• The Journal of Korean Obstetrics and Gynecology
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• v.20 no.1
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• pp.114-124
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• 2007

Purpose : The pharmacological effects of medicinal remedies traditionally used in Asian countries for improving the blood circulation were examined on isolated rat thoracic aorta strips in organ baths. Methods and results : Each experimental medicine was consecutively extracted under reflux with water. Of three medicinal remedies . Hirudo(HI) having the strongest acute relaxant activity in endothelium-intact arteries, Tabanus(TA), Empoly ohaga(EO) were showing dose-dependent relaxant activity. Long-term relaxant effects were showed in Hirudo(HI) and Empoly ohaga(EO). In endothelium-injury test using carbachol, Hirudo(HI), Tabanus(TA) and Empoly of ohaga(EO) were not damaged to endothelium. Conclusion: As a result of this study, the possibility that a part of medicinal remedy may contribute to the beneficial effects in blood circulation was proposed, but inter-individual variation has been observed. Also, further studies on the vasorelaxant effects of these remedies are still required.