• 제목/요약/키워드: Enyne

검색결과 13건 처리시간 0.018초

항암작용 가능성이 있는 10-Membered Enediyne의 선구물질인 14-Membered Phenylthio Enediyne Lactone의 합성 (Synthesis of 14-Membered Phenylthio Enediyne Lactone : A Precursor of the Potential Enediyne Antitumor Antibiotics)

  • 김기동
    • 대한화학회지
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    • 제39권2호
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    • pp.103-110
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    • 1995

  • 본 연구에서는 항암제로서의 가능성이 있는 10-membered enediyne(6)의 선구물질로 사용될 수 있는 14-membered phenylthio enediyne lactone을 성공적으로 합성할 수 있었다. 14-membered lactone은 Ireland-Clasisen rearrangement에 의해 10-membered enediyne(11)으로 변환되며 이물질(11)은 최종물질(8)로 전환될 수 있을 것으로 예상된다. 이 14-membered enediyned lactone(23)은 DCC/PTSA/Pyridine 하에 enediyne hydroxyl acid(22)의 락톤화 반응에 의해 합성되었다. Enediyne hydroxyl acid는 Pd(0) 촉매하에 methyl pentynoate(19)와 enyne alcohol(17)을 cis-1,2-dichloroethylene과 연속적으로 coupling 반응을 하여 좋은 수득율로 얻을 수 있었다. 그 때 필요한 enyne alcohol(17)은 vinyltin(12)을 출발물질로 하여 성공적으로 얻을 수 있었다.

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Synthesis of Cyclohexene Derivatives from 1,5-Enynes via Gold-Catalysis and Iodocyclization: A Comparative Study and Applications in the Synthesis of 7/5- or 8/5-Fused Rings and Biaryls

  • Lee, Young-Un;Lim, Choong-Min;Kim, Sung-Hwan;Shin, Seung-Hoon
    • Bulletin of the Korean Chemical Society
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    • 제31권3호
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    • pp.670-677
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    • 2010

  • A comparative study on the Au(I)-catalyzed and IBr-promoted tandem cyclization of 1,5-enyne was reported. This study provides a meaningful mechanistic insight to the concerted nature of this tandem reaction and also provides interesting applications in the synthesis of 7/5- or 8/5-fused bicycles and biaryls.

  • https://doi.org/10.5012/bkcs.2010.31.03.670 인용 PDF KSCI

Formation and Properties of Enyne Radical Cation

  • Kim, Bang-Duk;Shim, Sang-Chul;Noboyuki Ichinose;Sachiko Tojo;Tetsuro Majima
    • Journal of Photoscience
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    • 제8권2호
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    • pp.67-69
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    • 2001

  • Radical cations of DPBEY and PPCB were generated by ${\gamma}$-radiolysis and pulse radiolysis in halogenated solvents. The radical cation PPCB+ shows 505 (shoulder) and 520 nm absorption peaks with 700 ns lifetime in agreement with the laser flash photolysis work and strongly support the exciplex mechanism proposed for the photoreaction of PPCB and dimethylfumarate.

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