• Journal of Korean Neurosurgical Society
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• 제54권1호
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• pp.54-57
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• 2013

We report a case of 29-year-old man diagnosed as a primary eosinophilic granuloma (EG) lesion of the seventh cervical vertebra. He had paresthesia on both arms, and grasping weakness for 10 days. Cervical magnetic resonance image (MRI) showed an enhancing mass with ventral epidural bulging and cord compression on the seventh cervical vertebra. Additionally, we performed spine series MRI, bone scan and positive emission tomography for confirmation of other bone lesions. These studies showed no other pathological lesions. He underwent anterior cervical corpectomy of the seventh cervical vertebra and plate fixation with iliac bone graft. After surgical management, neurological symptoms were much improved. Histopathologic evaluation confirmed the diagnosis of EG. There was no evidence of tumor recurrence at 12 months postoperative cervical MRI follow-up. We reported symptomatic primary EG of cervical spine successfully treated with surgical resection.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제18권4호
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• pp.718-725
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• 1996

Histiocytosis X is the abnormal proliferation of histiocytes and usually a massive aggregation of eosinophilic leukocytes. The clinical features and prognosises of subclasses of histiocytosis X depend on the severity and extent of the organ involvement. The subclasses include Letterer-Siwe disease(Acute disseminated histiocytosis X), eosinophilic granuloma, Hand-Schuller-Christian disease. Letterer-Siwe disease(acute, subacute form) refers to the form of disease that is most often fatal because of the widespread skeletal, extraskeletal lesion ; this usually affects infants and children less than 3 years of age. Eosinophilic granuloma(histiocytosis X, localized) refers to a chronic form of disease with skeletal lesion ; It usually affects children and young adult. Hand-Schuller-Christian disease(chronic form) refers to a chronic form of disease with skeletal, extraskeletal lesions. It usually affects children over the age of 3 years. In our hospital, 8 year old female patient visited complaining of hard swelling of mandibule body, left side and 6 year old female patient visited complaining of painful swelling of mandibular angle, right side. We diagnosed eosinophilic granuloma and curetted the lesiones and refered to Dept. pediatrics for chemotherapy. We present 2 cases to you with literatures.

• 한국임상수의학회지
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• 제39권4호
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• pp.192-196
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• 2022

A two-year-old, intact male, 45 kg Doberman Pinscher was referred with dermal nodular lesions affecting the left hindlimb. The cytological examination revealed eosinophilic inflammation. Skin biopsy specimens showed canine eosinophilic granuloma (CEG). The dog was administered oral prednisolone (1.5 mg/kg/day) and azathioprine (2 mg/kg/day). After one week, the skin lesions diminished dramatically, but the dog presented with severe watery diarrhea. The prednisolone dose was reduced by 0.9 mg/kg/day. The lesions and diarrhea improved markedly after one week. Prednisolone was tapered by 25% of the previous dose every week to 0.2 mg/kg/day. Azathioprine was also reduced to therapy every other day. After seven weeks of combination treatment, the medications were withdrawn, but the dog had a recurrence one week later. Azathioprine (2 mg/kg/EOD) was reintroduced for two weeks. There was no relapse after all the medications had been withdrawn. This case indicates that CEG can be managed with prednisolone and azathioprine. Azathioprine may be an effective adjunctive immunosuppressive agent, and may be considered as a well-tolerated prednisolone sparing agent to treat CEG.

• Tuberculosis and Respiratory Diseases
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• 제39권2호
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• pp.186-193
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• 1992

호흡곤란을 호소한 2명의 젊은 남자에서 개흉폐조직 검사로 폐호산구성육아종으로 확진후 문헌 고찰과 함께 보고하는 바이다.

• Tuberculosis and Respiratory Diseases
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• 제45권2호
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• pp.421-428
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• 1998

기흉과 미만성 간질성 폐질환의 소견을 보인 흡연력이 없는 젊은 여자 환자에서 개흉 폐생검후 면역조직화학염색을 통하여 폐 호산구성 육아종을 진단한 1예를 경험하였기에 보고하는 바이다.

• 대한두개안면성형외과학회지
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• 제10권1호
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• pp.37-39
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• 2009

Purpose: Langerhans cell histiocytosis is a heterogenous group of Langerhans cell proliferative disorders and includes eosinophilic granuloma, Letterer-Siwe diseases, and Hand-Schuller Christian disease. We report a case of eosinophilic granuloma on frontal area. Methods: A 17-year-old male presented with swelling and tenderness on Lt. frontal and periorbital area. CT and MRI showed a $33{\times}25mm$ sized mass that involved Lt. frontal calvarium, frontotemporal meninges, and orbital roof. Results: Total excision of the mass and adjacent soft tissue, calvarium, and orbital roof was performed. Orbital roof defect was reconstructed with absorbable plate and calvarial defect was done with outer cortex of temporal bone flap. The histology revealed proliferation of histiocytes and eosinophils. Immunologically, these histiocytic cells expressed S-100 protein and CD1a. The patient is currently taking conservative treatment. Conclusion: The severity of these disease and their prognosis and treatments are various. For unifocal cranial Langerhans cell histiocytosis, complete excision is the treatment of choice. We report this case with review of literature.

• Parasites, Hosts and Diseases
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• 제61권3호
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• pp.292-297
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• 2023

Extra-gastrointestinal anisakidosis is rare. We herein report an Anisakis pegreffii infection in a patient with hepatic anisakidosis diagnosed based on its molecular identification. A 71-year-old male patient had a hepatic tumor presenting as a low-density area of 20 mm in diameter in segment 6 of the liver on abdominal ultrasonography, computed tomography, and magnetic resonance imaging. The surgically resected pathological specimen revealed a necrotizing eosinophilic granuloma containing nematode larvae, possibly an Anisakis larva. Molecular and phylogenetic analysis demonstrated Anisakis larvae belonging to A. pegreffii. The present results will help identify and characterize unknown Anisakis species in histological sections.

• Journal of Chest Surgery
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• 제34권6호
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• pp.506-510
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• 2001

Langerhans 세포 조직구증(LCH, Langerhans\` Cell Histiocytosis)은 Langerhans\` cell histiocyte의 이상 증식을 특징으로 하는 원인 불명의 질환이다. 이 질환은 eosinophilic granuloma, Hand-Sch ller-Christian씨 병, Letterer-Siwe병을 포함하는 것으로 과거에는 histiocytosis X로 불리던 질환이다. 피부, 림프절, 골, 골수 및 체내 모든 조직과 기관을 침범할 수 있으나 국내에서 흉벽에서 발생된 예는 보고된 증례가 많지않다. 18개월 된 남자 환아에서 흉벽의 늑골에서 기원하여 골용해 소견을 동반한 종괴가 있어 수술적 절제한 후 LCH로 확진된 증례가 있어 문헌고찰과 함께 보고하는 바이다

• 한국임상수의학회지
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• 제30권6호
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• pp.478-481
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• 2013

18살의 암컷 푸들의 구강에서 종괴가 발견되었다. 육안적으로, 종괴는 단단하고, 적자색을 띠었으며, 크기는 $1.5{\times}1.5{\times}1cm$ 였다. 조직병리학적으로 종괴는 과증식된 잇몸 상피와 혈관이 잘 발달된 기질로 구성되어 있었으며, 다형 세포 및 퐁부한 호산성 세포질과 다수의 핵을 가진 많은 수의 거대 세포가 관찰되었다. 면역조직화학적으로, 종양 세포는 alkaline phosphatase와 cytokeratin 7에 양성 반응이었지만, CD68에 음성 반응이었다. 종괴는 전형적인 임상적, 조직병리학적인 특징에 의해 구강내 거대세포 치은종으로 진단되었다.

• Journal of Chest Surgery
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• 제36권7호
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• pp.539-543
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• 2003

Langerhans 세포 조직구증은 과거에 조직구증 X로 불려진 질환으로서, 국소적 혹은 전신증상을 나타내며 비특이적인 조직구 증식을 특징으로 하는 질환군을 일컫는 말이다. 이 질환의 원인과 병리 기전은 아직 밝혀지지 않았으며, 호산구성 육아종, Hand-Shuller-Christian병, Letterer-Siwe병으로 대별되는 세 가지 질환 군에서 기본적인 병리학적 소견은 동일하다. 주로 어린 나이에 발생하나 어른에서도 발생한다. 저자들은 성인에서 늑골에 발생한 호산구성 육아종을 2예 치험하였다. 한 예는 요붕증을 동반하였고 다른 한 예는 늑골에만 발생한 경우였다.