• 제목/요약/키워드: Electrical remodeling

검색결과 29건 처리시간 0.024초

전기자극치료가 흰쥐 탈 신경근연접부에서 NT-3의 발현에 미치는 영향 (The effects of Electrical Stimulation Therapy on NT-3 Expression in the Denervated Neuromuscular Junction in Rat)

  • 남기원;구현모;천송희;이윤섭;강종호;김진상
    • The Journal of Korean Physical Therapy
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    • 제16권2호
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    • pp.63-71
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    • 2004
  • Denervated skeletal muscle produces muscle atrophy as well as changes at the neuromuscular junction which leads to terminal axonal sprouting and an ultrastructural remodeling. NT-3 is expressed in adult muscle and motoneurons. Normally NT-3 has a potential role in regulating adult neuromuscular jungtion and recovering following muscle atrophy. Also, it could influence synaptic neurotransmission between motoneurons and skeletal muscle cells. The purpose of this study was to investigate the effect of electrical stimulation therapy(EST) on NT-3 expression in neuromuscular junction following sciatic nerve transsection in rats. After EST application during 7 days, the immunoreactivity of NT-3 was increased in neuromuscular junction

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피부 재생능력 촉진을 위한 물리적 복합자극의 활용 연구 (Combinatorial Physical Stimulation and Synergistically-Enhanced Fibroblast Differentiation for Skin Regeneration)

  • 고웅현;홍정우;신현준;김철웅;신현정
    • 한국정밀공학회지
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    • 제32권8호
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    • pp.755-760
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    • 2015
  • For proper wound healing, dermal contraction and remodeling are critical; during the natural healing process, differentiated fibroblasts called "myofibroblasts" typically undertake these functions. For severe wounds, however, a critical mass of dermal matrix and fibroblasts are lost, making self-regeneration impossible. To overcome this impairment, synthetic wound patches with embedded functional cells can be used to promote healing. In this study, we developed a polydioxanone (PDO)-based cell-embedded sheet on which dermal fibroblasts were cultured and induced for differentiation into myofibroblasts, whereby the following combinatorial physicochemical stimuli were also applied: aligned topology, electric field (EF), and growth factor. The results show that both the aligned topology and EF synergistically enhanced the expression of alpha smooth-muscle actin (${\alpha}$-SMA), a key myofibroblast marker. Our proof-of-concept (POC) experiments demonstrated the potential applicability of a myofibroblast-embedded PDO sheet as a wound patch.

다종재료용 쾌속 임의형상가공시스템의 개발 (Development of Agile SFFS(Solid Freeform Fabrication System) for a Wide Variety of Engineering Materials)

  • 고민국;엄태준;주영철;공용해;천인국;방재철;김승우
    • 대한전기학회:학술대회논문집
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    • 대한전기학회 2001년도 합동 추계학술대회 논문집 정보 및 제어부문
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    • pp.311-314
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    • 2001
  • The objectives of this paper include the development of an agile prototype of SFFS, the $CAFL^{VM}$(Computer Aided fabrication of Lamination for Various Material), which is suitable for the multi-item and small-quantity production and various material fabrication. This paper includes remodeling of the layer slices for the 2D cutting, supplementing information of the layer slices and developing process conditions to fabricate products of various shape. And also includes developing control hardware as well as software by enhancing BOF of the manipulator to 3 degree for the precise 2D cutting. It will generate optimal layer trajectory considering the dynamic characteristics of the laser beam. The system can be used as a competitive agile protype system in terms of various materials, fabrication speed, and accuracy by CAD modeling precise layer slicing, material development, robot path control, and optimization of the support structure.

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방폭설비 성능유지 실태분석을 통한 관리방안 연구 (A Study on the Management Plan through Performance Maintenance Analysis of Explosion-proof Facilities)

  • 권용준;변정환
    • 한국안전학회지
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    • 제35권2호
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    • pp.8-16
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    • 2020
  • In Article 311 of the Regulation on Occupational Safety and Health Standards requires the use of Korean Industrial Standards Act in accordance with the Industrial Standardization Act. However, the classification, inspection, maintenance, design, selection, and installation of explosion hazard locations for explosion and explosion prevention and internalization of 'safety' in the performance maintenance phase of electrical machinery and equipment There is no technical and institutional management plan for remodeling and alteration. Analysis of actual conditions and problems related to the installation, use, and maintenance of explosion-proof equipment, comparative analysis of domestic and international technical standards and systems, technical, institutional and administrative systems and systems related to installation, use, and maintenance of explosion-proof equipment, technical personnel and qualifications, etc. It is to propose legislation, system improvement, and technical standard establishment related to the maintenance of explosion-proof facility performance through improvement of the necessity and feasibility study for establishment of the legal status of the management site and management plan. As technical measures, KS standard revision (draft), KOSHA guide (draft) and explosion-proof facility performance maintenance manual were presented. In addition, the institutional management plan proposed the revised rule on occupational safety and health standards, the revised rule on the restriction of employment of hazardous work, and the manpower training program related to the maintenance of explosion-proof facilities and the qualification plan. Enhance safety at the installation, use, and maintenance stage of explosion-proof structured electrical machinery. It is expected to be used to classify explosion hazards, select related equipment, and to update and standardize standards related to installation, use and maintenance.

맥동 전자기장이 백서의 배양 두개관세포에 미치는 영향 (IME EFFECT OF PULSED ELECTROMAGNETIC FIELD ON THE CULTURED CALVARIAL CELLS OF RAT)

  • 최병택;양원식
    • 대한치과교정학회지
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    • 제20권3호
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    • pp.499-517
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    • 1990
  • Electrical stimulation among several factors that influence bone remodeling has been studied by many investigators with great enthusiasm in orthodontic field. The action mechanisms of Pulsed Electromagnetic Field (PEMF) are different from those of the conventional electrode application method in that PEMF induces endogenous current in the living tissues. PEMF is known to have the healing effect in nonunion of bone and osteoporosis. It is widely used in orthopaedic scopes and the possibility of using the method in clinical orthodontics Is also conceivable. But the exact mechanisms by which the PEMF exerts its effects are not clearly understood. Therefore, the author wanted to see the effect of PEMF on five groups of rat calvarial cells obtained by sequential enzyme digestion method, and observed the changes in enzyme activation, collagen synthesis and $^3H-thymidine$ incorporation. The results were as follows: 1. Under the effect of PEMF, there were no changes in the alkaline phosphatase activity in five groups of cell populations. 2. Both the PEMF group and the PTH with PEMF group shelved no changes in acid phosphatase activities and there were no differences between two experimental groups. 3. Under the effect of PEMF, there was significant increase of collagen synthesis in the group V cell population. 4. Under the effect of PEMF, there were significant increases of $^3H-thymidine$ incorporation in the group IV and V cell populations.

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연료 감소율 검증을 위한 중소형 선박의 모델링 및 시뮬레이션 (Modeling and Simulation of Small and Medium-sized Ships for Fuel Reduction Rate Verification)

  • 김성동;김남호
    • 한국정보통신학회논문지
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    • 제26권6호
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    • pp.914-921
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    • 2022
  • 국제해사기구는 친환경규제로 2008년 대비 2050년까지 선박의 이산화탄소 배출량을 70%, 온실가스 배출량을 50% 줄이겠다는 목표를 세웠다. 선주 및 조선소에서는 이를 만족하기 위한 방법으로 LNG추진, 암모니아추진, 전기추진, CO2포집, 샤프트 제너레이터 등 다양한 연구개발을 추진하고 있다. 이중 샤프트 제너레이터는 개조공사를 통해 기존선에 바로 적용가능한 장점이 있다. 본 논문에서는 기존선에 샤프트 제너레이터를 적용함으로 얻을 수 있는 총 연료 감소율을 시뮬레이션을 통해 검증하였다. 이를 위해, 중형선의 크기를 정의하고, 조속기, 디젤엔진, 프로펠러, 토크 스위치, 샤프트 제너레이터용 발전기와 추진전동기, 선박모델 등에 대해 모델링하고 시뮬레이션하였다.

자동차 실내 인화성물질과 전기과부하에 의한 화재관련 사례 연구 (A Study for Examples of Fire including with Combustible Substance and electrical overload in Automotive Inside Room)

  • 한재오;함성훈;임하영;이일권
    • 한국가스학회지
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    • 제18권3호
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    • pp.38-43
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    • 2014
  • 이 논문은 자동차 실내의 인화성 물질과 전기적인 접촉 불량에 의한 화재사례를 분석하고 연구하는 것이다. 첫 번째 사례는 운전자가 에어컨 냄새 탈취제인 방향제를 사용 후 실내의 크래쉬 패드에 두고 내린 것이 외부의 복사열에 의해 폭발하면서 화재가 발생된 것으로 확인되었다. 두 번째 사례는 운전자가 자동차 실내에 전자기기 등을 사용하면서 전기적인 과부하가 걸려 단락현상에 의해 화재가 발생된 것으로 확인되었다. 세 번째 사례는 자동차 내부의 시트를 따뜻하게 하기 위해 열선을 설치하였다. 초기에 설치하였을 때는 화재의 위험성이 약했으나 5,000km를 운행하면서 이 열선의 내구성이 떨어지면서 순간적으로 전기적인 과부하가 발생되었고, 이 열이 시트에 옮겨 붙으면서 자동차 화재가 발생된 것으로 확인되었다. 네 번째 사례는 뒷좌석에 있던 승객이 담배를 피우던 중 완전히 소화하지 않은 상태로 둔 것이 가연성 종이에 옮겨 붙어 자동차가 전소된 것으로 확인되었다. 따라서, 실내의 인화성 물질이나 전기적인 시스템을 추가로 사용할 때는 화재가능성을 최대한 고려하고 이에 대한 세심한 대책을 강구하여야 한다.

One Stage Reconstruction of Skull Exposed by Burn Injury Using a Tissue Expansion Technique

  • Cho, Jae-Young;Jang, Young-Chul;Hur, Gi-Yeun;Koh, Jang-Hyu;Seo, Dong-Kook;Lee, Jong-Wook;Choi, Jai-Koo
    • Archives of Plastic Surgery
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    • 제39권2호
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    • pp.118-123
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    • 2012
  • Background : An area of the skull exposed by burn injury has been covered by various methods including local flap, skin graft, or free flap surgery. Each method has disadvantages, such as postoperative alopecia or donor site morbidities. Due to the risk of osteomyelitis in the injured skull during the expansion period, tissue expansion was excluded from primary reconstruction. However, successful primary reconstruction was possible in burned skull by tissue expansion. Methods : From January 2000 to 2011, tissue expansion surgery was performed on 10 patients who had sustained electrical burn injuries. In the 3 initial cases, removal of the injured part of the skull and a bone graft was performed. In the latter 7 cases, the injured skull tissue was preserved and covered with a scalp flap directly to obtain natural bone healing and bone remodeling. Results : The mean age of patients was $49.9{\pm}12.2$ years, with 8 male and 2 female. The size of the burn wound was an average of $119.6{\pm}36.7cm^2$. The mean expansion duration was $65.5{\pm}5.6$ days, and the inflation volume was an average of $615{\pm}197.6mL$. Mean defect size was $122.2{\pm}34.9cm^2$. The complications including infection, hematoma, and the exposure of the expander were observed in 4 cases. Nonetheless, only 1 case required revision. Conclusions : Successful coverage was performed by tissue expansion surgery in burned skull primarily and no secondary reconstruction was needed. Although the risks of osteomyelitis during the expansion period were present, constant coverage of the injured skull and active wound treatment helped successful primary reconstruction of burned skull by tissue expansion.

좌심방과 좌심방이의 전산화단층촬영 소견: 해부학, 정상변이 및 질환에 관한 임상화보 (Computed Tomography of the Left Atrium and Left Atrial Appendage: A Pictorial Essay on the Anatomy, Normal Variants, and Pathology)

  • 송민지;김성진;구현정;김문영;유진영
    • 대한영상의학회지
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    • 제81권2호
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    • pp.272-289
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    • 2020
  • 전산화단층촬영(이하 CT) 영상 기술의 발전으로 박동하는 심장에 대한 섬세한 영상의학적 평가가 가능해졌다. 심초음파 및 MRI에 비해 심장 CT의 강점은 대부분의 의료기관에 보급되어 있고 고품질 이미지의 빠른 생산이 가능하며 해부학적 묘사가 뛰어나다는 것이다. 좌심방과 좌심방이에서 생기는 대부분의 변이 혹은 병리적 상태들은 CT 상의 소견만으로도 추정 진단을 내릴 수 있다. 또한 CT 영상은 성공적인 카테터 기반 시술 또는 수술에 중요한 해부학적 정보들을 제공한다. 특히 좌심방과 좌심방이는 심방세동 환자들의 치료 및 관리에 중요한데, 이는 다양한 카테터 기반 시술들이 두 구조물의 기계적 혹은 전기적 차단을 목표로 하기 때문이다. 따라서 임상적으로 의미 있는 판독을 위해서는 병리적 상태의 CT 소견 기술과 함께 좌심방 및 좌심방이의 모양, 크기 및 주변 구조물과의 상대적 위치 관계 등에 대한 포괄적인 검토를 해야 한다.