Biomedical Science Letters (대한의생명과학회지)
- Volume 14 Issue 3
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- Pages.199-201
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- 2008
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- 1738-3226(pISSN)
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- 2288-7415(eISSN)
Monocyte Chemoattractant Protein-1 (MCP-1)/CCL2 Induces the Chemotactic Activity of Human Eosinophils
- Lee, Ji-Sook (Department of Biology, College of Natural Sciences, Daejeon University) ;
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Kim, In-Sik
(Department of Biomedical Laboratory Science, School of Medicine, Eulji University)
- Published : 2008.09.30
Abstract
Eosinophil is an improtant leukocyte in the development of various inflammatory diseases. Monocyte chemoattractant protein-1 (MCP-1) acts as a key regulator on monocyte movement, and activation of T cells and NK cells. However, the role of MCP-1 in eosinophils remains to be solved. In the present study, we examined the effect of MCP-1 on eosinophil migration, using human eosinophilic EoL-1 cells as an in vitro model of eosinophils. The surface expression of CCR2 in EoL-1 cells was little detected but MCP-1 strongly induced EoL-1 cell migration in a dose-dependent manner. Increased chemotactic activity due to MCP-1 was blocked by pertussis toxin, a