• Korean Journal of Pharmacognosy
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• v.4 no.2
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• pp.101-102
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• 1973

Three crude saponins having the same aglycone were isolated from the root of Caltha minor $N_{AKAI}$ which has been known to be of effect as emetics in the folk medicines of Korea. And they were confirmed to their saponoidal properties through the methods of hemolytic test and $L_{IEBERMANN}-B_{UCHARD}$ reaction.

• Archives of Pharmacal Research
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• v.6 no.2
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• pp.137-140
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• 1983

A rapid, high yield of N-norapomorphine from apomorphine was accomplished by allowing it to react with phenyl chloroformate without isolating and purifying the intermediate carbamate, and have found that the crude carbamate can be easily cleaved in situ with a 1:1 mixture of 64% and 95% hydrazine to afford analytically pure N-norapomorphine in 81% overall yields. Previously, various other methods gave an untoward ring opening reactions and scission of the hydropyridine ring in the apomorphine series.

• Korean Journal of Pharmacognosy
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• v.27 no.4
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• pp.389-396
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• 1996

Spiraea prunifolia var. simpliciflora (Rosaceae) is a deciduous. latifoliate shrub growing in most parts of Korea. The roots of this plant have been used for malaria, as antipyretics and emetics. From the roots of this plant, sterol glycoside and two triterpenoids were isolated and the structures were elucidated by chemical and spectroscopic methods. They were identified as $3{\beta}-hydroxyurs-12-ene-28-oic$ acid (ursolic acid.1), $2{\alpha}$, $3{\beta}$, $19{\alpha}-trihy-droxyurs-12-ene-28-oic$ acid (tormentic acid.2) and ${\beta}-sitoste-rol-3-O-{\beta}-D-glucopyranoside$ (3).

• YAKHAK HOEJI
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• v.38 no.6
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• pp.712-714
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• 1994

Some traditional herbal drugs have been used after processing to modify its activities. For example, roasted 'chiyu'(Sanguisorbae radix) has been used as antihemorrhagics while raw one used as anti-emetics. The composition of herbal drug is expected to be changed during this process. We tried to reveal the compositional difference between raw and roasted 'chiyu', and isolated a compound which is not present in raw one but in processed one. The structure of the isolated compound was elucidated as tomentosolic acid. The content of tomentosolic acid in roasted 'chiyu' was approximately 0.05%.

• YAKHAK HOEJI
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• v.38 no.6
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• pp.782-785
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• 1994

Some traditional herbal drugs have been used after processing to modify its activities. For example, roasted 'chiyu' (Sanguisorbae radix) has been used as antihemorrhagics while raw one used as anti-emetics. The composition of herbal drug is expected to be changed during this process. We tried to reveal the compositional difference between raw and roasted 'chiyu', and isolated the compounds which are changed in their contents. The structure of the isolated compounds were elucidated as pomolic acid and 3-O-acetyl pomolic acid. The contents of pomolic acid and 3-O-acetyl pomolic acid in raw 'chiyu' were ca. $4.5{\times}10^{-3}%$, $7.2{\times}10^{-4}%$, respectively, and in roasted 'chiyu' were ca. $7.3{\times}10^{-3}%$ and $1.1{\times}10^{-3}%$, respectively.

• The Journal of Korean Medicine
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• v.1 no.1
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• pp.63-73
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• 1980

Through the classical records of the oriental medicine my investigation of the authorities of the epilepsy by classifying the etiology, symptoms and the treatments of it and camparing them has led to the following conclusion. 1) The etiology of 'epilepsy' can be classified into wind(風), sputum(痰), fever(熱) convulsion and caul. 2) The symptoms of it fall into the following nine ones; Sudden strong contraction making Sounds within the mouth, unoonsciousness, mutual jerks of the facial muscules foaming form the mouth, trismus contractive of extremities general body rigidity recovering after the fit and no rest. 3) The symptoms of Epilepsy are classified into 'Um type epilepsy'(癲) and the 'yang type epilepsy'(癎), and then the former has nine kinds in sympatomatic state and latter seventeen. 4) The treatment of the case can be made by using of cold drugs mainly for the purpose of mind purification(淸心), fever abatement(降火), Sputum-elimination(化痰) and normalization of metabolism(順氣) and Sometimes the function of the liver should be normalized by giving liver function normalizing medicine after Emetics. In comparison with the western way of using Anti convelsents therapy and electricshock therapy, the way of its treatment based on the classification of the causes is considered to be far more desirable.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.6
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• pp.1331-1346
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• 2008

The aim of this study was to establish opinions of Kum Won Sa dea ga on jaundice and find out clinical significance. Contents dealing with jaundice were searched manually in works of Kum Won Sa dea ga. Those were translated into Korean and studied. Yoo wan so(劉完素) had opinion that jaundice is induced by dampness with heatness(濕熱) or dryness with heatness(濕熱) and should be treated with diuretics and laxatives. Jang jong jung(張從政) had opinion that jaundice is induced by spleen(脾) mainly and should be treated with diaphoretics, emetics, laxatives. Lee dong won(李東垣) had opinion that jaundice is induced by mistaken diaphoretics, dysfunction of spleen(脾), heatness(熱) and treatments should depend on six meridian pathways(六經). Ju jin hyeong(朱震亨) had opinion that jaundice is induced by dampness with heatness(濕熱) and coldness with dampness(濕熱) and should be treated with diuretics and detoxicant. Kum Won Sa dae ga thought jaundice in induced by dampness with heatness(濕熱) and explained pathology by the five viscera and the six entrails(五臟六腑). And they treated patients with jaundice according to etiologic source.

• The Korean Journal of Pain
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• v.32 no.1
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• pp.30-38
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• 2019

Background: The adductor canal block (ACB) is an effective intervention for postoperative analgesia following total knee arthroplasty (TKA). However, the ideal ACB regimen has not yet been established. We compared the analgesic effects between a continuous ACB group and fentanyl-based intravenous patient-controlled analgesia (IV-PCA) with a single-shot ACB group. Methods: Patients who underwent TKA were randomly allocated to either a continuous ACB group (Group CACB) or IV-PCA with a single-shot ACB group (Group IVACB). Before the surgery, ultrasound guided ACB with 0.5% ropivacaine 20 cc was provided to all patients. Before skin incision, the infusion system (0.2% ropivacaine through an adductor canal catheter in group CACB vs. intravenous fentanyl in group IVACB) was connected. The postoperative pain severity; the side effects of local anesthetics and opioids; administration of rescue analgesics and anti-emetics; and sensorimotor deficits were measured. Results: Postoperative pain severity was significantly higher in the IVACB group at 30 min, 4 h, 24 h, and 48 h after surgery. The averages and standard deviations (SD) of the NRS score of postoperative pain were $0.14{\pm}0.37$, $4.57{\pm}2.37$, $6.00{\pm}1.63$, and $4.28{\pm}1.49$, respectively in the IVACB group. Rescue analgesic requirements and quadriceps muscle strength were not statistically different between the groups throughout the postoperative period. Moreover, rescue antiemetic requirements were higher in group IVACB than group CACB. Conclusions: In this study, the continuous ACB provided superior analgesia and fewer side effects without any significant motor deficit than the IV-PCA with a single-shot ACB.

• Clinical and Experimental Pediatrics
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• v.46 no.12
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• pp.1217-1223
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• 2003

Purpose : This study was conducted to assess clinical practices related to the evaluation and treatment of patients with acute gastrointestinal infection(AGI) in infants and children. This survey also evaluated the current opinion regarding the use of rotavirus vaccine. Methods : This survey was conducted using a self-administered questionnaire provided to 82 pediatricians in private clinics of Jeonbuk province. From April to June, 2002, 63 of 82 pediatricians(76.8 %) responded to the survey. Results : The annual proportion of patients with AGI was 13%. The highest proportion of patients with diarrhea were reported for the months of October through December. For the treatment of diarrhea, pediatricians preferred to prescribe lactobacillus products, oral rehydration solution, enzyme products, anti-emetics, anti-diarrheal formula, nothing by mouth(NPO) and bowel movement inhibitors in descending order of frequency. Most pediatricians(79.4%) prescribed antibiotics in less than 20% of patients with AGI. Amoxicillin was the most commonly prescribed antibiotics followed by trimethoprim/sulfamethoxazole(TMP/SMX) and amoxicillin/clavulanate. Clinical manifestations that pediatricians considered as important factors in prescribing antibiotics were bloody diarrhea, mucoid diarrhea, high fever, persisting disease and abdominal pain. Diagnostic procedures that pediatricians preferred for AGI patients were stool examination(rotavirus antigen, RBC, WBC), abdominal X-ray, and serum electrolytes. Pediatricians had a strong interest in rotavirus vaccine(71.4%). Conclusion : Acute gastrointestinal illness remains a common problem, especially during the winter months in Korea. AGI manifesting as watery diarrhea is appropriately treated with commonly available agents but pediatricians appear ready to consider additional approaches to decrease the sizable disease burden of AGI among children in Korea.