• Genomics & Informatics
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• v.9 no.1
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• pp.39-43
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• 2011

MicroRNAs (miRNAs) are recently discovered small RNA molecules usually resulting in translational repression and gene silencing. Despite the fact that specific cloning of small RNA's is a method in practice, computational identification of miRNA's has been a major focus recent days, since is a rapid process following AB initio and sequence alignment methods. Here we developed new software called MiRPI that aims to identify the highly conserved miRNAs without any mismatches from given fasta formatted gene sequences by using non-repeated miRNA dataset of the user's interest. The new window embedded with the software is used to identify the targets for inputted mature miRNAs in the mRNA sequences. Also MiRPI is designed to measure the precursor miRNA statistics, majorly focusing the Adjusted Minimum Folding free Energy (AMFE) and Minimum Folding free Energy Index (MFEI), the most important parameters in miRNA confirmation. MiRPI is developed by PERL (Practical Extraction and Report Language) and Tk (Tool kit widgets) scripting languages. It is user friendly, portable offline software that works in all windows OS, sized to 3 MB.

• Journal of Digital Convergence
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• v.9 no.2
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• pp.141-152
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• 2011

The data center has become an increasingly important part of most business operations. An increasing demand for computation has led to increasing industry energy consumption. Therefore, higher-than-normal rates of energy efficiency have become a core issue in the life cycle of data center. In this paper, we proposed the framework of level diagnosis for green data centre that can be used to diagnose the levels of capability maturity model. This framework contains the 5 key areas such as construction, air-conditioning, electricity, information technology, organization and indicators that can be applied as basic level diagnosis guide for green data center.

• Journal of the Society of Naval Architects of Korea
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• v.54 no.2
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• pp.132-142
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• 2017

As the International Maritime Organization (IMO) recently introduced the Energy Efficiency Design Index (EEDI) for new ships building and the Energy Efficiency Operational Indicator (EEOI) for ship operation, thus an accurate estimation of added resistance of ships advancing in waves has become necessary. In the present study, OpenFOAM, computational fluid dynamics libraries of which source codes are opened to the public, was used to calculate the added resistance and motions of the KCS. Unstructured grid using a hanging-node and cut-cell method was used to generate dense grid around a wave and KCS. A dynamic deformation mesh method was used to consider the motions of the KCS. Five wavelengths from a short wavelength (${\lambda}/LPP=0.65$) to a long wavelength (${\lambda}/LPP=1.95$) were considered. The added resistance and the heave & pitch motions calculated for various waves were compared with the results of model experiments.

• Genomics & Informatics
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• v.8 no.2
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• pp.70-75
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• 2010

Asp66his, Asp54Lys, and Asp50Asn are mutations in connexin 26 that are observed in the clinic and give rise to autosomal dominant syndromes. They are the result of point mutations in the human gap junction ${\beta}-2$ gene. In order to investigate the structural mechanism of Bart-Pumphrey Syndrome, Keratitis-Ichthyosis-Deafness Syndrome, and Vohwinkel Syndrome, homology modeling was carried out. Asp66 has direct contact with Asn62 by two hydrogen bonds in the wild-type protein, and in Asp66His, the biggest change observed is a tremendous energy increase caused by hydrogen bond breakage to Asn62. Shifts in the side chain and new hydrogen bond formation are observed for Lys54 compared to the wild-type protein (Asn54) and result in closer contact to Val84. Asp50Asn causes a significant decrease in bond energy, and residual charge reversal repels the ion and metabolites and, hence, inhibits their transportation. Such perturbations are likely to be a factor contributing to abnormal functioning of ion channels, resulting cell death and disease.

• Journal of the Korean Society of Visualization
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• v.19 no.2
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• pp.26-31
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• 2021

The spanwise growth of turbulence structures in turbulent pipe flow was investigated using the direct numerical simulation data of Re_𝜏 = 544, 934 and 3008. Two-point correlations and pre-multiplied energy spectra of streamwise velocity fluctuations were examined along the spanwise direction. The arclength direction is defined as r𝛳, which is useful for an analogy with the spanwise direction for channels or boundary layers; here, r and 𝛳 are the radial distance from the core and the azimuthal angles, respectively. Both analyses showed that the arclength scales increased with increasing the wall-normal distance. It showed that the coherent structures were confined in the core region due to the crowding effect of a circular pipe geometry. The pipe flow simulation could describe a realistic geometrical flow along the azimuthal direction, unlike the simulations of turbulent channel or boundary layer flow using periodic boundary conditions along the spanwise direction. The present results provided the spanwise organization of energy-containing motions over a broad range of scales in turbulent pipe flow.

• Journal of the Korean Society of Industry Convergence
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• v.24 no.6_2
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• pp.745-751
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• 2021

The International Maritime Organization(IMO) has established Emission Control Areas(ECA) in the Baltic Sea, North Sea, and sea areas in the United States since 2012, and encourages the use of clean fuels such as Natural Gas(NG). To keep pace with the increase in international demand for LNG bunkering vessels, research for the localization of key equipment for LNG bunkering must also be performed in Korea. For research and development of core bunkering equipment and systems, in this study, heat transfer analysis and structural analysis were performed by modeling the saddle, which must first be secured structurally by directly receiving the load of the hose. As a result, the suitability of the model was reviewed by analyzing the temperature distribution and stress level through the analysis results of this study.

• Journal of the Korea Society of Computer and Information
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• v.14 no.7
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• pp.97-103
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• 2009

This paper proposes efficient routing scheme named MP-DD(MultiPath-Direct Diffusion) which is simple enough to be applicable to the wireless sensor networks. Conventional DD uses only one optimal path, therefore it consumes more energy of specific nodes. MP-DD uses multiple path and has a information of hop upstream node in the direction of the base-station is determined which are obtainable via the process of self-organization of the network. Simulation results show the feasibility of the simple routing schemes for the sensor networks.

• Journal of The Korea Institute of Healthcare Architecture
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• v.1 no.2
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• pp.53-61
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• 1996

The activation of operation department can be defined as man power, the space, energy and organization in the operation department. In this paper, we clarified the activation index of operation department and verified the relation between the activation index and the management index related to in patients. In addition, we studied the effect of the activation index on the construction and management of the operation department. As a result, we can find the followings. 1. The number of operation as the activation index of operation department regardless of the size of hospitals in Japan is smaller than in Korea and Taiwan. 2. Based on the study of the correlation between the activation index and the operation index connected to inpatient, it is found the activation of operation department is affected by average lengh of stay of inpatient. 3. It is found that plan of operation has been practically made on the basis of the number of beds. Howerver, the activation index of operation department should be utilized on the basis of the number of operation.

• Korean Journal of Environmental Biology
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• v.21 no.4
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• pp.321-327
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• 2003

Differences between the principles for the radiological protection of man and the environment are compared. The derived levels of exposure for man and biota recommended by the international agencies with dose rates for chronic radiation producing effects at different levels of biological organization were given in terms of the biological effects. Cytogenetic effects on plants after an exposure to ionizing radiation at low doses alone and in combination with other factors are discussed. A wide range of experimental data were analysed and the general conclusions were extracted to cover the topics such as non-linearity of dose response, synergistic and antagonistic effects of the combined exposure of different factors, radiation-induced genomic instability, and the phenomena of radioadaptation.

• Proceedings of the Polymer Society of Korea Conference
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• 2006.10a
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• pp.112-112
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• 2006

Detailed surface characteristics of polymer films have been investigated by atomistic molecular dynamics simulations and NEXAFS spectroscopy experiments. The geometric confinement of the surfaces and the necessity to minimize the surface energy lead to the significant molecular organization and orientation in polymer surfaces, with their properties strongly depending upon the atomistic monomer structures. As compared with polymers, oligomeric electronic materials are much more readily aligned by employing various surface anchoring forces, rendering them highly attractive as polarized-light emitting materials and active semiconducting materials in thin film transistors.