• Nuclear Engineering and Technology
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• v.41 no.7
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• pp.945-952
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• 2009

The Three Mile Island Unit 2 (TMI-2) accident provides unique full scale data, thus providing opportunities to check the capability of codes to model overall plant behavior and to perform a spectrum of sensitivity and uncertainty calculations. As part of the TMI-2 analysis benchmark exercise sponsored by the Organization for Economic Cooperation and Development Nuclear Energy Agency (OECD NEA), several member countries are continuing to improve their system analysis codes using the TMI-2 data. The Republic of Korea joined this benchmark exercise in November 2005. Seoul National University has analyzed the TMI-2 accident as well as the currently proposed alternative scenario along with a sensitivity study using the Modular Accident Analysis Program Version 4.03 (MAAP4.03) code in collaboration with the Korea Hydro and Nuclear Power Company. Two input files are required to simulate the TMI-2 accident with MAAP4: the parameter file and an input deck. The user inputs various parameters, such as volumes or masses, for each component. The parameter file contains the information on TMI-2 relevant to the plant geometry, system performance, controls, and initial conditions used to perform these benchmark calculations. The input deck defines the operator actions and boundary conditions during the course of the accident. The TMI-2 accident analysis provided good estimates of the accident output data compared with the OECD TMI-2 standard reference. The alternative scenario has proposed the initial event as a loss of main feed water and a small break on the hot leg. Analysis is in progress along with a sensitivity study concerning the break size and elevation.

• Hwankyungkyoyuk
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• v.12 no.1
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• pp.134-149
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• 1999

In this paper an attempt was made to establish a direction in systematizing the technical education with regard to the relation to environmental education. This study was made mainly through literature review concerning the relationship between technology and environment, and thus this study has a purpose of connecting the contents of technical education with environmental education. It will provide referential data for environmental education. The main text of this study dealt with which goal to establish in the technical education from the viewpoint of academical position considering the relationship between technical education and environmental education. Also, it dealt with the organization of contents of environmental education according to the 7th curriculum and, as a result, it reached the following conclusions: In the first place, technology and environmental education which have close relationship with each other should be considered in the developmental aspect. In the second place, technology, in any directions, affects natural environment. In the third place, environmental education should be done by the integrated approach and one of the alternatives can be through SET education including society and culture, environment, and technology all together. In the fouth place, the environmental education should be environmentally sound and developed sustainably so that the technology can be developed along with environment. One example can be found in the ecological architecture. In the fifth place, the environmental education which is a souce of technical education has its necessity in 8 aspects. In the sixth place, according to the 7th curriculum, the following can be the teaching contents which will connect technical education and environmental education: gardening, vegetable raising, planting and trimming, the future techniques, energy and transportation techniques, and so on. In the seventh place, the technical education can have seven goals concerning environment. In the eighth place, the environmental education in the technical education should be considered in the aspect of contents, of teaching and learning, of evaluation, and of the relations with subjects. In the ninth place, should be included as teaching materials of the units of technology textbooks where environment education will be dealt with.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.43 no.3
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• pp.101-111
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• 2020

Companies struggle to make their best products with high quality and service at a competitive price in global markets. However, customer needs and requirements keep changing with a variety of situations. Companies that face the changes can not stay the same and make an effort to adapt themselves to new circumstances. They would probably review the overall management system that is currently implementing to improve management efficiency. Among other things, quality might be considered to be a crucial element if they are manufacturing industries to be sustained in global markets. KSA (Korean Standards Association) is a government-affiliated organization under the Ministry of Trade, Infrastructure, and Energy. It is a Korean standards provider for quality and service industry. KSA confers national commendations for organizations, quality circles, artisans, QCEC (Quality Competitive Excellent Company), and the most honorable KNQA (Korean National Quality Award) every year. KSA established KNQA on the basis of Malcom Baldrige National Quality Award, Deming Prize, and European Quality Award. Research on quality awards shows that there are many similarities in the framework. Although KSA summarizes two factors for 13 evaluation indicators in the quality competitive excellent model of QCEC, the categorization is ambiguous to explain them according to earlier studies. We performed a deep analysis of foreign quality awards and background for KNQA and QCEC. We conducted a content analysis of KNQA and QCEC and matched evaluation items that were closely related. We proposed a quality competitiveness model with three factors, Technology, System, and Tools, summarizing 13 evaluation indicators in QCEC. Based on audit data for six years from 2012 to 2017 we carried out a confirmatory factor analysis for the proposed model by examining the model validity and fitness.

• Human Ecology Research
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• v.55 no.4
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• pp.441-450
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• 2017

Childcare related studies have focused on the characteristics of care work, policy aspects, user family satisfaction, and job satisfaction of childcare helpers. But there have been few studies on family system characteristics that support childcare givers. Thus, this study conducted on the topic, "How to characterize the family resilience of long-term childcare givers?" The subjects belong to a healthy family support center in U. City, who belong to a group with an income in the top 20 % of about 20 persons working for more than 3 years. In an interview, qualitative questions were used Walsh's family resilience. The results are as follows. First, they had economic hardship, but their family would stand together and build up a family's power based on the couple's faith. They had a family role model based on their parents' family that included inherited maternity qualities from their mother. Second, the flexibility of the family organization changed to autonomous or co-role type and the connectivity. Especially, they appear as a family's leader. Third, their family communication was active, shared-care, responsible and passionate with family affection and understanding. The conclusions results are as follows. Participants were high school graduates as well as had work experience. They were characterized by positive family energy, a family belief system, family-based resources, flexibility, connectivity, open family communication and expression skills. Therefore, it can be suggested that it is necessary to check the family's resilience during an interview for the reliable, long-term supply of human resources for childcare activities.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.20 no.10
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• pp.1895-1902
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• 2016

People and goods through the recent smart device, IoT to things and things are connected, it has emerged as the driving force of a new economic growth in the future. While conducting research of this international standardization organization in the IoT-based protocol, to the institutions and companies that belong to the standards bodies interests are different from each other, protocols have been developed also, different order, heterogeneous device interoperability has emerged is a problem that the lowering of. Therefore, in this paper, to investigate the structure of the MQTT and CoAP that are commonly used and trying to figure out the trend of low power consumption, a lightweight protocol that is suitable for IoT environment, process and standardization trends of evolution, features, analysis and on, to derive the advantages and disadvantages, and comparative analysis, it presented a development scheme for each protocol.

• Genomics & Informatics
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• v.12 no.4
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• pp.187-194
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• 2014

Metabolic syndrome (METS) is a disorder of energy utilization and storage and increases the risk of developing cardiovascular disease and diabetes. To identify the genetic risk factors of METS, we carried out a genome-wide association study (GWAS) for 2,657 cases and 5,917 controls in Korean populations. As a result, we could identify 2 single nucleotide polymorphisms (SNPs) with genome-wide significance level p-values (< $5{\times}10^{-8}$), 8 SNPs with genome-wide suggestive p-values ($5{\times}10^{-8}{\leq}$ p < $1{\times}10^{-5}$), and 2 SNPs of more functional variants with borderline p-values ($5{\times}10^{-5}{\leq}$ p < $1{\times}10^{-4}$). On the other hand, the multiple correction criteria of conventional GWASs exclude false-positive loci, but simultaneously, they discard many true-positive loci. To reconsider the discarded true-positive loci, we attempted to include the functional variants (nonsynonymous SNPs [nsSNPs] and expression quantitative trait loci [eQTL]) among the top 5,000 SNPs based on the proportion of phenotypic variance explained by genotypic variance. In total, 159 eQTLs and 18 nsSNPs were presented in the top 5,000 SNPs. Although they should be replicated in other independent populations, 6 eQTLs and 2 nsSNP loci were located in the molecular pathways of LPL, APOA5, and CHRM2, which were the significant or suggestive loci in the METS GWAS. Conclusively, our approach using the conventional GWAS, reconsidering functional variants and pathway-based interpretation, suggests a useful method to understand the GWAS results of complex traits and can be expanded in other genomewide association studies.

• Genomics & Informatics
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• v.14 no.3
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• pp.96-103
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• 2016

The influenza A (H1N1) virus, also known as swine flu is a leading cause of morbidity and mortality since 2009. There is a need to explore novel anti-viral drugs for overcoming the epidemics. Traditionally, different plant extracts of garlic, ginger, kalmegh, ajwain, green tea, turmeric, menthe, tulsi, etc. have been used as hopeful source of prevention and treatment of human influenza. The H1N1 virus contains an important glycoprotein, known as neuraminidase (NA) that is mainly responsible for initiation of viral infection and is essential for the life cycle of H1N1. It is responsible for sialic acid cleavage from glycans of the infected cell. We employed amino acid sequence of H1N1 NA to predict the tertiary structure using Phyre2 server and validated using ProCheck, ProSA, ProQ, and ERRAT server. Further, the modelled structure was docked with thirteen natural compounds of plant origin using AutoDock4.2. Most of the natural compounds showed effective inhibitory activity against H1N1 NA in binding condition. This study also highlights interaction of these natural inhibitors with amino residues of NA protein. Furthermore, among 13 natural compounds, theaflavin, found in green tea, was observed to inhibit H1N1 NA proteins strongly supported by lowest docking energy. Hence, it may be of interest to consider theaflavin for further in vitro and in vivo evaluation.

• Genomics & Informatics
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• v.14 no.3
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• pp.104-111
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• 2016

Zika virus (ZIKV) is a mosquito borne pathogen, belongs to Flaviviridae family having a positive-sense single-stranded RNA genome, currently known for causing large epidemics in Brazil. Its infection can cause microcephaly, a serious birth defect during pregnancy. The recent outbreak of ZIKV in February 2016 in Brazil realized it as a major health risk, demands an enhanced surveillance and a need to develop novel drugs against ZIKV. Amodiaquine, prochlorperazine, quinacrine, and berberine are few promising drugs approved by Food and Drug Administration against dengue virus which also belong to Flaviviridae family. In this study, we performed molecular docking analysis of these drugs against nonstructural 3 (NS3) protein of ZIKV. The protease activity of NS3 is necessary for viral replication and its prohibition could be considered as a strategy for treatment of ZIKV infection. Amongst these four drugs, berberine has shown highest binding affinity of -5.8 kcal/mol and it is binding around the active site region of the receptor. Based on the properties of berberine, more similar compounds were retrieved from ZINC database and a structure-based virtual screening was carried out by AutoDock Vina in PyRx 0.8. Best 10 novel drug-like compounds were identified and amongst them ZINC53047591 (2-(benzylsulfanyl)-3-cyclohexyl-3H-spiro[benzo[h]quinazoline-5,1'-cyclopentan]-4(6H)-one) was found to interact with NS3 protein with binding energy of -7.1 kcal/mol and formed H-bonds with Ser135 and Asn152 amino acid residues. Observations made in this study may extend an assuring platform for developing anti-viral competitive inhibitors against ZIKV infection.

• Plant Journal
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• v.12 no.4
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• pp.32-36
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• 2016

In this study, a penalty cost appropriation methodology for CGAM performance acceptance test was suggested. As the result of CGAM performance test, there were 0.31% decreases in electricity output, 0.39% decreases in heat rate on electricity output, 0.31% increases in heat output, and 0.23% increases in heat rate on heat output. As the result of penalty cost appropriation for above performance, the penalty cost was calculated as -$20,837 in electricity output, -$25,930 in heat rate on electricity output, +$10,340 in heat output, and +$7,715 in heat rate on heat output. Each penalty is appropriated as above fore kinds, however the total penalty should be determined as how to combine above fore kinds of penalty. In our calculation, the minimum total penalty was -$18,215 and the maximum total penalty was -$46,767. The methodology of total penalty appropriation should be determined in the contract between ordering organization and construction firm, and we can understand that it is very important.

• Genomics & Informatics
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• v.14 no.2
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• pp.53-61
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• 2016

Toxoplasma gondii is an intracellular Apicomplexan parasite and a causative agent of toxoplasmosis in human. It causes encephalitis, uveitis, chorioretinitis, and congenital infection. T. gondii invades the host cell by forming a moving junction (MJ) complex. This complex formation is initiated by intermolecular interactions between the two secretory parasitic proteins-namely, apical membrane antigen 1 (AMA1) and rhoptry neck protein 2 (RON2) and is critically essential for the host invasion process. By this study, we propose two potential leads, NSC95522 and NSC179676 that can efficiently target the AMA1 hydrophobic cleft, which is a hotspot for targeting MJ complex formation. The proposed leads are the result of an exhaustive conformational search-based virtual screen with multilevel precision scoring of the docking affinities. These two compounds surpassed all the precision levels of docking and also the stringent post docking and cumulative molecular dynamics evaluations. Moreover, the backbone flexibility of hotspot residues in the hydrophobic cleft, which has been previously reported to be essential for accommodative binding of RON2 to AMA1, was also highly perturbed by these compounds. Furthermore, binding free energy calculations of these two compounds also revealed a significant affinity to AMA1. Machine learning approaches also predicted these two compounds to possess more relevant activities. Hence, these two leads, NSC95522 and NSC179676, may prove to be potential inhibitors targeting AMA1-RON2 complex formation towards combating toxoplasmosis.