• The Korean Journal of Physiology and Pharmacology
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• v.23 no.6
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• pp.427-448
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• 2019

Nociceptin/orphanin FQ (N/OFQ) and its receptor, nociceptin opioid peptide (NOP) receptor, are localized in brain areas implicated in depression including the amygdala, bed nucleus of the stria terminalis, habenula, and monoaminergic nuclei in the brain stem. N/OFQ inhibits neuronal excitability of monoaminergic neurons and monoamine release from their terminals by activation of G protein-coupled inwardly rectifying $K^+$ channels and inhibition of voltage sensitive calcium channels, respectively. Therefore, NOP receptor antagonists have been proposed as a potential antidepressant. Indeed, mounting evidence shows that NOP receptor antagonists have antidepressant-like effects in various preclinical animal models of depression, and recent clinical studies again confirmed the idea that blockade of NOP receptor signaling could provide a novel strategy for the treatment of depression. In this review, we describe the pharmacological effects of N/OFQ in relation to depression and explore the possible mechanism of NOP receptor antagonists as potential antidepressants.

• The Korean Journal of Rehabilitation Nursing
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• v.8 no.1
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• pp.31-37
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• 2005

Purpose: This study was to evaluate the effects of foot reflexology on depression and anxiety in coal workers' pneumoconiosis. Method: The research design used was a non-equivalent control group pretest-posttest design. The foot reflexology was performed for 60 minutes twice a week through five weeks in the experimental group, not in the control group. The subjects of this study consisted of both the experimental group of twenty-nine and the control group of thirty coal workers' pneumoconiosis. The data were collected from December 10, 2002 to February 15, 2003. To evaluate the effects of foot reflexology the scores of depression and anxiety were measured before and after the experiment in both groups. Data of this experiment were analyzed by Chi-square test, t-test, unpaired t-test, ANCOVA and Repeated Measures ANOVA with the SAS Program. Results: The score of depression decreased in the experimental group, not in the control group. There was a significant difference of depression between the two groups. The score of anxiety decreased in the experimental group, not in the control group. There was a significant difference of anxiety between the two groups. Conclusion: As a summary of the study results, foot reflexology was regarded that it attributed to the emotional promotion of coal workers' pneumoconiosis. Therefore the foot reflexology is considered that might be used as an effective skill of nursing intervention program for coal workers' pneumoconiosis.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.15 no.4
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• pp.504-512
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• 2008

Purpose: The purpose of this study was to identify the effects of self foot reflexology on depression, sleep, and low back pain in elderly women. Method: The study was one group pre-posttest design. Data collection was done from December 2007 to January 2008 in D city. The participants were 47 women (65 years of age and over). After two weeks of reflexology education, the women did foot reflexology themselves for approximately 40 minutes, five times a week for four weeks. To verify the effects of foot reflexology, the scores for depression, sleep, and LBP were measured at baseline, after 4 weeks of self-treatment. Repeated measure ANOVA with the SPSS WIN 14.0 program were used to analyze the data. Results: There were significant differences in depression, sleep, and LBP between baseline, after 4 weeks of self-treatment. Conclusion: These findings suggest that self foot reflexology could be utilized as an effective nursing intervention for improving depression, sleep, and LBP in elderly women.

• Journal of Korean Academy of Nursing
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• v.42 no.4
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• pp.477-485
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• 2012

Purpose: This study was done to evaluate the effects of antenatal depression on birth outcomes. Methods: The participants were 255 pregnant women who were followed in a prospective study. Of these, 197 cases were examined included birth weight, Apgar scores at 5 minute, premature contraction, complication of labor, delivery types and laboratory data. Descriptive statistics, ANOVA, Chi square test of linear by linear association, Kruskal Wallis test, Relative Risk, univariate and adjusted multiple logistic regression were used for data analysis with SPSS/Win. Results: Level of antenatal depression was associated with low birth weight ($x^2$=7.69, p=.010). High risk pregnancy was a predictor of low birth weight (OR=6.98 [1.21-40.30]) and baby's weight (OR=2.12, [1.05-4.28]). Prepregnancy body mass index (BMI) was a predictor of complications in labor (OR=3.59, [1.03-12.48]). But there were no significant effects of antenatal depression on other birth outcomes. Conclusion: The results of this study indicate that women with antenatal depression, high risk pregnancy, prepregnancy $BMI{\geq}23kg/M^2$ should be monitored and managed to ensure favorable birth outcomes.

• Korean Journal of Adult Nursing
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• v.20 no.5
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• pp.756-764
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• 2008

Purpose: The purpose of this study was to examine the effects of aromatherapy on dysmenorrhea, menstrual pain, anxiety, and depression in female college students. Methods: A two-group cross-over design was used. The sample included a total of 20 female students who were enrolled in a 3 year nursing program. The treatments(aroma essential oil inhalation and the placebo inhalation) were given using a necklace. The data were analyzed by $x^2$-test, paired t-test, and Mann-Whitney test using SPSS/WIN 12.0 program. Results: The level of dysmenorrhea after the aroma treatment was not significantly different from the dysmenorrhea levels at pre-test and after the post-placebo treatment. The menstrual pain, anxiety and depression significantly improved after the aroma treatment. However, the levels of pain, anxiety, and depression after the aroma treatment were not significantly different from those after the placebo treatment. Conclusion: Aroma inhalation may be a effective in managing menstrual pain, anxiety, and depression. In order to further clarify the effect of aroma treatment on discomfort during menstruation, replication studies are necessary. Future studies need to examine the effects of different types of essential oils, administrating methods, and the lasting time of aroma treatment effect.

• Journal of Family Relations
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• v.20 no.4
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• pp.157-172
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• 2016

Object: This study investigated the effect of self-esteem on depression through family relations satisfaction and tested whether working types would moderate such associations. Method: The subjects were 2,145 elderly who are healthy enough to work and were selected for the ninth Korean Welfare Panel Study. The resulting data were analysed by using the statistical program SPSS 2.1 with reference to steps for testing mediation by Baron and Kenny, moderated mediation by Heyes. Results: Self-esteem has both direct and indirect significant effects, revealing that family relations satisfaction fully mediates the effects of coping strategies of family conflict on depression. From the working types, self-employed/employer and unpaid family worker, moderate the indirect effect of self-esteem on depression through family relations satisfaction. Conclusions: In practical intervention of elderly depression reduction, efforts to increase family relations satisfaction is effective when it is difficult to us address satisfaction. Moreover, we have to provide intervention for elderly with work in context of relationship of individual and familial factor.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.12 no.2
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• pp.240-246
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• 2005

Purpose: This study was done to examine the effects of foot massage as a nursing intervention on preoperative anxiety, depression and sleep satisfaction in patients with breast surgery. Method: Research design was a nonequivalent control group non-synchronized design. Forty-one patients were assigned to the control group (21) and the experimental group (20). The patients answered a questionnaire containing measures of anxiety, depression and sleep satisfaction before and after the intervention. The collected data were analyzed by means of descriptive statistics, Cronbach's ${\alpha}$, Chi-square test, and t test using the SPSS WIN 11.0 program. Result: Anxiety and depression for the experimental group were significantly lower than those for the control group(t=2.556, p=0.008, t=2.932, p=0.006). Sleep pattern of the experimental group was significantly higher than that of the control group (t=2.313, p=0.013). Conclusion: Judging from these results, it is suggested that foot massage might have beneficial effects on reducing preoperative anxiety, depression, and increasing sleep satisfaction.

• Korean Journal of Human Ecology
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• v.16 no.5
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• pp.909-920
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• 2007

The purpose of this study was to investigate the effects of group art therapy on increasing Self-Supporting Recipients Women's well-being and on decreasing their depression. This group art therapy program model was developed based on problem -solving theory and art therapy theory. This program was consisted of 15 session with 9 women focused on self understanding through perception of multiple problems of self-supporting recipients women. Dependent variables were index of well-being and depression. The results were as follows. This program showed the significant differences between post-test and pre-test scores in the scale of well-being and depression. Also that showed the significant difference between follow-up and post test score in the scales of well-being, but there is no difference between follow-up and post test. In Conclusion, group art therapy employed for this study have significant effects of increasing well-being and decreasing depression.

• Women's Health Nursing
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• v.19 no.2
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• pp.88-98
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• 2013

Purpose: To examine the effects of a case management program on self-efficacy, depression and anxiety in pregnant women with gestational diabetes mellitus. Methods: Thirty-seven patients who enrolled in a diabetes outpatient clinic were randomly assigned to either an experimental group (n=19) or a control group (n=18). The experimental group received a 2-week intervention composed of a series of one face-to-face interactive interview and five telephone interviews based on the National standards for diabetes self-management education and Bandura's self-efficacy resources of performance accomplishment, vicarious experience, verbal persuasion, and emotional arousal. The effects of the intervention were assessed by completion of a 9-item self-efficacy questionnaire, a 20-item depression questionnaire and a 20-item anxiety questionnaire prior to, and after the intervention. The statistical significances were examined using t-test. Results: The change in self-efficacy was significantly greater in the experimental group than in the control group. Depression and anxiety changes in the experimental group were significantly greater compared to those in the control group. Conclusion: The results of study suggest that a case management program improves self-efficacy, and decreases depression and anxiety in pregnant women with gestational diabetes mellitus.

• CELLMED
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• v.9 no.2
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• pp.2.1-2.1
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• 2019

Depression is common psychiatric diseases characterized by diverse physical and emotional symptoms including low mood, loss of interest in pleasurable activities, and feelings of worthlessness. Depression causes of death and disability. The first antidepressant was created by the idea that central serotonin mechanism. Selective serotonin reuptake inhibitor, fluoxetine is the first-line drug in the treatment of depressive disorder and their few side effects as opposed to tricyclic antidepressants. Not all people with depression respond adequately to standard treatments. Korean music playing/listening actions appear to be a reliable approach to developing recovery from depression.