• Journal of Environmental Science International
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• v.22 no.10
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• pp.1273-1278
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• 2013

Novel rhodamine 6G fluorescent chemosensors 1 and 2 for the detection of transition metal cations were synthesized through the condensation of rhodamine 6G ethylenediamine with each of 2-hydroxy-1-naphthaldehyde and 2,6-pyridinedicarbaldehyde, respectively. 1 and 2 were characterized using $^{13}C$ NMR, $^1H$ NMR and mass spectroscopy. Fluorometric and colorimetric measurements involving various metal ions revealed the ring opening of the rhodamine 6G spirocycle framework. In the absence of metal cations, 2 was colorless and non-fluorescent, whereas the addition of metal cations ($Hg^{2+}$ and others) changed the color to pink, accompanied by the appearance of an orange fluorescence. The chemosensors exhibited high selectivity for $Hg^{2+}$ over other divalent first-row transition metals. The complexes of $Hg^{2+}$ with 1 and 2 were successfully isolated. A huge enhancement in the fluorescence for both one- and two-photon excitations makes these compounds suitable candidates to be used for fluorescent labeling of biological systems.

• Environmental Mutagens and Carcinogens
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• v.19 no.1
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• pp.56-62
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• 1999

Resveratrol (3,5,4'-trihydroxy-trans-stilbene) has been considered to be as one of major antioxidants present in grapes responsible for beneficial effects of red wine consumption on coronary heart disease. This triphenolic stilbene has been suggested as a potential cancer chemopreventive agent based on its striking inhiitory effects on diverse cellular events associated with tumor initiation, promotion, and progression. The compound has strong antioxidative and anti-inflammatory activities which amy contribute to its chemopreventive/chemoprotective properties. In the present work, we have found that resveratrol reduces viability and DNA synthesis capability of cultured human promyelocytic leukemia (HL-60) cells. Likewise, the viability of human breast cancer cell line, MCF-7 was reduced by resveratrol treatment. The growth inhibitory and antiproliferative properties of resveratrol appear to be associated with its induction of apoptotic cell death as determined by morphological and ultrastructural changes, agarose gel electrphoretic analysis of internucleosomal DNA fragmentation, and in situ terminal end-labeling of fragmented DNA (TUNEL). This compound also inhibited the phorbol ester-induced expression of cyclooxygenase-2 (COX-2) protein in immortalized human mammary epithelial MCF-10A cells. These results suggest that resveratrol has the promising cancer therapeutic/chemopreventive potential.

• Journal of the East Asian Society of Dietary Life
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• v.20 no.4
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• pp.628-638
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• 2010

This study examined the current status of caution labels on cooking utensils made from plastics or glass, toward suggesting improvements in labeling for consumer's safe use. Distributors were categorized into four types, plastic kitchen utensils were categorized into seven types according to usage, and glass kitchen utensils were categorized into two types. Generally, the percentage of cooking utensils made from plastics or glass that have caution labels were not high. For the types of labels on cooking utensils made from plastic and glass, stickers were the most frequently used, and of these, a high percentage scored "fair" in label perception. On the basis of these results, regulations are needed to strengthen caution labels for kitchen utensils.

• Korean Journal of Organic Agriculture
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• v.20 no.2
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• pp.161-172
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• 2012

This study was carried out to estimate carbon footprint and to establish of LCA of garlic production system. We have case study in cultivate garlic 1 kg calculate in carbon footprint. LCA carried out to estimate carbon footprint and to establish of LCI (life cycle inventory) database of garlic production system. The data is from Research of Farmer's income in 2010 (RDA, 2011), and used Pass (5.0.0) program. The value of fertilizer, amount of pesticide input were shown the environmental effect and direct emission. Carbon footprint in agriculture guarantees the choice right the consumer to choose the lower carbon goods. Its can make to strengthen of agriculture and food industry's reduction effort of $CO_2$. Nowadays consumer requests food's safety and environment friendly process. Carbon footprint also needs consumer's relief and incentives.

• Korean Journal of Organic Agriculture
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• v.19 no.3
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• pp.291-308
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• 2011

This study was carried out to estimate carbon footprint and to establish of LCA of cherry-tomato production system. I have case study in cultivate cherry tomato (1 kg) calculate in carbon foot print. LCA carried out to estimate carbon foot print and to establish of LCI (life cycle inventory) database of cherry tomato production system. The data is from Research of Farmer's income in 2007 (RDA, 2008), and used Pass (4.1.3) program. The value of fertilizer, amount of pesticide input were show the environmental effect and direct emission. Carbon foot printing in agriculture guarantee the choice right th consumer th choose the row carbon goods. Its can make to strengthen of agriculture and food industry's reduction effort of $CO_2$. Nowadays consumer request food's safety and environment friendly process. Carbon foot printing needs consumer's relief and incentives.

• Proceedings of the KSRS Conference
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• 1999.11a
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• pp.439-442
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• 1999

It is important to analyze the seasonal change profiles of land cover type in large scale for establishing preservation strategy and environmental monitoring. Because the NOAA-AVHRR data sets provide global data with high temporal resolution, it is suitable for the land cover classification of the large area. The objectives of this study were to classify land cover of Korea, to investigate the phenological profiles of land cover. The NOAA-AVHRR data from Jan. 1998 to Dec. 1998 were received by Korea Ocean Research & Development Institute(KORDI) and were used for this study. The NDVI data were produced from this data. And monthly maximum value composite data were made for reducing cloud effect and temporal classification. And the data were classified using the method of supervised classification. To label the land cover classes, they were classified again using generalized vegetation map and Landsat-TM classified image. And the profiles of each class was analyzed according to each month. Results of this study can be summarized as follows. First, it was verified that the use of vegetation map and TM classified map was available to obtain the temporal class labeling with NOAA-AVHRR. Second, phenological characteristics of plant communities of Korea using NOAA-AVHRR was identified. Third, NDVI of North Korea is lower on Summer than that of South Korea. And finally, Forest cover is higher than another cover types. Broadleaf forest is highest on may. Outline of covertype profiles was investigated.

• Journal of Environmental Health Sciences
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• v.47 no.5
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• pp.462-471
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• 2021

Background: The number of synthesized chemicals has rapidly increased over the past decade. For many chemicals, there is a lack of information on toxicity. With the current movement toward reducing animal testing, the use of toxicity big data and deep learning could be a promising tool to screen potential toxicants. Objectives: This study identified potential chemicals related to reproductive and estrogen receptor (ER)-mediated toxicities for 1135 cleaning products and 886 laundry products. Methods: We listed chemicals contained in cleaning and laundry products from a publicly available database. Then, chemicals that potentially exhibited reproductive and ER-mediated toxicities were identified using the European Union Classification, Labeling and Packaging classification and ToxCast database, respectively. For chemicals absent from the ToxCast database, ER activity was predicted using deep learning models. Results: Among the 783 listed chemicals, there were 53 with potential reproductive toxicity and 310 with potential ER-mediated toxicity. Among the 473 chemicals not tested with ToxCast assays, deep learning models indicated that 42 chemicals exhibited ER-mediated toxicity. A total of 13 chemicals were identified as causing reproductive toxicity by reacting with the ER. Conclusions: We demonstrated a screening method to identify potential chemicals related to reproductive and ER-mediated toxicities utilizing chemical toxicity big data and deep learning. Integrating toxicity data from in vivo, in vitro, and deep learning models may contribute to screening chemicals in consumer products.

• Proceedings of the Korean Environmental Health Society Conference
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• 2005.06a
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• pp.240-248
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• 2005

To implement a globally harmonized system of classification and labeling of chemicals (GHS) in Korea, an interminsterial GHS working group involving 6 ministries established an expert working group composed of 7 experts from relevant organizations and one private consultant to prepare an officialKorean GHS version by March, 2005. As such, the translation and review of the official Korean GHS version, including annexes, started in October, 2004 and was completed on March 15, 2005. The official Korean GHS version has now been posted on the websites of the relevant ministries and organizations to solicit public opinions. The official Korean GHS version will be finalized after a public hearing scheduled forMay, 2005. Collaborative efforts as regards implementing and disseminating the GHS in Korea will be continued to avoid any confusion or duplication and for effective use of resources. The globally harmonized system of classifying and labeling chemicals (GHS) was originally adopted in 1992 at the United Nations Conference on Environment and Development (UNCED), as subsequently reflected in Agenda 21 chapter 19. The work was coordinated and managed under the auspices of the Interorganization Programme for the Sound Management of Chemicals(IOMC) Coordinating Group for the Harmonization of Chemical Classification Systems (UNCEGHS). The technical focal points for completing the work were the International Labour Organization (ILO); Organization for Economic Cooperation and Development (OECD); and United Nations Economic and Social Council's Subcommittee of Experts on the Transport of Dangerous Goods (UNSCETDG). The work was finalized in October 2002, and the World Summit on Sustainable Development in Johannesburg on 4 September 2002 encouraged countries to implement the new GHS as soon as possible with a view to having the system fully operational by 2008 (UN, 2003). Implementation has already started with pilot countries introducing the system to their national practices in different regions of the world. The GHS text, called the purple book, becameavailable as a W publication in early 2003. The GHS text, called the purple book, becameavailable as a UN publication in early 2003. The GHS system will be kept dynamic, and regularly revised and made more efficient as experience is gained in its implementation. While national or regional governments are the primary audiences for this document, it also contains sufficient context and guidance for those in industry who will ultimately be implementing the national requirements that will be introduced (UN, 2003). The Japanese government published their official Japanese GHS version, the first in Asia, in April 2004 after starting work in January 2003 based on an interministerial chemical coordination committee involving 7 ministries, including the Ministry of Foreign Affairs, Ministry of Internal Affairs and Communications, Ministry of Health, Labour, and Welfare, Ministry of Agriculture, Forestry and Fisheries, Ministry of Economy, Trade and Industry, Ministry of Land, Infrastructure, and Transport, and Ministry of Environment (MOE, 2004). Accordingly, similar to the Japanese GHS efforts, this paper presents the interministerial efforts involved in publishing the official Korean GHS version.

• Korean Journal of Environmental Biology
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• v.17 no.3
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• pp.263-270
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• 1999

In order to identify the morphological changes of tissues in mouse after irradiation. We have observed the redistribution of LDH isozymes and the morphological changes of skeletal muscle, heart, kidney, liver and testis in mouse according to variation amount with the time after the 1 Gray and 3 Gray irradiation each. As a result of H-E (hematoxylin-eosin) stain, the apoptotic bodies were more easily observed in the liver than the other tissues and the quantity of the apoptotic bodies was proportionated to radiation amount. The number of apoptotic bodies was shown the highest at 1 day in most tissues and at 7 day in testis after irradiation. TUNEL (terminal deoxyribonucleodtidyl transferase-mediated dUTP-digoxigenin nick end labeling) staining was shown the same results as H-E staining. After the irradiation, the protein content was reduced in tissues except kidney. And protein content was reduced in all tissues at the initial period of 2 hours after 3 Gy irradiation. But it increased at 7 days after irradiation. LDH (EC 1.1.1.27, lactate dehydrogenase) activity was increased mostly in tissues at the early stage after 1 Gy irradiation. The maximum activity was detected earlier stage after 1 Gy irradiation than 3 Gy irradiation. The activity of LDH $A_4$ isozyme was decreased in the skeletal muscle, heart, kidney, and testis. The activity of $B_4$ and $A_2$$B_2$ sozyme was increased in the skeletal muscle and heart, and the activity of heterotetramer isozyme was increased in kidney The activity of $A_4$ isozyme in liver was detected high level and the activity of isozyme including subunit C elevated in testis. Therefore, LDH isozyme seems to play a role of lactate oxidase in most tissues except liver after irradiation. These data support that LDH isozyme is predomintly involved in the aerobic metabolism.

• Journal of the Korea Society of Computer and Information
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• v.15 no.2
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• pp.41-46
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• 2010

In this paper, we propose a detection method of reduced computational complexity aimed at separating the moving objects from the background in a generic video sequence. In generally, indoor environments, it is difficult to accurately detect the object because environmental factors, such as lighting changes, shadows, reflections on the floor. First, the background image to detect an object is created. If an object exists in video, on a previously created background images for similarity comparison between the current input image and to detect objects through several operations to generate a mixture image. Mixed-use video and video inputs to detect objects. To complement the objects detected through the labeling process to remove noise components and then apply the technique of morphology complements the object area. Environment variable such as, lighting changes and shadows, to the strength of the object is detected. In this paper, we proposed that environmental factors, such as lighting changes, shadows, reflections on the floor, including the system uses mixture images. Therefore, the existing system more effectively than the object region is detected.