• 한국생물공학회:학술대회논문집
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• 2005.10a
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• pp.743-743
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• 2005

• Hwankyungkyoyuk
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• v.14 no.2
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• pp.95-105
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• 2001

Out-door learning activity in environmental education has been emphasized as an effective method in environmental education since the aims of environmental education emphasize students'value, attitude, actions as well as knowledge. In order to implement successfully out-door learning activity in environmental education classrooms, teachers'perceptions to environmental problems and experiences at fields are essential. An environmental education network among the metropolitan city and provincial office of education, nongovernmental organization of environmental movement and education and university was established and a teachers'in-service training program of out-door learning centered environmental education was implemented. The program was developed in order to 1) connect environmental education with the regional environmental situations, 2) provide teachers with opportunities to participate in an out-door learning program, and 3) train teachers to be environmental education leaders of out-door learning. For evaluation of the program, responses of participants to questionnaire were analyzed. Most of teachers responded that their perception of environment was changed positively after the participation in the program. This study suggested that a future planning of a teachers'in-service training program of out-door learning centered environmental education should be developed in considerations of arranging enough hours for out-door learning at regional environmental sites, applying performance assessment, providing teachers with multiple opportunities with programs in different levels including enriched programs, and establishing an environmental education network among nongovernmental organization of environment movement and education, university, and local offices and department of education.

• The Transactions of the Korea Information Processing Society
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• v.2 no.5
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• pp.733-745
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• 1995

This study is aimed at construction of a translator for a functional programming language. For this goal we define a functional programming language which has lazy semantics and develop a translator for it. The execution model selected is the G-machine-based combinator graph reduction. The translator is composed of 4 phases and translates a source program to a C program. The first phase of the translator translates a source program to a enriched lambda- calculus graph, the second phase transforms a lambda-calculus graph into supercombinators, the third phase translates supercombiantors to a G program and the last phase translates the G program to a C program. The final result of the translator, a C program, is compiled to an executable program by C compiler. The translator is implemented in C using compiler development tools such as TACC and Lex, under the UNIX environments. In this paper we present the design and implementation techniques for developing the translator and show results by executing some test problems.

• Journal of the Korea Society of Computer and Information
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• v.3 no.1
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• pp.25-34
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• 1998

There are two major method for expressing parallelim in functional languages. The one is the strictness analysis and the other the annotation. The strictness analysis is a method that a compiler detects parallelism and expresses the detected information in the object program. The annotation is a method that a programmer detects parallelism and expresses in the source program. This study is on the annotation and is aimed at construction of a translator for a functional language which has an annotation syntax. The translator translates a source program to enriched lambda-calculus graphs. The translator is implemented in C using compiler development tools such as YACC and Lex, under UNIX environments. In this paper we present the design and implementation techniques for developing the front-end of the translator.

• School Mathematics
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• v.17 no.2
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• pp.179-202
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• 2015

In this research, I explored how to apply the history of mathematics in teacher education and investigated the applicability of Chosun Sanhak (mathematics of Chosun Dynasty) as the program that enriched the mathematical knowledge for teaching of prospective elementary school teachers. This program included not only mathematical knowledge but also socio-cultural knowledge and connection knowledge. Prospective teachers participated in various mathematical activities such as explaining, reasoning and problem solving in this program. The effects of this program are as follows. Prospective teachers learned the subject matter knowledge(SMK) which was helpful in teaching basic concepts and skills of elementary mathematics. Next, this program produced the pedagogical content knowledge(PCK) to prospective teachers by giving ideas how to teach.

• Preventive Nutrition and Food Science
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• v.21 no.4
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• pp.297-309
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• 2016

Around the world, fermentation of foods has been adopted over many generations, primarily due to their commercial significance with enriched flavors and high-profile nutrients. The increasing application of fermented foods is further promoted by recent evidence on their health benefits, beyond the traditionally recognized effects on the digestive system. With recent advances in the understanding of gut-brain interactions, there have also been reports suggesting the fermented food's efficacy, particularly for cognitive function improvements. These results are strengthened by the proposed biological effects of fermented foods, including neuroprotection against neurotoxicity and reactive oxygen species. This paper reviews the beneficial health effects of fermented foods with particular emphasis on cognitive enhancement and neuroprotective effects. With an extensive review of fermented foods and their potential cognitive benefits, this paper may promote commercially feasible applications of fermented foods as natural remedies to cognitive problems.

• Microbiology and Biotechnology Letters
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• v.49 no.1
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• pp.65-74
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• 2021

Serine proteases are the most versatile proteolytic enzymes with tremendous applications in various industrial processes. This study was designed to investigate the biochemical properties, critical residues, and the catalytic potential of alkaline serine protease using in-silico approaches. The primary sequence was analyzed using ProtParam, SignalP, and Phyre2 tools to investigate biochemical properties, signal peptide, and secondary structure, respectively. The three-dimensional structure of the enzyme was modeled using the MODELLER program present in Discovery Studio followed by Molecular Dynamics simulation using GROMACS 5.0.7 package with CHARMM36m force field. The proteolytic potential was measured by performing docking with casein- and keratin-enriched residues, while the effect of the inhibitor was studied using phenylmethylsulfonyl fluoride, (PMSF) applying GOLDv5.2.2. Molecular weight, instability index, aliphatic index, and isoelectric point for serine protease were 39.53 kDa, 27.79, 82.20 and 8.91, respectively. The best model was selected based on the lowest MOLPDF score (1382.82) and DOPE score (-29984.07). The analysis using ProSA-web revealed a Z-score of -9.7, whereas 88.86% of the residues occupied the most favored region in the Ramachandran plot. Ser327, Asp138, Asn261, and Thr326 were found as critical residues involved in ligand binding and execution of biocatalysis. Our findings suggest that bioengineering of these critical residues may enhance the catalytic potential of this enzyme.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.3
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• pp.1011-1018
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• 2015

This study was conducted to investigate the plasma phosphoproteome and differential plasma phosphoproteins in cases of of Opisthorchis viverrini (OV)-related cholangiocarcinoma (CCA). Plasma phosphoproteomes from CCA patients (10) and non-CCA subjects (5 each for healthy subjects and OV infection) were investigated using gel-based and solution-based LC-MS/MS. Phosphoproteins in plasma samples were enriched and analyzed by LC-MS/MS. STRAP, PANTHER, iPath, and MeV programs were applied for the identification of their functions, signaling and metabolic pathways; and for the discrimination of potential biomarkers in CCA patients and non-CCA subjects, respectively. A total of 90 and 60 plasma phosphoproteins were identified by gel-based and solution-based LC-MS/MS, respectively. Most of the phosphoproteins were cytosol proteins which play roles in several cellular processes, signaling pathways, and metabolic pathways (STRAP, PANTHER, and iPath analysis). The absence of serine/arginine repetitive matrix protein 3 (A6NNA2), tubulin tyrosine ligase-like family, member 6, and biorientation of chromosomes in cell division protein 1-like (Q8NFC6) in plasma phosphoprotein were identified as potential biomarkers for the differentiation of healthy subjects from patients with CCA and OV infection. To differentiate CCA from OV infection, the absence of both serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform and coiled-coil domain-containing protein 126 precursor (Q96EE4) were then applied. A combination of 5 phosphoproteins may new alternative choices for CCA diagnosis.

• Women's Health Nursing
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• v.16 no.2
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• pp.105-115
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• 2010

Purpose: The purpose of this study was to determine the effects of an environmental enrichment program on barrier, benefit, confidence, and compliance of breast self-examination in women at 3 months after instruction. Methods: Nonequivalent control group pretest-posttest design was conducted among 62 healthy women. Data were collected through the self-reported questionnaires from December 2008 to March 2009. Women were assigned to one of two treatment groups: (a) no-support of environmental enrichment with the instruction control group; (b) the support of environmental enrichment with the instruction experimental group. All women received the same instruction on breast self-examination once a week for two weeks. Data were analyzed with paired t-test, McNemar test and ANCOVAs of controlling for age run using SPSS/WIN 17.0. Results: The experimental group was significantly lower than control group on perceived barrier (F=5.91, p=.02) and higher than control group on compliance of breast self-examination (F=4.57, p=.04) after environmental enrichment program. However the environmental enrichment program did not make significant differences on benefit (F=0.01, p=.91) and confidence (F=0.77, p=.38). Conclusion: Findings suggest that the environmental enrichment should be needed to support women's breast self-examination and expanded for compliance of breast self-examination to promote the secondary prevention of women breast cancer.

• Research in Community and Public Health Nursing
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• v.13 no.4
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• pp.778-785
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• 2002

Purpose: The purpose of this study was to develop a CD-ROM title for the prevention of sexual harassment and violence in middle school students. Method: The process for developing the CD-ROM title consisted of 10 steps proposed by Alessi and Trollip. Results: This CD-ROM title was composed of 4 domains, 11 subjects, and 31 detailed subjects. The 4 domains were: 1) understanding of sexual harassment and violence, 2) cases of sexual harassment and violence, 3) prevention and coping strategies, and 4) sexual knowledge. The subjects included texts, and the detailed subjects included graphics, animations, videos, and pictures. Conclusion: This CD-ROM may reduce the occurrence of sexual harassment and violence and accommodate enriched humanity in middle school students.