. Our initial concern was about where to draw line as of medical field and we defined medicine in more broad meaning. The book ${\ulcorner}$the Historical Records of the Three Kingdoms${\lrcorner}$ describes the world of mythology by way of medicine which is not clearly a conventional one. There appears records of birth of multiple offsprings 7 times in which cases are of triplets or more. Delivering multiple offsprings were rare phenomenon though such fertility was highly admired. This shows one aspect of ancient country having more population meant more power of the nation. Of those medical records conveyed in that book includes stories of childbirth such as giving birth to a son after praying, giving birth to Kim Yoo-shin after 20 months after mother's dream of conception, and a song longing for getting a laudable child. Plagues were prevalent throughout winter to spring season and one can observe various symptoms of plagues in the record. Of these epidemic diseases, cold type might have been more common than the heat one. Appearance of epidemic diseases frequently coincided with that of natural disasters that this suggests a linkage between plague and underlying doctrine on five elements' motion and six kinds of natural factors. There exists only a few names of diseases such as epidemic disease, wind disease, and syndrome characterized by dyspnea. Otherwise there appeared only afflictions that were not specified therefore it remains cluless to keep track of certain diseases of prevalence. Since this ${\ulcorner}$Historical Records of the Three Kingdoms'${\lrcorner}$ wasn't any sort of medical book, words and terms used were not technical kind and most were the ones used generally among lay people. Therefore any mechanisms of the diseases were hardly mentioned. Some of medicinal substances such as Calculus Bovis, Radix Ginseng, Gaboderma Luciderm, magnetitum were also in use in those days. 53 kinds of dietary supplies appears in the records and some of these might have been used as medicinal purpose. Records concerning dicipline of one's body includes activities such as hunting, archery, horseback riding etc. In Shilla dynasty there were positions such as professor of medicine, Naekongbong(內供奉), Kongbong's doctor(供奉醫師), Kongbong's diviner(供奉卜師). As an educational facility, medical school was built at the first year of King Hyoso's reign and it's curricula included various subjects as ${\ulcorner}$Shin Nong's Herbal classic${\lrcorner}$, ${\ulcorner}$Kabeul classic of acupuncture and moxbustion${\lrcorner}$, ${\ulcorner}$The Plain Questions of the Yellow Emperor's Classic of Internal Medicine${\lrcorner}$, ${\ulcorner}$Classic of Acupuncturer${\lrcorner}$, ${\ulcorner}$The Pulse Classic${\lrcorner}$, ${\ulcorner}$Classic of Channels and Acupuncture Points${\lrcorner}$ and ${\ulcorner}$Difficult Classic${\lrcorner}$. There were 2 medical professors who were in charge of education. To establish pharmacopoeia, 2 Shaji(舍知), 6 Sha(史), 2 Jongshaji(從舍知) were appointed. In Baekje dynasty, Department of Herb was maintained. Doing praying for the sake of health, doing phrenology also can be extended to medical arena. Those who survived over 100 years of age appear 3 times in the record, while 98 appears once. The earliest psychiatrist Nokjin differentiated symptoms to apply either therapies using acupuncture and drug or psychotherapy. There appears a case of rape, a case of burying alive with the dead, 8 cases of suicide that can characterize a prototype of forensic medicine. Deformity-related records include phrases as follow: 'there seems protrudent bone behind the head', 'a body which has two heads, two trunks, four arms.', 'a body equipped with two heads' In those times spa can be said to be used as a place for he리ing, convalescence, and relaxation seeing the records describing a person pretended illness and went to spa to enjoy with his friends. Priest doctors and millitary surgeons were in charge of the medical sevice in the period of the Three Kingdoms by the record written by Mookhoja(墨胡子) and Hoonkyeom(訓謙). Poor diet and regimen makes people more vulnerable to diseases. So there existed charity services for those poor people who couldn't live with one's own capacity such as single parents, orphans, the aged people no one to take care and those who are ill. The cause of affliction was frequently coined with human relation. There appeared the phenomenon of releasing prisoners and allowing people to become priests at the time of king's suffering. Besides, as a healing procedure, sutra-chanting was peformed. There appears 10 cases of death related records which varies from death by drowning, or by freezing, death from animals, death from war, death from wightloss and killing oneself at the moment of spouse's death and etc. There also exist certain records which suggest the knowledge of physiology and anatomy in those times. Since the taoist books such as ${\ulcorner}$Book of the Way and Its Power(老子道德經)${\lrcorner}$ were introduced in the period of Three Kingdoms, it can be considered that medicine was also influenced by taoism. Records of higher level of acupuncture, records which links the medicine and occult art of transformation existed. Although limited, we could figure out the medical state of ancient society.

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CVA환자의 일반적 특성 및 CVA와 관계되는 원인들의 역학적 조사 (General Characteristics of CVA and Epidemic Survey of the Cause Related CVA)

  • 김웅각
    • The Journal of Korean Physical Therapy
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    • 제10권1호
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    • pp.31-44
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    • 1998
  • This observation was made on 163 cases of CVA that were confirmed through survey. They were treated in the Bulgyo Oriental Hospital in Taegu from February to March 1998. The results was as follows, 1. The ration of male to female was 1:1:36 in whole groups. 2. Onset time was occurred $37.4\%$ at 06:00-12:00. $20.0\%$, 00:00-16:00. 3. Of 157 cases of cerebrovascular accidents cerebral infarction (included cerebral thrombosis & cerebral embolism) was presented in $47.4\%$, cerebral hemorrhage in $38.2\%$, subarachnoid hemorrhage in $5.1\%$, and others in $8.9\%$. 4. The most ordinary preceding disease was hypertension. 5. The family history was appeared as $12.9\%$ of the mother, $9.7\%$ of the father.(This observation was made on 155 cases) 6. The body weight of CAV patients was appeared $37.4\%$ in 51-60kg, $30.7\%$ in 61-70kg, $17.8\%$ in below 50kg, and $9.8\%$ in 71-80kg, $4.3\%$ in above 80kg. 7. Of 161 cases, $46.6\%$ did not exercise. 8. Of 163 cases, $65.6\%$ of them did not drink alcohol. 9. Of 162 cases, $63\%$ did not smoke cigarettes. 10. The food taste (food habit) of stroke patients was that they comprised a fancy as $38.0\%$ of salty food, $33.8\%$ of fresh food, and $24.7\%$ of hot food, $3.5\%$ of sweet food.(This observation was made on 143 cases) According to the above result, We must restrain salty food and control positively hypertension and in terms of CVA prevention.

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New Epidemic Rots on Fruit, Stem, and Root of Paprika Caused by Nectria hematococca

  • Jee, Hyeong-Jin;Lee, Sun-Mi;Nam, Ki-Woong;Cho, Weon-Dae
    • 한국식물병리학회:학술대회논문집
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    • 한국식물병리학회 2003년도 정기총회 및 추계학술발표회
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    • pp.125.2-125
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    • 2003
  • Since 2000, severe rots on aerial and underground parts of paprika( Capsicum annum L.) has occurred in most cultivation glasshouses throughout the country. Totally 169 isolates of a fungus were consistently isolated from the diseased plant tissues of fruits, stems, branches, and roots collected from 19 farms in six provinces. Anamorph stage of the fungus was identified as Fusarium solani based on morphological characteristics. However, the fungus readily produced sexual structure of perithecia on infected plant tissues and on agar medium. Since the fungus formed abundant perithecia by single isolate, it was considered as a homothallic strain of Nectria hematococn, the teleomorph of F. solani. Irregularly globose perithecia with orange to red color formed sparsely to gregariously on dead tissues of fruits and basal stems at the 3ate infection stage, which is a diagnostic sign for the disease. Abundancy of perithecium varied among isolates and they sized 125-220$\mu\textrm{m}$ in diam. Asci enveloping eight ascospores were cylindrical and measured 60-80x8-12$\mu\textrm{m}$. Ellipsoid to obovate ascospores are two-celled and measured 11-l8${\times}$4-7$\mu\textrm{m}$. Ascospores are hyaline, slightly constricted at the central septum, and revealed longitudinal striations that is a typical trait of the species. This fungus that has never been reported in Korea previously became a threat to paprika cultivation because of its strong pathogenicity and nationwide distribution.

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ANALYSIS OF SPATIAL FACTORS AFFECTING DENGUE EPIDEMICS USING GIS IN THAILAND

  • Nakhapakorn Kanchana;Tripatht Nitin;Nualchawee Kaew;Kusanagt Michiro;Pakpien Preeda
    • 대한원격탐사학회:학술대회논문집
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    • 대한원격탐사학회 2005년도 Proceedings of ISRS 2005
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    • pp.774-777
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    • 2005
  • Dengue Fever(DF) and Dengue haemorrhagic fever(DHF) has become a major international public health concern. Dengue Fever(DF) and Dengue haemorrhagic Fever (DHF) is also still the major health problem of Thailand, although many campaigns against it have been conducted throughout the country. GIS and Remotely Sensed data are used to evaluate the relationships between socio-spatial, environmental factors/indicators and the incidences of viral diseases. The aim of the study is to identify the spatial risk factors in Dengue and Dengue Haemorrhagic Fever in Sukhothai province, Thailand using statistical, spatial and GIS Modelling. Preliminary results demonstrated that physical factors derived from remotely sensed data could indicate variation in physical risk factors affecting DF and DHF. The present study emphasizes the potential of remotely sensed data and GIS in spatial factors affecting Dengue Risk Zone analysis. The relationship between land cover and the cases of incidence of DF and DHF by information value method revaluated that highest information value is obtained for Built-up area. A negative relationship was observed for the forest area. The relations between climate data and cases of incidence have shown high correlation with rainfall factors in rainy season but poor correlation with temperature and relative humidity. The present study explores the potential of remotely sensed data and GIS in spatial analysis of factors affecting Dengue epidemic, strong spatial analysis tools of GIS. The capabilities of GIS for analyst spatial factors influencing risk zone has made it possible to apply spatial statistical analysis in Disease risk zone.

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트위터에서 추출한 감기 증상의 사회적 신호와 영향요인과의 상관분석 (A Correlation Analysis between the Social Signals of Cold Symptoms Extracted from Twitter and the Influence Factors)

  • 윤진영;김석중;이범석;황병연
    • 한국멀티미디어학회논문지
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    • 제16권6호
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    • pp.667-677
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    • 2013
  • 소셜 네트워크 서비스의 인기가 증가하면서 현재 이슈가 되는 정보를 추출하거나 증상 등을 추적하는 분석연구가 활발히 진행되고 있다. 특히 트위터에서는 트윗을 통해 이벤트 현상에 대한 반응과 사용자의 개인적인 상태 등이 잘 반영되어 트윗을 센서로 적용한 이벤트 추출이 가능하다. 최근에는 지진과 같은 재난 이벤트뿐만 아니라 사회 전반적으로 관심을 갖고 있는 질환이나 질병에 대한 사회적 신호가 질병의 확산을 조기에 감지하는데 도움을 주고 있다. 논문에서는 감기를 대상 이벤트로 지정하여 트위터로부터 수집한 정보를 감기 신호라는 사회적 신호로 간주하고 분석하였다. 추출된 감기 신호의 신뢰성을 확인하기 위해 감기 확산의 환경적 요인으로 알려진 세 가지 기후 요소와 기상청에서 제공하는 감기 기상지수와의 상관분석을 통해 변수들 사이의 상관관계를 파악한다.

Correlation of Habits and Clinical Findings with Histopathological Diagnosis in Oral Submucosal Fibrosis Patients

  • Ara, Syeda Arshiya;Arora, Vini;Zakaullah, Syed;Raheel, Syed Ahmed;Rampure, Prakash;Ashraf, Sajna
    • Asian Pacific Journal of Cancer Prevention
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    • 제14권12호
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    • pp.7075-7080
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    • 2013
  • Background: Oral submucosal fibrosis (OSMF) is one of the most prevalent premalignant conditions in India which is easy to diagnose but difficult to manage. At present it is considered as irreversible and incurable. It has also been referred to as an epidemic in India. Aims and Objectives: To correlate the frequency and duration of habits with clinical staging, functional staging and histopathological grading and to correlate the clinical and functional staging with histopathological grading. Materials and Methods: The study included a total of 90 subjects, 80 with OSMF in the experimental group and 10 patients in the control group. Patient personal history was recorded with chewing habits, including frequency and duration of chewing. The site of keeping the quid, time duration and whether he/she swallows it or spits it were also noted. Clinical staging was done on the presence of palpable fibrous bands. Functional staging was accomplished by measuring mouth opening. Incisional biopsy was done for all the patients for histopathological examination. Histopathological grading was according to Pindborg and Sirsat. Results: The experimental group comprised 71 males and 9 females, the majority of which were in the age group of 21-30 years. Correlation of habits with clinical staging, functional staging and histopathological grading were significant (p<0.05). Clinical and functional staging did not correlate with histopathological grading, but the correlation of clinical and functional staging was highly significant (p<0.01). Conclusions: The widespread habit of chewing gutkha is a major risk factor for OSMF, especially in the younger age group. In this study, it was found that with increase in the duration and frequency of the habit the severity of the disease increased.

Nano-Micelle of Moringa Oleifera Seed Oil Triggers Mitochondrial Cancer Cell Apoptosis

  • Abd-Rabou, Ahmed A;Zoheir, Khairy M A;Kishta, Mohamed S;Shalby, Aziza B;Ezzo, Mohamed I
    • Asian Pacific Journal of Cancer Prevention
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    • 제17권11호
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    • pp.4929-4934
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    • 2016
  • Cancer, a worldwide epidemic disease with diverse origins, involves abnormal cell growth with the potential to invade other parts of the body. Globally, it is the main cause of mortality and morbidity. To overcome the drawbacks of the commercially available chemotherapies, natural products-loaded nano-composites are recommended to improve cancer targetability and decrease the harmful impact on normal cells. This study aimed at exploring the anti-cancer impacts of Moringa oleifera seed oil in its free- (MO) and nano-formulations (MOn) through studying whether it mechanistically promotes mitochondrial apoptosis-mediating cell death. Mitochondrial-based cytotoxicity and flow cytometric-based apoptosis analyses were performed on cancer HepG2, MCF7, HCT 116, and Caco-2 cell lines against normal kidney BHK-21 cell line. The present study resulted that MOn triggered colorectal cancer Caco-2 and HCT 116 cytotoxicity via mitochondrial dysfunction more powerful than its free counterpart (MO). On the other side, MOn and MO remarkably induces HCT 116 mitochondrial apoptosis, while sparing normal BHK-21 cells with minimal cytotoxic effect. The present results concluded that nano-micelle of Moringa oleifera seed oil (MOn) can provide a novel therapeutic approach for colorectal and breast cancers via mitochondrial-mediated apoptosis, while sparing normal and even liver cancer cells a bit healthy or with minimal harmful effect. Intriguingly, MOn induced breast cancer not hepatocellular carcinoma cell death.