• 대한치과교정학회지
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• 제52권6호
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• pp.399-411
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• 2022

Objective: The objective of this randomized clinical trial was to study the skeletal and dental effects of low-level laser therapy (LLLT) along with a miniscrew-assisted expander (Hyrax) after six months of retention. Methods: After sequence generation, concealed allocation, and implementation, 24 female patients were randomly divided (1:1) into two-groups: bone-borne rapid palatal expansion (BBE) without LLLT (n = 12) and BBE with LLLT (n = 12). Eligibility criteria included female patients aged 10-13 years old with bilateral posterior crossbites. Intraoral and extraoral photographs, cone-beam computed tomography images, and digital study models were obtained before expansion and six months after retention. The 7 mm Hyrax appliance was anchored to four palatal mini-screws, which were activated twice daily for 15 days, then locked and kept in place as a retainer. LLLT was performed in the laser group during expansion and retention, according to the guidelines provided. Results: The records of 24 patients were analyzed. According to the post-retention measurements, both groups showed a significant increase in nasal and maxillary widths and total facial height. In the laser group, the Sella-Nasion-Point A and Point A-Nasion-Point B angles and the interpremolar apical distance were significantly increased. Conclusions: Within the limitations of this study, the results suggest that the parameters and protocol of LLLT do not clinically affect the efficiency of BBE in prepubertal and pubertal patients.

• 한국기후변화학회지
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• 제34권13호
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• pp.5243-5256
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• 2021

The North Pacific Oscillation (NPO), a primary atmospheric mode over the North Pacific Ocean in boreal winter, is known to trigger El Niño-Southern Oscillation (ENSO) in the following winter, the process of which is recognized as the seasonal footprinting mechanism (SFM). On the basis of the analysis of model simulations from phase 5 of the Coupled Model Intercomparison Project (CMIP5), we found that the SFM acts differently among models, and the correlation between the NPO and subsequent ENSO events, called the SFM efficiency, depends on the background mean state of the model. That is, SFM efficiency becomes stronger as the climatological position of the Pacific intertropical convergence zone (ITCZ) moves poleward, representing an intensification of the northern branch of the ITCZ. When the Pacific ITCZ is located poleward, the wind-evaporation-sea surface temperature (SST) feedback becomes stronger as the precipitation response to the SST anomaly is stronger in higher latitudes than that in lower latitudes. In addition, such active ocean-atmosphere interactions enhance NPO variability, favoring the SFM to operate efficiently and trigger an ENSO event. Consistent with the model results, the observed SFM efficiency increased during the decades in which the northern branch of the climatological ITCZ was intensified, supporting the importance of the tropical mean state of precipitation around the Pacific ITCZ.

• 대한화학회지
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• 제64권1호
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• pp.7-18
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• 2020

An efficient and facile procedure has been developed for the synthesis of novel bichalcone derivatives (4a, 4b). The key step contains the solvent-free aldol synthesis of bichalcones based on quinones. Bichalcones (4a, 4b) were used as precursors for the synthesis of some interesting heterocyclic compounds like, diazepines (5a, 5b), pyrazolo-pyrimidines (7a, 7b), and pyrazoline derivatives (8a, 8b). Moreover, new thioxopyrimidine derivatives (9a, 9b) were furnished and used as a functionalizing agent to produce the triazole-pyrimidines (11, 12) and the carbonitrile derivative (14). All the synthesized compounds were fully characterized using physical and spectral data like, FT-IR, ¹H NMR, ¹³C NMR, and MS. Bichalcones (4a, 4b) and diazepines (5a, 5b) were screened for their anticonvulsant activity, where compounds (4a, 5a, and 5b) revealed potent anticonvulsant activity compared to diazepam. On the other hand, some of the prepared compounds were screened for their antiproliferative activity and they showed significant cytotoxic effects on most of the cancer cell lines with regard to broad spectrum antitumor activity.

• 한국잠사곤충학회지
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• 제34권2호
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• pp.13-19
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• 1992

몇 가지 교잡원종에 있어서 란의 크기가 차대잠의 계량형질에 미치는 영향에 대한 실험결과는 다음과 같다. 1. 공시한 모든 품종에 있어서 란의 크기와 의잠체중은 정의 상관관계가 있었으며 2령까지의 유충체중에 있어서도 대형란구의 유충이 가장 무거웠고 소형란구의 유충이 가장 가벼웠다. 장잠기 유충체중은 유럽종 E16을 제외한 모든 품종에서 대형란구의 유충이 가장 무거웠으나 정상란구와의 차이는 적었다. 2. 유충경과일수에 있어서는 유럽종 El6을 제외하고는 대형란구가 가장 짧았으며 란의 크기와 화용비율과는 일정한 경향이 없었다. 유충체중, 유충경과일수 등의 형질은 품종에 따른 영향이 란의 크기에서 오는 영향보다 컸으며 견형질에 있어서는 대형란구가 가장 우수한 것으로 나타났다.

• Natural Product Sciences
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• 제11권4호
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• pp.233-239
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• 2005

The aerial parts of Gomphocarpus sinaicus Boiss. yielded four flavonoids that were identified as isorhamnetin 3-O-rhamnoglucoside (1), luteolin-7-O-glucoside-3-O-rhamnoside (2), rutin (3) and rutin-7-O-rhamnoside (4). All of the isolated flavonoids were identified by spectroscopic methods (UV, FAB-MS, $^1H-NMR\;&\;^{13}C-NMR$) and in comparison with the literature data. The isolated flavonoids 1, 2 and 4 are reported here for the first time from Gomphocarpus sinaicus Boiss. Three sets of experiments were carried out using the defatted alcoholic extract of Gomphocarpus sinaicus Boiss: the $1^{st}$ experiment indicated that the $LD_{50}$ was 49.82 mg/100 g b.wt. of intraperitoneally (i.p.) injected mice. The toxic signs were recorded within the first 24 hr post-injection. The $2^{nd}$ experiment revealed that the extract of the plant exhibited significant anti-inflammatory effects in normal rats. The $3^{rd}$ experiment was found that the tested doses of the extract in diabetic rats induced a significant decrease in serum glucose, AST, ALT, triglycerides, cholesterol and LDL, while HDL caused a significant increase.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2006년도 추계학술대회 논문집 Vol.19
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• pp.296-297
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• 2006

유기EL의 발광재료로 쓰일 수 있는 이핵 루테늄착체는 $Ru(bpy)_2Cl_2$와 새롭게 디자인한 가교체 (Bis(-2,2'-dipyridyl ketenylidene)-N,N-1,6-diphenylene diamine)의 반응으로부터 합성하였고, FT-IR, $^1H$-NMR, $^{13}C$-NMR, UV-vis, P.L, C.V를 이용하여 착체의 구조분석, 광학적 특성과 전기화학적인 특성을 측정하였다.

• Mycobiology
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• 제44권3호
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• pp.171-179
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• 2016

In the screening of marine mangrove derived fungi for lovastatin productivity, endophytic Aspergillus luchuensis MERV10 exhibited the highest lovastatin productivity (9.5 mg/gds) in solid state fermentation (SSF) using rice bran. Aspergillus luchuensis MERV10 was used as the parental strain in which to induce genetic variabilities after application of different mixtures as well as doses of mutagens followed by three successive rounds of genome shuffling. Four potent mutants, UN6, UN28, NE11, and NE23, with lovastatin productivity equal to 2.0-, 2.11-, 1.95-, and 2.11-fold higher than the parental strain, respectively, were applied for three rounds of genome shuffling as the initial mutants. Four hereditarily stable recombinants (F3/3, F3/7, F3/9, and F3/13) were obtained with lovastatin productivity equal to 50.8, 57.0, 49.7, and 51.0 mg/gds, respectively. Recombinant strain F3/7 yielded 57.0 mg/gds of lovastatin, which is 6-fold and 2.85-fold higher, respectively, than the initial parental strain and the highest mutants UN28 and NE23. It was therefore selected for the optimization of lovastatin production through improvement of SSF parameters. Lovastatin productivity was increased 32-fold through strain improvement methods, including mutations and three successive rounds of genome shuffling followed by optimizing SSF factors.

• Journal of Computational Design and Engineering
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• 제3권1호
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• pp.1-13
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• 2016

The increase of consumer needs for quality metal cutting related products with more precise tolerances and better product surface roughness has driven the metal cutting industry to continuously improve quality control of metal cutting processes. In this paper, two different approaches are discussed. First, design of experiments (DOE) is used to determine the significant factors and then fuzzy logic approach is presented for the prediction of surface roughness. The data used for the training and checking the fuzzy logic performance is derived from the experiments conducted on a CNC milling machine. In order to obtain better surface roughness, the proper sets of cutting parameters are determined before the process takes place. The factors considered for DOE in the experiment were the depth of cut, feed rate per tooth, cutting speed, tool nose radius, the use of cutting fluid and the three components of the cutting force. Finally the significant factors were used as input factors for fuzzy logic mechanism and surface roughness is predicted with empirical formula developed. Test results show good agreement between the actual process output and the predicted surface roughness.

• 한국태양에너지학회:학술대회논문집
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• 한국태양에너지학회 2012년도 춘계학술발표대회 논문집
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• pp.91-95
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• 2012

본 연구에서는 열충격 시험을 통하여 Cell레벨에서의 효율저하 특성을 분석하였다. 열충격 시험은 PV모듈의 시험 규격인 KS C IEC-61215를 이용하여 보다 가혹한 조건인 $-40^{\circ}C$에서 $120^{\circ}C$의 조건으로 500사이클 수행하였다. I-V 측정을 통하여 효율을 분석한 결과, 열충격 시험 전 13.9%에서 열충격 시험 후 11.0%로 효율이 저하 됐으며, 감소율은 20.9% 나타났다.EL촬영을 통해 표면을 분석한 결과 Ribbon접합부 및 Gridfinger의 손상으로 확인 됐으며, 보다 정확한 효율 저하의 원인을 분석하기 위해 단면분석을 실시한 결과 표면손상으로 확인 되었던 위치의 Cell내부에서도 Crack을 확인 할 수 있었다. 또한 FF값을 분석한 결과 열충격 시험 전 72.3%에서 시험 후 62.0%로 11.8%의 감소율을 보였다. 따라서, 경년 시 나타나는 효율저하는 Cell자체의 소모전력 증가와 외부환경에 의한 표면 손상 및 Cell내부의 Crack에 기인하여 가속된다고 판단된다.

• Journal of Microbiology
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• 제44권4호
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• pp.432-438
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• 2006

Twelve actinomycete strains were isolated from Egyptian soil. The isolated actinomycete strains were then screened with regard to their potential to generate antibiotics. The most potent of the producer strains was selected and identified. The cultural and physiological characteristics of the strain identified. the strain as a member of the genus Streptomyces. The nucleotide sequence of the 16S rRNA gene (1.5kb) of the most potent strain evidenced a 99% similarity with Streptomyces spp. and S. aureofaciens 16S rRNA genes, and the isolated strain was ultimately identified as Streptomyces sp. MAR01. The extraction of the fermentation broth of this strain resulted in the isolation of one major compound, which was active in vitro against gram-positive, gram-negative representatives and Candida albicans. The chemical structure of this bioactive compound was elucidated based on the spectroscopic data obtained from the application of MS, IR, UV, $^1H$ NMR, $^{13}C$ NMR, and elemental analysis techniques. Via comparison to the reference data in the relevant literature and in the database search, this antibiotic, which had a molecular formula of $C_{19}H_{29}NO_2$ and a molecular weight of 303.44, was determined to differ from those produced by this genus as well as the available known antibiotics. Therefore, this antibiotic was designated Meroparamycin.