• Journal of electromagnetic engineering and science
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• v.14 no.1
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• pp.36-42
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• 2014

In this paper, an epsilon near zero (ENZ) tunneling circuit using a double-ridge rectangular waveguide (RWG) is proposed for the miniaturization of a waveguide component. The proposed ENZ channel and is located in the middle of the input-output RWG (IORWG). The ratio of the height to the width of the channel waveguide is very small compared to the IORWG. By properly adjusting the ridge dimensions, the tunneling frequency of the proposed ENZ channel can be lowered to near the cut-off frequency of the IORWG. For the proposed ENZ tunneling circuit, the approach adopted for extracting the effective permittivity, effective permeability;normalized effective wave impedance, and propagation constant from the simulated scattering parameters was explained. The extracted parameters verified that the proposed channel is an ENZ channel and electromagnetic energy is tunneling through the channel. Simulation and measurement results of the fabricated ENZ channel structure agreed.

• Proceedings of the Korean Society of Applied Pharmacology
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• 2006.04a
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• pp.123-135
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• 2006

Alzheimer's disease (AD) is the most common form of dementia in the aging population and is clinically characterized by a progressive loss of cognitive abilities. Pathologically, it is defined by the appearance of senile plaques - extracellular insoluble, congophilic protein aggregates composed of amyloid $\beta$ (A$\beta$) and neurofibrillary tangles (NFTs) - inyracellular lesions consisting of paired helical filaments from hyperphosphorylated cytoskeletal tau protein as described by Alois Alzheimer a century ago. These hallmarks still serve as the major criteria for a definite diagnosis of the disease. Consequently, one of the key strategy for drug development in this disease area focuses on reducing the concentration of cerebral A$\beta$ plaque by using substances that inhibit A$\beta$ fibril formation. We focused on developing inhibitors by synthesizing several kinds of aromatic molecules. The synthetic compounds were initially screened to evaluate the effective compound by tioflavin T fluorescence assay. The selected effective compounds were tested cytotoxicity and protective effect from A$\beta$-induced neuronal toxicity by cell based MTT assay with HT22 hippocampal neurons. The BBB permeability on effectors was also tested in in vitro co-culture model(HUVEC/C6 cell line). The behavior test wea carried out in mutant APP/PS1 transgenic mouse model of Alzheimer's disease. And inhibition of A$\beta$ fibril formation by the effective compound was monitored with transmitted electron microscopic images.

• Journal of the Korean Society of Clothing and Textiles
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• v.22 no.5
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• pp.565-574
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• 1998

The purpose of the study was to determine the effect of air velocity on the thermal resistance of wool ensembles. Three suits for men with different weaving structure and density were made with the same design and size for the study. In addition, Y-shirt, underwear, and socks were prepared for constructing the ensembles. Thermal insulation of air layer and 3 ensembles were measured by using thermal manikin in environmental chamber controlled at 2$0^{\circ}C$ and 65% RH with various air velocity. The results were as follows: 1. Thermal resistance of air layer was 0.079 m2.$^{\circ}C$/W with no air velocity(less than 0.2m/sec). 2. Thermal resistance of air layer decreased with increasing the air velocity rapidly. When the air velocity was 0.25 and 2.89 m/sec, the decreasing rate was 15% and 61%, respectively compared with no air velocity. 3. While there was little difference among the effective thermal insulation of 3 ensembles having different weaving structure and density with no air velocity, there was sharp difference among them when the air velocity increased. That is, the decreasing rate of effective thermal insulation of the ensemble which has higher air permeability was higher. 4. The decreasing rates of the effective thermal resistances of plain, twill and satin ensemble were 61, 54, and 49%, respectively when the air velocity was 2.89 m/sec which was a maximum air velocity in this study.

• The Journal of Engineering Geology
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• v.12 no.3
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• pp.319-332
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• 2002

This study is focused on the characterization of an effective hydraulic conductivity in each hydrogeologic unit assumed as an equivalent continuum medium in the granitic area. Four boreholes of 3" diameter were installed and a Multi-packer system was facilitated in the selected borehole. Various in-situ tests including the fracture logging, constant injection and fall-off tests, slug and pulse tests were carried out. A hydrogeologic unit was defined into the upper and lower zones based on the variation of fracture properties and hydraulic conductivities. The difference of the result obtained by the various hydraulic tests and the effective characterization techniques on rock mass permeability are also discussed. The effective hydraulic conductivity of the upper unit was measured by two times(5.27E-10 m/s~7.57E-10 m/s) that of the lower unit(2.45E-10 m/s~6.81E-10 m/s)through the constant injection and fall-off tests.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.23 no.3
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• pp.402-405
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• 2012

In this paper, we proposed a novel metamaterial unit cell utilizing an interdigital capacitor(IDC) with non-bianisotropic property. Due to the induced magnetic resonance of an IDC unit cell, exotic effective constitutive parameters can be realized like a split ring resonator(SRR). Furthermore, the proposed unit cell is electrically smaller than a conventional SRR unit cell. The effective parameters retrieved from the transmission responses of waveguide measurement method and simulated results show good agreement.

• Journal of Korean Society of Water and Wastewater
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• v.28 no.2
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• pp.181-193
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• 2014

Various treatment system for residuals have applied to save water resources, but most of them were not be satisfied with legal standard consistently. In this study, submerged membrane treatment system was operated to treat water treatment plant residuals and operation parameters was evaluated. Result of this experiment, high concentration organic matters contributed to high increase Transmembrane pressure(TMP) of membrane system(from 0.05 bar to 0.35 bar). And backwash process was effective to stabilize membrane system operation. After Cleaning-In-Place(CIP), permeability was recovered about 100 % from first operation condition. Inorganic matters (Fe, Mn, Al, Ca, Mg) were not effective membrane filtration performance. The quality of residual treatment was satisfied with drinking water quality standard and a treated water from that system was suitable for water reuse.

• Proceedings of the KSRS Conference
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• v.2
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• pp.717-720
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• 2006

In this study, we predicted locations vulnerable to ground subsidence hazard using fuzzy logic and geographic information system (GIS). Test was carried out at an abandoned underground coal mine in Samcheok City, Korea. Estimation of relative ratings of eight major factors influencing subsidence and determination of effective fuzzy operators are presented. Eight major factors causing ground subsidence were extracted and constructed as a spatial database using the spatial analysis and the probability analysis functions. The eight factors include geology, slope, landuse, depth of mined tunnel, distance from mined tunnel, RMR, permeability, and depth of ground water. A frequency ratio model was applied to calculate relative rating of each factor, and the ratings were integrated using fuzzy membership function and five different fuzzy operators to produce a ground subsidence susceptibility map. The ground subsidence susceptibility map was verified by comparing it with the existing ground subsidences. The obtained susceptibility map well agreed with the actual ground subsidence areas. Especially, ${\gamma}-operator$ and algebraic product operator were the most effective among the tested fuzzy operators.

• Archives of Pharmacal Research
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• v.25 no.5
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• pp.572-584
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• 2002

Rapid development in molecular biology and recent advancement in recombinant technology increase identification and commercialization of potential protein drugs. Traditional forms of administrations for the peptide and protein drugs often rely on their parenteral injection, since the bioavailability of these therapeutic agents is poor when administered nonparenterally. Tremendous efforts by numerous investigators in the world have been put to improve protein formulations and as a result, a few successful formulations have been developed including sustained-release human growth hormone. For a promising protein delivery technology, efficacy and safety are the first requirement to meet. However, these systems still require periodic injection and increase the incidence of patient compliance. The development of an oral dosage form that improves the absorption of peptide and especially protein drugs is the most desirable formulation but one of the greatest challenges in the pharmaceutical field. The major barriers to developing oral formulations for peptides and proteins are metabolic enzymes and impermeable mucosal tissues in the intestine. Furthermore, chemical and conformational instability of protein drugs is not a small issue in protein pharmaceuticals. Conventional pharmaceutical approaches to address these barriers, which have been successful with traditional organic drug molecules, have not been effective for peptide and protein formulations. It is likely that effective oral formulations for peptides and proteins will remain highly compound specific. A number of innovative oral drug delivery approaches have been recently developed, including the drug entrapment within small vesicles or their passage through the intestinal paracellular pathway. This review provides a summary of the novel approaches currently in progress in the protein oral delivery followed by factors affecting protein oral absorption.

• Proceedings of the Korean Geotechical Society Conference
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• 2009.09a
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• pp.1170-1180
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• 2009

Recently this country has carried out the coast reclamation centering on the west and south coast for effective practical use of a country, considering purchase of materials and environmental problem, most reclaiming work is processing to spoil reclamation which is easy to secure the amount of materials. In case of weak ground that is formed by spoil reclamation like this, initial moisture content is high, as slurry state that is rarely revealed ground strength, compressibility and water permeability have been shown nonlinear change by compaction progress. Analysis of weak ground is unreasonable because the existing Terzaghi compaction theory analyzes compaction fixed number to regular invariable number for prediction of compaction state. This study computes the relation with void ratio-effective pressure and void ratio-finite transformation which is the most basic matter to predict finite strain compaction state of the south coast spoil, and analyze the basic feature to predict compaction feature of the south coast spoil reclaimed ground.

• Membrane and Water Treatment
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• v.14 no.3
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• pp.107-114
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• 2023

Graphene oxide (GO) membranes have attracted extensive attention in water treatment and related fields. However, GO films are unstable and have low permeability, which have hindered their further development. In this paper, a simple and effective method was used in which GO and single-layer graphene (GN) were mixed, and the layer spacing was effectively controlled by accurately controlling the ratio of GO to GN. GO-GN composite membranes have excellent stability, salt rejection (95.4%), and water flux (26 L m^-2 h^-1 bar^-1). This unique design structure can be used for precise and effective regulation of the layer spacing in GO, improving the rejection rate, and increasing water flux via the enhancement of low-friction capillary action. The rational development and use of this unique composite membrane provides a reference for the water treatment field.