• 운동영양학회지
• /
• 제13권1호
• /
• pp.37-44
• /
• 2009

The purpose of this study was to investigate the change of bone metabolic parameters between climbing exercise training and treadmill running training with alpha lipoic acid supplementation in ovariectomized rats. Fifty-six Sparague-Dawley, 8 weeks of age, were assigned into nine groups: normal control at pre-test (Pre-NC), normal control at post-test (NC), sham-sedentary (SS), ovariectomized-control (OVX-Con), ovariectomized-ALA inject (OVX-ALA), ovariectomized-climbing exercise (OVX-CE), ovariectomized-ALA inject+climbing exercise (OVX-ACE), ovariectomized-treadmill exercise (OVX-TE) and ovariectomized-ALA inject+treadmill exercise (OVX-ATE). The climbing exercise group voluntarily climbed the 200 cm tower to drinking water from the bottle set at the top of it. The treadmill exercise group was performed the 60 min treadmill running with grade 6-8%, and velocity 10-15 m/min. The frequency of exercise training was performed 6 days per wk in both training intervention. For the comparison of bone metabolic responses following to different training intervention, the strength, length and weight of femur, total bone density, bone mineral contents, deoxypyridioline, osteocalcin and parathyroid hormone, estradiol and lutenizing hormone were measured in this study. The body weight was higher in the OVX-Con, OVX-ALA and OVX-TE groups as compared to NC group. The total bone mineral density of OVX-ACE showed a higher value than SS, OVX-Con, OVX-ATE and OVX-TE. But urine and blood metabolic parameters showed no significance among groups. In conclusion, this study results suggested that climbing exercise training and alpha lipoic acid supplementation may an effective intervention for prevention of osteoporosis in ovriectomized rats.

• 한국작물학회지
• /
• 제69권1호
• /
• pp.15-24
• /
• 2024

Environmental factors play an important role in crop growth and development. In recent years, climate change has become a challenge that limits environmental factors. Light is an important environmental factor for photosynthesis in rice. In addition, temperature is one of the most important factors for rice production; thus, a 1℃ increase in temperature because of climate change can affect rice growth and development. Therefore, we investigated the effect of shading on the growth characteristics of rice under different temperature conditions from the vegetative stage to the flowering stage. Plants were grown at three different temperatures: 26℃/16℃ for 21℃, 29℃/19℃ for 24℃, and 22℃/32℃ for 27℃ in a phytotron. A 55% shade treatment was applied after 10 days of transplanting until the flowering stage. Plant height was not affected by the shading treatment. In the maximum tiller number response to shading, a lower tiller number and growth speed of tiller was found in the 27℃ condition. Among leaf characteristics, shading increased the flag leaf area, length, width, and effective leaf area; however, it decreased the leaf number on the main stem, especially at 27℃. In terms of stem characteristics, shading affected culm wall thickness in both varieties. Finally, regarding the panicle characteristics, lower panicle numbers, spikelet numbers per panicle, primary numbers, and secondary numbers per panicle were found under the shading treatment. Most of the desirable characteristics were affected by the shading treatment at 27℃. Overall, these results indicated that shading had a greater effect on rice plant growth at high temperature.

• Hip & pelvis
• /
• 제36권2호
• /
• pp.87-100
• /
• 2024

Total hip arthroplasty (THA) is an effective treatment for osteoarthritis, and the popularity of the direct anterior approach has increased due to more rapid recovery and increased stability. Instability, commonly caused by component malposition, remains a significant concern. The dynamic relationship between the pelvis and lumbar spine, deemed spinopelvic motion, is considered an important factor in stability. Various parameters are used in evaluating spinopelvic motion. Understanding spinopelvic motion is critical, and executing a precise plan for positioning the implant can be difficult with manual instrumentation. Robotic and/or navigation systems have been developed in the effort to enhance THA outcomes and for implementing spinopelvic parameters. These systems can be classified into three categories: X-ray/fluoroscopy-based, imageless, and computed tomography (CT)-based. Each system has advantages and limitations. When using CT-based systems, preoperative CT scans are used to assist with preoperative planning and intraoperative execution, providing feedback on implant position and restoration of hip biomechanics within a functional safe zone developed according to each patient's specific spinopelvic parameters. Several studies have demonstrated the accuracy and reproducibility of robotic systems with regard to implant positioning and leg length discrepancy. Some studies have reported better radiographic and clinical outcomes with use of robotic-assisted THA. However, clinical outcomes comparable to those for manual THA have also been reported. Robotic systems offer advantages in terms of accuracy, precision, and potentially reduced rates of dislocation. Additional research, including conduct of randomized controlled trials, will be required in order to evaluate the long-term outcomes and cost-effectiveness of robotic-assisted THA.

• 지능정보연구
• /
• 제22권1호
• /
• pp.83-105
• /
• 2016

의료IT 서비스의 유망 분야인 정신건강 증진을 위한 주관적 웰빙 서비스(subjective well-being service) 구현의 핵심은 개인의 주관적 웰빙 상태를 정확하고 무구속적이며 비용 효율적으로 측정하는 것인데 이를 위해 보편적으로 사용되는 설문지에 의한 자기보고나 신체부착형 센서 기반의 측정 방법론은 정확성은 뛰어나나 비용효율성과 무구속성에 취약하다. 비용효율성과 무구속성을 보강하기 위한 온라인 텍스트 기반의 측정 방법은 사전에 준비된 감정어 어휘만을 사용함으로써 상황에 따라 감정어로 볼 수 있는 이른바 상황적 긍부정성(contextual polarity)을 고려하지 못하여 측정 정확도가 낮다. 한편 기존의 상황적 긍부정성을 활용한 감성분석으로는 주관적 웰빙 상태인 맥락에서의 감성분석을 할 수 있는 감정어휘사전이나 온톨로지가 구축되어 있지 않다. 더구나 온톨로지 구축도 매우 노력이 소요되는 작업이다. 따라서 본 연구의 목적은 온라인상에 사용자의 의견이 표출된 비정형 텍스트로부터 주관적 웰빙과 관련한 상황감정어를 추출하고, 이를 근거로 상황적 긍부정성 파악의 정확도를 개선하는 방법을 제안하는 것이다. 기본 절차는 다음과 같다. 먼저 일반 감정어휘사전을 준비한다. 본 연구에서는 가장 대표적인 디지털 감정어휘사전인 SentiWordNet을 사용하였다. 둘째, 정신건강지수를 동적으로 추정하는데 필요한 비정형 자료인 Corpora를 온라인 서베이로 확보하였다. 셋째, Corpora로부터 세 가지 종류의 자원을 확보하였다. 넷째, 자원을 입력변수로 하고 특정 정신건강 상태의 지수값을 종속변수로 하는 추론 모형을 구축하고 추론 규칙을 추출하였다. 마지막으로, 추론 규칙으로 정신건강 상태를 추론하였다. 본 연구는 감정을 분석함에 있어, 기존의 연구들과 달리 상황적 감정어를 적용하여 특정 도메인에 따라 다양한 감정 어휘를 파악할 수 있다는 점에서 독창성이 있다.

• 한국산학기술학회논문지
• /
• 제18권10호
• /
• pp.227-236
• /
• 2017

본 연구는 황기의 사포닌 성분 Astragaloside를 첨가한 모영양제 화장품을 제조하여 눈썹의 성장 및 발육에 미치는 영향을 살펴보고 제품개발의 가능성을 제시하고자 하였다. 실험 전 설문을 통해 일반인을 대상으로 모(毛)영양제 사용 실태를 조사한 후, 연구대상자의 모(毛)특성상 실험군과 대조군을 동일인으로 하여 우측 눈의 눈썹을 사포닌군(Astragaloside 0.5% 첨가), 좌측 눈의 눈썹을 대조군(Astragaloside를 무첨가)으로 나누어 6주간 실험을 진행하였다. 본 연구결과 대조군에서는 눈썹 길이 및 눈썹의 굵기 변화가 유의미하게 나타나지 않았으나, Astragaloside 0.5% 첨가한 사포닌군에서는 눈썹의 길이, 눈썹 모근과 눈썹 중간 굵기가 유의미하게 증가하여 효과적인 천연물 소재임을 확인할 수 있었다. 또한 연구대상자들의 주관적 평가인 사용성 평가, 제품성 평가, 만족감 평가 결과는 사포닌 성분 Astragaloside의 사용성이나 제품성에 있어서 적합성을 뒷받침해 주었다. 이와 같은 결과는 눈썹의 숱이나 길이 감소로 고민하는 사람들을 위해 황기의 사포닌 성분인 Astragaloside를 첨가한 모영양제 화장품 도포는 눈썹 성장을 개선하고 유지하는데 도움이 될 것으로 사료되며, 향후 제품 개발의 가능성이 있음을 알 수 있었다.

• 한국지반환경공학회 논문집
• /
• 제23권2호
• /
• pp.25-36
• /
• 2022

본 연구에서는 감압정의 침투수 처리 효과를 정량적으로 분석하여 소규모 필댐과 하천제방에서 제체를 통과하는 침투수의 처리 효과를 확인하였다. 이를 위해 댐과 제방에서의 제체와 기초지반의 투수 특성에 따른 침투해석을 수행하여 침투수의 거동특성을 파악하여 댐 제체 선단에 작용하는 양압력을 분석하였다. 또한 감압정의 설치 조건을 변수로 분석하여 댐 또는 제방의 제체 선단에 작용하는 양압력의 감소 효과를 분석함으로써 침투수 처리 효과를 분석하였다. 감압정은 파이핑 현상 또는 양압력을 유발하는 제체의 선단 하부 기초지반에서의 작용 간극수압을 감소시키는 효과가 있는 것으로 평가되었으며, 제체의 높이 및 비탈면 기울기와 같은 기하학적 조건에 크게 영향을 받지 않고 간극수압을 관리할 수 있는 것으로 확인되었다. 투수성이 상대적으로 큰 조립토 지반에 비해 세립토 지반에서 감압정의 간극수압 저감 효과는 상대적으로 저하되지만 감압정이 설치되지 않은 조건에 비해서 간극수압 저감 효과를 기대할 수 있는 것으로 확인되었다. 감압정의 직경, 설치 깊이에 따라서 감압정의 저감 효과는 상대적으로 차이가 발생하지만 감압정의 설치 깊이가 침투수 관리에 가장 효과적인 것으로 확인되었다.

• Journal of Ginseng Research
• /
• 제46권5호
• /
• pp.628-635
• /
• 2022

Background: Ulcerative colitis (UC) is the large intestine disease that results in chronic inflammation and ulcers in the colon. Rg3-enriched Korean Red Ginseng extract (Rg3-RGE) is known for its pharmacological activities. Persicaria tinctoria (PT) is also used in the treatment of various inflammatory diseases. The aim of this study is to investigate the attenuating effects of Rg3-RGE with PT on oxazolone (OXA)-induced UC in mice. Methods: A total of six groups of mice including control group, OXA (as model group, 1.5%) group, sulfasalazine (75 mg/kg) group, Rg3-RGE (20 mg/kg) group, PT (300 mg/kg) group, and Rg3-RGE (10 mg/kg) with PT (150 mg/kg) group. Data on the colon length, body weight, disease activity index (DAI), histological changes, nitric oxide (NO) assay, Real-time PCR of inflammatory factors, ELISA of inflammatory factors, Western blot, and flow cytometry analysis were obtained. Results: Overall, the combination treatment of Rg3-RGE and PT significantly improved the colon length and body weight and decreased the DAI in mice compared with the treatment with OXA. Additionally, the histological injury was also reduced by the combination treatment. Moreover, the NO production level and inflammatory mediators and cytokines were significantly downregulated in the Rg3-RGE with the PT group compared with the model group. Also, NLR family pyrin domain containing 3 (NLRP3) inflammasome and nuclear factor kappa B (NF-𝛋B) were suppressed in the combination treatment group compared with the OXA group. Furthermore, the number of immune cell subtypes of CD4⁺ T-helper cells, CD19⁺ B-cells, and CD4⁺ and CD25⁺ regulatory T-cells (Tregs) was improved in the Rg3-RGE with the PT group compared with the OXA group. Conclusion: Overall, the mixture of Rg3-RGE and PT is an effective therapeutic treatment for UC.

• 보건행정학회지
• /
• 제33권3호
• /
• pp.311-324
• /
• 2023

Background: Long-term care insurance for the elderly has been stably established along with the quantitative expansion of long-term care facilities. Indeed, the need for a paradigm about human rights-based service approach is being raised throughout society from a service perspective. Therefore, this study aimed to analyze the association between elderly human rights awareness and quality of service by considering human rights education as a moderate variable. Methods: This study conducted surveys with 138 caregivers working in long-term care facilities located in Seoul and Gangwon. General characteristics, awareness of human rights, and the level of service quality were examined using descriptive statistics, frequency analysis, and correlation analysis. And multi-variable linear regression with a hierarchical framework was employed. These analyses were performed using IBM SPSS ver. 25.0. Results: Of the 138 caregivers, 97.1% were female, 87.7% were more than 50 years old, and most of their education level was high-school graduates. Their length of employment ranged from more than 5 years to less than 10 years. The level of awareness regarding elderly human rights of the elderly was below normal (mean=2.21), but the quality of service was high (mean=4.21), and the need for human rights education was also high (mean=4.28). Among the general characteristics, the length of employment was significantly associated with awareness of elderly human rights. Moreover, political rights awareness, included as sub-domains of human rights, was positively associated with quality of service. However, the moderating variable, human rights education, was not significantly associated with the quality of service. Conclusion: In this study, human rights education, as a moderating variable, did not have a statistically significant effect on caregivers' human rights awareness in relation to service quality. This finding is inconsistent with previous research results. These results can be explained by the fact that the frequency of education in long-term care facilities was a significant factor in the practice of protecting the human rights of the elderly. Therefore ongoing encouragement for the frequency of current human rights education and improvements in the educational approach appear to be necessary. In addition, these findings reveal the need for strength of education policies and effective in-depth research about human rights and quality of service to respect the human rights of the elderly.

• 대한약침학회지
• /
• 제27권2호
• /
• pp.59-69
• /
• 2024

This study investigates the therapeutic potential of Indigo Naturalis (IN) in treating a Inflammatory Bowel Disease (IBD). The objective is to comprehensively examine the effects and pharmacological mechanisms of IN on IBD, assessing its potential as an novel treatment for IBD. Analysis of 11 selected papers is conducted to understand the effects of IN, focusing on compounds like indirubin, isatin, indigo, and tryptanthrin. This study evaluates their impact on Disease Activity Index (DAI) score, colon length, mucosal damage, and macrophage infiltration in Dextran Sulfate Sodium (DSS)-induced colitis mice. Additionally, It investigate into the anti-inflammatory mechanisms, including Aryl hydrocarbon Receptor (AhR) pathway activation, Nuclear Factor kappa B (NF-κB)/nod-like receptor family pyrin domain containing 3 (NLRP3)/Interleukin 1 beta (IL-1β) inhibition, and modulation of Toll-like receptor 4 (TLR4)/myeloid differentiation primary response 88 (MYD88)/NF-κB and Mitogen Activated Protein Kinase (MAPK) pathways. Immunomodulatory effects on T helper 17 (Th17)/regulatory T cell (Treg cell) balance and Glycogen synthase kinase-3 beta (GSK3-β) expression are also explored. Furthermore, the study addresses the role of IN in restoring intestinal microbiota diversity, reducing pathogenic bacteria, and increasing beneficial bacteria. The findings reveal that IN, particularly indirubin and indigo, demonstrates significant improvements in DAI score, colon length, mucosal damage, and macrophage infiltration in DSS-induced colitis mice. The anti-inflammatory effects are attributed to the activation of the AhR pathway, inhibition of inflammatory pathways, and modulation of immune responses. These results exhibit the potential of IN in IBD treatment. Notably, the restoration of intestinal microbiota diversity and balance further supports its efficacy. IN emerges as a promising and effective treatment for IBD, demonstrating anti-inflammatory effects and positive outcomes in preclinical studies. However, potential side effects necessitate further investigation for safe therapeutic development. The study underscores the need for future research to explore a broader range of active ingredients in IN to enhance therapeutic efficacy and safety.

• 한국건축시공학회지
• /
• 제22권4호
• /
• pp.359-370
• /
• 2022

현장의 안전사고율을 낮추려는 지속적인 노력에도 불구하고 여전히 건설산업은 치명적인 사고율이 높은 고위험군으로 분류된다. 건설 안전사고율을 낮추기 위한 방법 중 하나로 설계 단계에서 안전위해요소를 관리하는 DFS(Design for safety)를 적용하고 있다. 그러나 설계자의 제한된 지식 때문에 설계 결과가 건설, 운영 및 유지보수와 같은 project lifecycle 동안 어떤 위험을 초래하는지 설계자는 인식하지 못하는 경우가 많다. 만일 설계자가 건물의 형상이 안전사고율에 미치는 영향과 이에 대응하는 안전관리비에 미치는 영향을 이해한다면, 효과적인 DFS를 진행할 수 있다. 안전관리비중 가장 많은 비중을 차지하는 낙하방지 그물망, 안전 펜스와 같은 안전시설비는 동일 건축면적이라 하더라도 건물의 형상에 따라 달라질 것이다. 본 연구의 목적은 건물의 외주길이가 안전관리비에 미치는 영향을 분석하는 것이다. 아파트(apartment building)를 대상으로 건물의 외주길이가 안전관리비에 미치는 영향을 분석한다. 본 연구를 위해 21개의 프로젝트 데이터를 수집한 후 외주길이와 건물형상계수, 건축면적을 독립변수로 안전관리비를 종속변수로 분석한다. 그 결과 외주길이와 안전관리비의 상관관계는 R²가 0.876, 형상계수와 안전관리비의 상관관계는 R²가 0.801, 건축면적과 안전관리비의 상관관계는 R²가 0.792로 매우 밀접한 관계가 있는 것으로 분석되었다.