• Title/Summary/Keyword: EoI

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Determination and Ethylene Oxide(EO) Separation of Polysorbates by RP-HPLC (역상 HPLC에 의한 polysorbates의 산화에틸렌(EO) 분리 및 정량분석)

  • Lee, Yong-Hwa
    • Journal of the Korean Applied Science and Technology
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    • v.29 no.4
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    • pp.585-593
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    • 2012
  • The EO separation and quantitative determination of polysorbate 20, polysorbate 40, polysorbate 60 and polysorbate 80 was carried out by reversed phase HPLC. The water/acetonitrile was used for the mobile phase of gradient conditions. An YMC Pack Ph ($250mm{\times}4.6mm$ i.d., $5{\mu}m$) and Phenomenex C4 ($250mm{\times}4.6mm$ i.d., $5{\mu}m$) and the selected ELSD detector was applied. The analysis results of HPLC showed good linearity with correlation coefficient of $r^2$=0.997 in the rage of $180.2{\sim}980.5{\mu}g/mL$ and detection limit.

Effect of Salt Concentration on Electrolyte Membranes for Dye Sensitized Solar Cells (염료감응형 태양전지를 위한 고분자 전해질막에서의 이온농도의 효과)

  • Kwon, So-Young;Yun, Mi-Hye;Cho, Doo-Hyun;Jung, Yoo-Young;Koo, Ja-Kyung
    • Membrane Journal
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    • v.21 no.3
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    • pp.213-221
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    • 2011
  • Using poly(ethylene oxide) (PEO) as a polymer host, poly(ethylene glycol) (PEG) as a plasticizer, potassium iodide and iodine as sources of $I^-/I_3^-$, polymer electrolyte membranes were prepared. Based on the polymer electrolytes, solid-state dye-sensitized solar cell (DSSC)s were fabricated. The content of PEG in the electrolyte was controlled to be 95%. The mole number of KI per 1 mole of EO ([KI]/[EO] ratio) in the electrolyte was changed to be 0.022, 0.044, 0.066 and 0.088. The electrolyte membrane showed wax phase in ambient temperature. The ionic conductivity increased with increasing KI content to reach the maximum value at which [KI]/[EO] ratio is 0.066. After the maximum value, the ionic conductivity decreased with increasing KI content. In the case of DSSC, the Voc decreased continuously with increasing KI content in the polymeric electrolyte membrane. The $J_{SC}$ increased with increasing KI content to show maximum value at which [KI]/[EO] ratio is 0.044. In the higher KI content region, $J_{SC}$ value decreased with increasing KI content.

Different Protein Expression between Human Eosinophilic Leukemia Cells, EoL-1 and Imatinib-resistant EoL-1 Cells, EoL-1-IR

  • Sung, Kee-Hyung;Kim, In-Sik;Lee, Ji-Sook
    • Biomedical Science Letters
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    • v.24 no.4
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    • pp.426-429
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    • 2018
  • Chronic eosinophilic leukemia (CEL) is characterized by eosinophilia and organ damage. Imatinib is widely used for treating CEL, chronic myeloid leukemia (CML) and acute myeloid leukemia (AML). Unfortunately, the cancer cells gain resistance against the drug after prolonged molecular-targeted therapies. Imatinib-resistant EoL-1 (EoL-1-IR) cells were produced from chronic eosinophilic leukemia cells (EoL-1) after treatment with imatinib for a long duration. Two-dimensional electrophoresis (2-DE) analysis revealed numerous protein variations in the EoL-1 and EoL-1-IR sub-types. Compared to the EoL-1 cells, expression levels of TIP49, RBBP7, ${\alpha}$-enolase, adenosine deaminase, C protein, galactokinase, eukaryotic translation initiation factor, $IFN-{\gamma}$, and human protein homologous to DROER were increased, whereas core I protein, proteasome subunit p42, heterogeneous ribonuclear particle protein, chain B, and nucleoside diphosphate were decreased in the EoL-1-IR cells. Taken together, these results contribute to understanding the pathogenic mechanism of drug-resistant diseases.

Three-axis Spring Element Modeling of Ball Bearing Applied to EO/IR Camera and Structural Response Analysis of EO/IR Camera (EO/IR 카메라에 적용된 볼 베어링의 3축 스프링 요소 모델 및 EO/IR 카메라의 구조 응답해석)

  • Cho, Hee-Keun;Rhee, Ju-Hun;Lee, Jun-Ho
    • Journal of the Korean Society for Aeronautical & Space Sciences
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    • v.39 no.12
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    • pp.1160-1165
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    • 2011
  • This study is focused on the structural dynamic responses, i.e., vibration analysis results of the high-accuracy observation multi-axial camera, which is installed and operated for the UAV (Unmanned Aerial Vehicle) and helicopter etc. And, the authors newly suggest a modeling technology of the ball bearing applied to the camera by using three-axis spring elements. The vibration analysis results well agreed to the randum vibration test results. Also, the vibration responses characteristics of the multi-axial camera through the time history analysis of the random vibration were analyzed and evaluated. The above results can be applied to the FE-modeling of the ball bearings used for the space cameras.

Anti-inflammatory Activities of Chopi (Zanthoxylum piperitum A.P. DC) Essential Oil: Suppression of the Inducible Nitric Oxide Synthase and Cellular Adhesion

  • Lee, Je-Hyuk;Chang, Kyung-Mi;Kim, Gun-Hee
    • Food Science and Biotechnology
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    • v.18 no.6
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    • pp.1371-1378
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    • 2009
  • The aim of this study is to elucidate the anti-inflammatory activities of chopi (Zanthoxylum piperitum A.P. DC.) essential oil. Essential oil (EO) of chopi was extracted by steam distillation method, and its major constituents were limonene and geranyl acetate. Chopi-EO decreased approximately 38% of nitrite production, as compared to the lipopolysaccharde (LPS)-induced nitrite production. However, chopi-EO and its components did not quench nitric oxide (NO) chemically in cellfree system, and markedly inhibited approximately 40.4% of inducible nitric oxide synthase (iNOS) mRNA transcription. In addition, the inhibition of E-selectin gene transcription by chopi-EO caused the suppression of cellular adhesion. These results suggest that chopi-EO may exert potential anti-immunological inflammatory activity.

Electrochemical Properties of PVdF Gel Polymer Electrolyte with Plasticizer for Lithium/sulfur Battery (리튬 유황 전지용 PVdF 겔 고분자 전해질의 가소제에 따른 전기화학적 특성 평가)

  • Ryu, Ho-Suk;Kim, Jong-Seon;Kim, Dong-Ju;Kim, Dong-Yeon;Kim, Ic-Pyo;Ahn, Hyo-Jun;Kim, Ki-Won;Ahn, Jou-Hyeon;Lee, Gun-Hwan
    • Journal of the Korean Electrochemical Society
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    • v.10 no.3
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    • pp.213-218
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    • 2007
  • In order to find out proper PVdF gel polymer electrolyte for Li/S battery, we investigated PVdF gel polymer electrolytes with various glyme type plasticizer such as polyglyme, tetraglyme, triglyme. The organic solvents as triglyme, tetraglyme, polyglyme (Mn = 250, 500) has different chain length of ethylene oxide(EO) in solvent of glyme system. ionic conductivity decreased as increasing chain length of EO in plasticizers. Ionic conductivity of PVdF gel electrolyte with tetraglyme, triglyme, polyglyme (Mn = 250, 500) at room temperature was $5{\times}10^{-4},\;3{\times}10^{-4},\;6{\times}10^{-5},\;3{\times}10^{-5}\;S/cm$, respectively. Li/S cell with PVdF gel polymer electrolyte using tetraglyme plasticizer had low interfacial resistance and the highest initial discharge capacity of 1232 mAh/g of active sulfur, which was about 70% utilization of theoretical value.

A Study on the Spiritual Formation Process of Modern Christian Women : Focusing on Hwang Ester and Eo Yoon Hee (근대 여성기독교인의 영성형성과정 연구 : 황에스터와 어윤희를 중심으로)

  • Kim, Hee Young
    • Journal of Christian Education in Korea
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    • v.64
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    • pp.369-407
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    • 2020
  • This article studies the spiritual formation of modern Christian women in the cases of Hwang Ester and Eo Yoon-Hee. I take McGrath's definition of Christian spirituality as my starting point, namely, "Christian spirituality concerns the queset for a fulfilled and authentic Christian existence, involving the bringing together of the fundamental ideas of Christianity and the whole experience of living on the basis of and within the scope of the Christian faith." I center the terms of Christian existence and whole experience of living from McGrath's text, and understand Christian existence to relate to being a disciple and whole experience of living to relate to being a citizen. This study looks at the life history of Hwang Ester and Eo Yun-Hee, and looked at the spirituality of these women with the focus on discipleship and citizenship. Thus, I find that, for modern Christian women, becoming a disciple is inseparable from becoming a citizen. Also, I can see that, in modern women's spirituality, being a true disciple leads to becoming a right citizen.

Monocyte Chemoattractant Protein-1 (MCP-1)/CCL2 Induces the Chemotactic Activity of Human Eosinophils

  • Lee, Ji-Sook;Kim, In-Sik
    • Biomedical Science Letters
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    • v.14 no.3
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    • pp.199-201
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    • 2008
  • Eosinophil is an improtant leukocyte in the development of various inflammatory diseases. Monocyte chemoattractant protein-1 (MCP-1) acts as a key regulator on monocyte movement, and activation of T cells and NK cells. However, the role of MCP-1 in eosinophils remains to be solved. In the present study, we examined the effect of MCP-1 on eosinophil migration, using human eosinophilic EoL-1 cells as an in vitro model of eosinophils. The surface expression of CCR2 in EoL-1 cells was little detected but MCP-1 strongly induced EoL-1 cell migration in a dose-dependent manner. Increased chemotactic activity due to MCP-1 was blocked by pertussis toxin, a $G_i/G_o$ protein inhibitor and U73122, a phospholipase C (PLC) inhibitor. These results suggest that MCP-1 activates $G_i/G_o$ protein and PLC and this signal pathway is involved in eosinphil movement. This finding supports the elucidation of pathogenic mechanism of eosinophilic inflammation such as asthma and atopic dermatitis.

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Magnetic Exchange Interactions in a 2D Grid-like Copper(II) Polymer with Bridging End-on Cyanato and Pyrazine Ligands: A DFT Study

  • Kang, Dae-Bok
    • Bulletin of the Korean Chemical Society
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    • v.31 no.6
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    • pp.1704-1710
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    • 2010
  • The structure of a 2D grid-like copper(II) complex [Cu$(NCO)_2$(pyz)](pyz=pyrazine) (1) consists of 1D chains of Cu-pyz units connected by double end-on (EO) cyanato bridges. Each Cu(II) ion has a distorted octahedral coordination, completed by the four EO cyanato and two pyrazine ligands. Magnetic interactions through EO cyanato and pyrazine bridges in 1 are discussed on the basis of DFT broken-symmetry calculations at the B3LYP level. For model dicopper(II) complexes I (bridged by cyanato) and II (bridged by pyrazine), electronic structure calculations reproduce very well the experimental couplings for the S = 1/2 ferromagnetic and antiferromagnetic exchange-coupled 2D system: the calculated exchange parameters J are +1.25 $cm^{-1}$ and -3.07 $cm^{-1}$ for I and II, respectively. The $\sigma$ orbital interactions between the Cu $x^2-y^2$ magnetic orbitals and the nitrogen lone-pair orbitals of pyrazine are analyzed from the viewpoint of through-bond interaction. The energy splitting of 0.106 eV between two SOMOs indicates that the superexchange interaction should be antiferromagnetic in II. On the other hand, there are no bridging orbitals that efficiently connect the two copper(II) magnetic orbitals in I because the HOMOs of the basal-apical NCO bridge do not play a role in the formation of overlap interaction pathway. The energy separation in the pair of SOMOs of I is calculated to be very small (0.054 eV). This result is consistent with the occurrence of weakly ferromagnetic properties in I.