• The Bulletin of The Korean Astronomical Society
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• 제39권1호
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• pp.63.2-63.2
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• 2014

As a part of the "Dust, Ice, and Gas In Time" (DIGIT) key program on Herschel, we observed GSS30-IRS1, a Class I protostar located in Ophiuchus (d =125 pc), with Herschel/Photodetector Array Camera and Spectrometer (PACS). More than 70 lines were detected within a wavelength range from 50 ${\mu}m$ to 200 ${\mu}m$: CO lines from J = 14-13 to 41-40, several $H_2O$ lines of Eup = 100 K to 1500 K, 16 transitions of OH rotational lines, and two atomic [O I] lines at 63 and 145 ${\mu}m$. The [C II] line, known as a tracer of externally heated gas by the interstellar radiation field, is also detected at 158 ${\mu}m$. All lines, except [O I] and [C II], are detected only at the central spaxel of $9^{\prime\prime}.4{\times}9^{\prime\prime}.4$. The [O I] emission is extended along a NE-SW orientation, which is consistent with the known outflow direction, while the [C II] line is detected over all spaxels. One possible explanation of the detection of the [C II] line and no correlation of its spatial distribution with any other molecular emission is the existence of the enhanced ISRF nearby GSS30-IRS1. One interesting feature of GSS30-IRS1 is that the continuum emission is extended beyond the point-spread function (PSF), unlike the molecular line emission, indicative of significant external heating. The best-fit continuum model of GSS30-IRS1 with the physical structure including flared disk, envelope, and outflow shows that the internal luminosity is 11 $L_{\odot}$, and the region is also externally heated by a radiation field enhanced by a factor of 25 compared to the local standard interstellar field.

• Journal of Ginseng Research
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• 제46권1호
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• pp.115-125
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• 2022

Background: Ginsenosides (GS) have potential value as cosmetic additives for prevention of skin photoaging. However, their protective mechanisms against skin barrier damage and their active monomeric constituents are unknown. Methods: GS monomer types and their relative proportions were identified. A UVB-irradiated BALB/c hairless mouse model was used to assess protective effects of GS components on skin epidermal thickness and transepidermal water loss (TEWL). Skin barrier function, reflected by filaggrin (FLG), involucrin (IVL), claudin-1 (Cldn-1), and aquaporin 3 (AQP3) levels and MAPK phosphorylation patterns, were analyzed in UVB-irradiated hairless mice or HaCaT cells. Results: Total GS monomeric content detected by UPLC was 85.45% and was largely attributed to 17 main monomers that included Re (16.73%), Rd (13.36%), and Rg1 (13.38%). In hairless mice, GS ameliorated UVB-induced epidermal barrier dysfunction manifesting as increased epidermal thickness, increased TEWL, and decreased stratum corneum water content without weight change. Furthermore, GS treatment of UVB-irradiated mice restored protein expression levels and epidermal tissue distributions of FLG, IVL, Cldn-1, and AQP3, with consistent mRNA and protein expression results obtained in UVB-irradiated HaCaT cells (except for unchanging Cldn-1 expression). Mechanistically, GS inhibited JNK, p38, and ERK phosphorylation in UVB-irradiated HaCaT cells, with a mixture of Rg2, Rg3, Rk3, F2, Rd, and Rb3 providing the same protective MAPK pathway inhibition-associated upregulation of IVL and AQP3 expression as provided by intact GS treatment. Conclusion: GS protection against UVB-irradiated skin barrier damage depends on activities of six ginsenoside monomeric constituents that inhibit the MAPK signaling pathway.

• BMB Reports
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• 제40권5호
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• pp.611-616
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• 2007

$E^{rns}$ is an envelope glycoprotein of classical swine fever virus (CSFV) and has an unusual feature of RNase activity. In the present study, we demonstrate that $E^{rns}$ counteracts Newcastle disease virus (NDV)-mediated induction of IFN-$\beta$. For this purpose, $E^{rns}$ fused to the enhanced green fluorescent protein (EGFP) was transiently expressed in porcine kidney 15 (PK15) cells. In luciferase activity assay, $E^{rns}$-EGFP was found to prevent IFN-$\beta$ promoter-driven luciferase expression and block the induction of IFN-$\beta$ promoter mediated by NDV in a dose-dependent manner. Through IFN-specific semi-quantitative RT-PCR detection, obvious decrease of IFN-$\beta$ mRNA in NDV-infected PK15 cells was observed in the presence of $E^{rns}$-EGFP. In contrast, EGFP alone showed none of this block capacity. In addition, $E^{rns}$-EGFP mutations with RNase inactivation were also found to block NDV-mediated induction of IFN-$\beta$. These evidences establish a novel function for CSFV $E^{rns}$ glycoprotein in counteraction of the IFN-$\beta$ induction pathway.

• Wind and Structures
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• 제14권5호
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• pp.383-411
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• 2011

Roof is an integral part of building envelope. It protects occupants from environmental forces such as wind, rain, snow and others. Among those environmental forces, wind is a major factor that can cause structural roof damages. Roof due to wind actions can exhibit either flexible or rigid system responses. At present, a dynamic test procedure available is CSA A123.21-04 for the wind uplift resistance evaluation of flexible membrane-roofing systems and there is no dynamic test procedure available in North America for wind uplift resistance evaluation of rigid membrane-roofing system. In order to incorporate rigid membrane-roofing systems into the CSA A123.21-04 testing procedure, this paper presents the development of a load cycle. For this process, the present study compared the wind performance of rigid systems with the flexible systems. Analysis of the pressure time histories data using probability distribution function and power spectral density verified that these two roofs types exhibit different system responses under wind forces. Rain flow counting method was applied on the wind tunnel time histories data. Calculated wind load cycles were compared with the existing load cycle of CSA A123.21-04. With the input from the roof manufacturers and roofing associations, the developed load cycles had been generalized and extended to evaluate the ultimate wind uplift resistance capacity of rigid roofs. This new knowledge is integrated into the new edition of CSA A123.21-10 so that the standard can be used to evaluate wind uplift resistance capacity of membrane roofing systems.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• 제26권1호
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• pp.14-19
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• 1990

This paper describes on the characteristics of the acoustic echoes from the scattering layers by the aggregation of marine organisms which was measured by using a 50kHz echo sounder on board of the training ship SAEBADA belong to National Fisheries University of Pusan during the summer, 1989 in the East China Sea. A data acquisition system was used to record digitally the envelope of the echoes and the frequency distribution of echo amplitudes on the whole water column was examined as a function of time during the sunrise and sunset periods. Acoustic data showed that the abundance distribution of marine organisms according to depth in the servery area changed with time and that the organisms were most active during the twilight of morning, and the echo strength on the water column or scattering layer was also strongest during this time. Additional results of this survey suggest that other interest, such as the relationship between environmental conditions and biomass depth distribution, could be also investigated in hydroacoustic method.

• Journal of the Korean Institute of Educational Facilities
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• 제2권2호
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• pp.17-25
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• 1995

Because of energy crisis and environment pollution, we have become more conscious of the need to conserve heat in buildings. In response to this need. new requirements have been developed for insulation and other matters relating to energy consumption. Among others, more promising is to use the energy that is all around us in the dynamic forces of nature:the wind, tides, waves, rivers, geothermal hot spots, and the sun. The problem is that we have not been forced to find the technological means to convert these natural energies into usable forms because it has been too easy simply to dig or pump our energy out of the ground. Now, the problem is not a shortage of energy itself, but a shortage of technology for converting the energy that lies aoo around us into usable forms. Energy-conversion technology is the real issue, and solar energy is one of the brightest and most promising frontiers in energy conversion. All buildings are wrapped in a skin. Generally skins protect the person in stay from rain, wind, dust, noise, cold, hot etc.. However, there are some skins that provide energy from given environment into the building. Out of aoo, transparent insulation material is one of these materials that most effectively satisfies this kind of envelope function. Since, there are no research on transparent insulation in Korea, it has been studied very actively in Europe and in America. Thus, in this thesis, we will theoratically study and analyze how the heat flows through a trans arrent insulated opaque wall of a school building in Korea. It will be an important information for the effective using guidelines of transparent insulation materials in Korea.

• Journal of the Korean Society for Advanced Composite Structures
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• 제4권2호
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• pp.15-24
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• 2013

This project is mainly related to evaluation of total energy consumption of low energy house, the exterior envelope of which was wholly composed of structural insulated panels(SIP). The U-value of applied SIP was in the range of 0.189 to $0.269W/m^2{\cdot}K$ and the U-value of pair glass from 0.78 to $1.298W/m^2{\cdot}K$ was applied for window dependent to its function respectively. For comparison of total energy performance, the energy simulation for pilot house was performed to compare with the control house having insulation criteria of Korean building regulation in 2009. Based on simulation of dynamic energy performance, the pilot house saved 48.3% of annual energy consumption while the control house in 2009 consumed as 85.7GJ/y. In case of heating, the result showed that the energy saving ratio amounted to 76.7%. For $CO_2$ emission, the pilot house diminished approximately 35.4% from $6,208.4kgCO_2$ to $4,009.2kgCO_2$. In payback period to early investment, it was analyzed the pilot house took 7.8 years, when the low energy house built by other insulation method with same thermal perfusion took 11.5 years. From this result, it is considered that the SIP is more effective, economic to Green Home application.

• Journal of Microbiology and Biotechnology
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• 제21권5호
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• pp.483-493
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• 2011

An acid phosphatase (HppA) activated by $NH_4Cl$ was purified 192- and 34-fold from the periplasmic and membrane fractions of Helicobacter pylori, respectively. SDS-polyacrylamide gel electrophoresis revealed that HppA from the latter appears to be several kilodaltons larger in molecular mass than from the former by about 24 kDa. Under acidic conditions (pH${\leq}$4.5), the enzyme activity was entirely dependent on the presence of certain mono- and/or divalent metal cations (e.g., $K^+$,$ NH_4{^+}$, and/or $Ni^{2+}$). In particular, $Ni^{2+}$ appeared to lower the enzyme's $K_m$ for the substrates, without changing $V_{max}$. The purified enzyme showed differential specificity against nucleotide substrates with pH; for example, the enzyme hydrolyzed adenosine nucleotides more rapidly at pH 5.5 than at pH 6.0, and vice versa for CTP or TTP. Analyses of the enzyme's N-terminal sequence and of an $HppA^-$ H. pylori mutant revealed that the purified enzyme is identical to rHppA, a cloned H. pylori class C acid phosphatase, and shown to be the sole bacterial 5'-nucleotidase uniquely activated by $NH_4Cl$. In contrast to wild type, $HppA^-$ H. pylori cells grew more slowly. Strikingly, they imported $Mg^{2+}$ at a markedly lowered rate, but assimilated urea rapidly, with a subsequent increase in extracellular pH. Moreover, mutant cells were much more sensitive to extracellular potassium ions, as well as to metronidazole, omeprazole, or thiophenol, with considerably lowered MIC values, than wild-type cells. From these data, we suggest that the role of the acid phosphatase HppA in H. pylori may extend beyond 5'-nucleotidase function to include cation-flux as well as pH regulation on the cell envelope.

• Journal of Korea Water Resources Association
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• 제30권3호
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• pp.225-233
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• 1997

The nonlinear effects on the statistical properties of wave groups in terms of the average nomber of waves in a group and the mean number of waves in a high run is studied in this paper utilizing the complex envelope and total phase function, random variable transformation technique and perturbation method. It tures out that the phase distribution is modified significantly by nonlinearities and it show systematic excess of values near the mean phase and the corresponding symmetrical deficiency on both sides away from the mean. for the case of threshold crossing rate, it turns out that threshold crossing rate reaches its maxima just below the mean water level rather than zero and considerable amount of probability mass is shifted toward the larger values of water surface elevation as nonlinearity is getting profound. Furthermore, the mean waves in a high run associated with nonlinear wave are shown to have larger values than the linear counterpart. Similar trend can also be found in the average number of waves in a group.

• The Journal of the Acoustical Society of Korea
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• 제13권2E호
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• pp.20-25
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• 1994

The major drawback to the Code Excited Linear Prediction(CELP) type vocoders is their large computational requirements. In this paper, a simple method is proposed to reduce the pitch searching time in the pitch filter almost without degradation of quality. Bease upon the observational regularity of the correlation function of speech, the searching range can be restricted to the positive side in pitch search. This is done by skipping the negative side with the width which is estimated from the previous positive envelope. In addition to that, the maximum number of available lags can be limited by the threshold, $L_T$, which is set on 58 empirically. So, only the limited numbers of lags are considered in pitch search, which is less than a half of that of the full search method. By using the proposed method in pitch search, its required computations are greatly reduced. Experimental result shows 51% time reduction almost without lowering the speech quality in segmental SNR measure.