• The Korean Journal of Physiology and Pharmacology
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• v.16 no.1
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• pp.49-57
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• 2012

It has been shown that QGC isolated and purified from Rumecis folium found protective effects of gastritis and esophagitis which EXT is an ethanol extract of it. We examined acute toxicity and the general pharmacological action of QGC EXT to search for any side effects of it in rats, mice, guinea pigs, and cats. In a single dose toxicity study, QGC EXT didn't show toxicological effects in rats and mice, and the $LD_{50}$ was over 5 g/kg in both animals, and there were also no changes in weight, feed and water intake during these toxicological experimental periods. We examined the general pharmacological action on central controlled behavior responses, and peripheral organs including blood pressure, heart rate, respiration and gastrointestinal system, We found that there were no significant changes in body temperature, locomotors activity, stereotyped behaviors, sleeping time, and convulsion. In other studies, writhing reaction, normal body temperature, there did not appear to be any changes. The large intestine movement and electrical field stimulation-induced contraction was not changes by its EXT. In addition, the influences on blood pressure, heart rates, and respiration by QGC EXT were not found. These results indicate that QGC EXT may be very safe as a new drug, since its $LD_{50}$ was very high over 5 g/kg and any side effects were not found.

• Journal of Biomedical Engineering Research
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• v.24 no.5
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• pp.459-464
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• 2003

The source current distribution in a heart was reconstructed from the magnetocardiogram (MCG) and its clinical usefulness was demonstrated. MCG was measured using 40-channel superconducting quantum interference device (SQUID) gradiometers for a patient of Wolff-Parkinson-White (WPW) syndrome, which has an accessory pathway between the atria and the ventricles. Reconstruction of source current distribution in a plane below the chest surface was performed using minimum norm estimation (MNE) algorithm and truncated singular value decomposition (SVD), In the simulation, we confirmed that the current distributions. which were computed for the test dipoles, represented well the essential feature of the test current configurations, In the current map of WPW syndrome, we observed abnormal currents that would bypass the atrioventricular junction at a delta wave. However, we could not observe such currents any more after the surgery. These results showed that the obtained current distribution using MCG signals is consistent with the electrical activity in a heart and has clinical usefulness.

• Journal of the Korea Society of Computer and Information
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• v.27 no.2
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• pp.187-194
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• 2022

This study is to encourage physical activity and exercise in people with spinal cord disabilities so that they can have a positive effect on health outcomes. Current evidence shows that IT-based muscle strength and muscle endurance, cardiopulmonary exercise, electrical stimulation exercise, and robot exercise can all improve physical components, reduce the risk of secondary health complications, and have a positive impact on the overall health of people with chronic physical disabilities. To improve muscle strength and muscle endurance, exercise frequency should be conducted twice and three sets a week, <5 Reps to improve muscle strength, general strength should be repeated 6 to 15 times, and 15 to 30 times to improve muscle endurance. In order to improve cardiopulmonary ability, it should be conducted 3-5 times a week, 20-60 minutes, and 50-80% of the maximum heart rate. Therefore, higher resource investment is needed to realize various IT-based exercise benefits and access professional equipment, facilities and trainers.

• Journal of Physiology & Pathology in Korean Medicine
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• v.26 no.4
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• pp.532-538
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• 2012

The aim of this study was to find correlation between EGG and HRV parameters in dyspeptic patients. 39 patients (male 8, female 31) were enrolled. EGG and HRV was measured in all patients. EGG parameters like % of gastric slow wave and power ratio were used to classify patients as normal or abnormal EGG groups. HRV parameters which were included TP (total power), LF(low frequency density), HF (high frequency density), and LF/HF ratio were compared between them. EGG parameters were compared among normal, sympathetic hyperactivity, and parasympathetic hyperactivity groups classified by LF/HF ratio. There was no difference in HRV parameters between normal and abnormal EGG groups. Comparing EGG parameters among normal, sympathetic hyperactivity, and parasympathetic hyperactivity groups, both sympathetic and parasympathetic hyperactivity groups had lower value of postprandial regularity of gastric slow wave than normal group. Abnormal value of LF/HF ratio(both sympathetic and parasympathetic hyperactivity) may be related with disturbance of electrical gastric activity in patients with dyspepsia.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.50 no.2
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• pp.163-170
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• 2024

In the literature, inhalation of cosmetic fragrances, including natural extracts or natural essential oils, has been reported to induce brainwave changes. Angelica gigas (AG) and Cnidium officinale (CO) are widely used in East Asian countries as traditional medicines to improve health, but there have been no previous reports of inhaling their aromas and assessing changes in brain activity through electroencephalogram (EEG) recordings. In this study, the scent of natural herbal extracts such as Artemisia princeps var. orientalis (Compositae), AG, and CO was inhaled and evaluated whether emotional state changes were caused by olfactory stimuli, and brain activity was confirmed through EEG records before and after inhaling the scent of natural herbal extracts in subjects aged 20 to 30. We also used an electrocardiogram (ECG) to record the electrical activity of the heart during fragrance administration. The test results indicated that inhaling the scents of Compositae, AG, and CO extracts, as well as the positive control lavender, significantly increased the relative alpha power and the alpha/beta ratio of brain waves across the brain regions. The ECG recordings indicated that the inhalation of Compositae fragrance significantly decreased the low-frequency/high-frequency ratio, and that the inhalation of traditional herbal extract fragrances resulted in comfort and relaxation.

• Journal of IKEEE
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• v.21 no.3
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• pp.309-319
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• 2017

The research investigates the inhibition of fatty acid biosynthesis of the human Acetyl-CoA Carboxylase enzyme by the aromatic-structure inhibitors (also known as ligands) containing variables of substituents, contributing an important role in the treatment of fatty-acid metabolic syndrome expressed by the group of cardiovascular risk factors increasing the incidence of coronary heart disease and type-2 diabetes. The effective interoperability between ligand and enzyme is characterized by a 50% concentration of enzyme inhibitor ($IC_{50}$) which was determined by experiment, and the factor of geometry structure of the ligands which are modeled by quantum mechanical methods using HyperChem 8.0.10 and Gaussian 09W softwares, combining with the calculation of quantum chemical and chemico-physical structural parameters using HyperChem 8.0.10 and Padel Descriptor 2.21 softwares. The result data are processed with the combination of classical statistical methods and modern bioinformatics methods using the statistical softwares of Department of Pharmaceutical Technology - Jadavpur University - India and R v3.3.1 software in order to accomplish a model of the quantitative structure - activity relationship between aromatic-structure ligands inhibiting fatty acid biosynthesis of the human Acetyl-CoA Carboxylase.

• Animal cells and systems
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• v.11 no.2
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• pp.169-173
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• 2007

Hyperpolarization-activated nonselective cation channels (HCNs) play a pivotal role in producing rhythmic electrical activity in the heart and the nerve cells. In our previous experiments, voltage-dependent $Cd^{2+}$ access to one of the substituted cysteines in S6, T464C, supports the existence of an intracellular voltage-dependent activation gate. Direct binding of intracellular cAMP to HCN channels also modulates gating. Here we attempted to locate the cAMP-modulated structure that can modify the gating of HCN channels. SpHCN channels, a sea urchin homologue of the HCN family, became inactivated rapidly and intracellular cAMP removed this inactivation, resulting in about eight-fold increase of steady-state current level. T464C was probed with $Cd^{2+}$ applied to the intracellular side of the channel. We found that access of $Cd^{2+}$ to T464C was strongly gated by cAMP as well as voltage. Release of bound $Cd^{2+}$ by DMPS was also gated in a cAMP-dependent manner. Our results suggest the existence of an intracellular cAMP-modulated gate in the lower S6 region of spHCN channels.

• Journal of the Korea Fashion and Costume Design Association
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• v.12 no.2
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• pp.119-129
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• 2010

오늘날 인간의 수명이 연장되고, 웰빙과 건강에 대한 관심이 증가됨에 따라서 언제 어디서나 건강을 모니터링 할 수 있는 건강 스마트 의류 시스템이 개발되고 있다. 이를 위하여 최근에는 생체신호의 모니터링이 가능하도록 디자인된 의류에 통합된 형태의 직물 전극이 개발되고 있다. 혁신적으로 의류 시스템에 통합되어 착용 가능한 니트, 우븐, 자수방식의 텍스타일 전극에 대한 다양한 연구가 개발 제시되고 있으며, 이의 일부는 상용화되어 있다. 이에 본 연구는 경위사의 일정한 직조제어 자동화 시스템이 가능한 컴퓨터 자카드 직기의 캐드(CAD) 직조디자인 방식을 통하여 생체신호 센싱 기능이 향상된 새로운 텍스타일 전극디자인을 연구하고자 하였다. 이를 위하여 본 연구에서는 기존 생체신호 센싱 전극의 개발 및 연구 동향, 비직물/전극 타입에 대한 단점과 장점에 대한 비교 분석을 이론적으로 살펴보고, 자카드 직조 직물 기반으로 심전도 센싱용 텍스타일 전극을 디자인하여 실험 연구하였다. 자카드 직조 방식의 심전도 센싱용 직물 전극은 전극 인터페이스 디자인 방식, 이중직물형 직조 디자인 방식, 사가공 등의 요인들을 고려하여 개발하였다. 본 연구에서 도출된 최종 자카드 직조 직물 기반의 텍스타일 전극은 스마트 의류에 통합시킨 텍스타일 전극 모듈로서 적용되여 향후 상용화 방안을 모색할 수 있다.

• Journal of Digital Convergence
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• v.14 no.9
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• pp.331-339
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• 2016

Chronic diseases are increasing nowadays as daily habits changed due to economic growth. Among chronic diseases, heart cerebrovascular disease is one of the major causes of death in South Korea that accounts for approximately 20% of mortality. Tests to measure anomaly of the heart is ECG tests, which measures and analyzes the electrical heart activity. Any mistakes in lead attachment location critically affects ECG testings, and statistical facts showed that only 2.8% of the nurses properly located leads to patients. As a solution, this paper proposes a system based on a projection-based augmented reality technology to generate X-ray images to the patient's chest to point out exact attachment locations of ECG leads. Evaluation comparison results showed a 2.6 cm difference between the conventional system and the proposed system. ECG test results also showed significant signal differences between the systems in leads V1, V2, and V3. The ECG measured accurately by the proposed system would help greatly in patient management and clinical decisions of clinicians.

• Journal of Chest Surgery
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• v.42 no.2
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• pp.214-219
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• 2009

Background: Primary focal hyperhidrosis is characterized by overactivity of the sympathetic nervous function, and this has been effectively treated with endoscopic thoracic sympathetic denervation (ESD). The imbalance of sympathetic and parasympathetic nervous system that's created by ESD may affect the heart, lung and other thoracic organs. We analyzed the heart rate and ECG changes after performing ESD at our hospital, and this is the first such study that has been conducted on this. Material and Method: Of the 263 patients who underwent ESD between October 1996 and October 2006, 130 had ECG before and after ESD, and they were classified into 3 groups according to the level of ESD: Group I (n=40) patients underwent ESD at the 2nd rib (T2ESD), Group II (n=80) at the 3rd rib (T3ESD) and Group III (n=10) at the 4th rib (T4ESD). Result: There was no mortality or major morbidity. Heart rate (HR) was significantly decreased from $71.6{\pm}10.6/min\;to\;66.8{\pm}10.2/min$ after ESD (p<0.01); however, the PR (from $148.6{\pm}21.2$ msec to $152.8{\pm}20.5$ msec) and QTc (from $399.2{\pm}15.4$ msec to $404.0{\pm}15.1$ msec) intervals were significantly increased after ESD in the patients who suffered with primary hyperhidrosis (p<0.01). According to the level of ESD, there were significant changes in the HR and QTc interval in group I (T2ESD), the HR and PR interval in group II and the QTc interval in Group III. Conclusion: There were significant changes in the heart rate and ECG findings after ESD. The thoracic sympathetic denervation of T2, T3 and T4 affected the electrical activity of the heart at the resting state.