• Title/Summary/Keyword: Environmental Effect Factor

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Inhibitory Effect of Kaempferol on Apoptosis Induced by Phorbol Ester via the Reduction of ROS in Normal Human Dermal Fibroblast

  • Park, Su-Ji;Lee, Sei-Jung
    • Proceedings of the Korean Environmental Sciences Society Conference
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    • 2020.10a
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    • pp.219-219
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    • 2020
  • Kaempferol (3,4',5,7-tetrahydroxyflavone), a flavonoid found in beans, broccoli, garlic, etc., has been used in natural medicine as an anti-inflammatory and antioxidant. This experiment was carried out to evaluate the anti-apoptotic effect of kaempferol in 12-O-tetradecanoylphorbol 13-acetate (TPA)-treated Normal Human Dermal Fibroblast (NHDF). Kaempferol inhibited the production of intracellular Reactive Oxygen Species (ROS) induced by TPA in NHDF. Kaempferol significantly blocks the phosphorylation of extracellular signal-regulated kinase responsible for the activation of nuclear factor-kappa B. In addition, kaempferol significantly attenuated the expression of Bax and cleaved caspase-3 as regulated by the phosphorylation of nuclear factor-kappa B during its blockage of TPA-induced apoptotic cell death. These findings suggest that kaempferol protects the apoptotic signaling pathway induced by TPA through modulating intracellular ROS in NHDF.

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A damage mechanics based random-aggregate mesoscale model for concrete fracture and size effect analysis

  • Ni Zhen;Xudong Qian
    • Computers and Concrete
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    • v.33 no.2
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    • pp.147-162
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    • 2024
  • This study presents a random-aggregate mesoscale model integrating the random distribution of the coarse aggerates and the damage mechanics of the mortar and interfacial transition zone (ITZ). This mesoscale model can generate the random distribution of the coarse aggregates according to the prescribed particle size distribution which enables the automation of the current methodology with different coarse aggregates' distribution. The main innovation of this work is to propose the "correction factor" to eliminate the dimensionally dependent mesh sensitivity of the concrete damaged plasticity (CDP) model. After implementing the correction factor through the user-defined subroutine in the randomly meshed mesoscale model, the predicted fracture resistance is in good agreement with the average experimental results of a series of geometrically similar single-edge-notched beams (SENB) concrete specimens. The simulated cracking pattern is also more realistic than the conventional concrete material models. The proposed random-aggregate mesoscale model hence demonstrates its validity in the application of concrete fracture failure and statistical size effect analysis.

A Study on the Influencing to Satisfaction of College Life (대학생활만족에 영향을 미치는 요인에 관한 연구)

  • Lee Kong-Seob
    • Management & Information Systems Review
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    • v.18
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    • pp.223-251
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    • 2006
  • This study examines the factors that have an effect on the satisfaction of student campus life in two college. By the survey questionnaire, three factors selected from 14 questionnaire by factor analysis in the college environmental character. Those factors ware analyzed to estimate the results of this study. And the effect and type of word of mouth communication surveyed by one questionnaire respectively. The major results of this study are as follow; First, the factors that effected on satisfaction of students are the distinction of sex, the division of major field and the distinction of college. But the academic grade factor is not available, Second, the factors of tutors/curriculums and education support service effected on satisfaction of students in campus life, but the factor of education convenience facility is not. Finally, the effect and communication of word of mouth resulted in effectiveness for on satisfaction of students in campus life.

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오염집약도와 국제경쟁력의 변화: 1993~98

  • Kim, Dong-Seok
    • KDI Journal of Economic Policy
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    • v.24 no.1
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    • pp.113-190
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    • 2002
  • The purpose of this paper is to perform empirical studies on the impact of pollution intensity on international competitiveness using 1993 and 1998 data, and to estimate the change in environmental regulation level faced by the firms during 1993~1998. Collecting relevant data and providing them for further studies in the area are another purposes of the paper. The first method is the regression of various indices of international competitiveness on factor costs, such as labor, capital, R&D and pollution abatement costs. Goal of the regression analysis is to estimate the scarcity and comparative advantage effect of each production factor, especially environmental resource. Regression results show that those industries which employ more environmental resource have higher comparative advantage in both years, which implies that Korean firms are endowed with abundant environmental resource compared to other countries. The second method is to compute the relative scarcity indices(HOVL indices) of production factors, proposed by Leamer based on Vanek's generalized Hecksher-Ohlin Theorem. This method estimates the relative scarcity of production factors by computing factor costs embodied in import and export of commodities. This method shows similar results as the regression method; i.e., trade pattern of production factors implies that the manufacturing sector in Korea is endowed with abundant environmental resource compared to other countries. Considering population density, water resource endowment, intensity of economic activity per unit area and current air and water pollution levels, it is evident that Korea is never endowed with abundant environmental resource compared to other countries. Then the abundance of environmental resource revealed by the trade patterns of commodities and production factors implies that Korea's environmental regulation level is excessively generous compared to environmental capacity, and that this increased the environmental resource endowment supplied to firms and thus distorted the inter-industry comparative advantages. Both regression and HOVL methods, on the other hand, show that overall environmental regulation level faced by the firms has been strengthened during 1993~1998.

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Study on Characteristics of Corrosion Fatigue Crack Growh Rate of SUS 304 Stainlss Steel (SUS 304강의 부식피로균열 운전속도 특성에 관한 연구)

  • 임우조;김부안
    • Journal of Ocean Engineering and Technology
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    • v.1 no.2
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    • pp.93-100
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    • 1987
  • Corrosion fatigue cracking of the austenitic stainless steel(bese metal & heat affected zone by TIG weld) was studied experimentally under the environments of various specific resistance and air. The characteristics of corrosion fatigue crack growth rate and the environmental constants of paris' rule were investigated for SUS 304 weldments in the various specific resistance. The influences of stress intensity factor range and corrosion on the crack growth rate were compared. The characteristics of corrosion fatigue cracking for the weldments were inspected from mechanical, electrochemical and microstructural point of view. Main results obtained are as follows: 1) As the specific resistance decreases, the environmental constant C of paris'rule increases(hence the corrosion fatigue crack growth rate is rapid), but the environmental constant m decreases, so the effect of corrosion to the crack growth rate is more susceptible than thet of stress intensity factor range. 2) As the stress intensity factor range decreases, the corrosion fatigue crack growth rate of heat affected zone is more susceptible than that of the base metal. 3) The corrosion fatigue crack growth rate of the heat affected zone is more rapid than that of the base metal, because of the phenomenon of softening and the less noble potential coused by wedlding heat cycle. 4) The corrosion fatigue cracking of SUS 304 weldment appears transgranular fracture.

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Stability analyses of dual porosity soil slope

  • Satyanaga, Alfrendo;Moon, Sung-Woo;Kim, Jong R.
    • Geomechanics and Engineering
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    • v.28 no.1
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    • pp.77-87
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    • 2022
  • Many geotechnical analyses require the investigation of water flow within partially saturated soil zone to incorporate the effect of climatic conditions. It is widely understood that the hydraulic properties of the partially saturated soil should be included in the transient seepage analyses. However, the characteristics of dual porosity soils with dual-mode water retention curve are normally modelled using single-mode mathematical equation for simplification of the analysis. In reality, the rainwater flow can be affected significantly by the dual-mode hydraulic properties of the soil. This paper presents the variations of safety factor for dual porosity soil slope with dual-mode water retention curve and dual-mode unsaturated permeability. This paper includes the development of the new dual-mode unsaturated permeability to represent the characteristics of soil with the dual-mode water retention curve. The finite element analyses were conducted to examine the role of dual-mode water retention curve and dual-mode unsaturated permeability on the variations of safety factor under rainfall loading. The results indicate that the safety factor variations of dual porosity soil slope modelled using the dual-mode water retention curve and the unsaturated permeability equation are lower than those of dual porosity slope modelled using single-mode water retention curve and unsaturated permeability equations.

Verification of lavender(Lavandula angustifolia cv.Hidcote) and lawn(Zoysia japonica Steud.)'s Curative Effect, as a Green Space Composition Factor (녹지구성 인자로써 라벤더(Lavandula angustifolia cv.Hidcote)와 잔디(Zoysia japonica Steud.)의 치유적 효과)

  • Yutaka, Iwasaki;Kim, Yu-Yeong;Cho, Tae-Dong
    • Journal of Environmental Science International
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    • v.21 no.12
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    • pp.1487-1494
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    • 2012
  • This study has been carried out to verify curative effect of lavender and lawn, a green space composition factor. Thus, the physiological index value of blood pressure, heart rate and salivary amylase were measured with object of 16 women in their 20~30s for stress relaxation effect at lavender garden and lawn square, and impression assessment upon SD method as for psychological value was performed in this study. And a survey was conducted on necessity and reason of urban green space with object of 345 men and women urban workers. As a result of variance analysis between groups and multi test of Turkey upon object place, the blood pressure was lowered the same at lavender garden and lawn square, and especially, high blood pressure was greatly lowered to 30 mmHG at lavender garden. On the other hand, low blood pressure group showed the tendency of a little increasing at the same places. And for the pulse, there was difference between high blood pressure group and normal group at the same places. To conclude, at lavender garden and lawn square the blood pressure was made to be lowered when it's high, and when it's low, the effect of returning to sound status, the function of increasing, was verified. In case of impression assessment upon SD method, the lawn square was assessed as resting place and lavender garden diversional place. And over 90% of urban workers responded to the green space's necessity and curative effect, diversion and resting place were adopted for the reason in high-ranking items. As above the green space pattern that urban workers require and curative effect of lavender garden and lawn square were verified. Therefore, the functional green space plan is required, which curative effect, diversion and resting place are considered, for the future green space plan design.

POD-based representation of the alongwind Equivalent Static Force for long-span bridges

  • Fiore, Alessandra;Monaco, Pietro
    • Wind and Structures
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    • v.12 no.3
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    • pp.239-257
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    • 2009
  • This paper develops and discusses a method by which it is possible to evaluate the Equivalent Static Force (ESF) of wind in the case of long-span bridges. Attention is focused on the alongwind direction. The study herein carried out deals with the classical problems of determining the maximum effects due to the alongwind action and the corresponding ESFs. The mean value of the maximum alongwind displacement of the deck is firstly obtained both by the spectral analysis and the Gust Response Factor (GRF) technique. Successively, in order to derive the other wind-induced effects acting on the deck, the Gust Effect Factor (GEF) technique is extended to long-span bridges. By adopting the GRF technique, it is possible to define the ESF that applied on the structure produces the maximum alongwind displacement. Nevertheless the application of the ESF so obtained does not furnish the correct maximum values of other wind-induced effects acting on the deck such as bending moments or shears. Based on this observation, a new technique is proposed which allows to define an ESF able to simultaneously reproduce the maximum alongwind effects of the bridge deck. The proposed technique is based on the GEF and the POD techniques and represents a valid instrument of research for the understanding of the wind excitation mechanism.

An anti-clastogenic Role of Selenium in Arsenic- and Chromium-induced Oxidative Stress Causing Chromosomal Damages (비소와 크롬에 의한 산화적 스트레스와 염색체 상해에 대한 셀레늄의 방어 효과)

  • 기혜성;손은희;박영철;맹승희;정해원
    • Journal of Environmental Health Sciences
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    • v.23 no.4
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    • pp.9-15
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    • 1997
  • This experiment was carried out to examine the roles of selenium in arsenic- and chromium-induced oxidative stress, which results in chromosomal damage, such as sister chromatid exchange (SCE) and chromosomal aberration (CA). For this purpose, the frequency of CA and SCE related to the level of 0xidative stress were analyzed. Selenium decreased the frequency of CA induced by As. In order to evaluate the effect of selenium on clastogenic factors, media from As- and Cr-treated cells were ultrafiltered and added again to cells in the presence or absence of selenium. Selenium decreased the frequency of SCE by As and Cr. This observation indicates the possibility of presence of clastogenic factor. In addition, the clastogenic factor would be involed in oxidative stress since selenium decreased the level of oxidative stress. Thus, it is suggested that selenium may play a role as an anti-clastogenic effector by preventing the oxidative stress, thereby decreasing the frequency of Asand Cr-induced chromosomal damage.

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The Relationship between Stress and Leisure Satisfaction of College Student Athletes (대학 운동부 학생들의 스트레스와 여가만족과의 관계)

  • Chon, Tae-Jun
    • Journal of Wellness
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    • v.6 no.2
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    • pp.139-147
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    • 2011
  • The purpose of this study was to examine the relationship between stress and leisure satisfaction of college student athletes. The participants comprised 140 of the college student athletes. The measures were composed of stress inventory and leisure satisfaction scale. The data were analyzed by SPSS 17.0 Version frequency analysis, reliability analysis, confirmatory factor analysis, independent sample t-test, one-way ANOVA, and multiple regression analysis were performed. The level of significance was set up .05. The results were as follows: First, according to college, there was significant difference in economic burden, environmental condition, and course factor. Second, in regard with multiple regression analysis on relationships between the stress and leisure satisfaction of the college student athletes, discriminative evaluation, environmental condition, and course factor had positive effect on leisure satisfaction.