• 생약학회지
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• 제4권2호
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• pp.101-102
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• 1973

Three crude saponins having the same aglycone were isolated from the root of Caltha minor $N_{AKAI}$ which has been known to be of effect as emetics in the folk medicines of Korea. And they were confirmed to their saponoidal properties through the methods of hemolytic test and $L_{IEBERMANN}-B_{UCHARD}$ reaction.

• Archives of Pharmacal Research
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• 제6권2호
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• pp.137-140
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• 1983

A rapid, high yield of N-norapomorphine from apomorphine was accomplished by allowing it to react with phenyl chloroformate without isolating and purifying the intermediate carbamate, and have found that the crude carbamate can be easily cleaved in situ with a 1:1 mixture of 64% and 95% hydrazine to afford analytically pure N-norapomorphine in 81% overall yields. Previously, various other methods gave an untoward ring opening reactions and scission of the hydropyridine ring in the apomorphine series.

• 생약학회지
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• 제27권4호
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• pp.389-396
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• 1996

Spiraea prunifolia var. simpliciflora (Rosaceae) is a deciduous. latifoliate shrub growing in most parts of Korea. The roots of this plant have been used for malaria, as antipyretics and emetics. From the roots of this plant, sterol glycoside and two triterpenoids were isolated and the structures were elucidated by chemical and spectroscopic methods. They were identified as $3{\beta}-hydroxyurs-12-ene-28-oic$ acid (ursolic acid.1), $2{\alpha}$, $3{\beta}$, $19{\alpha}-trihy-droxyurs-12-ene-28-oic$ acid (tormentic acid.2) and ${\beta}-sitoste-rol-3-O-{\beta}-D-glucopyranoside$ (3).

• 약학회지
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• 제38권6호
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• pp.712-714
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• 1994

Some traditional herbal drugs have been used after processing to modify its activities. For example, roasted 'chiyu'(Sanguisorbae radix) has been used as antihemorrhagics while raw one used as anti-emetics. The composition of herbal drug is expected to be changed during this process. We tried to reveal the compositional difference between raw and roasted 'chiyu', and isolated a compound which is not present in raw one but in processed one. The structure of the isolated compound was elucidated as tomentosolic acid. The content of tomentosolic acid in roasted 'chiyu' was approximately 0.05%.

• 약학회지
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• 제38권6호
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• pp.782-785
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• 1994

Some traditional herbal drugs have been used after processing to modify its activities. For example, roasted 'chiyu' (Sanguisorbae radix) has been used as antihemorrhagics while raw one used as anti-emetics. The composition of herbal drug is expected to be changed during this process. We tried to reveal the compositional difference between raw and roasted 'chiyu', and isolated the compounds which are changed in their contents. The structure of the isolated compounds were elucidated as pomolic acid and 3-O-acetyl pomolic acid. The contents of pomolic acid and 3-O-acetyl pomolic acid in raw 'chiyu' were ca. $4.5{\times}10^{-3}%$, $7.2{\times}10^{-4}%$, respectively, and in roasted 'chiyu' were ca. $7.3{\times}10^{-3}%$ and $1.1{\times}10^{-3}%$, respectively.

• 대한한의학회지
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• 제1권1호
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• pp.63-73
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• 1980

Through the classical records of the oriental medicine my investigation of the authorities of the epilepsy by classifying the etiology, symptoms and the treatments of it and camparing them has led to the following conclusion. 1) The etiology of 'epilepsy' can be classified into wind(風), sputum(痰), fever(熱) convulsion and caul. 2) The symptoms of it fall into the following nine ones; Sudden strong contraction making Sounds within the mouth, unoonsciousness, mutual jerks of the facial muscules foaming form the mouth, trismus contractive of extremities general body rigidity recovering after the fit and no rest. 3) The symptoms of Epilepsy are classified into 'Um type epilepsy'(癲) and the 'yang type epilepsy'(癎), and then the former has nine kinds in sympatomatic state and latter seventeen. 4) The treatment of the case can be made by using of cold drugs mainly for the purpose of mind purification(淸心), fever abatement(降火), Sputum-elimination(化痰) and normalization of metabolism(順氣) and Sometimes the function of the liver should be normalized by giving liver function normalizing medicine after Emetics. In comparison with the western way of using Anti convelsents therapy and electricshock therapy, the way of its treatment based on the classification of the causes is considered to be far more desirable.

• 동의생리병리학회지
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• 제22권6호
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• pp.1331-1346
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• 2008

The aim of this study was to establish opinions of Kum Won Sa dea ga on jaundice and find out clinical significance. Contents dealing with jaundice were searched manually in works of Kum Won Sa dea ga. Those were translated into Korean and studied. Yoo wan so(劉完素) had opinion that jaundice is induced by dampness with heatness(濕熱) or dryness with heatness(濕熱) and should be treated with diuretics and laxatives. Jang jong jung(張從政) had opinion that jaundice is induced by spleen(脾) mainly and should be treated with diaphoretics, emetics, laxatives. Lee dong won(李東垣) had opinion that jaundice is induced by mistaken diaphoretics, dysfunction of spleen(脾), heatness(熱) and treatments should depend on six meridian pathways(六經). Ju jin hyeong(朱震亨) had opinion that jaundice is induced by dampness with heatness(濕熱) and coldness with dampness(濕熱) and should be treated with diuretics and detoxicant. Kum Won Sa dae ga thought jaundice in induced by dampness with heatness(濕熱) and explained pathology by the five viscera and the six entrails(五臟六腑). And they treated patients with jaundice according to etiologic source.

• The Korean Journal of Pain
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• 제32권1호
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• pp.30-38
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• 2019

Background: The adductor canal block (ACB) is an effective intervention for postoperative analgesia following total knee arthroplasty (TKA). However, the ideal ACB regimen has not yet been established. We compared the analgesic effects between a continuous ACB group and fentanyl-based intravenous patient-controlled analgesia (IV-PCA) with a single-shot ACB group. Methods: Patients who underwent TKA were randomly allocated to either a continuous ACB group (Group CACB) or IV-PCA with a single-shot ACB group (Group IVACB). Before the surgery, ultrasound guided ACB with 0.5% ropivacaine 20 cc was provided to all patients. Before skin incision, the infusion system (0.2% ropivacaine through an adductor canal catheter in group CACB vs. intravenous fentanyl in group IVACB) was connected. The postoperative pain severity; the side effects of local anesthetics and opioids; administration of rescue analgesics and anti-emetics; and sensorimotor deficits were measured. Results: Postoperative pain severity was significantly higher in the IVACB group at 30 min, 4 h, 24 h, and 48 h after surgery. The averages and standard deviations (SD) of the NRS score of postoperative pain were $0.14{\pm}0.37$, $4.57{\pm}2.37$, $6.00{\pm}1.63$, and $4.28{\pm}1.49$, respectively in the IVACB group. Rescue analgesic requirements and quadriceps muscle strength were not statistically different between the groups throughout the postoperative period. Moreover, rescue antiemetic requirements were higher in group IVACB than group CACB. Conclusions: In this study, the continuous ACB provided superior analgesia and fewer side effects without any significant motor deficit than the IV-PCA with a single-shot ACB.

• Clinical and Experimental Pediatrics
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• 제46권12호
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• pp.1217-1223
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• 2003

목 적 : 전라북도 소아과 개원의의 급성 위장염에 대한 이해와 환자의 진단과 치료에 대한 경험과 인식을 알아보고 최근 개발된 로타 바이러스 백신에 대한 인식을 알아보고자 하였다. 방 법 : 2002년 4월부터 6월까지 전라북도에서 소아과 의원을 개원하고 있는 소아과 전문의를 대상으로 미리 작성된 설문지를 이용하여 우편배달을 통해 조사하였다. 배포된 설문지 수는 총 82매였고 이 중 63명의 소아과 전문의가 응답하여 회수율은 76.8%였다. 급성 위장염 환자의 비율, 선호하는 치료제 및 방법, 항생제 사용빈도 및 종류, 항생제 사용을 고려하는 임상소견, 급성 위장염 환자에서 시행해 보고 싶은 검사, 로타 바이러스 백신에 대한 관심도와 사용 계획에 대해 조사하였다. 결 과 : 급성 위장염 환자는 연중 발생하였으며 겨울과 봄에 약간 많았다. 주로 사용하는 치료제로는 유산균 제제(84.1%), 경구용 수액제(79.4%), 효소제(58.8%)를 선호하였다. 대부분 의사들이 전체 위장염 환자의 20% 이하에서 항생제를 사용하였고, 주로 사용하는 항생제는 amoxicillin(61.3%)과 trimethoprim/sulfamethoxazole(39.7%)이였으며, 항생제 사용을 고려하는 임상증상은 혈변이나 점액변, 고열 등의 증상이었다. 급성위장염 환아에서 중요하다고 생각하거나 가능하면 해보고 싶은 검사는 대변 검사(로타 바이러스 항원, 적혈구, 백혈구), 복부 방사선 검사, 혈청 전해질 검사 등이었다. 대부분의 의사들이 로타 바이러스 백신에 대해 긍정적인 관심을 가지고 백신이 도입될 경우 사용하겠다고 하였으며, 백신사용을 결정할 때 중요하게 생각하는 점으로는 예방효과와 부작용이었다. 결 론 : 전라북도 소아과 개원의들의 급성 위장염 환자에 대한 인식은 대체로 긍정적인 것으로 판단되었으며, 앞으로 보다 적극적인 검사방법의 개발과 이용이 중요할 것으로 생각된다.